Monday, May 21, 2012

Clinical Pharmacology and Therapeutics - Table of Contents alert Volume 91 Issue 6

TABLE OF CONTENTS

Volume 91, Issue 6 (June 2012)

In this issue
In This Issue
Editorial
News & Views
Perspectives
Clinical Trials
State of the Art
Review
Research
Discovery & Development
Corrigendum

Also new
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A new online open access journal from Clinical Pharmacology & Therapeutics in the pharmacometrics and systems pharmacology space.

Stay updated on newly published research from the beginning.

Coming Summer 2012
 

In This Issue

Top

In This Issue

Clin Pharmacol Ther 2012 91: 947; 10.1038/clpt.2012.60

Full Text

Editorial

Top

Translational Bioinformatics: Data-driven Drug Discovery and Development

A J Butte and S Ito

Clin Pharmacol Ther 2012 91: 949-952; 10.1038/clpt.2012.55

Abstract | Full Text

News & Views

Top

HIGHLIGHTS

Highlights

Clin Pharmacol Ther 2012 91: 954-955; 10.1038/clpt.2012.59

Full Text

ASCPT NEWS

ASCPT News

Clin Pharmacol Ther 2012 91: 956-959; 10.1038/clpt.2012.56

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MACROSCOPY

Drug Research and Translational Bioinformatics

L J Lesko

Clin Pharmacol Ther 2012 91: 960-962; 10.1038/clpt.2012.45

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Perspectives

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OPINION

Needs for an Expanded Ontology-Based Classification of Adverse Drug Reactions and Related Mechanisms

P E Zhichkin, B D Athey, M I Avigan and D R Abernethy

Clin Pharmacol Ther 2012 91: 963-965; 10.1038/clpt.2012.41

Abstract | Full Text

Healthy Volunteer Registries and Ethical Research Principles

E A Kupetsky-Rincon and W K Kraft

Clin Pharmacol Ther 2012 91: 965-968; 10.1038/clpt.2012.32

Abstract | Full Text

COMMENTARY

The Perils of Gene Patents

S L Salzberg

Clin Pharmacol Ther 2012 91: 969-971; 10.1038/clpt.2012.6

Abstract | Full Text

LETTERS TO THE EDITOR

The Role of Cannabinoids in Chronic Pain Patients Remains Hazy

B C Chen and R S Hoffman

Clin Pharmacol Ther 2012 91: 972; advance online publication, April 25, 2012; 10.1038/clpt.2012.27

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Response to “The Role of Cannabinoids in Chronic Pain Patients Remains Hazy”

D I Abrams, P Couey, S B Shade, M E Kelly and N L Benowitz

Clin Pharmacol Ther 2012 91: 972-973; advance online publication, April 25, 2012; 10.1038/clpt.2012.36

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Tissue-Engineered Airway in the Clinical Setting: A Call for Information Disclosure

A Wurtz and E Kipnis

Clin Pharmacol Ther 2012 91: 973-974; advance online publication, April 25, 2012; 10.1038/clpt.2012.7

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Response to “Tissue-Engineered Airway in the Clinical Setting: A Call for Information Disclosure”

P Macchiarini and P Jungebluth

Clin Pharmacol Ther 2012 91: 974; advance online publication, May 2, 2012; 10.1038/clpt.2012.52

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Clinical Trials

Top

Orexin Receptor Antagonism, a New Sleep-Enabling Paradigm: A Proof-of-Concept Clinical Trial

P Hoever, G Dorffner, H Beneš, T Penzel, H Danker-Hopfe, M J Barbanoj, G Pillar, B Saletu, O Polo, D Kunz, J Zeitlhofer, S Berg, M Partinen, C L Bassetti, B Högl, I O Ebrahim, E Holsboer-Trachsler, H Bengtsson, Y Peker, U-M Hemmeter, E Chiossi, G Hajak and J Dingemanse

Clin Pharmacol Ther 2012 91: 975-985; advance online publication, May 2, 2012; 10.1038/clpt.2011.370

Abstract | Full Text

Comparative Impact on Prostanoid Biosynthesis of Celecoxib and the Novel Nonsteroidal Anti-Inflammatory Drug CG100649

C Skarke, N Alamuddin, J A Lawson, L Cen, K J Propert and G A FitzGerald

Clin Pharmacol Ther 2012 91: 986-993; advance online publication, January 25, 2012; 10.1038/clpt.2012.3

Abstract | Full Text

State of the Art

Top

Translational Bioinformatics: Linking the Molecular World to the Clinical World

R B Altman

Clin Pharmacol Ther 2012 91: 994-1000; advance online publication, May 2, 2012; 10.1038/clpt.2012.49

