Nature Reviews Immunology Contents April 2012 Volume 12 Number 4 pp 227-315

TABLE OF CONTENTS
April 2012 Volume 12 Number 4
Impact Factor 35.196 *	In this issue Research Highlights Foreword Focus on: Tumour immunology & immunotherapy Reviews Also this month  Featured article: Integration of B cell responses through Toll-like receptors and antigen receptors David J. Rawlings, Marc A. Schwartz, Shaun W. Jackson & Almut Meyer-Bahlburg
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RESEARCH HIGHLIGHTS Top Tumour immunology: A close-range dual hit for tumour immunity p227 | doi:10.1038/nri3189 Engineering tumour cells to activate both TLRs and NLRs induces effective antitumour immunity. PDF Gene regulation: Clocking on for TLR9 p228 | doi:10.1038/nri3194 TLR9 expression levels and immune responsiveness are under circadian control. PDF B cells: An innate talent uncovered p228 | doi:10.1038/nri3200 Innate functions of B cells are important for antiviral immunity. PDF Innate immunity: Linking mitochondria and microbes to inflammasomes p229 | doi:10.1038/nri3195 Activating stimuli identified for the NLRP3 and NLRP7 inflammasomes. PDF Autoimmunity: Fortune tellers p230 | doi:10.1038/nri3199 A new MRI technique can accurately predict diabetes development in NOD mice. PDF T cell memory: Skin-deep memory p230 | doi:10.1038/nri3201 Skin-resident effector memory CD8+ T cells provide long-lasting immune protection in the skin. PDF T cell development: Tonsils turn out T cells too p232 | doi:10.1038/nri3196 A stepwise programme of T cell development in human tonsils. PDF Tumour immunology: Editorial selection demystified p233 | doi:10.1038/nri3202 Two studies uncover details of the antigens and immune responses that are involved in cancer immunoediting. PDF IN BRIEF Tumour immunology: Keeping virus-driven lymphomas in check | Immunotherapy: A killer combination | Tumour immunology: Hope in a sticky situation | Dendritic cells: Side-effects of DC depletion | Autoimmunity: Restoring natural order | Cell migration: HMGB1-mediated inflammatory cell recruitment PDF Immunology JOBS of the week Associate professor in cancer biology or immunology Universsity of Southern Denmark, The Department of Cancer and Inflammation, Institute of Molecular Medicine, Research Scientist on Systems Immunology / Biology Massachusetts General Hospital (MGH) University of Thessaly offers a position of Associate Professor at the Faculty of Medicine in the academic field of Laboratory Immunology University of Thessaly Endowed Research Chair in Immunology of Infectious Diseases University of Manitoba VP, Safety Science Immunology / Virology / Ophthalmology Therapeutic Head Genentech More Science jobs from Immunology EVENT Cell Symposia: Human Immunity 19.-21.08.12 Lisbon, Portugal More science events from
FOREWORD		Top
Tumour immunotherapy — leukocytes take up the fight Gemma K. Alderton & Yvonne Bordon p237 | doi:10.1038/nri3197 Abstract | Full Text | PDF
Focus on: Tumour immunology & immunotherapy REVIEWS Top Targeting natural killer cells and natural killer T cells in cancer Eric Vivier, Sophie Ugolini, Didier Blaise, Christian Chabannon & Laurent Brossay p239 | doi:10.1038/nri3174 In this Review article, the authors describe the mechanisms by which natural killer cells and natural killer T cells can promote tumour cell elimination. Furthermore, they discuss the new therapies that are being used to boost the antitumour properties of these cells in the clinic. Abstract | Full Text | PDF Coordinated regulation of myeloid cells by tumours Dmitry I. Gabrilovich, Suzanne Ostrand-Rosenberg & Vincenzo Bronte p253 | doi:10.1038/nri3175 Here, the authors discuss how the immune activities of myeloid cells, such as macrophages and dendritic cells, are affected by the immunosuppressive tumour environment. They propose that tumours can evade the immune system by promoting aberrant differentiation and function of the entire myeloid system. Abstract | Full Text | PDF Adoptive immunotherapy for cancer: harnessing the T cell response Nicholas P. Restifo, Mark E. Dudley & Steven A. Rosenberg p269 | doi:10.1038/nri3191 This article discusses how T cells promote antitumour immunity in patients with cancer. In certain cancer types, T cell populations that are isolated from tumours and expanded in vitro can promote cancer remission when re-infused into patients. The authors explain the pros and cons of this type of immunotherapy. Abstract | Full Text | PDF
REVIEWS		Top
Integration of B cell responses through Toll-like receptors and antigen receptors David J. Rawlings, Marc A. Schwartz, Shaun W. Jackson & Almut Meyer-Bahlburg p282 | doi:10.1038/nri3190 B cells are unique in their ability to link the innate and adaptive immune systems owing to their expression of both an antigen-specific B cell receptor (BCR) and pattern-recognizing Toll-like receptors (TLRs). This article focuses on the role of dual BCR and TLR signalling in fine-tuning B cell responses, with a particular emphasis on B cell-intrinsic events. Abstract | Full Text | PDF
Regulating the adaptive immune response to respiratory virus infection Thomas J. Braciale, Jie Sun & Taeg S. Kim p295 | doi:10.1038/nri3166 This article reviews the interplay between innate and adaptive immune cells in the response to viral infection of the lower respiratory tract and describes the fine-tuning mechanisms that control antiviral T cells in the lungs but that can also predispose an individual to subsequent pulmonary bacterial infections. Abstract | Full Text | PDF | Supplementary information
The molecular basis of the memory T cell response: differential gene expression and its epigenetic regulation Nan-ping Weng, Yasuto Araki & Kalpana Subedi p306 | doi:10.1038/nri3173 Here, the authors discuss what is known about the gene expression and chromatin modifications in memory T cells that make these cells distinct from naive T cells, and provide some opinions on the future direction of the field. Abstract | Full Text | PDF
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*2010 Journal Citation Report (Thomson Reuters, 2011)

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