The EMBO Journal - Table of Contents alert Volume 31 Issue 10

TABLE OF CONTENTS 16 May 2012 | Volume 31, Issue 10 Have you seen? Articles Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Have you seen? Top A bacterial actin unites to divide bacterial cells The bacterial cytoskeleton functions analogously to its eukaryotic counterparts. Recent work revealed the structure of bacterial FtsA polymerizing into actin-like filaments, and demonstrated the importance of this self-interaction for proper cell division Jennifer R Juarez and William Margolin The EMBO Journal (2012), 31, 2235 - 2236; 10.1038/emboj.2012.113 Abstract | Full text | PDF Published online: 17 April 2012 Shifting a complex debate on γ-secretase cleavage and Alzheimer's disease Bart de Strooper and colleagues examine the effects of different Alzheimer's disease (AD) causing mutations on γ-Secretase intramembrane cleavage. These data should settle the long-standing debate of how PSEN/γ-secretase contributes to AD. Todd E Golde, Yong Ran and Kevin M Felsenstein The EMBO Journal (2012), 31, 2237 - 2239; 10.1038/emboj.2012.111 Abstract | Full text | PDF Published online: 13 April 2012 Putting the brakes on FOXO1 in fat The novel Foxo1-corepressor [FCoR] controls insulin sensitivity and energy metabolism, adding to the complexity of Foxo1-regulation. Jane J Kim, Wuqiang Fan and Jerrold M Olefsky The EMBO Journal (2012), 31, 2240 - 2241; 10.1038/emboj.2012.116 Abstract | Full text | PDF Published online: 17 April 2012 New romance between RNA degradation pathways: Mmi1 and RNAi meet on heterochromatic islands Studies published in The EMBO Journal and Science reveal how the Mmi1 RNA surveillance machinery orchestrates the RNAi pathway and heterochromation formation in fission yeast to silence meiosis-specific genes during vegetative growth. Lærke Rebekka Holm and Geneviève Thon The EMBO Journal (2012), 31, 2242 - 2243; 10.1038/emboj.2012.138 Abstract | Full text | PDF Published online: 01 May 2012 Direct conversion in the heart: a simple twist of fate Direct injection of reprogramming transcription factors into infarcted hearts of mice transforms cardiac fibroblast into functional cardiomyocytes providing crucial support for in-vivo transdifferentiation as alternative route for tissue regeneration. Natalie D DeWitt and Alan Trounson The EMBO Journal (2012), 31, 2244 - 2246; 10.1038/emboj.2012.114 Abstract | Full text | PDF Published online: 20 April 2012 Epigenetic reprogramming: Prdm14 hits the accelerator The cooperation of Prdm14/Klf2 accelerates the reversion from mouse epiblast stem cells to a naive pluripotent state, offering mechanistic insights into key determinants of reprogramming in early germ cells. Niels Geijsen The EMBO Journal (2012), 31, 2247 - 2248; 10.1038/emboj.2012.117 Abstract | Full text | PDF Published online: 20 April 2012 Articles Top FtsA forms actin-like protofilaments This study provides the first structural analysis of the interaction between the bacterial cytokinesis proteins FtsZ and FtsA. FtsA forms actin-like filaments in vivo that are required for proper cell division. Piotr Szwedziak, Qing Wang, Stefan MV Freund and Jan Löwe The EMBO Journal (2012), 31, 2249 - 2260; 10.1038/emboj.2012.76 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 30 March 2012 The mechanism of γ-Secretase dysfunction in familial Alzheimer disease Mutations in presenilin (PSEN) and amyloid precursor protein (APP) cause dominant early-onset Alzheimer’s disease (AD), but the mechanism involved is debated. Here, such mutations are shown to alter γ-secretase activity, leading to changes in Aβ peptide cleavage patterns. Lucía Chávez-Gutiérrez, Leen Bammens, Iryna Benilova, Annelies Vandersteen, Manasi Benurwar, Marianne Borgers, Sam Lismont, Lujia Zhou, Simon Van Cleynenbreugel, Hermann Esselmann, Jens Wiltfang, Lutgarde Serneels, Eric Karran, Harrie Gijsen, Joost Schymkowitz, Frederic Rousseau, Kerensa Broersen and Bart De Strooper The EMBO