Tuesday, May 8, 2012

Molecular Systems Biology - New articles published 8 May 2012

Molecular Systems Biology
 
Latest Articles 8th May 2012
 
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The EMBO Meeting 2012
22 - 25 September in Nice, France

Keynotes: Paul Nurse & Linda Partridge

20 concurrent sessions covering the life sciences

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Featured Article

Prediction and identification of sequences coding for orphan enzymes using genomic and metagenomic neighbours

Many characterized metabolic enzymes currently lack associated gene and protein sequences. Here, pathway and genomic neighbour data are used to assign genes to these ‘orphan enzymes,’ and the predictions are validated with experimental assays and genome-scale metabolic modelling.

Takuji Yamada, Alison S Waller, Jeroen Raes, Aleksej Zelezniak, Nadia Perchat, Alain Perret, Marcel Salanoubat, Kiran R Patil, Jean Weissenbach & Peer Bork

Molecular Systems Biology 8:581; doi:10.1038/msb.2012.13; published 8 May 2012

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Research Article

A dynamical model of the spindle position checkpoint

The spindle position checkpoint (SPOC) is an important surveillance mechanism in the budding yeast cell cycle. An integrated approach, combining quantitative experimental cell biology with mathematical modeling, reveals how the SPOC inhibits mitotic exit at the molecular level.

Ayse Koca Caydasi, Maiko Lohel, Gerd Grünert, Peter Dittrich, Gislene Pereira & Bashar Ibrahim

Molecular Systems Biology :582; doi:10.1038/msb.2012.15; published 8 May 2012

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