Nature Reviews Genetics Contents August 2012 Volume 13 Number 8 pp 517 - 594

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TABLE OF CONTENTS
August 2012 Volume 13 Number 8		Advertisement
Impact Factor 38.075 *	In this issue Research Highlights Reviews Perspectives Also this month Article series: Disease mechanisms Study designs Applications of next-generation sequencing  Featured article: Genetic architectures of psychiatric disorders: the emerging picture and its implications Patrick F. Sullivan, Mark J. Daly & Michael O'Donovan	Get the most from your NGS data with Sequenom’s MassARRAY® system • Validate from tens to thousands of samples across tens to hundreds of SNPs • Design you own assays against any SNP of interest • Run a variety of applications including genotyping, DNA methylation and somatic mutation analysis
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RESEARCH HIGHLIGHTS Top Epigenetics: Detecting the dynamics and memory of heterochromatin p517 | doi:10.1038/nrg3283 PDF Alternative splicing: Proteomic rewiring through transcriptomic diversity p518 | doi:10.1038/nrg3288 PDF Small RNAs: piRNA surveillance in the C. elegans germline p518 | doi:10.1038/nrg3289 PDF DNA methylation: In vivo enzyme action p520 | doi:10.1038/nrg3284 PDF Cancer genomics: Indicators for drug response from sequencing p520 | doi:10.1038/nrg3285 PDF Telomeres: Stem cells, cancer and telomerase linked by WNT p521 | doi:10.1038/nrg3286 PDF Evolution: The birth of new genes p521 | doi:10.1038/nrg3287 PDF IN BRIEF Development: Retroviruses as cell fate regulators | Microbiology: The Human Microbiome Project | Genetic interactions: Improved yield through interaction studies under different conditions | Gene regulation: Transcription factors slide to find binding sites in vivo | Ageing: Longevity by design | Gene expression: Transcriptional roles for DNA repair factors | Pathogen genomics: Within-host sequencing of malaria parasites | Evolutionary genomics: The genomic landscape of maize PDF Genetics JOBS of the week Postdoctoral Fellowship in Statistical Genetics University of Texas Southwestern Medical Center at Dallas Postdoc : yeast genetics, microfluidics, live cell imaging IGBMC / CNRS Position in Human Genetics / Molecular Biology Mayo Clinic Florida Postdoc in quantitative / population genetics Aarhus University - Denmark Chair in Population Genetics Department of Epidemiology Tulane University More Science jobs from Genetics EVENT 25th Annual Mouse Molecular Genetics Conference 02.-06.10.12 CA, US More science events from
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REVIEWS		Top
Computational tools for prioritizing candidate genes: boosting disease gene discovery Yves Moreau & Léon-Charles Tranchevent p523 | doi:10.1038/nrg3253 Various studies (such as genetic linkage or 'omics'-based approaches) generate large lists of candidate genes, of which only a minority may be biologically relevant for a phenotype or disease of interest. This Review discusses computational tools for gene prioritization, emphasizing key considerations for how biologists can incorporate these tools into their research, and it includes hands-on tutorials. Abstract | Full Text | PDF | Supplementary information
Article series: Disease mechanisms Genetic architectures of psychiatric disorders: the emerging picture and its implications Patrick F. Sullivan, Mark J. Daly & Michael O'Donovan p537 | doi:10.1038/nrg3240 This Review considers recent findings — from genome-wide association studies, structural variant studies and exome sequencing — about the genetics of nine psychiatric disorders. The authors evaluate the implications of our current picture of the genetic architectures of these conditions for future research strategies. Abstract | Full Text | PDF | Supplementary information
Article series: Study designs Studying and modelling dynamic biological processes using time-series gene expression data Ziv Bar-Joseph, Anthony Gitter & Itamar Simon p552 | doi:10.1038/nrg3244 Biological processes are inherently dynamic and therefore capturing data about gene expression at multiple time points can provide valuable insights into biological systems. This Review discusses experimental and analytical considerations for studies of gene expression dynamics, and the possibilities for integration with other data sets. Abstract | Full Text | PDF
Article series: Applications of next-generation sequencing De novo mutations in human genetic disease Joris A. Veltman & Han G. Brunner p565 | doi:10.1038/nrg3241 Recent family-based genomic studies are providing a window into the incidence of new mutations in human genomes. This Review discusses our understanding of various types of de novo mutation, including the determinants and consequences of their occurrence rates, and the challenges both for their detection and for linking them to disease pathogenesis. Abstract | Full Text | PDF
Article series: Disease mechanisms Genetics of osteoporosis from genome-wide association studies: advances and challenges J. Brent Richards, Hou-Feng Zheng & Tim D. Spector p576 | doi:10.1038/nrg3228 Genome-wide association studies have recently furthered the understanding of the genetics of osteoporosis. The authors here present the major findings from these studies, the pathways that have been highlighted in the progress of the disease and strategies for future diagnosis and therapy development. Abstract | Full Text | PDF
PERSPECTIVES		Top
VIEWPOINT The place of genetics in ageing research Nir Barzilai, Leonard Guarente, Thomas B. L. Kirkwood, Linda Partridge, Thomas A. Rando & P. Eline Slagboom p589 | doi:10.1038/nrg3290 Is ageing in our genes? In this Viewpoint, six experts present their views on the extent to which ageing is genetic and discuss future strategies for research into ageing and longevity. Abstract | Full Text | PDF
Erratum: Transcriptome-wide N 6-methyladenosine analysis Hannah Stower p594 | doi:10.1038/nrg3292 Full Text | PDF
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*2011 Journal Citation Report (Thomson Reuters, 2012)

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