Nature Reviews Immunology Contents May 2012 Volume 12 Number 4 pp 317-396

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TABLE OF CONTENTS
May 2012 Volume 12 Number 5
Impact Factor 35.196 *	In this issue Comment Research Highlights Reviews Correspondence Also this month  Featured article: Fine-tuning of dendritic cell biology by the TNF superfamily Leslie Summers deLuca & Jennifer L. Gommerman
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Comment: The storm has cleared: lessons from the CD28 superagonist TGN1412 trial Thomas Hünig p317 | doi:10.1038/nri3192 Abstract | Full Text | PDF | Supplementary information
RESEARCH HIGHLIGHTS Top Mucosal immunology: The good the gut bugs do p319 | doi:10.1038/nri3213 Three papers describe mechanistic links between commensal bacteria and immune disease susceptibility. PDF Development: Pulling RANK p320 | doi:10.1038/nri3214 The development of medullary thymic epithelial cells and γδ T cells is linked through RANK signalling. PDF Tolerance: Reversing diabetes in mice p320 | doi:10.1038/nri3224 Oral treatment with Lactococcus lactis modified to secrete pro-insulin and IL-10, when combined with systemic low-dose CD3-specific antibodies, reverses diabetes in NOD mice. PDF Dendritic cells: Actin a dangerous part p321 | doi:10.1038/nri3222 Actin filaments exposed by dying cells are a damage-associated molecular pattern sensed by dendritic cells. PDF Macrophages: Yolky beginnings p322 | doi:10.1038/nri3217 Most tissue macrophages in mice are derived from the yolk sac and not from haematopoietic stem cells. PDF Innate immunity: The NLRP3 inflammasome — a good site for sore eyes p322 | doi:10.1038/nri3218 Inflammasome activation has a protective effect in age-related macular degeneration. PDF Dendritic cells: Changing of the guard p323 | doi:10.1038/nri3223 Immunostimulatory conventional dendritic cells can differentiate into immunosuppressive macrophage-like cells. PDF IN BRIEF Antibody responses: FcRL4 and FcRL5 bind like the real thing | Immunotherapy: Therapeutic targeting of IL-17 for psoriasis | Regulatory T cells: UBC13 helps TReg cells keep their cool PDF Immunology JOBS of the week Post Doctoral Position in Immunology Mount Sinai Hospitali School of Medicine Immunology Technician Long Island Opus Scientific Molecular Immunology Karamanos Cancer Institute Post-Doctoral (S Nath) - Genetic epidemiology of Systemic Lupus Erythematosus (SLE) - Arthritis and Clinical Immunology Oklahoma Medical Research Foundation (OMRF) Post Doc position in Cellular / Molecular Immunology, and Vaccine Development University of California Irvine More Science jobs from Immunology EVENT Cell Symposia: Human Immunity 19.-21.08.12 Lisbon, Portugal More science events from
REVIEWS		Top
Regulation and function of mTOR signalling in T cell fate decisions Hongbo Chi p325 | doi:10.1038/nri3198 In T cells, the kinase mTOR (mammalian target of rapamycin) integrates immune signals and metabolic cues to control T cell maintenance and activation. This Review describes the role of mTOR in determining T cell fate decisions and the implications of targeting mTOR in the treatment of disease. Abstract | Full Text | PDF
Fine-tuning of dendritic cell biology by the TNF superfamily Leslie Summers deLuca & Jennifer L. Gommerman p339 | doi:10.1038/nri3193 Dendritic cells (DCs) are the master regulators of T cell responses to foreign antigens. This Review discusses how the tumour necrosis factor (TNF) superfamily of molecules influences DC biology and the outcome for T cell immune responses. Abstract | Full Text | PDF
Revisiting the role of the granuloma in tuberculosis Lalita Ramakrishnan p352 | doi:10.1038/nri3211 This Review argues against the historical view of the granuloma as a host-protective structure and provides evidence that the innate immune mechanisms of tuberculous granulomas are involved in the expansion and dissemination of infection. Abstract | Full Text | PDF
Interferon-inducible effector mechanisms in cell-autonomous immunity John D. MacMicking p367 | doi:10.1038/nri3210 Here, John MacMicking provides a broad overview of the recently described functional properties of interferon-inducible effector proteins that mediate cell-autonomous host defence against internalized bacteria, protozoa and viruses. Abstract | Full Text | PDF | Supplementary information
Multipotent mesenchymal stromal cells and the innate immune system Katarina Le Blanc & Dimitrios Mougiakakos p383 | doi:10.1038/nri3209 This article looks at the crosstalk between multipotent mesenchymal stromal cells (MSCs) and innate immunity, ranging from haematopoiesis to antimicrobial defences. Abstract | Full Text | PDF
CORRESPONDENCE		Top
Subjectivity and flow cytometric variability Gisela Pachón, Isabel Caragol & Jordi Petriz p396 | doi:10.1038/nri3158-c1 Full Text | PDF
Reducing variability in flow cytometry Holden T. Maecker, J. Philip McCoy & Robert Nussenblatt p396 | doi:10.1038/nri3158-c2 Full Text | PDF
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