Nature Reviews Cancer contents January 2012 Volume 12 Number 1 pp 1-78

TABLE OF CONTENTS
January 2012 Volume 12 Number 1
Impact Factor 37.178 *	In this issue Research Highlights Reviews Perspectives Also this month Article Series: Genomic instability in cancer  Featured article: Epithelial cell polarity, stem cells and canceras Fernando Martin-Belmonte & Mirna Perez-Moreno
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Nature Reviews Cancer POSTER - Proteasome inhibition and cancer therapy Author: Q. Ping Dou This poster highlights recent achievements and progress in targeting the ubiquitin-proteasome degradation pathway for cancer therapy. Access the Poster FREE online! www.nature.com/nrc/posters/proteasome This Poster is freely available thanks to sponsorship from Onyx Pharmaceuticals, Inc.
RESEARCH HIGHLIGHTS Top Cancer genomics: Finding a rare variant p1 | doi:10.1038/nrc3190 Two studies reported in Nature have identified a mutation in microphthalmia-associated transcription factor (MITF) that predisposes to familial melanoma, as well as to sporadic melanoma and renal cell carcinoma. PDF Epigenetics: Worth another look? p2 | doi:10.1038/nrc3187 The treatment of patients with refractory non-small-cell lung cancer with a low-dose DNA methyltransferase inhibitor and a histone deacetylase inhibitor shows promise for a subset of patients. PDF Microenvironment: Protective surroundings p2 | doi:10.1038/nrc3196 Johanna Joyce and colleagues show that tumour-associated macrophages protect breast tumour cells from cell death mediated by various chemotherapeutic agents. PDF Biomarkers: Major mathematical hurdles for biomarker-based screening p3 | doi:10.1038/nrc3191 A new study uses mathematical modelling to investigate the limitations of blood-based biomarkers for cancer screening. PDF Breast cancer: Staking a claim p4 | doi:10.1038/nrc3192 PBX1 can function as a pioneer factor in ERα-positive breast cancer. PDF Metastasis: Signalling in transit p4 | doi:10.1038/nrc3193 A paper published in Cancer Cell reports that platelets can provide pro-metastatic signals to circulating tumour cells. PDF Therapeutics: Opening the door to a new class of proteasome inhibitors p5 | doi:10.1038/nrc3203 This paper describes a new proteasome inhibitor that targets the 19S regulatory subunit. PDF Senescence: Tumorigenesis under surveillance p6 | doi:10.1038/nrc3188 A new study characterizes a role for the adaptive immune response in tumour suppression through the immune surveillance of premalignant hepatocytes. PDF Genetics: IDH mosaicism in enchondromatosis syndromes p6 | doi:10.1038/nrc3194 Two papers in Nature Genetics show that the isocitrate dehydrogenases IDH1 and IDH2 are mutated in two subtypes of the cancer-prone enchondromatosis syndrome. PDF IN BRIEF Metastasis: Awakening a sleeping giant | Metabolism: Working around defective mitochondria | Melanoma: An exchange factor drives metastasis | Neuroblastoma: The right type of ALK | Nanotechnology: Size matters | Breast cancer: NOTCH and MAST are rearranged, but rarely PDF Cancer JOBS of the week Cancer Systems, Senior Scientist Sage Bionetworks Postdoctoral Position Roswell Park Cancer Institute Hypoxia effect on cancer stem cell of musculoskeletal sarcoma ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA - - DIP. SCIENZE ANATOMICHE UMANE E FISIOPAT. APPARATO LOCOMOTORE Faculty Position: Academic Gastroenterologist Moffitt Cancer Center Senior Research Technician, Solid Tumor Immunology Laboratory Memorial Sloan-Kettering Cancer Center More Science jobs from Cancer EVENT 10th International Congress on Targeted Anticancer Therapies 08.-10.03.12 Amsterdam, Netherlands More science events from
REVIEWS		Top
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression Brian Keith, Randall S. Johnson & M. Celeste Simon p9 | doi:10.1038/nrc3183 The α-subunits that form the oxygen-sensitive component of the hypoxia-inducible factor (HIF) transcription factor have unique and overlapping roles in mediating cellular responses to hypoxia. Surprisingly, they can also have opposing roles, and the differences between HIF1α and HIF2α are discussed in this Review. Abstract | Full Text | PDF
Epithelial cell polarity, stem cells and cancer Fernando Martin-Belmonte & Mirna Perez-Moreno p23 | doi:10.1038/nrc3169 The regulation of cell polarity has pleiotropic effects on cell morphology and function, which has implications for tumorigenesis and tumour progression. This Review discusses how polarity complexes affect tumour cell biology and their crosstalk with other important cancer pathways. Abstract | Full Text | PDF | Supplementary information
Treating metastatic cancer with nanotechnology Avi Schroeder, Daniel A. Heller, Monte M. Winslow, James E. Dahlman, George W. Pratt, Robert Langer, Tyler Jacks & Daniel G. Anderson p39 | doi:10.1038/nrc3180 Metastasis accounts for the vast majority of cancer deaths. The potential of using nanoparticles to diagnose and to treat metastatic cancer is highlighted in this Review. Abstract | Full Text | PDF
PERSPECTIVES		Top
Safe harbours for the integration of new DNA in the human genome Michel Sadelain, Eirini P. Papapetrou & Frederic D. Bushman p51 | doi:10.1038/nrc3179 Human cell engineering has made considerable progress, but where to insert foreign sequences in the human genome to maximize safety and efficacy is still uncertain. This Opinion article discusses genomic safe harbours, which are chromosomal locations where therapeutic transgenes can integrate and function without perturbing endogenous gene activity or promoting cancer. Abstract | Full Text | PDF
Programmed cell removal: a new obstacle in the road to developing cancer Mark P. Chao, Ravindra Majeti & Irving L. Weissman p58 | doi:10.1038/nrc3171 Recent evidence indicates that successful cancer clones must have overcome programmed cell removal. In this Opinion article, the authors explore the role of programmed cell removal in both normal and neoplastic cells. Abstract | Full Text | PDF
Article series: Genomic instability in cancer BRCA1 and BRCA2: different roles in a common pathway of genome protection Rohini Roy, Jarin Chun & Simon N. Powell p68 | doi:10.1038/nrc3181 Inherited inactivating mutations in BRCA1 or BRCA2 seem to cause a similar predisposition to breast and ovarian cancer, but a closer look reveals many differences as well. This Perspective discusses the similarities and differences between BRCA1 and BRCA2 and their effects on cancer phenotypes. Abstract | Full Text | PDF
Erratum: Regulatory RNA: Layer by layer p78 | doi:10.1038/nrc3189 Full Text | PDF
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*2010 Journal Citation Report (Thomson Reuters, 2011)

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