Nature Reviews Immunology Contents January 2012 Volume 12 Number 1 pp 1-72

TABLE OF CONTENTS
January 2012 Volume 12 Number 1
Impact Factor 35.196 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: Molecular programming of B cell memory Michael McHeyzer-Williams, Shinji Okitsu, Nathaniel Wang & Louise McHeyzer-Williams
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Nature Reviews Immunology Focus on Monocytes & macrophages FREE online access is available until the end of November. Read articles from Peter Murray & Tom Wynn, Miriam Merad, Chris Glass, Eric Pamer, Ajay Chawla, Toby Lawrence & Gioacchino Natoli www.nature.com/nri/focus/macrophages
RESEARCH HIGHLIGHTS Top Immune regulation: Immune response to tissue stress p1 | doi:10.1038/nri3142 Polymorphic NKG2D ligands regulate γδ T cell responses to tissue stress. PDF Mucosal immunology: Hungry for the fight p2 | doi:10.1038/nri3136 Intestinal epithelial cells switch from metabolic to immune functions in the absence of B cells. PDF Viral immunity: Shelter from interferons p2 | doi:10.1038/nri3137 CD169+ macrophages allow viral replication for the promotion of adaptive immunity. PDF Inflammation: Trauma kicks up a storm p3 | doi:10.1038/nri3138 Serious trauma in humans is associated with a genomic storm in leukocytes. PDF Regulatory T cells: Practise makes perfect p4 | doi:10.1038/nri3135 Regulatory T cells develop into memory populations that limit autoimmune attacks. PDF Neuroimmunology: A CNS guard as prickly as a hedgehog p4 | doi:10.1038/nri3143 Hedgehog signalling protects against neuroinflammation. PDF Natural killer T cells: More help for B cells p5 | doi:10.1038/nri3148 Invariant NKT cells can provide cognate help for B cell responses. PDF Mucosal immunology: A safety catch to prevent intestinal inflammation p6 | doi:10.1038/nri3144 Intestinal dendritic cells make the requirements for TH17 cell induction in the gut more stringent than in systemic tissues. PDF Innate immunity: TLR9 mutations reveal a new level of self tolerance p7 | doi:10.1038/nri3134 Processing-independent activation of a TLR9 mutant overcomes self tolerance. PDF IN BRIEF Technique: New strategies for boosting immunity to pathogens and cancer | Immunotherapy: Low-dose IL-2 therapy expands human regulatory T cell populations | Macrophages: Responding to a chill by alternative activation | T cells: Heating up T cell activation | B cells: Maturity matters for IgE class switch PDF Immunology JOBS of the week Research Coordinator Transgene Assistant / Associate Professor Virology Saint Louis University Top-quality PhD Programme in the School of Biological Sciences, NTU, Singapore Nanyang Technological University (NTU) Senior Research Associate--Biochemical & Cellular Pharmacology Genentech Postdoctoral position in Immunology Institut Pasteur More Science jobs from Immunology EVENT Vaccines for Chronic Diseases Symposium 07.-09.02.12 TX, US More science events from
REVIEWS		Top
The impact of perinatal immune development on mucosal homeostasis and chronic inflammation Harald Renz, Per Brandtzaeg & Mathias Hornef p9 | doi:10.1038/nri3112 In this Review article, the authors describe the perinatal development of intestinal and respiratory mucosal immune systems. Moreover, they discuss how environmental factors, such as the neonatal composition of commensal bacteria, can affect the maturation of mucosal immune systems, leading to the development of chronic inflammatory disorders later in life. Abstract | Full Text | PDF
Molecular programming of B cell memory Michael McHeyzer-Williams, Shinji Okitsu, Nathaniel Wang & Louise McHeyzer-Williams p24 | doi:10.1038/nri3128 Understanding the molecular events that orchestrate the formation of high-affinity memory B cells will help to improve vaccination strategies. In this Review article, McHeyzer-Williams and colleagues discuss the cellular and molecular interactions that regulate commitment to B cell memory, the germinal centre reaction and the generation of memory plasma cells following antigen recall. Abstract | Full Text | PDF
The role of ubiquitylation in immune defence and pathogen evasion Xiaomo Jiang & Zhijian J. Chen p35 | doi:10.1038/nri3111 As discussed here, ubiquitylation is involved in many aspects of the immune system, including the innate immune response to pathogens, antigen presentation and the activation of the adaptive immune system. As a result, pathogens have evolved many ways to exploit this form of immune regulation. Abstract | Full Text | PDF
The bone marrow at the crossroads of blood and immunity Francois E. Mercier, Christine Ragu & David T. Scadden p49 | doi:10.1038/nri3132 This Review describes the dynamic interactions that occur between haematopoietic stem cells (HSCs), immune cells and their specialized niches in the bone marrow. The authors discuss how the signals provided by the niche help HSCs and immune cells to respond to injury or inflammation in peripheral tissues. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Experimental mouse tumour models: what can be learnt about human cancer immunology? Glenn Dranoff p61 | doi:10.1038/nri3129 In this short Perspective article, Glenn Dranoff summarizes the strengths and limitations of three of the most commonly used mouse tumour model systems for investigating host antitumour immune responses and the potential clinical efficacy of novel immunotherapies. Abstract | Full Text | PDF
SCIENCE AND SOCIETY Vaccines targeting drugs of abuse: is the glass half-empty or half-full? Kim D. Janda & Jennifer B. Treweek p67 | doi:10.1038/nri3130 Vaccines have been highly successful in protecting us from infectious disease and there is now much interest in the use of vaccination to tackle other health issues. This article discusses the feasibility, as well as the ethical implications, of vaccinating patients against drugs of abuse. Abstract | Full Text | PDF
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