Clinical Pharmacology and Therapeutics - Table of Contents alert Volume 91 Issue 2

TABLE OF CONTENTS Volume 91, Issue 2 (February 2012) In this issue In This Issue Editorial News & Views Perspectives Clinical Trial State of the Art Research Discovery & Development Regulation & Use Also new AOP Advertisement The 3rd Annual World PK/PD Summit gives you the chance to make huge savings in cost and, critically, development time by making your PK/PD analysis exceptional. Learn how drug attrition in your discovery process can be minimized by the integration of predictive PK/PD models early on. Ultimately, get better drugs to patients quicker. Join BMS, Pfizer, GSK & Merck etc. View Agenda Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement Clinpharmpod- Download and discover. Join us on clinpharmpod as we delve into the advances in the nature, action, efficacy, and evaluation of therapeutics in this cross-disciplinary field of experimental and clinical medicine featuring highlighted content from Clinical Pharmacology & Therapeutics.   In This Issue Top In This Issue Clin Pharmacol Ther 2012 91: 151; 10.1038/clpt.2011.348 Full Text Editorial Top EDITORIAL Twenty-First-Century Neuroscience: The Potential for Innovative Therapies for Brain Disorders S L Miksys, K Uhl and R F Tyndale Clin Pharmacol Ther 2012 91: 153-157; 10.1038/clpt.2011.310 Full Text News & Views Top HIGHLIGHTS Clin Pharmacol Ther 2012 91: 158-159; 10.1038/clpt.2011.347 Full Text ASCPT NEWS Clin Pharmacol Ther 2012 91: 160-162; 10.1038/clpt.2011.327 Full Text Perspectives Top OPINION Direct Brain Interventions to “Treat” Disfavored Human Behaviors: Ethical and Social Issues H T Greely Clin Pharmacol Ther 2012 91: 163-165; 10.1038/clpt.2011.292 Abstract | Full Text Challenges in Designing Comparative-Effectiveness Trials for Antidepressants A C Leon Clin Pharmacol Ther 2012 91: 165-167; 10.1038/clpt.2011.208 Abstract | Full Text Broadening Our Understanding of Clinical Quality: From Attribution Error to Situated Cognition A R Artino, Jr, S J Durning, D M Waechter, K L Leary and W R Gilliland Clin Pharmacol Ther 2012 91: 167-169; 10.1038/clpt.2011.229 Abstract | Full Text COMMENTARIES CYP2C19 and Clopidogrel Response: More Than Validation in the Real World A R Shuldiner Clin Pharmacol Ther 2012 91: 170-171; 10.1038/clpt.2011.324 Abstract | Full Text Clinical Trial Top CLINICAL TRIAL The Effects of Extended Pre-Quit Varenicline Treatment on Smoking Behavior and Short-Term Abstinence: A Randomized Clinical Trial L W Hawk, Jr, R L Ashare, S F Lohnes, N J Schlienz, J D Rhodes, S T Tiffany, J C Gass, K M Cummings and M C Mahoney Clin Pharmacol Ther 2012 91: 172-180; advance online publication, November 30, 2011; 10.1038/clpt.2011.317 Abstract | Full Text State of the Art Top STATE OF THE ART The Genetics of Anorexia Nervosa T K Clarke, A R D Weiss and W H Berrettini Clin Pharmacol Ther 2012 91: 181-188; advance online publication, December 21, 2011; 10.1038/clpt.2011.253 Abstract | Full Text Pathways to Drug Development for Autism Spectrum Disorders D R Hampson, S Gholizadeh and L K K Pacey Clin Pharmacol Ther 2012 91: 189-200; advance online publication, December 28, 2011; 10.1038/clpt.2011.245 Abstract | Full Text Neuroimaging Markers of Cellular Function in Major Depressive Disorder: Implications for Therapeutics, Personalized Medicine, and Prevention J H Meyer Clin Pharmacol Ther 2012 91: 201-214; advance online publication, January 4, 2012; 10.1038/clpt.2011.285 Abstract | Full Text Research Top ARTICLES A Novel Metric to Assess the Clinical Utility of a Drug in the Presence of Efficacy and Dropout Information N Goyal and R Gomeni Clin Pharmacol Ther 2012 91: 215-219; advance online publication, November 16, 2011; 10.1038/clpt.2011.197 Abstract | Full Text Plasma Noradrenaline and State Anxiety Levels Predict Placebo Response in Learned Immunosuppression K Ober, S Benson, M Vogelsang, A Bylica, D Günther, O Witzke, A Kribben, H Engler and M Schedlowski Clin Pharmacol Ther 2012 91: 220-226; advance online publication, December 14, 2011; 10.1038/clpt.2011.214 Abstract | Full Text Pgp-Mediated Interaction Between (R)-[11C]Verapamil and Tariquidar at the Human Blood–Brain Barrier: A Comparison With Rat Data M Bauer, M Zeitlinger, R Karch, P Matzneller, J Stanek, W Jäger, M Böhmdorfer, W Wadsak, M Mitterhauser, J P Bankstahl, W Löscher, M Koepp, C Kuntner, M Müller and Oliver Langer Clin Pharmacol Ther 2012 91: 227-233; advance online publication, December 14, 2011; 10.1038/clpt.2011.217 Abstract | Full Text Pharmacokinetic Similarity of Biologics: Analysis Using Nonlinear Mixed-Effects Modeling A Dubois, S Gsteiger, S Balser, E Pigeolet, J L Steimer, G Pillai and F Mentré Clin Pharmacol Ther 2012 91: 234-242; advance online publication, December 28, 2011; 10.1038/clpt.2011.216 Abstract | Full