The EMBO Journal - Table of Contents alert Volume 31 Issue 14

TABLE OF CONTENTS 18 July 2012 | Volume 31, Issue 14 Have you seen? Review Articles Corrigenda Also new AOP Advertisement WHET YOUR APP-ETITE - Arteriosclerosis, Thrombosis, and Vascular Biology for the iPad®. Research that's critical to your profession is now brought to you on the iPad. Sample issue is available - click here to download the app for free today! Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement A balancing act: aneuploidy in focus - A new review series in EMBO reports Substantial efforts have been made to understand chromosomal aneuploidy, which causes a range of serious health issues, including cancer. EMBO reports asked ten leading researchers to analyze recent advances in this field in a new series of four Review articles. Access the focus online today.   Have you seen? Top Microtubule deacetylation sets the stage for successful axon regeneration Yongchol Cho and Valeria Cavalli uncover a novel role for HDAC5-mediated microtubule deacetylation in axon regeneration. HDAC5 is locally activated by PKC downstream of axotomy-induced calcium influx. Li Chen and Melissa M Rolls The EMBO Journal (2012), 31, 3033 - 3035; 10.1038/emboj.2012.175 Abstract | Full text | PDF | Related article Published online: 26 June 2012 NURDs are required for diversity NURD was recently shown to functionally recruit PRC2 to a set of common target genes. A new study in Cell Stem Cell reveals a crucial role for NURD in embryonic stem cell lineage commitment by regulating the transcriptional heterogeneity of pluripotency factors. Thomas G Fazzio and Oliver J Rando The EMBO Journal (2012), 31, 3036 - 3037; 10.1038/emboj.2012.137 Abstract | Full text | PDF | Related article Published online: 11 May 2012 Review Top Mitochondrial dysfunction in Parkinson’s disease: molecular mechanisms and pathophysiological consequences Konstanze Winklhofer and colleagues review the various aspects of mitochondrial biology that is affected in Parkinson’s disease including mitochondrial biogenesis, bioenergetics, dynamics, transport, and quality control. Nicole Exner, Anne Kathrin Lutz, Christian Haass and Konstanze F Winklhofer The EMBO Journal (2012), 31, 3038 - 3062; 10.1038/emboj.2012.170 Abstract | Full text | PDF Published online: 26 June 2012 Articles Top HDAC5 is a novel injury-regulated tubulin deacetylase controlling axon regeneration Axon injury induces calcium influx that leads to PKC-mediated activation of HDAC5. Activated HDAC5, at site of injury, promotes tubulin deacetylation and microtubule stability to regulate axon regeneration in vivo. Yongcheol Cho and Valeria Cavalli The EMBO Journal (2012), 31, 3063 - 3078; 10.1038/emboj.2012.160 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 12 June 2012 The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers Transcriptome and proteome analyses of Lgr5-positive intestinal cells define the signature of bona fide intestinal stem cells (ISCs) population. These results offer further insight into the nature of ISCs and will instruct further research on this therapeutically highly relevant topic. Javier Muñoz, Daniel E Stange, Arnout G Schepers, Marc van de Wetering, Bon-Kyoung Koo, Shalev Itzkovitz, Richard Volckmann, Kevin S Kung, Jan Koster, Sorina Radulescu, Kevin Myant, Rogier Versteeg, Owen J Sansom, Johan H van Es, Nick Barker, Alexander van Oudenaarden, Shabaz Mohammed, Albert J R Heck and Hans Clevers The EMBO Journal (2012), 31, 3079 - 3091; 10.1038/emboj.2012.166 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 12 June 2012 Inactivation of Rb in stromal fibroblasts promotes epithelial cell invasion Cancer-associated fibroblasts (CAFs) promote invasiveness in epithelial tumour cells via a cell non-autonomous mechanism involving reduced levels of retinoblastoma activity. This effect is caused in part by the secretion of keratinocyte growth factor by CAFs, which activates MMP-1 through Akt and Ets2. Adam Pickard, Ann-Christin Cichon, Anna Barry, Declan Kieran, Daksha Patel, Peter Hamilton, Manuel Salto-Tellez, Jacqueline James and Dennis J McCance The EMBO Journal (2012), 31, 3092 - 3103; 10.1038/emboj.2012.153 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 29 May 2012 Identification of a novel Wnt5a–CK1ε–Dvl2–Plk1-mediated primary cilia disassembly pathway Cilia defects are associated with various disorders. The identification of Plk1 and Dvl2 as regulators of HEF1/Aurora-A-mediated cilia disassembly offers novel molecular insights into cilia-dynamics and their coordination with the cell-division cycle. Kyung Ho Lee, Yoshikazu Johmura, Li-Rong Yu, Jung-Eun Park, Yuan Gao, Jeong K Bang, Ming Zhou, Timothy D Veenstra, Bo Yeon Kim and Kyung S Lee The EMBO Journal (2012), 31, 3104 - 3117; 10.1038/emboj.2012.144 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 18 May 2012 GPCR activation of Ras and PI3Kγ in neutrophils depends on PLCβ2/β3 and the RasGEF RasGRP4 RasGRP4, a RasGEF, is the missing link between GPCR-mediated activation of Ras and PI3Kγ in pro-inflammatory signalling in mouse and human neutrophils. Sabine Suire, Charlotte Lécureuil, Karen E Anderson, George Damoulakis, Izabella Niewczas, Keith Davidson, Hervé Guillou, Dingxin Pan, Jonathan Clark, Phillip T Hawkins and Len Stephens The EMBO Journal (2012), 31, 3118 - 3129; 10.1038/emboj.2012.167 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 22 June 2012 The B-cell identity factor Pax5 regulates distinct transcriptional programmes in early and late