Nature Immunology Contents: September 2012 Volume 13 pp 797 - 899

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There's never been a better time to buy the best-in-class solution for bead-based immunoassays. bdbiosciences.com/go/c6beads Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Online-only personal subscriptions now available to Nature Immunology For only 49 USD/29 GBP/29 EUR Subscribe now!   Correspondence Top Reassessing genomic targeting of AID   pp797 - 798 Marc A Hogenbirk, Arno Velds, Ron M Kerkhoven and Heinz Jacobs doi:10.1038/ni.2367 See also: Correspondence by Yamane et al. Reply to "Reassessing genomic targeting of AID"   pp798 - 800 Arito Yamane, Wolfgang Resch, Michel Nussezweig and Rafael Casellas doi:10.1038/ni.2368 See also: Correspondence by Hogenbirk et al. Obituary Top Norman Letvin 1949-2012   p801 Andrew James McMichael doi:10.1038/ni.2399 Commentary Top Technical considerations for functional sequencing assays   pp802 - 807 Weihua Zeng and Ali Mortazavi doi:10.1038/ni.2407 News and Views Top Tumor immunity times out: TIM-3 and HMGB1   pp808 - 810 Daolin Tang and Michael T Lotze doi:10.1038/ni.2396 The characteristics of the tumor microenvironment vary widely. New work shows that after tumor-associated expression of the receptor TIM-3 by dendritic cells, TIM-3 inhibits the antitumor efficacy of DNA vaccines and chemotherapy by binding to the damage-associated molecular pattern molecule, HMGB1. See also: Article by Chiba et al. A voltage-gated sodium channel mediates positive selection of T cells   pp810 - 812 Bernard Malissen doi:10.1038/ni.2400 The activation of T cells requires the entry of calcium ions through the plasma membrane. A study now identifies a voltage-gated sodium channel as being essential for the sustained entry of calcium needed for the developmental process of positive selection. See also: Article by Lo et al. EPCR: a stress trigger for γδ T cells   pp812 - 814 Deborah A Witherden and Wendy L Havran doi:10.1038/ni.2398 The mechanism by which γδ T cells are triggered to respond to stress elicited by infection or malignancy has remained a mystery. New data identify endothelial protein C receptor as a stress ligand for γδ T cells that is induced by cytomegalovirus infection. See also: Article by Willcox et al. The yin and yang of CD1d recognition   pp814 - 815 Erin J Adams and Adrienne M Luoma doi:10.1038/ni.2401 Structural studies identify considerable differences in the recognition of CD1d-lipid complexes by the TCRs of type II and type I (invariant) natural killer T cells. See also: Article by Girardi et al. | Article by Patel et al. Immunology JOBS of the week Postdoctoral positions available in pharmaceutical immunology National Taiwan University Post-doctoral Fellow (S Nath) - Genetic epidemiology of Systemic Lupus Erythematosus (SLE) - Arthritis and Clinical Immunology Oklahoma Medical Research Foundation (OMRF) Postdoctoral Fellow - Beckman Research Institute - Immunology City of Hope Beckman Research Institute Postdoctoral fellow in molecular immunology City of Hope Microbiology Lab Assistant Kelly Scientific Resources More Science jobs from Immunology EVENT Frontiers in Basic Immunology: 2012 4th October - 5th October 2012 MD, US More science events from Research Highlights Top Tolerant mammals | Building an immune synapse | Location dictates function | Family heritage | Allosteric IgE recognition | Local immunity Review Top C-type lectin receptors orchestrate antifungal immunity   pp817 - 822 Sarah E Hardison and Gordon D Brown doi:10.1038/ni.2369 Articles Top The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB   pp823 - 831 Monika Schneider, Albert G Zimmermann, Reid A Roberts, Lu Zhang, Karen V Swanson, Haitao Wen, Beckley K Davis, Irving C Allen, Eda K Holl, Zhengmao Ye, Adeeb H Rahman, Brian J Conti, Timothy K Eitas, Beverly H Koller and Jenny P-Y Ting doi:10.1038/ni.2378 Sensors of the NLR family generally activate innate immunity. Ting et al., however, demonstrate that the little-known NLRC3 negatively regulates Toll-like receptor signaling by altering ubiquitination of the signaling adaptor TRAF6. Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1   pp832 - 842 Shigeki Chiba, Muhammad Baghdadi, Hisaya Akiba, Hironori Yoshiyama, Ichiro Kinoshita, Hirotoshi Dosaka-Akita, Yoichiro Fujioka, Yusuke Ohba, Jacob V Gorman, John D Colgan, Mitsuomi Hirashima, Toshimitsu Uede, Akinori Takaoka, Hideo Yagita and Masahisa Jinushi doi:10.1038/ni.2376 The receptor TIM-3 was initially identified as a negative regulator of T helper type 1 responses. Jinushi and colleagues now show it has high expression by tumor associated-dendritic cells, in which it perturbs immunogenic recognition of nucleic acids. See also: News and Views by Tang & Lotze TGF-β is responsible for NK cell immaturity during ontogeny and increased susceptibility to infection during mouse infancy   pp843 - 850 Jeffrey P Marcoe, James R Lim, Keri L Schaubert, Nassima Fodil-Cornu, Marsel Matka, Alexandra L McCubbrey, Alexander R Farr, Silvia M Vidal and Yasmina Laouar doi:10.1038/ni.2388 New-born and young mice are more susceptible to viral infections. Laouar and colleagues show this sensitivity is due in part to age-dependent TGF-β-mediated suppression of natural killer cell production. Type II natural killer T cells use features of both innate-like and conventional T cells to recognize sulfatide self antigens   pp851 - 856 Enrico Girardi, Igor Maricic, Jing Wang, Thien-Thi Mac, Pooja Iyer, Vipin Kumar and Dirk M Zajonc doi:10.1038/ni.2371 Natural killer T cells (NKT cells) recognize lipid antigens presented by CD1d. Zajonc and Rossjohn and their colleagues describe molecular interactions between type II NKT cell antigen receptors and CD1d-ligand complexes, which demonstrate distinct modes of recognition used by the receptors. See also: News and Views by Adams & Luoma Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptor   pp857 - 863 Onisha Patel, Daniel G Pellicci, Stephanie Gras, Maria L Sandoval-Romero, Adam P Uldrich, Thierry Mallevaey, Andrew J Clarke, Jérôme Le Nours, Alex Theodossis, Susanna L Cardell, Laurent Gapin, Dale I Godfrey and Jamie Rossjohn doi:10.1038/ni.2372 Natural killer T cells (NKT cells) recognize lipid antigens presented by CD1d. Zajonc and Rossjohn and their colleagues describe molecular interactions between type II NKT cell antigen receptors and CD1d-ligand complexes, which demonstrate distinct modes of recognition used by the receptors. See also: News and Views by Adams & Luoma Mouse Hobit is a homolog of the transcriptional repressor Blimp-1 that regulates NKT cell effector differentiation   pp864 - 871 Klaas P J M van Gisbergen, Natasja A M Kragten, Kirsten M L Hertoghs, Felix M Wensveen, Stipan Jonjic, Jörg Hamann, Martijn A Nolte and Rene A W van Lier doi:10.1038/ni.2393 Van Gisbergen and colleagues report that Hobit, a homolog of the transcription factor Blimp-1, controls the maintenance of mature mouse natural killer T cells and regulates their effector functions in a species-specific way. Cytomegalovirus and tumor stress surveillance by binding of a human γδ T cell antigen receptor to endothelial protein C receptor   pp872 - 879 Carrie R Willcox, Vincent Pitard, Sonia Netzer, Lionel Couzi, Mahboob Salim, Tobias Silberzahn, Jean-François Moreau, Adrian C Hayday, Benjamin E Willcox and Julie Déchanet-Merville doi:10.1038/ni.2394 How γδ T cells 'see' antigen is poorly defined. Dechanet-Merville and colleagues demonstrate that a subset of γδ T cells functionally recognize the stress-associated self molecule EPCR on both virus-infected and transformed cells. See also: News and Views by Witherden & Havran A voltage-gated sodium channel is essential for the positive selection of CD4+ T cells   pp880 - 887 Wan-Lin Lo, David L Donermeyer and Paul M Allen doi:10.1038/ni.2379 Calcium signals are required for thymocyte positive selection. Allen and colleagues show that thymic selecting ligands induce SCN5a-SCN4b voltage-gated sodium channels and sustained calcium influx necessary for CD4+ selection. See also: News and Views by Malissen Resource Top Deciphering the transcriptional network of the dendritic cell lineage   pp888 - 899 Jennifer C Miller, Brian D Brown, Tal Shay, Emmanuel L Gautier, Vladimir Jojic, Ariella Cohain, Gaurav Pandey, Marylene Leboeuf, Kutlu G Elpek, Julie Helft, Daigo Hashimoto, Andrew Chow, Jeremy Price, Melanie Greter, Milena Bogunovic, Angelique Bellemare-Pelletier, Paul S Frenette, Gwendalyn J Randolph, Shannon J Turley, Miriam Merad and the Immunological Genome Consortium doi:10.1038/ni.2370 The transcriptional regulation of commitment to the dendritic cell (DC) lineage and functional specialization of DCs in vivo is poorly understood. In this Resource, Merad and colleagues identify the lineage relationships among various tissue DC subsets. Top Advertisement Mucosal Immunology's new impact factor is 6.963! Thank you to all our authors, readers, editors, and reviewers for their contributions and support. 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