Nature Reviews Molecular Cell Biology contents August 2012 Volume 13 Number 8 pp477-535

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TABLE OF CONTENTS
August 2012 Volume 13 Number 8
Impact Factor 39.123 *	In this issue Research Highlights Progress Reviews Also this month Article series: Post-translational modifications  Featured article: Atypical ubiquitylation — the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages Yogesh Kulathu & David Komander
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RESEARCH HIGHLIGHTS Top Small RNAs: Transmitting silence through generations p477 | doi:10.1038/nrm3406 Silencing established by both endogenous piRNAs and environmental RNAi can be transmitted through generations. PDF Protein evolution: Keeping BUBR1 intact p478 | doi:10.1038/nrm3399 BUBR1 is a pseudokinase and uses its kinase domain for structural integrity. PDF Chromatin: RNA eviction by HP1 p478 | doi:10.1038/nrm3400 HP1Swi6 binding with heterochromatic mRNAs triggers its dissociation from chromatin to promote mRNA decay. PDF Cell death: Multitasking p53 promotes necrosis p480 | doi:10.1038/nrm3401 p53 triggers necrosis by inducing the opening of mitochondrial permeability transition pore (PTP). PDF Cell adhesion: Regulating RHO at adherens junctions p481 | doi:10.1038/nrm3402 α-catenin and centralspindlin control RHO signalling at adherens junctions. PDF IN BRIEF Cell migration: Neutrophils cast slings against the flow | Organelle dynamics: A mitochondrial flirtation with the nucleus | Translation: Lessons in maturation | Cell cycle: A role for BRCA2 in abscission | Autophagy: BIM doubles its responsibilities | Circadian rhythms: Small molecule time management PDF Molecular Cell Biology JOBS of the week Postdoctoral Researcher in Yeast Molecular Genetics NUI Galway Ireland Post-doc position in molecular spectroscopy University of Louisville Molecular and Cell biologist Baylor College of Medicine (BCM) Assistant Professor - Biology, Molecular Biology, or Forensic Biology JOhn Jay College of Criminal Justice Molecular And Evolutionary Genomics Of Endogenous Retroviruses Mary Poss More Science jobs from Molecular Cell Biology EVENT Molecular Diagnostics World Congress 25.-26.09.12 CA, US More science events from
PROGRESS		Top
Orchestrating vesicle transport, ESCRTs and kinase surveillance during abscission Chun-Ting Chen, Heidi Hehnly & Stephen J. Doxsey p483 | doi:10.1038/nrm3395 Successful abscission — the final stage of cell division — involves the precise coordination of different events, culminating in the separation of two daughter cells. Endocytic and secretory vesicle trafficking, ESCRT-mediated scission and signalling through mitotic kinases have emerged as key players in this process. Abstract | Full Text | PDF
REVIEWS		Top
New lives for old: evolution of pseudoenzyme function illustrated by iRhoms Colin Adrain & Matthew Freeman p489 | doi:10.1038/nrm3392 The conservation and prevalence of inactive homologues in most enzyme families suggests that they may have significant functions that have been largely overlooked. Mechanistic understanding and evolutionary lessons are now emerging from the study of a broad range of such 'dead' enzymes including the recently discovered iRhoms. Abstract | Full Text | PDF
Article series: Post-translational modifications H2S signalling through protein sulfhydration and beyond Bindu D. Paul & Solomon H. Snyder p499 | doi:10.1038/nrm3391 The identification of an hydrogen sulfide (H2S)-mediated post-translational modification (protein sulfhydration) has provided novel insights into H2S signalling, which controls many cellular functions. As a result, a new research area has arisen that investigates how metabolic stress and other environmental signals influence protein function through Cys modification by H2S. Abstract | Full Text | PDF
Article series: Post-translational modifications Atypical ubiquitylation — the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages Yogesh Kulathu & David Komander p508 | doi:10.1038/nrm3394 Ubiquitin can form eight structurally distinct chain types. Recent advances have elucidated the mechanisms of linkage-specific chain assembly, recognition and hydrolysis. The cellular roles of the six 'atypical' ubiquitin chains (linked via Lys6, Lys11, Lys27, Lys29, Lys33 or Met1 of ubiquitin) are beginning to emerge, highlighting how they can each act as independent post-translational modifications. Abstract | Full Text | PDF
Navigating the epigenetic landscape of pluripotent stem cells Mo Li, Guang-Hui Liu & Juan Carlos Izpisua Belmonte p524 | doi:10.1038/nrm3393 Embryonic stem (ES) cells and induced pluripotent stem (iPS) cells use a complex network of genetic and epigenetic pathways to maintain a delicate balance between self-renewal and multilineage differentiation. Studies using high-throughput genomic tools suggest that there is extensive crosstalk among epigenetic pathways that function at the level of DNA, histone and nucleosome. Mapping of higher-order chromatin structures and chromatin–nuclear matrix interactions provides insights into the three-dimensional organization of the genome and can reveal new rules of gene regulation. Abstract | Full Text | PDF | Supplementary information
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