B lymphopoiesis Genome-wide sequencing approaches reveal that the transcription factor Pax5 controls the identity and function of B cells by regulating the expression of distinct target genes in pro-B and mature B cells. Roger Revilla-i-Domingo, Ivan Bilic, Bojan Vilagos, Hiromi Tagoh, Anja Ebert, Ido M Tamir, Leonie Smeenk, Johanna Trupke, Andreas Sommer, Markus Jaritz and Meinrad Busslinger The EMBO Journal (2012), 31, 3130 - 3146; 10.1038/emboj.2012.155 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 05 June 2012 Coordinated signal integration at the M-type potassium channel upon muscarinic stimulation Neurotransmitters govern the action potential threshold of M-channels, encoded by the KCNQ gene family. Muscarine promotes PKC-mediated phosphorylation of KCNQ2 to regulate calmodulin binding, which determines PIP2 affinity and channel activity. Anastasia Kosenko, Seungwoo Kang, Ida M Smith, Derek L Greene, Lorene K Langeberg, John D Scott and Naoto Hoshi The EMBO Journal (2012), 31, 3147 - 3156; 10.1038/emboj.2012.156 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 29 May 2012 Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons BACE1 (β-secretase) mediates plasma membrane shedding of the amyloid precursor protein (APP), the first step in the generation of A(β) peptide in Alzheimer’s disease. A novel quantitative secretome technique identifies physiological substrates of BACE1, pointing to a central function of the protease in neurite outgrowth and synapse formation. Peer-Hendrik Kuhn, Katarzyna Koroniak, Sebastian Hogl, Alessio Colombo, Ulrike Zeitschel, Michael Willem, Christiane Volbracht, Ute Schepers, Axel Imhof, Albrecht Hoffmeister, Christian Haass, Steffen Roßner, Stefan Bräse and Stefan F Lichtenthaler The EMBO Journal (2012), 31, 3157 - 3168; 10.1038/emboj.2012.173 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 22 June 2012 Glutathione redox potential in the mitochondrial intermembrane space is linked to the cytosol and impacts the Mia40 redox state Glutathione pools in the cytosol and mitochondrial intermembrane space (IMS) are connected. Interestingly, the redox state of Glutathione in the IMS is mainly regulated by the cytosolic Glutathione reductase system, which directly impinges on the activity of IMS enzymes such as Mia40. Kerstin Kojer, Melanie Bien, Heike Gangel, Bruce Morgan, Tobias P Dick and Jan Riemer The EMBO Journal (2012), 31, 3169 - 3182; 10.1038/emboj.2012.165 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 15 June 2012 Structure of human POFUT2: insights into thrombospondin type 1 repeat fold and O-fucosylation This study presents the first crystal structure of human O-fucosyltransferase 2 bound to its substrate, the thrombospondin type I repeat present in numerous proteins. Functional analysis provides insight into the catalytic mechanism generating this post-translational modification and structure encoded substrate specificity. Chun-I Chen, Jeremy J Keusch, Dominique Klein, Daniel Hess, Jan Hofsteenge and Heinz Gut The EMBO Journal (2012), 31, 3183 - 3197; 10.1038/emboj.2012.143 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 15 May 2012 A MatP–divisome interaction coordinates chromosome segregation with cell division in E. coli The major chromosome organizer MatP interacts with the cytokinetic ring protein ZapB to position chromosomal domains, shedding light on the coordination of chromosome replication and cell division in bacteria. Olivier Espéli, Romain Borne, Pauline Dupaigne, Axel Thiel, Emmanuelle Gigant, Romain Mercier and Frédéric Boccard The EMBO Journal (2012), 31, 3198 - 3211; 10.1038/emboj.2012.128 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 11 May 2012 HPV-16 E2 contributes to induction of HPV-16 late gene expression by inhibiting early polyadenylation The human papillomavirus (HPV) protein E2 induces a read-through of the early transcript polyadenylation signal by disrupting the CPSF polyadenylation complex. Thus, E2 allows the expression of the L1 and L2 late mRNAs while reducing the expression of early genes, including the pro-mitotic E6 and E7. Cecilia Johansson, Monika Somberg, Xiaoze Li, Ellenor Backström Winquist, Joanna Fay, Fergus Ryan, David Pim, Lawrence Banks and Stefan Schwartz The EMBO Journal (2012), 31, 3212 - 3227; 10.1038/emboj.2012.147 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 22 May 2012 Corrigenda Top Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis Eiji Morita, Virginie Sandrin, Hyo-Young Chung, Scott G Morham, Steven P Gygi, Christopher K Rodesch and Wesley I Sundquist The EMBO Journal (2012), 31, 3228; 10.1038/emboj.2012.184 Full text | PDF Published online: 18 July 2012 Codanin-1, mutated in the anaemic disease CDAI, regulates Asf1 function in S-phase histone supply Katrine Ask, Zuzana Jasencakova, Patrice Menard, Yunpeng Feng, Geneviève Almouzni and Anja Groth The EMBO Journal (2012), 31, 3229; 10.1038/emboj.2012.187 Full text | PDF Published online: 18 July 2012 Advertisement Nature Genetics and the Wellcome Trust present: The Genomics of Common Diseases 2012 September 19-22, 2012 - Potomac, MD, USA Keynote Speakers: Francis Collins (National Institutes of Health, USA), Thomas Hudson (Ontario Institute for Cancer Research, Canada), Neil Risch (University of California, San Francisco, USA), Sarah Tishkoff (University of Pennsylvania School of Medicine, USA) Register today!   Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to The EMBO Journal. 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