Nature Genetics Contents: August 2011 pp 721 - 815

Advertisement See the Light. Make the Switch. Stop Cloning! The LightSwitch Luciferase Assay System provides everything you need for reporter assays: pre-cloned human promoters and 3'UTRs in luciferase reporter vectors plus optimized luciferase reagents to measure promoter induction and miRNA target validation. Visit SwitchGear Genomics and explore our genome-wide collections and validated pathway sets. TABLE OF CONTENTS August 2011 Volume 43, Issue 8 Recommend to your library Web feed Available online only Subscribe Editorial News and Views Research Highlights Brief Communications Articles Letters Erratum Corrigendum Advertisement RNA-Seq just went from complicated to compatible. EA will provide your data in a format you are used to -- 100% microarray compatible format. Now you can have your data and use it too! Expression Analysis will help you detect 2x more differentially expressed transcripts, novel isoforms and SNVs and can achieve >97% alignment to your reference genome. 919-405-2248 Advertisement Announcing Principles of Biology, an interactive textbook from Nature Publishing Group Principles of Biology is a peer-reviewed, affordable textbook solution for university-level Introductory Biology courses, featuring 200+ customizable learning modules, 175+ interactive exercises, 3,000+ assessment questions, and access from laptops, smartphones, or tablets. Learn more.   Editorial Top Policy-ready science p721 doi:10.1038/ng.901 Although Nature Genetics generally urges authors to keep their claims within the research arena, basic research occasionally turns up results that are ready for immediate application. In these cases we aim to assign some peer referees familiar with the needs of policy makers and to provide accompanying commentary that puts the research into an appropriate societal perspective. Full Text | PDF News and Views Top Transition zone proteins and cilia dynamics pp723 - 724 Thomas Benzing and Bernhard Schermer doi:10.1038/ng.896 New work has identified networks of protein interactions at the transition zones of cilia. These discoveries provide insights into the molecular pathogenesis of ciliopathies and illustrate the power of linking proteomics technologies with human genetics to uncover critical disease pathways. Full Text | PDF See also: Article by Garcia-Gonzalo et al. Epigenetic variation and cellular Darwinism pp724 - 726 Jean-Pierre Issa doi:10.1038/ng.897 The human genome contains large areas with hypervariable DNA methylation that are associated with deregulation of gene expression. This epigenetic variation may be necessary for differentiation, but it also provides a mechanism for Darwinian evolution at the cellular level that may underlie age-related diseases such as cancer. Full Text | PDF See also: Article by Hansen et al. The timing of mitochondrial DNA mutations in aging pp726 - 727 Konstantin Khrapko doi:10.1038/ng.895 Somatic mutations in mitochondrial DNA build up in aging tissues and are thought to contribute to physiological aging. Surprisingly, it is not known if these mutations occur early or late in life. A new study looks at mechanisms of accelerated mitochondrial aging in HIV-infected individuals treated with nucleoside analog anti-retroviral drugs and offers support for an early origin of mitochondrial DNA mutations. Full Text | PDF See also: Letter by Payne et al. Research Highlights Research highlights p728 doi:10.1038/ng.899 Full Text | PDF Genetics JOBS of the week Assistant Professorships Swiss Federal Institute of Technology Zurich Zurich, Switzerland Associate Director EMBL / EMBL-EBI Hinxton, United Kingdom Postdoc: Computational Cancer Biology The Netherlands Cancer Institute & Astra Zeneca Amsterdam, The Netherlands Two PostDoc positions available in Systems and Synthetic Biology Telethon Institute of Genetics and Medicine Naples, Italy PhD Studentship in Cambridge in Cheminformatics / Computer-Aided Drug Design University of Cambridge Cambridge, UK More Science jobs from Genetics EVENT Genomics: Gene Discovery and Clinical Applications for Cardiovascular, Lung, and Blood Diseases 12 - 13 September 11 MD, US More science events from Brief Communications Top De novo nonsense mutations in ASXL1 cause Bohring-Opitz syndrome pp729 - 731 Alexander Hoischen, Bregje W M van Bon, Benjamin Rodriguez-Santiago, Christian Gilissen, Lisenka E L M Vissers, Petra de Vries, Irene Janssen, Bart van Lier, Rob Hastings, Sarah F Smithson, Ruth Newbury-Ecob, Susanne Kjaergaard, Judith Goodship, Ruth McGowan, Deborah Bartholdi, Anita Rauch, Maarit Peippo, Jan M Cobben, Dagmar Wieczorek, Gabriele Gillessen-Kaesbach, Joris A Veltman, Han G Brunner and Bert B B A de Vries doi:10.1038/ng.868 Han Brunner and colleagues report the identification of de novo nonsense mutations in ASXL1 in individuals with Bohring-Opitz syndrome, which is characterized by intellectual disability, distinctive facial features and multiple congenital malformations. First paragraph | Full Text | PDF NBEAL2 is mutated in gray platelet syndrome and is required for biogenesis of platelet α-granules pp732 - 734 Meral Gunay-Aygun, Tzipora C