Abstract | Full Text

Whole-Genome Sequencing in Personalized Therapeutics

P Cordero and E A Ashley

Clin Pharmacol Ther 2012 91: 1001-1009; advance online publication, May 2, 2012; 10.1038/clpt.2012.51

Abstract | Full Text

Review

Top

Novel Data-Mining Methodologies for Adverse Drug Event Discovery and Analysis

R Harpaz, W DuMouchel, N H Shah, D Madigan, P Ryan and C Friedman

Clin Pharmacol Ther 2012 91: 1010-1021; advance online publication, May 2, 2012; 10.1038/clpt.2012.50

Abstract | Full Text

Research

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REPORT

Associations Between ABCC2 Polymorphisms and Cisplatin Disposition and Efficacy

J A Sprowl, V Gregorc, C Lazzari, R H Mathijssen, W J Loos and A Sparreboom

Clin Pharmacol Ther 2012 91: 1022-1026; advance online publication, April 25, 2012; 10.1038/clpt.2011.330

Abstract | Full Text

ARTICLES

Prediction of Weight Loss and Regain Following Dietary, Lifestyle, and Pharmacologic Intervention

A Napolitano, S R Miller, P R Murgatroyd, B Delafont, A Brooke, M Elkhawad, C Y Tan, S Virtue, A Vidal-Puig and D J Nunez

Clin Pharmacol Ther 2012 91: 1027-1034; advance online publication, February 15, 2012; 10.1038/clpt.2011.333

Abstract | Full Text

PhRMA Survey of Pharmacogenomic and Pharmacodynamic Evaluations: What Next?

N Grecco, N Cohen, A W Warner, C Lopez-Correa, S L Truter, A Snapir, S P Piccoli, D Wang, A Westelinck, L Hinman and M A Franc ; on behalf of the Industry Pharmacogenomics Working Group

Clin Pharmacol Ther 2012 91: 1035-1043; advance online publication, April 25, 2012; 10.1038/clpt.2011.334

Abstract | Full Text

PPARA: A Novel Genetic Determinant of CYP3A4 In Vitro and In Vivo

Kathrin Klein, Maria Thomas, Stefan Winter, Andreas K. Nussler, Mikko Niemi, Matthias Schwab and Ulrich M. Zanger

Clin Pharmacol Ther 2012 91: 1044-1052; advance online publication, April 18, 2012; 10.1038/clpt.2011.336

Abstract | Full Text

Transporter-Mediated Drug–Drug Interactions Involving OATP Substrates: Predictions Based on In Vitro Inhibition Studies

K Yoshida, K Maeda and Y Sugiyama

Clin Pharmacol Ther 2012 91: 1053-1064; advance online publication, April 25, 2012; 10.1038/clpt.2011.351

Abstract | Full Text

Comparative Effects of Angiotensin Receptor Blockade and ACE Inhibition on the Fibrinolytic and Inflammatory Responses to Cardiopulmonary Bypass

F T Billings, IV, J M Balaguer, C Yu, P Wright, M R Petracek, J G Byrne, N J Brown and M Pretorius

Clin Pharmacol Ther 2012 91: 1065-1073; advance online publication, May 2, 2012; 10.1038/clpt.2011.356

Abstract | Full Text

Dermal Application of Nitric Oxide In Vivo: Kinetics, Biological Responses, and Therapeutic Potential in Humans

C Opländer, A Römer, A Paunel-Görgülü, T Fritsch, E E van Faassen, M Mürtz, A Bozkurt, G Grieb, Paul Fuchs, Norbert Pallua and C V Suschek

Clin Pharmacol Ther 2012 91: 1074-1082; advance online publication, May 2, 2012; 10.1038/clpt.2011.366

Abstract | Full Text

Discovery & Development

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TRANSLATION

Electronic Medical Records as a Tool in Clinical Pharmacology: Opportunities and Challenges

D M Roden, H Xu, J C Denny and R A Wilke

Clin Pharmacol Ther 2012 91: 1083-1086; advance online publication, April 25, 2012; 10.1038/clpt.2012.42

Abstract | Full Text

Corrigendum

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CORRIGENDUM: Activity Levels of Tamoxifen Metabolites at the Estrogen Receptor and the Impact of Genetic Polymorphisms of Phase I and II Enzymes on Their Concentration Levels in Plasma

Clin Pharmacol Ther 2012 91: 1087; 10.1038/clpt.2012.33

Full Text

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