| Can't view this email? Click here to view in your browser. | | | | Volume 488 Number 7412 | | | nature | | The science that matters. Every week. | | | | | | |
| | |
| Jump to the content that matters to you | | | | |
| | | | | Rate of de novo mutations and the importance of father's age to disease risk | A study of mutation rate in 78 Icelandic parent-offspring trios shows that the age of the father at conception is a dominant factor in determining the number of de novo mutations in the child. Taken together with the previous results, these findings emphasize the importance of a father's age for the risk of their offspring developing schizophrenia and autism. | | | | | | | | | Long-term decline of global atmospheric ethane concentrations and implications for methane | Ethane is the most abundant non-methane hydrocarbon in the remote atmosphere and is a precursor to tropospheric ozone. This paper presents the longest continuous record of global atmospheric ethane levels and finds that global ethane emission rates decreased by 21% between 1984 and 2010. This decline can be attributed to reduced emissions from fossil fuel sources. Ethane's major emission sources are shared with methane, suggesting that reduced fugitive fossil fuel emissions also account for much of the decrease in methane's global emissions. | | | | | | | | | The protein kinase Pstol1 from traditional rice confers tolerance of phosphorus deficiency | Rice is a staple crop for much of Asia but rice yields in the region are often low due to limited availability of phosphorus. Sigrid Heuer and colleagues report the characterization of a gene, phosphorus-starvation tolerance 1 (PSTOL1), that confers tolerance to phosphorus deficiency. The gene is present in the traditional rice variety Kasalath but absent from many modern varieties. PSTOL1 enhances early root growth, enabling plants to acquire more phosphorus and other nutrients. Introduction of this gene into locally adapted rice varieties should enhance productivity in poor soils. | | | | | | | | | | | | | | | Nurture your career with the new-look Naturejobs As the world's largest dedicated jobs boards for the scientific community, Naturejobs is the ideal resource to build your career. Our new and improved functionality enables you to search, save and apply for jobs quickly and easily. Search over 10,000 vacancies to find exactly the right job for you at: www.naturejobs.com | | | | | | | | | | | | | | | In this week's podcast: how dad's age can affect baby's risk of disease, the effects of antibiotics in early life, and the latest on the Himalayan glaciers. | | | | | | |
| | | | | | | | | | | | | | | | | Social dimensions to biodiversity ▶ | | | The international body set up to address the loss of biodiversity must take account of more than just science if it is to fulfil its mission. | | | | | | | | The name game ▶ | | | Nomenclature rules can disrupt planetary scientists' fun, but they serve a purpose. | | | | | | | | | | | | | | | | | Seven days: 17–23 August 2012 ▶ | | | The week in science: Gene patents upheld again; NASA picks next Mars mission; and Australia's plans to control tobacco survive legal challenge. | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| | | | | | | | | | | | | | | | | | | Antibiotics in early life alter the murine colonic microbiome and adiposity ▶ | | | Ilseung Cho, Shingo Yamanishi, Laura Cox, Barbara A. Methé, Jiri Zavadil et al. | | | Treatment of young mice with low levels of antibiotics results in increases in adiposity and causes both a change in the composition of the intestinal microbial community and an alteration in the activity of microbial metabolic pathways, leading to increased short-chain fatty acid production. | | | | | | | | | | | T cells become licensed in the lung to enter the central nervous system ▶ | | | Francesca Odoardi, Christopher Sie, Kristina Streyl, Vijay K. Ulaganathan, Christian Schläger et al. | | | A Lewis rat model of experimental autoimmune encephalomyelitis is used to show that on their way to the CNS, encephalitogenic T-cell blasts are temporarily resident in the lung, where they reprogram their gene-expression profile and functional properties to enable them to transgress the blood–brain barrier into the CNS. | | | | | | | | Endogenous antigen tunes the responsiveness of naive B cells but not T cells ▶ | | | Julie Zikherman, Ramya Parameswaran & Arthur Weiss | | | Mature B cells encounter antigens during development that induce anergy or functional unresponsiveness; this large reservoir