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| | | 17 April 2012 | | | Featured image: | |  | | | Pasquale et al. produce self-assembled cages from carboxylic acid derivatives and the uranyl cation UO22+. | | | | | | |
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Listen to our FREE podcast now! | | | | | | | Latest Articles | View all Articles | | | | | Convergence and coevolution of Hepatitis B virus drug resistance OPEN | | | Hong Thai, David S. Campo, James Lara, Zoya Dimitrova, Sumathi Ramachandran, Guoliang Xia, Lilia Ganova-Raeva, Chong-Gee Teo, Anna Lok and Yury Khudyakov | | | Lamivudine treatment of hepatitis B is associated with drug-resistance mutations in the virus' DNA polymerase. In this study, 11 patients with drug resistance are investigated and the primary mutation in the DNA polymerase shown to be essential but not sufficient for establishing drug resistance. | | | 17 Apr | Nat Commun 3:789 doi:10.1038/ncomms1794 (2012) | | | Biological sciences Genetics | | | Microbiology | | | Virology | | | Abstract | Full Text | PDF (666 kB) |
| Combinatorial targeting and discovery of ligand-receptors in organelles of mammalian cells OPEN | | | Roberto Rangel, Liliana Guzman-Rojas, Lucia G. le Roux, Fernanda I. Staquicini, Hitomi Hosoya, E. Magda Barbu, Michael G. Ozawa, Jing Nie, Kenneth Dunner Jr, Robert R. Langley, E. Helene Sage, Erkki Koivunen, Juri G. Gelovani, Roy R. Lobb, Richard L. Sidman, Renata Pasqualini and Wadih Arap | | | Phage display screening can unravel protein–protein interactions, but its application has been mainly restricted to the cell surface. Here, a phage-based reagent is introduced that allows the targeting of combinatorial peptides to cell organelles, providing a tool for the discovery of intracellular ligand-receptors. | | | 17 Apr | Nat Commun 3:788 doi:10.1038/ncomms1773 (2012) | | | Biological sciences Cell biology | | | | Abstract | Full Text | PDF (2,042 kB) |
Supplementary Information |
| Ordinary percolation with discontinuous transitions | | | Stefan Boettcher, Vijay Singh and Robert M. Ziff | | | Percolation transitions indicate the threshold above which a network can operate. This work examines a general class of models known as hierarchical networks, and shows they can be made to percolate explosively, if they share features of so-called 'small-world' networks. | | | 17 Apr | Nat Commun 3:787 doi:10.1038/ncomms1774 (2012) | | | Physical sciences Condensed matter | | | Theoretical physics | | Abstract | Full Text | PDF (460 kB) |
Supplementary Information |
| Strong-coupling d-wave superconductivity in PuCoGa5 probed by point-contact spectroscopy OPEN | | | D. Daghero, M. Tortello, G.A. Ummarino, J.-C. Griveau, E. Colineau, R. Eloirdi, A.B. Shick, J. Kolorenc, A.I. Lichtenstein and R. Caciuffo | | | The heavy-fermion material PuCoGa5 is characterized by unconventional superconducting properties. By combining point-contact spectroscopy and first-principles calculations, this study reveals a d-wave symmetry in the system's order parameter. | | | 17 Apr | Nat Commun 3:786 doi:10.1038/ncomms1785 (2012) | | | Physical sciences Condensed matter | | | Materials science | | Abstract | Full Text | PDF (846 kB) |
Supplementary Information |
| Giant regular polyhedra from calixarene carboxylates and uranyl OPEN | | | Sara Pasquale, Sara Sattin, Eduardo C. Escudero-Adán, Marta Martínez-Belmonte and Javier de Mendoza | | | Self-assembly of multi-component systems can be used to construct discrete, well-defined, nanoscopic-sized cages. Pasquale et al. report the self-assembly of conical-shaped carboxylic acid derivatives of calix[4]arene and calix[5]arene, and the uranyl cation UO22+ into octahedral and icosahedral anionic metallocages. | | | 17 Apr | Nat Commun 3:785 doi:10.1038/ncomms1793 (2012) | | | Chemical sciences Inorganic chemistry | | | Organic chemistry | | Abstract | Full Text | PDF (1,370 kB) |
