Nature Reviews Molecular Cell Biology contents April 2012 Volume 13 Number 4 pp205-276

TABLE OF CONTENTS
April 2012 Volume 13 Number 4
Impact Factor 38.65 *	In this issue Research Highlights Focus on: Metabolism Also this month  Featured article: Sirtuins as regulators of metabolism and healthspan Riekelt H. Houtkooper, Eija Pirinen & Johan Auwerx
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In this issue p205 | doi:10.1038/nrm3315 Full Text
RESEARCH HIGHLIGHTS Top Cell signalling: Building strong muscles p206 | doi:10.1038/nrm3317 Two studies unravel the signalling mechanisms that underlie the regulation of skeletal muscle mass and energy metabolism. PDF Metabolism: Fat discovers a new ancestor p207 | doi:10.1038/nrm3306 Endothelial cells (ECs) or EC-like cells can give rise to white and brown adipocytes. PDF JOURNAL CLUB Sirtuins and calorie restriction p207 | doi:10.1038/nrm3308 Studies in mice have indicated that sirtuins do have a role in mediating the effects of CR. PDF Apoptosis: A lipid trigger of MOMP p208 | doi:10.1038/nrm3316 Activation of BAX and BCL-2 antagonist/killer (BAK) is linked to sphingolipid metabolism in apoptosis. PDF Telomeres: The perils of peripheral damage p208 | doi:10.1038/nrm3318 DNA damage at telomeres persists and is a trigger for senescence. PDF IN THE NEWS A toast to health p209 | doi:10.1038/nrm3309 A study has identified the direct target of resveratrol. PDF Technique: Lights on gene expression p210 | doi:10.1038/nrm3307 Light-inducible gene expression through a synthetic transcriptional activator. PDF Cell cycle: Finding space in the APC/C p210 | doi:10.1038/nrm3319 MCC inhibits APC/C by obstructing degron recognition and altering Cdc20 position. PDF Development: Leading a programmed death p210 | doi:10.1038/nrm3323 The poly-Glut-repeat protein PQN-41 is required for linker cell death in Caenorhabditis elegans. PDF IN BRIEF Cell growth: A new target for TOR | Signalling: Insulin at work without AKT | Autophagy: Dietary lipids hinder quality control | Circadian rhythms: Temperature oscillations set peripheral clocks | Cell migration: Chemotaxis without ARP2/3 | Meiosis: Homeostatic control of meiotic crossovers PDF Molecular Cell Biology JOBS of the week PhD-position or early Post-doc in Plant Functional Genomics and Biochemistry in a Marie Curie EU International Training Network (ITN): P4FIFTY CNRS-Institite of Plant Molecular Biology, Strasbourg Group Leader Position In Molecular Evolutionary Biology Uppsala University, Sweden Cell Biologist / Senior Cell Biologist Fahy Gurteen Laboratories More Science jobs from Molecular Cell Biology EVENT Cellular Signaling & Molecular Medicine 25.-29.05.12 Dubrovnik, Croatia More science events from
Focus on: Metabolism REVIEWS Top Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR Anna C. Calkin & Peter Tontonoz p213 | doi:10.1038/nrm3312 Nuclear receptors integrate hormonal and nutritional signals, resulting in changes to key metabolic pathways within the body. The liver X receptor (LXR) and the farnesoid X receptor (FXR), which are activated by oxysterols and bile acids, respectively, have essential roles in the regulation of cholesterol and bile acid metabolism but are also key integrators of sterol, fatty acid and glucose metabolism. Abstract | Full Text | PDF Sirtuins as regulators of metabolism and healthspan Riekelt H. Houtkooper, Eija Pirinen & Johan Auwerx p225 | doi:10.1038/nrm3293 Sirtuins are a family of deacetylases that target histones and proteins in several cellular compartments. Sirtuins are crucial regulators of energy homeostasis, as they detect physiological changes in energy levels and modulate glucose and lipid metabolism accordingly. As such, they affect health in a pleiotropic manner. Abstract | Full Text | PDF MicroRNAs in metabolism and metabolic disorders Veerle Rottiers & Anders M. Näär p239 | doi:10.1038/nrm3313 MicroRNAs (miRNAs) have recently emerged as key regulators of metabolism. For example, miR-33a and miR-33b control cholesterol and lipid metabolism in concert with their host genes, the sterol-regulatory element-binding protein (SREBP) transcription factors. miRNAs also regulate insulin and glucose homeostasis. Thus, miRNAs may be potential therapeutic targets for ameliorating cardiometabolic disorders. Abstract | Full Text | PDF AMPK: a nutrient and energy sensor that maintains energy homeostasis D. Grahame Hardie, Fiona A. Ross & Simon A. Hawley p251 | doi:10.1038/nrm3311 AMPK acts as an intracellular energy sensor, as its activity is tuned by the relative levels of ATP, ADP and AMP. Therefore, it has a central role in the regulation of cellular metabolic pathways and in the control of whole-body energy balance. Abstract | Full Text | PDF PERSPECTIVES Top Innovation: Metabolomics: the apogee of the omics trilogy Gary J. Patti, Oscar Yanes & Gary Siuzdak p263 | doi:10.1038/nrm3314 Metabolomics enables the comprehensive profiling of cellular metabolites at the systems level, thereby providing a direct readout of biochemical activity that can be correlated with phenotype and used to identify therapeutic targets. Although several challenges remain to be addressed, emerging mass spectrometric and bioinformatic technologies have already proven to be effective tools for diagnostics and for providing insights into cell metabolism. Abstract | Full Text | PDF OPINION A two-way street: reciprocal regulation of metabolism and signalling Kathryn E. Wellen & Craig B. Thompson p270 | doi:10.1038/nrm3305 Signalling is known to regulate metabolism, and it is becoming clear that this regulation is reciprocal, with signalling pathways being regulated by the availability of nutrient-sensitive modifications, such as acetylation and glycosylation. This tight link between signalling and metabolism allows cells to modulate their activities according to metabolic status. Abstract | Full Text | PDF
Erratum: Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions Carsten Janke & Jeannette Chloë Bulinski p276 | doi:10.1038/nrm3310 Full Text | PDF
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