Nature Reviews Genetics Contents April 2012 Volume 13 Number 4 pp 221-296

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TABLE OF CONTENTS
April 2012 Volume 13 Number 4
Impact Factor 32.745 *	In this issue Research Highlights Progress Reviews Correspondence Also this month Article series: Regulatory elements Applications of next-generation sequencing Non-coding RNA  Featured article: MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship Amy E. Pasquinelli
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Nature Insight Regulatory RNA In-depth sequencing studies have revealed an unexpected complexity to the nature and function of RNAs encoded by DNA. This Insight includes an explanation of how dynamic reorganization of RNA structure directs many cellular processes, discusses systems controlled by specific RNAs and offers a modular model for the function of long non-coding RNAs. Access the Insight online.
RESEARCH HIGHLIGHTS Top Human disease: Germline selection for deleterious mutation in males p221 | doi:10.1038/nrg3200 PDF Ageing: MicroRNA tunes ageing pathway in flies p222 | doi:10.1038/nrg3205 PDF Genomics: How pervasive are defective genes? p222 | doi:10.1038/nrg3206 PDF Development: Many roads lead to commitment p224 | doi:10.1038/nrg3202 PDF Gene expression: Transposon terminators p224 | doi:10.1038/nrg3203 PDF Technology: Cancer-cell-targeting robots p225 | doi:10.1038/nrg3201 PDF Development: Robust but responsive protein gradients p225 | doi:10.1038/nrg3204 PDF IN BRIEF Mouse genetics: Fruits of the Collaborative Cross | Technology: High-throughput enhancer screening | Human disease: Small RNAs in Huntington's disease | Development: Model of leaf morphogenesis | Evolution: Speciation in archaea despite gene flow | Cancer: Profiling the translational targets of mTOR signalling | Genetic architecture: Statistical approach to detecting maternal genetic effects | Small RNAs: A new mechanism of microRNA target recognition PDF Genetics JOBS of the week Postdoctoral Fellow in Computational and Statistical Genetics Vanderbilt University Medical Center (VUMC) Postdoctoral Associate-Epidemiology, Biostatistics, Genetics, Computer Programming or a related discipline Tufts University - Boston Postdoctoral Research Scientist in Computational Genetics Columbia University Medical Center Postdoc Molecular Genetics The Netherlands Cancer Institute (NKI-AvL) Project Leader Applied Genetics and Genomics Cluster PhD-Jobs.NET More Science jobs from Genetics EVENT Genomic Epidemiology of Malaria 10.-13.06.12 Cambridge, UK More science events from
PROGRESS		Top
Insights into the regulation of protein abundance from proteomic and transcriptomic analyses Christine Vogel & Edward M. Marcotte p227 | doi:10.1038/nrg3185 Recent large-scale quantitative assessment of the proteome and transcriptome has revealed that transcript abundances only partially predict protein abundances. This article discusses ways in which such studies are informing our knowledge of protein expression regulation. Abstract | Full Text | PDF
REVIEWS		Top
Article series: Regulatory elements Metazoan promoters: emerging characteristics and insights into transcriptional regulation Boris Lenhard, Albin Sandelin & Piero Carninci p233 | doi:10.1038/nrg3163 The improving functional annotation of genomes through the analysis of genome-wide data sets is revealing important characteristics of promoters. Similar classes of promoters are now emerging across diverse metazoan species, and novel features that contribute to gene regulation are being identified. Abstract | Full Text | PDF
Regulation of cytoplasmic mRNA decay Daniel R. Schoenberg & Lynne E. Maquat p246 | doi:10.1038/nrg3160 mRNA decay is a post-transcriptional means by which to modulate protein expression. This Review summarizes the current understanding of the mechanisms and pathways involved in the regulation of the multiple mRNA decay processes that contribute to a responsive output of gene expression. Abstract | Full Text | PDF
Article series: Applications of next-generation sequencing The human microbiome: at the interface of health and disease Ilseung Cho & Martin J. Blaser p260 | doi:10.1038/nrg3182 A growing understanding of the relationship between the microbiome and human health is made possible by advances in sequencing technologies and computational tools. These studies highlight how the composition and function of the microbiome varies across individuals and anatomical sites, over time, and also in disease. Abstract | Full Text | PDF
Article series: Non-coding RNA MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship Amy E. Pasquinelli p271 | doi:10.1038/nrg3162 MicroRNAs are key regulators of gene expression. Emerging evidence points towards a reciprocal relationship between microRNAs and their targets and for roles of non-target RNAs and proteins in this crosstalk. Abstract | Full Text | PDF
Endogenous viruses: insights into viral evolution and impact on host biology Cédric Feschotte & Clément Gilbert p283 | doi:10.1038/nrg3199 A large array of viral sequences is being uncovered in eukaryotic genome sequences, revealing that almost any type of virus — not just retroviruses — can become part of host genomes. These discoveries provide new information about the origins and evolution of modern day viruses and host–virus relationships. Abstract | Full Text | PDF
CORRESPONDENCE		Top
Correspondence: Assessing pleiotropy and its evolutionary consequences: pleiotropy is not necessarily limited, nor need it hinder the evolution of complexity William G. Hill & Xu-Sheng Zhang p296 | doi:10.1038/nrg2949-c1 Full Text | PDF
Author Reply: Universal pleiotropy is not a valid null hypothesis: reply to Hill and Zhang Günter P. Wagner & Jianzhi Zhang p296 | doi:10.1038/nrg2949-c2 Full Text | PDF
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*2010 Journal Citation Report (Thomson Reuters, 2011)

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