Drug Discovery@nature.com 20 January 2012

TABLE OF CONTENTS 20 January 2012 News Analysis Research Highlights Research & Reviews Careers Nature Reviews Drug Discovery is on Twitter Advertisement Nature Reviews Cancer POSTER - Proteasome inhibition and cancer therapy Author: Q. Ping Dou This poster highlights recent achievements and progress in targeting the ubiquitin-proteasome degradation pathway for cancer therapy. Access the Poster FREE online! www.nature.com/nrc/posters/proteasome This Poster is freely available thanks to sponsorship from Onyx Pharmaceuticals, Inc.   News Top Safety profiles come to fore as more drugs approach MS market doi:10.1038/nbt0112-6c Achieving an acceptable trade-off between safety and efficacy is a major theme in the quest to develop drugs to treat multiple sclerosis. Full Text Embryonic stem cell pioneer Geron exits field, cuts losses doi:10.1038/nbt0112-12 Geron, the company that pioneered translational research into human embryonic stem cell therapies, announced at the end of last year that it is dropping its entire program owing to financial concerns. Full Text Next-generation proteasome blockers promise safer cancer therapy doi:10.1038/nm0112-7a Doctors could soon have proteasome-blocking agents that are less toxic than bortezomib, and that might also be effective in a broad range of cancers beyond multiple myeloma, in their arsenal. Full Text Russian fund steps up investments in innovative biotechs doi:10.1038/nbt0112-9a Organizational reforms are building confidence among foreign firms looking to engage with Russia, at a time when access to the Russian clinic trial network is proving attractive to both Western biotechs and big pharma. Full Text Analysis Top VCAM-1 engine drives bone metastases doi:10.1038/scibx.2012.30 Researchers have shown that inhibiting vascular cell adhesion molecule-1/integrin α4 signaling could prevent bone metastases of breast cancer, thus handing companies with integrin α4 inhibitors on the market or in the clinic a potential repurposing opportunity. Full Text Fresh from the Pipeline: Brentuximab vedotin doi:10.1038/nrd3629 In August 2011, brentuximab vedotin (Adcetris; Seattle Genetics), a CD30-specific antibody–drug conjugate, was approved by the US Food and Drug Administration for the treatment of patients with Hodgkin's lymphoma and patients with systemic anaplastic large cell lymphoma. Full Text From the analyst's couch: A decade of change doi:10.1038/nrd3630 Data on indicators such as the number and success rate of research and development projects illustrate trends in the pharmaceutical industry over the past decade. Full Text Research Highlights Top Vaccines: Enhancing glycan presentation increases vaccine efficacy doi:10.1038/nrd3637 By maximizing the presentation of carbohydrate epitopes to T cells, scientists have constructed a vaccine against group B streptococcus that is significantly more potent than currently available vaccines. Full Text Antiparasitic drugs: Two-pronged tactics for malaria control doi:10.1038/nrd3635 An academia–industry consortium has identified a new class of compounds that confer complete protection against parasite challenge in rodent models of malaria, as well as showing potent in vivo activity against blood-stage parasites. Full Text Epigenetics: Worth another look? doi:10.1038/nrc3187 Patients with non-small-cell lung cancer with tumours that have a specific subset of methylated genes might benefit from combined treatment with a low-dose DNA methyltransferase inhibitor and a histone deacetylase inhibitor. Full Text Research & Reviews Top The pharmacological landscape and therapeutic potential of serine hydrolases doi:10.1038/nrd3620 This article outlines the current state of pharmacology for mammalian serine hydrolases, including marketed drugs, compounds that are under clinical investigation and selective inhibitors emerging from academic probe development efforts. Full Text Cancer immunotherapy comes of age doi:10.1038/nature10673 Advances in the understanding of how tolerance, immunity and immunosuppression regulate antitumour immune responses, together with the advent of targeted therapies, suggest that active immunotherapy represents a path to obtain a durable and long-lasting response in cancer patients. Full Text Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons doi:10.1038/nature10726 Findings from a recent Nature study suggest a therapeutic strategy for reactivating the functional but dormant allele of Ube3a in patients with Angelman syndrome using topoisomerase inhibitors. Full Text Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential doi:10.1038/nm.2582 Antibodies that bind and inhibit activated matrix metalloproteinases 2 and 9 in a manner analogous to the mechanism of action of tissue inhibitors of metalloproteinases are therapeutically effective in mouse models of inflammatory bowel disease. Full Text Drug Discovery JOBS of the week Associate or Full Professor UIC College of Pharmacy Stem Cells for Drug Discovery and Neural Repair UC Davis Regulatory Submissions Associate Fforde Management Endowed Chair - Immunology of Infectious Diseases Vanderbilt University MRes in Drug Discovery and Development Imperial College London More Science jobs from Drug Discovery EVENT 2nd Ubiquitin Research and Drug Discovery Conference 27.-28.02.12 Las Vegas, US More science events from Careers Top Career snapshots archive Career snapshots feature people associated with drug discovery and drug development, with the aim of providing expert insights and advice on a wide range of positions and career paths in this field. Full Text Top Advertisement SciBX: Science-Business eXchange is a weekly publication that identifies and analyzes the most important translational research articles from over 40 journals. Find out which papers have real scientific and commercial potential, and why. 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