Nature Chemistry Contents May 2012 Volume 4 Number 5 pp 335-426

Advertisement High Impact Biological Chemistry RSC Publishing Biology Journals are creating a new paradigm in biology by addressing real problems and real scientific issues of concern in today's world www.rsc.org/Biologicalport TABLE OF CONTENTS May 2012 Volume 4, Issue 5 Books and Arts Research Highlights Blogroll News and Views Articles Addendum In Your Element Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Nature Nanotechnology is pleased to announce a special focus on nanotoxicology Includes free online access to selected articles for a limited time Sponsored by:   Books and Arts Top The human science p335 Ashutosh S. Jogalekar reviews Roald Hoffmann on the Philosophy, Art and Science of Chemistry by Jeffrey Kovac and Michael Weisberg doi:10.1038/nchem.1334 Full Text | PDF Research Highlights Top Organocadmium compounds: Preparing peroxides | Microscopy: Force microscopy takes charge | Bullvalenes: Shape-shifting sensors | Reaction dynamics: Roaming recognized | Asymmetric hydrogenation: Cobalt competes Blogroll Top Blogroll: Arnie and artemisinin p337 doi:10.1038/nchem.1349 Full Text | PDF News and Views Top Custom labware: Chemical creativity with 3D printing pp338 - 339 R. Daniel Johnson doi:10.1038/nchem.1333 The cost, time and expertise needed for custom fabrication is a limiting factor when it comes to the development and production of new labware. With an increase in the popularity and accessibility of three-dimensional printing techniques, that may be about to change. Full Text | PDF See also: Article by Symes et al. Infrared spectroscopy: Mapping protein–contacts pp339 - 341 Minhaeng Cho doi:10.1038/nchem.1336 Obtaining detailed structural information about the interactions between amyloid-forming proteins and inhibitors can be extremely difficult. Two-dimensional infrared spectroscopy has now risen to this challenge to show the mapping of protein–protein contact sites in real time. Full Text | PDF See also: Article by Middleton et al. Total synthesis: Welwitindolinone is well worth it pp341 - 343 John L. Wood doi:10.1038/nchem.1335 Recent syntheses of the natural product 3-hydroxy-N-methylwelwitindolinone C isothiocyanate are taken as examples to answer an oft-raised question about the value of total synthesis. Full Text | PDF Main group chemistry: A heavier-element ketone at last pp343 - 344 Philip P. Power doi:10.1038/nchem.1309 The first heavier main-group-14-element analogue of a ketone, which contains a three-coordinate germanium atom multiply bonded to oxygen, has been prepared and characterized. Full Text | PDF See also: Article by Li et al. Asymmetric catalysis: Correlating sterics in catalysis pp344 - 345 Scott J. Miller doi:10.1038/nchem.1339 Recognizing that an analogy can be drawn between steric effects in drug discovery and asymmetric catalysis has led to a powerful technique that can explain and potentially predict the outcome of asymmetric reactions. Full Text | PDF See also: Article by Harper et al. Self-assembly: Proteins on parade pp346 - 347 John C. Sinclair doi:10.1038/nchem.1337 A protein is modified to assemble with metal ions through judiciously designed coordination and dimerization sites. This elegantly controlled process arranges the protein into crystalline arrays — a useful form for exploring and exploiting protein properties. Full Text | PDF See also: Article by Brodin et al. Magnetic anisotropy: The orientation is in the details pp347 - 348 Muralee Murugesu doi:10.1038/nchem.1341 A detailed magnetic, structural and luminescence characterization unveils that what may have looked like mere details have a significant influence on the magnetic properties of a dysprosium complex. Full Text | PDF Chemistry JOBS of the week Implementation of standard analytical methods used by the Chemistry Laboratory of Public Health and Infectious Diseases Department Dip. di Sanità Pubblica e Malattie Infettive - Università di Roma Chemistry Lab Technician Kelly Scientific Resources Postdoctoral Research Fellow - Protein Chemistry / Immuno-receptor biology Genentech Research Associate / Senior Research Assoc, Protein Analytical Chemistry Genentech More Science jobs