Drug Discovery@nature.com 17 August 2012

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Access Nature Middle East - your free portal for news, features, jobs and events in the Arabic speaking world. www.nature.com/nmiddleeast Follow us: Facebook, Twitter, Google +   News Top Potential first-in-class osteoporosis drug speeds through trials doi:10.1038/nm0812-1158 Merck’s oral drug odanacatib inhibits the bone resorption enzyme cathepsin K and, if approved, will be the first in its class to reach the market. Full Text An Audience With: Jane Reese-Coulbourne doi:10.1038/nrd3812 The Reagan-Udall Foundation’s executive director talks to Asher Mullard about the organization’s existing and future projects. Full Text Study finds up to $5 billion in potential trial cost savings doi:10.1038/nm0812-1159b Extraneous procedures in clinical trials are costing the drug industry up to $5 billion each year, according to a new analysis from the Tufts University Center for the Study of Drug Development. Full Text Adult stem cell therapies walk the line doi:10.1038/nbt.2321 Tension between practitioners who believe autologous stem cells should be considered a service and the FDA, which considers some of them biologics, has come to a head in recent months. Full Text Analysis Top Hitting histone demethylases doi:10.1038/scibx.2012.805 A GSK–Structural Genomics Consortium team has identified the first potent and selective histone demethylase inhibitor and shown that the molecule dampens the macrophage inflammatory response. Full Text Fresh from the pipeline: Pasireotide doi:10.1038/nrd3788 In April 2012, pasireotide was granted European marketing authorization for the treatment of Cushing's disease, providing a new option for patients for whom surgery has failed. Full Text From the analyst's couch: A new dawn in the sleep disorders pipeline? doi:10.1038/nrd3789 This analysis article looks at the growing interest in novel molecular targets for sleep disorders, and the market opportunities in this area of significant unmet need. Full Text Research Highlights Top Cancer: PD1 makes waves in anticancer immunotherapy doi:10.1038/nrd3806 Two papers describe early-stage clinical trials of two monoclonal antibodies that target signalling through the T cell co-inhibitory receptor programmed cell death protein 1, suggesting that such antibodies might provide a new benchmark for anticancer immunotherapy. Full Text Metabolic disorders: New target for appetite control doi:10.1038/nrd3803 The G protein-coupled receptor GPR17 has been identified as a direct target of the forkhead box protein O1 transcription factor, which activates AGRP-expressing neurons to regulate food intake in mice. Full Text Neurodegenerative disorders: Reversing Huntington's disease doi:10.1038/nrd3804 New research shows that transient infusion of single-stranded antisense oligonucleotides in a mouse model results in sustained improvements in motor function and behaviour. Full Text Research & Reviews Top Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases doi:10.1038/nrd3800 This review looks at current and future drugs that may be available to treat a broad range of inflammation-related conditions by blocking interleukin-1. Full Text G protein-coupled receptors for energy metabolites as new therapeutic targets doi:10.1038/nrd3777 This review summarizes the functions of several recently discovered metabolite-sensing GPCRs and discusses the emerging pharmacological agents being developed to target these for metabolic disorders. Full Text A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response doi:10.1038/nature11262 A paper in Nature provides encouragement for designing small-molecule inhibitors to allow selective pharmacological intervention across the JMJ family. Full Text MDM4 is a key therapeutic target in cutaneous melanoma doi:10.1038/nm.2863 A paper in Nature Medicine identifies MDM4 as a key determinant of impaired p53 function in human melanoma and designates MDM4 as a promising target for antimelanoma combination therapy. Full Text Drug Discovery JOBS of the week 4 Tenure Track Positions-Diagnostics, Targeted Therapy, Imaging Guided Therapy, Drug Delivery Georgia State University Postdoctoral Research Associate - Drug Metabolism and Pharmacokinetics Scripps Fl Principal Investigator positions in Biological Chemistry & Drug Discovery University of Dundee, College of Life Sciences Institute Research Scientist � Drug Metabolism MD Anderson Cancer Center PhD studentship on large-scale quantum chemistry methods applied to drug discovery University of Southampton - Chemistry More Science jobs from Drug Discovery EVENT Orphan Drugs & Rare Diseases 08.-09.10.12 London, UK More science events from Careers Top Career snapshots archive Career snapshots feature people associated with drug discovery and drug development, with the aim of providing expert insights and advice on a wide range of positions and career paths in this field. 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