of dormant autoreactive B cells may serve as a pool of extended antibody specificity for purposes of protective immunity, as well as the source of pathogenic autoantibodies that characterize rheumatic diseases such as systemic lupus erythematosus. | | | | | | | | | | | Dopamine neurons modulate pheromone responses in Drosophila courtship learning ▶ | | | Krystyna Keleman, Eleftheria Vrontou, Sebastian Krüttner, Jai Y. Yu, Amina Kurtovic-Kozaric et al. | | | Young male fruitflies learn to avoid futile courtship of non-virgin females because the latter are scented with the male pheromone cis-vaccenyl acetate; this behaviour results from an increase in the males’ innate sensitivity for the pheromone and is controlled by a small set of dopaminergic neurons. | | | | | | | | | | | | | | Rate of de novo mutations and the importance of father’s age to disease risk ▶ | | | Augustine Kong, Michael L. Frigge, Gisli Masson, Soren Besenbacher, Patrick Sulem et al. | | | Whole-genome sequencing of 78 Icelandic parent–offspring trios is used to study the de novo mutation rate at the genome-wide level; the rate is shown to increase by about two mutations a year as a function of the increasing age of the father at conception, highlighting the importance of father’s age on the risk of diseases such as autism and schizophrenia. | | | | | | | | Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis ▶ | | | Chi-Hong Wu, Claudia Fallini, Nicola Ticozzi, Pamela J. Keagle, Peter C. Sapp et al. | | | Mutations in the profilin 1 (PFN1) gene, which is crucial for the conversion of monomeric to filamentous actin, can cause familial amyotrophic lateral sclerosis, suggesting that alterations in cytoskeletal pathways contribute to disease pathogenesis. | | | | | | | | | | | | | | A subset of dopamine neurons signals reward for odour memory in Drosophila ▶ | | | Chang Liu, Pierre-Yves Plaçais, Nobuhiro Yamagata, Barret D. Pfeiffer, Yoshinori Aso et al. | | | A group of dopamine neurons that are distinct from those mediating aversive reinforcement is found to signal sugar reward in the fly brain, highlighting the evolutionarily conserved function of dopamine neurons in reward processing. | | | | | | | | | | | | | | Defining the mode of tumour growth by clonal analysis ▶ | | | Gregory Driessens, Benjamin Beck, Amélie Caauwe, Benjamin D. Simons & Cédric Blanpain | | | Using genetic lineage tracing, tumour cells are traced in vivo in an unperturbed solid tumour; in a carcinogen-induced papilloma mouse model, cells in these benign lesions are found to mirror the clonal hierarchy organization of normal tissue. | | | | | | | | NRT/PTR transporters are essential for translocation of glucosinolate defence compounds to seeds ▶ | | | Hussam Hassan Nour-Eldin, Tonni Grube Andersen, Meike Burow, Svend Roesen Madsen, Morten Egevang Jørgensen et al. | | | Two high-affinity proton-dependent transporters of glucosinolates have been identified in Arabidopsis and termed GTR1 and GTR2; these transporters are essential for transporting glucosinolates to seeds, offering a means to control the allocation of defence compounds in a tissue-specific manner, which may have agricultural biotechnology implications. | | | | | | | | The protein kinase Pstol1 from traditional rice confers tolerance of phosphorus deficiency ▶ | | | Rico Gamuyao, Joong Hyoun Chin, Juan Pariasca-Tanaka, Paolo Pesaresi, Sheryl Catausan et al. | | | A gene that is present in phosphate-deficiency-tolerant rice but absent from modern rice varieties is characterized and named phosphorus-starvation tolerance 1 (PSTOL1); overexpression of PSTOL1 in rice species that naturally lack this gene confers tolerance to low phosphorus conditions, a finding that may have implications for agricultural productivity in rice-growing countries. | | | | | | | | The human CST complex is a terminator of telomerase activity ▶ | | | Liuh-Yow Chen, Sophie Redon & Joachim Lingner | | | The human CST complex is shown to interact with the telomeric primer and the POT1–TPP1 complex to inhibit telomerase activity in late S phase, thereby keeping unrestrained telomere lengthening in check. | | | | | | | | | | | | | | | | | | | | | | | Brief Communications Arising | | | | | | | | | | | | | | Yeretssian et al. reply ▶ | | | Garabet Yeretssian, Ricardo G. Correa, Karine Doiron, Patrick Fitzgerald, Christopher P. Dillon et al. | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| | | | | | | For the 5th year running, Nature will be sponsoring the 'Scientific Merit' and 'Audience' awards at the Imagine Science Film Festival (ISFF). For information, or to submit your film and compete for the $2,500 Nature Scientific Merit Award and the $1,000 Nature Audience Award. www.imaginesciencefilms.org/festival/submit-your-film | | | | | | | | |