from Chemistry EVENT Organometallic chemistry GRC 8th -13th July 2012 RI, US More science events from Articles Top Integrated 3D-printed reactionware for chemical synthesis and analysis pp349 - 354 Mark D. Symes, Philip J. Kitson, Jun Yan, Craig J. Richmond, Geoffrey J. T. Cooper, Richard W. Bowman, Turlif Vilbrandt and Leroy Cronin doi:10.1038/nchem.1313 A low-cost 3D printer is used to combine chemical reactions and the reactor to produce an active 'reactionware' system for organic and inorganic synthesis. Active elements such as catalysts can be incorporated into the walls of printed reactors, and other printed-in components that enable electrochemical and spectroscopic analysis can also be included. Abstract | Full Text | PDF | Chemical compounds See also: News and Views by Johnson Two-dimensional infrared spectroscopy reveals the complex behaviour of an amyloid fibril inhibitor pp355 - 360 Chris T. Middleton, Peter Marek, Ping Cao, Chi-cheng Chiu, Sadanand Singh, Ann Marie Woys, Juan J. de Pablo, Daniel P. Raleigh and Martin T. Zanni doi:10.1038/nchem.1293 Molecular inhibitors of amyloid formation could help combat Alzheimer's disease, type 2 diabetes, and other major human diseases. Here, two-dimensional infrared spectroscopy and residue-specific isotope labelling are used to obtain detailed structural information on amyloid-inhibitor complexes. The unexpected behaviour observed helps to explain the moderate activity of the inhibitor studied. Abstract | Full Text | PDF See also: News and Views by Cho A stable germanone as the first isolated heavy ketone with a terminal oxygen atom pp361 - 365 Liangchun Li, Tomohide Fukawa, Tsukasa Matsuo, Daisuke Hashizume, Hiroyuki Fueno, Kazuyoshi Tanaka and Kohei Tamao doi:10.1038/nchem.1305 Heavier analogues of ketones — containing a double bond between a group 14 element and oxygen — have so far not been isolated as stable compounds. Now, a stable monomeric germanone with a highly polarized Ge=O double bond has been isolated, stabilized by rigid bulky ligands. Abstract | Full Text | PDF See also: News and Views by Power Multidimensional steric parameters in the analysis of asymmetric catalytic reactions pp366 - 374 Kaid C. Harper, Elizabeth N. Bess and Matthew S. Sigman doi:10.1038/nchem.1297 Many parameters have been designed to describe steric size, but few have been able to explain consistently the selectivity of asymmetric catalytic reactions. Here, Sterimol parameters — originally used to develop quantitative structure–activity relationships in medicinal chemistry — have been used to quantify enantioselectivity in a diverse collection of asymmetric catalytic reactions. Abstract | Full Text | PDF See also: News and Views by Miller Metal-directed, chemically tunable assembly of one-, two- and three-dimensional crystalline protein arrays pp375 - 382 Jeffrey D. Brodin, X. I. Ambroggio, Chunyan Tang, Kristin N. Parent, Timothy S. Baker and F. Akif Tezcan doi:10.1038/nchem.1290 The self-assembly of proteins into ordered yet dynamic nanoscale architectures is a crucial biological process and an inspiration for supramolecular chemistry, but has remained largely inaccessible synthetically. A monomeric protein has now been prepared that assembles with zinc ions into one-, two- and three-dimensional crystalline arrays with nano- and microscale order. Abstract | Full Text | PDF See also: News and Views by Sinclair Reversible hydrogen storage using CO2 and a proton-switchable iridium catalyst in aqueous media under mild temperatures and pressures pp383 - 388 Jonathan F. Hull, Yuichiro Himeda, Wan-Hui Wang, Brian Hashiguchi, Roy Periana, David J. Szalda, James T. Muckerman and Etsuko Fujita doi:10.1038/nchem.1295 When operating at near-ambient conditions, using water as a solvent, a high-turnover iridium catalyst enables a reversible hydrogen storage system that uses carbon dioxide, formate and formic acid. Proton-responsive ligands in the catalyst allow it to be turned on or off by controlling the pH of the solution. Abstract | Full Text | PDF | Chemical compounds Elucidation of the timescales and origins of quantum electronic coherence in LHCII pp389 - 395 Gabriela S. Schlau-Cohen, Akihito Ishizaki, Tessa