Nature Reviews Molecular Cell Biology contents June 2012 Volume 13 Number 6

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TABLE OF CONTENTS
June 2012 Volume 13 Number 6
Impact Factor 38.65 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: Axis of ageing: telomeres, p53 and mitochondria Ergün Sahin & Ronald A. DePinho
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The EMBO Meeting 2012 22-25 September in Nice, France Keynotes: Paul Nurse & Linda Partridge 20 concurrent sessions covering the life sciences Speakers include: Kari Alitalo, Karl Deisseroth, Steven Henikoff, Ruth Lehmann, Dirk Schübeler & Rob Singer Abstract submission & early registration: 12 June 2012 www.the-embo-meeting.org
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Nature and Nature Reviews Cancer WEB FOCUS: CANCER METABOLISM A renaissance in the field of cancer metabolism has demonstrated links between oncogenic pathways and the mechanistic basis of tumour cell metabolism. This joint Nature and Nature Reviews Cancer Web Focus highlights recent progress in the field and the promise of therapeutics based on interfering with metabolic pathways. Access the Web Focus at: www.nature.com/focus/cancermetabolism
RESEARCH HIGHLIGHTS Top Organelle biogenesis: When two become one p337 | doi:10.1038/nrm3358 ER-mediated sorting of peroxisomal translocon components controls peroxisome biogenesis. PDF Protein folding: Sequestration at the IPOD stops division p338 | doi:10.1038/nrm3357 Prions block the cell cycle by sequestering a spindle body component. PDF Cell migration: Switching to 3D p338 | doi:10.1038/nrm3365 Cells can switch between lamellipodium-based and lobopodium-based migration in 3D. PDF Metabolism: WNT chews the fat with glucose uptake p339 | doi:10.1038/nrm3355 Active β-catenin in adipose progenitor cells induces glucose uptake in muscle. PDF Small RNAs: miRNAs' strict schedule p340 | doi:10.1038/nrm3354 mRNA decay follows translation repression during microRNA-mediated gene silencing. PDF Chromosomes: Keeping centromeric identity p340 | doi:10.1038/nrm3356 MIS18a interacts with DNMT3A and DNMT3B to ensure CENPA centromeric localization. PDF JOURNAL CLUB ICLs: a chicken without an egg p342 | doi:10.1038/nrm3348 Two studies identify aldehyde metabolites as a potential endogenous source of ICLs. PDF Cell signalling: Preventing WNT signalling p342 | doi:10.1038/nrm3360 ZNRF3 lowers WNT receptor membrane levels and R-spondin controls this inhibitory function. PDF IN BRIEF Genome instability: An autophagy-independent role for UVRAG | Stem cells: Ready to die fast | Telomeres: Shelterin fends off six repair pathways | Nuclear transport: Hikeshi 'puts out the fire' in the nucleus | Post-translational modification: Keeping cell cycle progression in check PDF Molecular Cell Biology JOBS of the week FEMTECH Internship - Molecular Biology or Bioinformatics Lexogen GmbH Molecular Medicine Postdoc Dulbecco Telethon Institute and San Raffaele Scientific Institute Full Professorship (W3) of Molecular Biosystems Ludwig-Maximilians-Universit�t M�nchen PhD Position in Molecular Neurobiology Medical University of Vienna (MUW), Vienna, Austria Postdoctoral Position in Molecular Endocrinology Karolinska Institute More Science jobs from Molecular Cell Biology EVENT Introduction to Molecular Biology Techniques - Applications in Biotechnology and Pharmaceutical Industries 05.-07.09.12 PA, US More science events from
Erratum: How chromosomes find their 'soul mate' Rachel David p340 | doi:10.1038/nrm3368 Full Text | PDF
REVIEWS		Top
TFIIH: when transcription met DNA repair Emmanuel Compe & Jean-Marc Egly p343 | doi:10.1038/nrm3350 The TFIIH complex has an integral role in both nucleotide excision repair and transcription. Studies of TFIIH are therefore defining a new model for crosstalk between the factors that orchestrate DNA repair and transcription, as well as the concept of 'transcription diseases'. Abstract | Full Text | PDF
Specialized ribosomes: a new frontier in gene regulation and organismal biology Shifeng Xue & Maria Barna p355 | doi:10.1038/nrm3359 Traditionally, ribosomes have been viewed as invariable complexes with ubiquitous function in mRNA translation. However, ribosome specialization, resulting from the differential expression and cell type-specific modification of its components, seems to greatly contribute to the diversity of biological processes. Abstract | Full Text | PDF
Geometry and force behind kinetochore orientation: lessons from meiosis Yoshinori Watanabe p370 | doi:10.1038/nrm3349 During the first division of meiosis, homologous chromosomes are pulled to opposite poles and segregated to daughter cells. This form of chromosome segregation, which differs from what occurs in mitosis, is facilitated by meiosis-specific changes to chromosomes as well as by kinetochore geometry and tension exerted by microtubules. Abstract | Full Text | PDF
Regulation of glucose transport by insulin: traffic control of GLUT4 Dara Leto & Alan R. Saltiel p383 | doi:10.1038/nrm3351 The glucose transporter GLUT4 ensures controlled glucose uptake into fat and muscle cells. By targeting several steps in the membrane trafficking of GLUT4, insulin signalling allows tight regulation of glucose homeostasis and prevents the development of insulin resistance. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Axis of ageing: telomeres, p53 and mitochondria Ergün Sahin & Ronald A. DePinho p397 | doi:10.1038/nrm3352 Metabolic signalling pathways and telomere shortening are both thought to, independently, have crucial roles in driving the ageing process. But links between these two processes suggest that they may converge on mitochondria to compromise energy maintenance, thereby driving ageing. Abstract | Full Text | PDF
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