| | | | | | | | | | | | | | | | | | | | | | Room-temperature ferroelectricity in supramolecular networks of charge-transfer complexes ▶ | | | Alok S. Tayi, Alexander K. Shveyd, Andrew C.-H. Sue, Jodi M. Szarko, Brian S. Rolczynski et al. | | | Organic ferroelectrics with switchable electrical polarization would be an attractive prospect for applications if their Curie temperature—below which these materials display ferroelectric behaviour—could be raised to room temperature or above; this goal has now been achieved with a family of organic materials characterized by a supramolecular structural motif. | | | | | | | | Long-term decline of global atmospheric ethane concentrations and implications for methane ▶ | | | Isobel J. Simpson, Mads P. Sulbaek Andersen, Simone Meinardi, Lori Bruhwiler, Nicola J. Blake et al. | | | The longest continuous record of global atmospheric ethane levels is presented, showing that global ethane emission rates decreased by 21 per cent from 1984 to 2010, probably owing to decreased venting and flaring of natural gas in oil fields; decreased venting and flaring also account for at least 30 to 70 per cent of the decrease in methane emissions over the same period. | | | | | | | | The human CST complex is a terminator of telomerase activity ▶ | | | Liuh-Yow Chen, Sophie Redon & Joachim Lingner | | | The human CST complex is shown to interact with the telomeric primer and the POT1–TPP1 complex to inhibit telomerase activity in late S phase, thereby keeping unrestrained telomere lengthening in check. | | | | | | | | Brief Communications Arising | | | | | | | | | | | | | | Yeretssian et al. reply ▶ | | | Garabet Yeretssian, Ricardo G. Correa, Karine Doiron, Patrick Fitzgerald, Christopher P. Dillon et al. | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Recent Antarctic Peninsula warming relative to Holocene climate and ice-shelf history ▶ | | | Robert Mulvaney, Nerilie J. Abram, Richard C. A. Hindmarsh, Carol Arrowsmith, Louise Fleet et al. | | | An ice-core record from the northeastern Antarctic Peninsula shows that the present warming period in the region is unusual in the context of natural climate variability over the past two thousand years, and that continued warming could cause ice-shelf instability farther south along the peninsula. | | | | | | | | | | | Non-classical light generated by quantum-noise-driven cavity optomechanics ▶ | | | Daniel W. C. Brooks, Thierry Botter, Sydney Schreppler, Thomas P. Purdy, Nathan Brahms et al. | | | The effect of quantum radiation-pressure fluctuations on the collective motion of ultracold atoms is observed in a cavity-optomechanical system, and the back-action of this motion on the cavity light field is shown to produce sub-shot-noise optical squeezing. | | | | | | | | Exciton condensation and perfect Coulomb drag ▶ | | | D. Nandi, A. D. K. Finck, J. P. Eisenstein, L. N. Pfeiffer & K. W. West | | | An electronic current flowing in one conductor can induce a drag current in another spatially separated conductor by means of Coulomb interactions; when these interactions are sufficiently strong the currents become equal and the drag therefore ‘perfect’, as shown here for a bilayer two-dimensional electron system. | | | | | | | | Room-temperature ferroelectricity in supramolecular networks of charge-transfer complexes ▶ | | | Alok S. Tayi, Alexander K. Shveyd, Andrew C.-H. Sue, Jodi M. Szarko, Brian S. Rolczynski et al. | | | Organic ferroelectrics with switchable electrical polarization would be an attractive prospect for applications if their Curie temperature—below which these materials display ferroelectric behaviour—could be raised to room temperature or above; this goal has now been achieved with a family of organic materials characterized by a supramolecular structural motif. | | | | | | | | Long-term decline of global atmospheric ethane concentrations and implications for methane ▶ | | | Isobel J. Simpson, Mads P. Sulbaek Andersen, Simone Meinardi, Lori Bruhwiler, Nicola J. Blake et al. | | | The longest continuous record of global atmospheric ethane levels is presented, showing that global ethane emission rates decreased by 21 per cent from 1984 to 2010, probably owing to decreased venting and flaring of natural gas in oil fields; decreased venting and