Journal (2012), 31, 2261 - 2274; 10.1038/emboj.2012.79 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 13 April 2012 Novel repressor regulates insulin sensitivity through interaction with Foxo1 This study characterizes a novel Foxo1 CoRepressor (FCoR) that regulates insulin sensitivity and energy metabolism as revealed by whole-body knockout. As target of PKA phosphorylation, FCoR modulates Foxo's acetylation known to control Foxo's biological activity. Jun Nakae, Yongheng Cao, Fumihiko Hakuno, Hiroshi Takemori, Yoshinaga Kawano, Risa Sekioka, Takaya Abe, Hiroshi Kiyonari, Toshiya Tanaka, Juro Sakai, Shin-Ichiro Takahashi and Hiroshi Itoh The EMBO Journal (2012), 31, 2275 - 2295; 10.1038/emboj.2012.97 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 17 April 2012 Mmi1 RNA surveillance machinery directs RNAi complex RITS to specific meiotic genes in fission yeast The Mmi1 RNA surveillance machinery degrades meiotic mRNAs during vegetative growth in fission yeast. This study reveals an additional function in recruiting the RNA-Induced Transcriptional Silencing (RITS) RNAi complex to these meiotic targets to induce heterochromatin formation. Edwige Hiriart, Aurélia Vavasseur, Leila Touat-Todeschini, Akira Yamashita, Benoit Gilquin, Emeline Lambert, Jonathan Perot, Yuichi Shichino, Nicolas Nazaret, Cyril Boyault, Joel Lachuer, Daniel Perazza, Masayuki Yamamoto and André Verdel The EMBO Journal (2012), 31, 2296 - 2308; 10.1038/emboj.2012.105 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 20 April 2012 CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion Mouse knockout analysis of CTC1, part of the telomeric RPA-like CST complex in mammals and recently found mutated in human ‘Coats plus’ disease, reveals its key role in telomere replication rather than telomere protection. Peili Gu, Jin-Na Min, Yang Wang, Chenhui Huang, Tao Peng, Weihang Chai and Sandy Chang The EMBO Journal (2012), 31, 2309 - 2321; 10.1038/emboj.2012.96 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 24 April 2012 BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α ER stress is sensed by IRE1α, inducing mRNA splicing of the transcription factor XBP-1. The BH3-only proteins PUMA and BIM interact with IRE1α, enhancing its RNase activity and ensuring sustained XBP-1 mRNA splicing after prolonged ER stress and during antibody secretion by B cells. Diego A Rodriguez, Sebastian Zamorano, Fernanda Lisbona, Diego Rojas-Rivera, Hery Urra, Juan R Cubillos-Ruiz, Ricardo Armisen, Daniel R Henriquez, Emily H Cheng, Michal Letek, Tomas Vaisar, Thergiory Irrazabal, Christian Gonzalez-Billault, Anthony Letai, Felipe X Pimentel-Muiños, Guido Kroemer and Claudio Hetz The EMBO Journal (2012), 31, 2322 - 2335; 10.1038/emboj.2012.84 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 17 April 2012 Disabled-2 (Dab2) inhibits Wnt/β-catenin signalling by binding LRP6 and promoting its internalization through clathrin Wnt signalling requires caveolin-dependent endocytic uptake of the Fz/LRP6 receptor complex. The tumour suppressor Disabled-2 inhibits Wnt signalling by sequestering CK2-phosphorylated LRP6 into an alternative clathrin-dependent endocytic pathway. Yong Jiang, Xi He and Philip H Howe The EMBO Journal (2012), 31, 2336 - 2349; 10.1038/emboj.2012.83 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 10 April 2012 Oligomers of the ATPase EHD2 confine caveolae to the plasma membrane through association with actin Caveolae are plasma membrane microdomains that play important roles in signalling and endocytosis. The ATPase EHD2 shuttles on and off the static population of caveolae in an ATPase cycledependent manner and links caveolae to actin filaments confining them to the plasma membrane. Miriam Stoeber, Ina Karen Stoeck, Christine Hänni, Christopher Karl Ernst Bleck, Giuseppe Balistreri and Ari Helenius The EMBO Journal (2012), 31, 2350 - 2364; 10.1038/emboj.2012.98 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 13 April 