Text Assessment of Lopinavir Pharmacokinetics With Respect to Developmental Changes in Infants and the Impact on Weight Band–Based Dosing M Nikanjam, E G Chadwick, B Robbins, C Alvero, P Palumbo, R Yogev, J Pinto, R Hazra, M L Hughes, B E Heckman and E V Capparelli ; and the IMPAACT P1030 Team Clin Pharmacol Ther 2012 91: 243-249; advance online publication, December 21, 2011; 10.1038/clpt.2011.218 Abstract | Full Text The Use of Modeling and Simulation to Guide Clinical Development of Olmesartan Medoxomil in Pediatric Subjects D E Salazar, S H Song, J Shi, S Rohatagi, R Heyrman, D R Wada and T J Carrothers Clin Pharmacol Ther 2012 91: 250-256; advance online publication, December 28, 2011; 10.1038/clpt.2011.220 Abstract | Full Text Predicting Clopidogrel Response Using DNA Samples Linked to an Electronic Health Record J T Delaney, A H Ramirez, E Bowton, J M Pulley, M A Basford, J S Schildcrout, Y Shi, R Zink, M Oetjens, H Xu, J H Cleator, E Jahangir, M D Ritchie, D R Masys, D M Roden, D C Crawford and J C Denny Clin Pharmacol Ther 2012 91: 257-263; advance online publication, December 21, 2011; 10.1038/clpt.2011.221 Abstract | Full Text Evaluation and Characterization of the Effects of Ticagrelor on Serum and Urinary Uric Acid in Healthy Volunteers K Butler and R Teng Clin Pharmacol Ther 2012 91: 264-271; advance online publication, December 21, 2011; 10.1038/clpt.2011.223 Abstract | Full Text Pharmacokinetics of Antiretroviral Drug Varies With Formulation in the Target Population of Children With HIV-1 P Kasirye, L Kendall, K K Adkison, C Tumusiime, M Ssenyonga, S Bakeera-Kitaka, P Nahirya-Ntege, T Mhute, A Kekitiinwa, W Snowden, D M Burger, D M Gibb and A S Walker ; on behalf of the ARROW Trial Team Clin Pharmacol Ther 2012 91: 272-280; advance online publication, December 21, 2011; 10.1038/clpt.2011.225 Abstract | Full Text The Cost-Effectiveness of Drug Regulation: The Example of Thorough QT/QTc Studies J C Bouvy, M A Koopmanschap, R R Shah and H Schellekens Clin Pharmacol Ther 2012 91: 281-288; advance online publication, December 28, 2011; 10.1038/clpt.2011.224 Abstract | Full Text Mineralocorticoid Receptor Blocker Eplerenone Improves Endothelial Function and Inhibits Rho-Associated Kinase Activity in Patients With Hypertension N Fujimura, K Noma, T Hata, J Soga, T Hidaka, N Idei, Y Fujii, S Mikami, T Maruhashi, Y Iwamoto, Y Kihara, K Chayama, H Kato, J K Liao and Y Higashi ; for the ROCK Study Group Clin Pharmacol Ther 2012 91: 289-297; advance online publication, December 28, 2011; 10.1038/clpt.2011.227 Abstract | Full Text Discovery & Development Top DISCOVERY Uncoupling the Dopamine D1–D2 Receptor Complex: A Novel Target for Antidepressant Treatment A H C Wong and F Liu Clin Pharmacol Ther 2012 91: 298-302; advance online publication, December 28, 2011; 10.1038/clpt.2011.311 Full Text Ketamine as a Novel Antidepressant: From Synapse to Behavior J W Murrough Clin Pharmacol Ther 2012 91: 303-309; advance online publication, December 28, 2011; 10.1038/clpt.2011.244 Abstract | Full Text TRANSLATION The Epigenetic Code in Depression: Implications for Treatment M Schroeder, T Hillemacher, S Bleich and H Frieling Clin Pharmacol Ther 2012 91: 310-314; advance online publication, December 28, 2011; 10.1038/clpt.2011.282 Full Text TRANSLATION Applications of Imaging Biomarkers in the Early Clinical Development of Central Nervous System Therapeutic Agents P E Cole, A J Schwarz and M E Schmidt Clin Pharmacol Ther 2012 91: 315-320; advance online publication, January 4, 2012; 10.1038/clpt.2011.286 Abstract | Full Text TRANSLATION Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Codeine Therapy in the Context of Cytochrome P450 2D6 (CYP2D6) Genotype K R Crews, A Gaedigk, H M Dunnenberger, T E Klein, D D Shen, J T Callaghan, E D Kharasch and T C Skaar Clin Pharmacol Ther 2012 91: 321-326; advance online publication, December 28, 2011; 10.1038/clpt.2011.287 Full Text Cyclin-Dependent Kinase Inhibition With Roscovitine: Neuroprotection in Acute Ischemic Stroke S Timsit and B Menn Clin Pharmacol Ther 2012 91: 327-332; advance online publication, January 4, 2012; 10.1038/clpt.2011.312 Full Text DEVELOPMENT The Roles of Neurotrophic Factor and Wnt Signaling in Depression B Voleti and R S Duman Clin Pharmacol Ther 2012 91: 333-338; advance online publication, December 28, 2011; 10.1038/clpt.2011.296 Full Text Regulation & Use Top PRACTICE Rational Opioid Dosing in the Elderly: Dose and Dosing Interval When Initiating Opioid Therapy D K Gupta and M J Avram Clin Pharmacol Ther 2012 91: 339-343; advance online publication, December 28, 2011; 10.1038/clpt.2011.307 Full Text Advertisement Ensure your access If you are unable to access the articles in thisalert, your library may not subscribe to this journal. 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