flaring also account for at least 30 to 70 per cent of the decrease in methane emissions over the same period. | | | | | | | | Contrasting patterns of early twenty-first-century glacier mass change in the Himalayas ▶ | | | Andreas Kääb, Etienne Berthier, Christopher Nuth, Julie Gardelle & Yves Arnaud | | | Data for the Hindu Kush–Karakoram–Himalaya region from satellite laser altimetry and a global elevation model shows that glacier thinning varied by an order of magnitude across the region, with surface debris not seeming to provide effective insulation, and that the melting ice added several per cent to the annual discharge of the mountain rivers. | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Recent Antarctic Peninsula warming relative to Holocene climate and ice-shelf history ▶ | | | Robert Mulvaney, Nerilie J. Abram, Richard C. A. Hindmarsh, Carol Arrowsmith, Louise Fleet et al. | | | An ice-core record from the northeastern Antarctic Peninsula shows that the present warming period in the region is unusual in the context of natural climate variability over the past two thousand years, and that continued warming could cause ice-shelf instability farther south along the peninsula. | | | | | | | | | | | Long-term decline of global atmospheric ethane concentrations and implications for methane ▶ | | | Isobel J. Simpson, Mads P. Sulbaek Andersen, Simone Meinardi, Lori Bruhwiler, Nicola J. Blake et al. | | | The longest continuous record of global atmospheric ethane levels is presented, showing that global ethane emission rates decreased by 21 per cent from 1984 to 2010, probably owing to decreased venting and flaring of natural gas in oil fields; decreased venting and flaring also account for at least 30 to 70 per cent of the decrease in methane emissions over the same period. | | | | | | | | Contrasting patterns of early twenty-first-century glacier mass change in the Himalayas ▶ | | | Andreas Kääb, Etienne Berthier, Christopher Nuth, Julie Gardelle & Yves Arnaud | | | Data for the Hindu Kush–Karakoram–Himalaya region from satellite laser altimetry and a global elevation model shows that glacier thinning varied by an order of magnitude across the region, with surface debris not seeming to provide effective insulation, and that the melting ice added several per cent to the annual discharge of the mountain rivers. | | | | | | | | The protein kinase Pstol1 from traditional rice confers tolerance of phosphorus deficiency ▶ | | | Rico Gamuyao, Joong Hyoun Chin, Juan Pariasca-Tanaka, Paolo Pesaresi, Sheryl Catausan et al. | | | A gene that is present in phosphate-deficiency-tolerant rice but absent from modern rice varieties is characterized and named phosphorus-starvation tolerance 1 (PSTOL1); overexpression of PSTOL1 in rice species that naturally lack this gene confers tolerance to low phosphorus conditions, a finding that may have implications for agricultural productivity in rice-growing countries. | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| | |
|
| | | | | | | | | | | | | | | | | | | | | Careers related news & comment | | | | | | | | | | | | |
| | | naturejobs.com Science jobs of the week | | | | | | | | | | | | | | | No matter what your career stage, student, postdoc or senior scientist, you will find articles on naturejobs.com to help guide you in your science career. Keep up-to-date with the latest sector trends, vote in our reader poll and sign-up to receive the monthly Naturejobs newsletter. | | | | | | | • Nature events featured events | | | | | | natureevents featured events | | | | | | | Nature events is the premier resource for scientists looking for the latest scientific conferences, courses, meetings and symposia. Featured across Nature Publishing Group journals and centrally at natureevents.com it is an essential reference guide to scientific events worldwide. | | | | |
| | | | | | | | | | | | Your email address is in the Nature mailing list. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact subscriptions@nature.com For other enquiries, please contact feedback@nature.com | Nature Publishing Group | 75 Varick Street, 9th floor | New York | NY 10013-1917 | USA
Nature Publishing Group's offices: Principal offices: London - New York - Tokyo Worldwide offices: Basingstoke - Boston - Buenos Aires - Delhi - Hong Kong - Madrid - Melbourne - Munich - Paris - San Francisco - Seoul - Washington DC
Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2012 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. | | | |
No comments:
Post a Comment