2012 Chk1 phosphorylates the tumour suppressor Mig-6, regulating the activation of EGF signalling While characterizing the EGF receptor (EGFR) feedback inhibitor Mig6 as Chk1 target, this paper provides the first mechanistic explanation for DNA damage-independent functions of Chk1 in the regulation of growth factor signalling and cellular proliferation. Ning Liu, Masaki Matsumoto, Kyoko Kitagawa, Yojiro Kotake, Sayuri Suzuki, Senji Shirasawa, Keiichi I Nakayama, Makoto Nakanishi, Hiroyuki Niida and Masatoshi Kitagawa The EMBO Journal (2012), 31, 2365 - 2377; 10.1038/emboj.2012.88 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 13 April 2012 The location of splenic NKT cells favours their rapid activation by blood-borne antigen NKT cells play an important role in the immune responses to blood-borne infections. In vivo analysis shows that most NKT cells patrol the marginal zone and red pulp of the spleen. In response to bacterial antigens, NKT cells arrest and become activated to secrete cytokines. Patricia Barral, María Dolores Sánchez-Niño, Nico van Rooijen, Vincenzo Cerundolo and Facundo D Batista The EMBO Journal (2012), 31, 2378 - 2390; 10.1038/emboj.2012.87 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 13 April 2012 Breaking the HAC Barrier: Histone H3K9 acetyl/methyl balance regulates CENP-A assembly Establishment of Human Artificial Chromosomes (HACs) depends on an interplay of H3 lysine 9 modifications at centromeres, providing insights into the pathways that control incorporation of the kinetochore-specificing histone H3 variant CENP-A. Jun-ichirou Ohzeki, Jan H Bergmann, Natalay Kouprina, Vladimir N Noskov, Megumi Nakano, Hiroshi Kimura, William C Earnshaw, Vladimir Larionov and Hiroshi Masumoto The EMBO Journal (2012), 31, 2391 - 2402; 10.1038/emboj.2012.82 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 03 April 2012 Phosphoproteomic analysis reveals that PP4 dephosphorylates KAP-1 impacting the DNA damage response ATM-dependent phosphorylation of KAP1, which opens heterochromatin to allow DNA repair, is reverted by PP4, revealing a key phosphatase target in the DNA damage response. Dong-Hyun Lee, Aaron A Goodarzi, Guillaume O Adelmant, Yunfeng Pan, Penelope A Jeggo, Jarrod A Marto and Dipanjan Chowdhury The EMBO Journal (2012), 31, 2403 - 2415; 10.1038/emboj.2012.86 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 10 April 2012 Short nucleosome repeats impose rotational modulations on chromatin fibre folding Folding of nucleosome arrays into higher-order structures depends on nucleosome repeat length and the total twist of linker DNA, supporting recent genome-wide mappings of nucleosome positions. Sarah J Correll, Michaela H Schubert and Sergei A Grigoryev The EMBO Journal (2012), 31, 2416 - 2426; 10.1038/emboj.2012.80 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 30 March 2012 The yeast RPL9B gene is regulated by modulation between two modes of transcription termination Expression of the ribosomal protein Rpl9p mRNA is autoregulated by switching between two different modes of transcription termination, the canonical pathway and the Nrd1-dependent termination pathway favoured by non-coding RNAs. Rajani Kanth Gudipati, Helen Neil, Frank Feuerbach, Christophe Malabat and Alain Jacquier The EMBO Journal (2012), 31, 2427 - 2437; 10.1038/emboj.2012.81 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 13 April 2012 Advertisement Nature Genetics and the Wellcome Trust present: The Genomics of Common Diseases 2012 September 19-22, 2012 - Potomac, MD, USA For more information and to register, visit: www.nature.com/natureconferences/gcd2012 Abstract submission deadline- June 28, 2012   Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to The EMBO Journal. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. For other enquiries, please contact our customer feedback department. Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © European Molecular Biology Organization