R. Calhoun, Naomi S. Ginsberg, Matteo Ballottari, Roberto Bassi and Graham R. Fleming doi:10.1038/nchem.1303 Quantum coherence has been observed in the major light-harvesting complex of photosystem II (LHCII) from green plants. By controlling the laser pulse polarization in two-dimensional electronic spectroscopy, signals from quantum coherence have been separated from other molecular processes, offering insight into the role of quantum coherence in photosynthetic light-harvesting. Abstract | Full Text | PDF Electronic coherence lineshapes reveal hidden excitonic correlations in photosynthetic light harvesting pp396 - 404 Cathy Y. Wong, Richard M. Alvey, Daniel B. Turner, Krystyna E. Wilk, Donald A. Bryant, Paul M. G. Curmi, Robert J. Silbey and Gregory D. Scholes doi:10.1038/nchem.1302 Quantum beating has been observed in photosynthetic systems, suggesting that energy-transfer processes in natural light harvesting could involve quantum effects. Now, extensive beating is found in the light-harvesting protein of a cryptophyte alga, and shown to be electronic. The implications of these observations on the free-energy surfaces and exciton delocalization were investigated. Abstract | Full Text | PDF A gold-catalysed enantioselective Cope rearrangement of achiral 1,5-dienes pp405 - 409 Ryan J. Felix, Dieter Weber, Osvaldo Gutierrez, Dean J. Tantillo and Michel R. Gagné doi:10.1038/nchem.1327 The Cope rearrangement has been known since the 1940s but, until now, no catalytic asymmetric variant has been reported. Here, a gold(I) catalyst is shown to induce an asymmetric Cope rearrangement of achiral 1,5-dienes containing a cyclopropylidene moiety to produce vinyl cyclopropanes in high yield and good to excellent enantioselectivities. Abstract | Full Text | PDF | Chemical compounds Protein fold determined by paramagnetic magic-angle spinning solid-state NMR spectroscopy pp410 - 417 Ishita Sengupta, Philippe S. Nadaud, Jonathan J. Helmus, Charles D. Schwieters and Christopher P. Jaroniec doi:10.1038/nchem.1299 Despite recent progress, solving protein structures using solid-state NMR spectroscopy is not routine. Now, a method for the rapid determination of global protein fold is reported, based on measurements of 15N longitudinal paramagnetic relaxation enhancements in several protein variants modified with covalently attached cysteine–EDTA–Cu2+ tags. Abstract | Full Text | PDF A molecular ruthenium catalyst with water-oxidation activity comparable to that of photosystem II pp418 - 423 Lele Duan, Fernando Bozoglian, Sukanta Mandal, Beverly Stewart, Timofei Privalov, Antoni Llobet and Licheng Sun doi:10.1038/nchem.1301 Increasing the efficiency and speed of the water-oxidation reaction is crucial to realizing light-driven water splitting. Now, a mononuclear ruthenium complex achieves fast water-oxidation catalysis with a high reaction rate of more than 300 turnovers per second, comparable to the activity of the oxygen-evolving complex in photosystem II. Abstract | Full Text | PDF | Chemical compounds Addendum Top A versatile approach to high-throughput microarrays using thiol-ene chemistry p424 Nalini Gupta, Brian F. Lin, Luis M. Campos, Michael D. Dimitriou, Sherry T. Hikita, Neil D. Treat, Matthew V. Tirrell, Dennis O. Clegg, Edward J. Kramer and Craig J. Hawker doi:10.1038/nchem.1328 Full Text | PDF In Your Element Top The four worlds of carbon p426 Simon H. Friedman doi:10.1038/nchem.1340 Simon H. Friedman explores the various ways in which carbon is inherently tied to our lives — beyond its elegant, treasured role in organic chemistry. Full Text | PDF Top Advertisement Nature Outlook Graphene Owing to its extraordinary electronic and optical properties, this super-strong form of carbon could radically advance technologies ranging from transistors to touch screens to solar cells to bionic implants. Access the Outlook free online for six months. Produced with support from: POSCO, LG Electronics, Graphene Square, Inc   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant) For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our customer feedback department Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2012 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.