Nature Reviews Molecular Cell Biology contents May 2012 Volume 13 Number 5

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TABLE OF CONTENTS
May 2012 Volume 13 Number 5		Advertisement
Impact Factor 38.65 *	In this issue Research Highlights Reviews Perspectives Also this month Article series: Post-translational modifications Featured article: Molecular mechanisms and potential functions of histone demethylases Susanne Marije Kooistra & Kristian Helin	BEYOND BASIC - Circulation Research for the iPad®. Basic cardiovascular research that's critical to your profession is now brought to you on the iPad. Sample issue is available - click here to download the app for free today!
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The EMBO Meeting 2012 22-25 September in Nice, France Keynotes: Paul Nurse & Linda Partridge 20 concurrent sessions covering the life sciences Speakers include: Kari Alitalo, Karl Deisseroth, Steven Henikoff, Ruth Lehmann, Dirk Schübeler & Rob Singer Abstract submission & early registration: 12 June 2012 www.the-embo-meeting.org
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Nature Reviews Molecular Cell Biology FOCUS ON METABOLISM Cells rapidly adapt to changes in nutrient availability and integrate this information about their metabolic state to drive cellular processes. Unprecedented insights are being gained into the molecular basis of how metabolic pathways interface with cell biological processes and how this can be disrupted in metabolic disorders. Read the Focus online at: www.nature.com/nrm/focus/metabolism
RESEARCH HIGHLIGHTS Top Signalling: Stop refilling (Ca2+ stores) p277 | doi:10.1038/nrm3343 SARAF inactivates store-operated Ca2+ entry and prevents excessive ER Ca2+ refill. PDF Morphogenesis: Spindle in position for symmetric division p278 | doi:10.1038/nrm3329 Opposing forces regulate dynamic spindle positioning in symmetrically dividing cells. PDF Stem cells: Holding tight onto the niche p278 | doi:10.1038/nrm3342 ID and RAP1 activities maintain anchorage of the neural stem cells to their niche. PDF Development: Musical chairs at the epithelium p279 | doi:10.1038/nrm3344 Epithelium maintenance through overcrowding-induced extrusion of live cells. PDF Cell cycle: Relaying membrane status p280 | doi:10.1038/nrm3333 A signalling relay between membrane traffic and cell cycle factors. PDF Cell signalling: Rho1 keeps an eye on TORC1 p280 | doi:10.1038/nrm3336 Rho1 regulates TORC1 in response to stress, but TORC1 is also an upstream regulator of Rho1. PDF STRUCTURE WATCH Re-evaluating the decoding principle p280 | doi:10.1038/nrm3339 PDF STRUCTURE WATCH Freeing stalled ribosomes p280 | doi:10.1038/nrm3340 PDF JOURNAL CLUB New temptations in SMC research p282 | doi:10.1038/nrm3331 SMC complexes have roles in segregation repair, transcription and replication. PDF Small RNAs: Small RNAs reach out for repair p282 | doi:10.1038/nrm3341 Damage-induced small RNAs promote double-strand break repair. PDF IN BRIEF Technique: Live imaging of sugars | DNA repair: How chromosomes find their 'soul mate' | Gene expression: Keeping p53 targets quiet PDF Molecular Cell Biology JOBS of the week Post-Doctoral (W Wang) - Stem Cell Biology and Regenerative Medicine Oklahoma Medical Research Foundation (OMRF) Phd Student - molecular biology of parasitic diseases focusing on RNA metabolism and protein secretion. Bar Ilan University PhD applicant in molecular biology, DNA repair, acetylation, calorie restriction Bar Ilan University Post Doc position in Cellular / Molecular Immunology, and Vaccine Development University of California Irvine Molecular Biology Scientist 1724 Beijing Merck Pharmaceuti More Science jobs from Molecular Cell Biology EVENT Cellular Signaling & Molecular Medicine 25.-29.05.12 Dubrovnik, Croatia More science events from
Erratum: MicroRNAs in metabolism and metabolic disorders Veerle Rottiers & Anders M. Näär p1 | doi:10.1038/nrm3328 Full Text | PDF
REVIEWS		Top
The functions and regulation of the PTEN tumour suppressor Min Sup Song, Leonardo Salmena & Pier Paolo Pandolfi p283 | doi:10.1038/nrm3330 Phosphatase and tensin homologue (PTEN) governs a plethora of cellular processes including survival, proliferation, energy metabolism and cellular architecture. Unravelling its enzymatic activities, its signalling partners, and the molecular mechanisms involved in the multiple levels of PTEN regulation will aid the design of novel PTEN-based therapeutic interventions in cancer. Abstract | Full Text | PDF | Supplementary information
Article series: Post-translational modifications Molecular mechanisms and potential functions of histone demethylases Susanne Marije Kooistra & Kristian Helin p297 | doi:10.1038/nrm3327 Histone demethylases are important for both chromatin structure and transcription. The insights being gained into their regulation and target specificity have important implications for both normal development and disease. Abstract | Full Text | PDF
Article series: Post-translational modifications Bittersweet memories: linking metabolism to epigenetics through O-GlcNAcylation John A. Hanover, Michael W. Krause & Dona C. Love p312 | doi:10.1038/nrm3334 O-GlcNAcylation is a post-translational modification that seems to regulate the function of numerous target proteins in a nutrient-sensitive manner. Recent evidence suggests an important role for O-GlcNAcylation in epigenetic regulation. Abstract | Full Text | PDF | Supplementary information
PERSPECTIVES		Top
OPINION Getting active: protein sorting in endocytic recycling Victor W. Hsu, Ming Bai & Jian Li p323 | doi:10.1038/nrm3332 Endocytic recycling, for some time considered to occur by default, is now emerging as an active sorting process. These studies are increasing our understanding of the physiological events that require recycling. Abstract | Full Text | PDF
OPINION Intercellular communication: diverse structures for exchange of genetic information Maria Mittelbrunn & Francisco Sánchez-Madrid p328 | doi:10.1038/nrm3335 Increasing evidence suggests that cell-to-cell communication in mammals can occur through the exchange of genetic information, mainly in the form of microRNAs (miRNAs). This exchange can be mediated by extracellular vesicles such as exosomes through intimate membrane contacts between donor and acceptor cells, or a combination of both. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2011

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