The EDGE: Molecular Systems Biology - New articles published 24 April 2012

Single-cell analysis of population context advances RNAi screening at multiple levels

A large set of high-content RNAi screens investigating mammalian virus infection and multiple cellular activities is analysed to reveal the impact of population context on phenotypic variability and to identify indirect RNAi effects.

Berend Snijder, Raphael Sacher, Pauli Rämö, Prisca Liberali, Karin Mench, Nina Wolfrum, Laura Burleigh, Cameron C Scott, Monique H Verheije, Jason Mercer, Stefan Moese, Thomas Heger, Kristina Theusner, Andreas Jurgeit, David Lamparter, Giuseppe Balistreri, Mario Schelhaas, Cornelis A M De Haan, Varpu Marjomäki, Timo Hyypiä, Peter J M Rottier, Beate Sodeik, Mark Marsh, Jean Gruenberg, Ali Amara, Urs Greber, Ari Helenius & Lucas Pelkmans

Molecular Systems Biology 8:579; doi:10.1038/msb.2012.9; published 24 April 2012

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Research Article

A framework for mapping, visualisation and automatic model creation of signal-transduction networks

An intuitive formalism for reconstructing cellular networks from empirical data is presented, and used to build a comprehensive yeast MAP kinase network. The accompanying rxncon software tool can convert networks to a range of standard graphical formats and mathematical models.

Carl-Fredrik Tiger, Falko Krause, Gunnar Cedersund, Robert Palmér, Edda Klipp, Stefan Hohmann, Hiroaki Kitano & Marcus Krantz

Molecular Systems Biology :578; doi:10.1038/msb.2012.12; published 24 April 2012

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Report

Asymmetric positive feedback loops reliably control biological responses

A common regulatory motif, where a heterodimeric transcriptional regulator positively autoregulates only one of its components, is found to have particular properties that enable precise and robust control of cellular responses to environmental stimuli, providing an explanation for the prevalence of this motif in evolved regulatory networks.

Alexander V Ratushny, Ramsey A Saleem, Katherine Sitko, Stephen A Ramsey & John D Aitchison

Molecular Systems Biology 8:577; doi:10.1038/msb.2012.10; published 24 April 2012

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News and Views

A direct look at RNAi screens

Alexis R Barr & Chris Bakal

Molecular Systems Biology :580; doi:10.1038/msb.2012.14; published 24 April 2012

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