Supplementary Information |
| Fully functional hair follicle regeneration through the rearrangement of stem cells and their niches OPEN | | | Koh-ei Toyoshima, Kyosuke Asakawa, Naoko Ishibashi, Hiroshi Toki, Miho Ogawa, Tomoko Hasegawa, Tarou Irié, Tetsuhiko Tachikawa, Akio Sato, Akira Takeda and Takashi Tsuji | | | Bioengineered hair follicles can be produced from embryonic follicle germ cells, but whether these follicles can interact with the surrounding tissue and function normally is unknown. Here, bioengineered hair follicles transplanted into mouse dermis make connections with the surrounding tissue and show normal hair cycles. | | | 17 Apr | Nat Commun 3:784 doi:10.1038/ncomms1784 (2012) | | | Biological sciences Bioengineering | | | Medical research | | Abstract | Full Text | PDF (2,268 kB) |
Supplementary Information |
| Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels OPEN | | | Hiroshi Harada, Masahiro Inoue, Satoshi Itasaka, Kiichi Hirota, Akiyo Morinibu, Kazumi Shinomiya, Lihua Zeng, Guangfei Ou, Yuxi Zhu, Michio Yoshimura, W. Gillies McKenna, Ruth J. Muschel and Masahiro Hiraoka | | | Radiotherapy is used to treat many cancers but radiation-resistant cells can result in recurrence of the tumour. Here, Harada and colleagues develop a method to track cells that persist after radiation treatment and show that the cells acquire transcriptional activity of HIF-1 and move towards blood vessels. | | | 17 Apr | Nat Commun 3:783 doi:10.1038/ncomms1786 (2012) | | | Biological sciences Cancer | | | Medical research | | | Molecular biology | | Abstract | Full Text | PDF (1,381 kB) |
Supplementary Information |
| The structure of the FANCM–MHF complex reveals physical features for functional assembly | | | Yuyong Tao, Changjiang Jin, Xu Li, Shali Qi, Lingluo Chu, Liwen Niu, Xuebiao Yao and Maikun Teng | | | Fanconi's anaemia is characterized by an inability to repair DNA damage and is associated with mutations in the Fanconi anaemia nuclear complex, which includes the protein FANCM. This study reports the crystal structures of a fragment of FANCM bound to the histone-fold-containing protein complex, MHF1–MHF2. | | | 17 Apr | Nat Commun 3:782 doi:10.1038/ncomms1779 (2012) | | | Biological sciences Molecular biology | | Abstract | Full Text | PDF (2,510 kB) |
Supplementary Information |
| miR-484 regulates mitochondrial network through targeting Fis1 | | | Kun Wang, Bo Long, Jian-Qin Jiao, Jian-Xun Wang, Jin-Ping Liu, Qian Li and Pei-Feng Li | | | Abnormal mitochondrial fission leads to apoptosis and disease. Li and colleagues reveal the mechanism with which the transcription factor Foxo3a suppresses Fis1-mediated mitochondrial fission and apoptosis in cardiomyocytes and adrenocortical cancer cells, which involves miR-484 inhibition of Fis1 translation. | | | 17 Apr | Nat Commun 3:781 doi:10.1038/ncomms1770 (2012) | | | Biological sciences Cell biology Molecular biology | | Abstract | Full Text | PDF (958 kB) |
Supplementary Information |
| Broadband graphene terahertz modulators enabled by intraband transitions | | | Berardi Sensale-Rodriguez, Rusen Yan, Michelle M. Kelly, Tian Fang, Kristof Tahy, Wan Sik Hwang, Debdeep Jena, Lei Liu and Huili Grace Xing | | | The terahertz spectral region is desirable for applications such as imaging or spectroscopy, but progress is hampered by a lack of efficient terahertz devices. By exploiting intraband transitions in graphene, Sensale-Rodriguez et al. demonstrate a broadband intensity modulator working at terahertz frequencies. | | | 17 Apr | Nat Commun 3:780 doi:10.1038/ncomms1787 (2012) | | | Physical sciences Applied physics | | | Condensed matter Optical physics | | | | Abstract | Full Text | PDF (525 kB) |
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