Falik-Zaccai, Thierry Vilboux, Yifat Zivony-Elboum, Fatma Gumruk, Mualla Cetin, Morad Khayat, Cornelius F Boerkoel, Nehama Kfir, Yan Huang, Dawn Maynard, Heidi Dorward, Katherine Berger, Robert Kleta, Yair Anikster, Mutlu Arat, Andrew S Freiberg, Beate E Kehrel, Kerstin Jurk, Pedro Cruz, Jim C Mullikin, James G White, Marjan Huizing and William A Gahl doi:10.1038/ng.883 Meral Gunay-Aygun and colleagues report that NBEAL2 is mutated in gray platelet syndrome (GPS). GPS is a recessive platelet disorder that can lead to severe bleeding. First paragraph | Full Text | PDF Exome sequencing identifies NBEAL2 as the causative gene for gray platelet syndrome pp735 - 737 Cornelis A Albers, Ana Cvejic, Rémi Favier, Evelien E Bouwmans, Marie-Christine Alessi, Paul Bertone, Gregory Jordan, Ross N W Kettleborough, Graham Kiddle, Myrto Kostadima, Randy J Read, Botond Sipos, Suthesh Sivapalaratnam, Peter A Smethurst, Jonathan Stephens, Katrin Voss, Alan Nurden, Augusto Rendon, Paquita Nurden & Willem H Ouwehand doi:10.1038/ng.885 Cornelis Albers and colleagues identify NBEAL2 as the causative gene for gray platelet syndrome (GPS). Knockdown of this gene in zebrafish leads to spontaneous bleeding and defects in thrombocyte formation. First paragraph | Full Text | PDF Mutations in NBEAL2, encoding a BEACH protein, cause gray platelet syndrome pp738 - 740 Walter HA Kahr, Jesse Hinckley, Ling Li, Hansjorg Schwertz, Hilary Christensen, Jesse W Rowley, Fred G Pluthero, Denisa Urban, Shay Fabbro, Brie Nixon, Rick Gadzinski, Mike Storck, Kai Wang, Gi-Yung Ryu, Shawn M Jobe, Brian C Schutte, Jack Moseley, Noeleen B Loughran, John Parkinson, Andrew S Weyrich and Jorge Di Paola doi:10.1038/ng.884 Walter Kahr and colleagues report mutations in NBEAL2 in gray platelet syndrome (GPS). Using RNA-seq, the authors observed abnormal pre-mRNA processing in NBEAL2 in platelets from an individual with GPS. First paragraph | Full Text | PDF Analyses of X-linked and autosomal genetic variation in population-scale whole genome sequencing pp741 - 743 Srikanth Gottipati, Leonardo Arbiza, Adam Siepel, Andrew G Clark and Alon Keinan doi:10.1038/ng.877 Alon Keinan and colleagues estimate the ratio of genetic diversity on the X chromosome to that on the autosome (X/A) on the basis of whole-genome sequencing of 69 females from the 1000 Genomes Project. They find that across populations, the X/A ratio increases with genetic distance from genes. They further find that this ratio is reduced in Europeans compared to West Africans, which may be explained by demographic history. First paragraph | Full Text | PDF Advertisement Effectively screen formalin fixed tissue Formalin-Fixed Paraffin Embedded tissue can provide invaluable information, but is notoriously difficult to use. The MassARRAY® system enables highly sensitive, reproducible somatic mutation profiling and methylation analysis even with minimal amounts of degraded FFPE tissue. Discover the potential of your archival samples. www.sequenom.com   Articles Top Extensive genomic and transcriptional diversity identified through massively parallel DNA and RNA sequencing of eighteen Korean individuals pp745 - 752 Young Seok Ju, Jong-Il Kim, Sheehyun Kim, Dongwan Hong, Hansoo Park, Jong-Yeon Shin, Seungbok Lee, Won-Chul Lee, Sujung Kim, Saet-Byeol Yu, Sung-Soo Park, Seung-Hyun Seo, Ji-Young Yun, Hyun-Jin Kim, Dong-Sung Lee, Maryam Yavartanoo, Hyunseok Peter Kang, Omer Gokcumen, Diddahally R Govindaraju, Jung Hee Jung, Hyonyong Chong, Kap-Seok Yang, Hyungtae Kim, Charles Lee and Jeong-Sun Seo doi:10.1038/ng.872 Jeong Sun-Seo and colleagues report whole-genome sequencing of ten Korean individuals and exome sequencing on an additional eight Korean individuals. They also performed transcriptome sequencing on 17 of these individuals. The authors identified approximately 1.83 million previously unidentified SNPs. Abstract | Full Text | PDF Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile pp753 - 760 Tuomas O Kilpeläinen, M Carola Zillikens, Alena Stančákova, Francis M Finucane, Janina S Ried, Claudia Langenberg, Weihua Zhang, Jacques S Beckmann, Jian'an Luan, Liesbeth Vandenput, Unnur Styrkarsdottir, Yanhua Zhou, Albert Vernon Smith, Jing-Hua Zhao, Najaf Amin, Sailaja Vedantam, So-Youn Shin, Talin Haritunians, Mao Fu, Mary F Feitosa, Meena Kumari, Bjarni V Halldorsson, Emmi Tikkanen, Massimo Mangino, Caroline Hayward, Ci Song, Alice M Arnold, Yurii S Aulchenko, Ben A Oostra, Harry Campbell, L Adrienne Cupples, Kathryn E Davis, Angela Döring, Gudny Eiriksdottir, Karol Estrada, José Manuel Fernández-Real, Melissa Garcia, Christian Gieger, Nicole L Glazer, Candace Guiducci, Albert Hofman, Steve E Humphries, Bo Isomaa, Leonie C Jacobs, Antti Jula, David Karasik, Magnus K Karlsson, Kay-Tee Khaw, Lauren J Kim, Mika Kivimäki, Norman Klopp, Brigitte Kühnel, Johanna Kuusisto, Yongmei Liu, Östen Ljunggren, Mattias Lorentzon, Robert N Luben, Barbara McKnight, Dan Mellström, Braxton D Mitchell, Vincent Mooser, José Maria Moreno, Satu Männistö, Jeffery R O'Connell, Laura Pascoe, Leena Peltonen, Belén Peral, Markus Perola, Bruce M Psaty, Veikko Salomaa, David B Savage, Robert K Semple, Tatjana Skaric-Juric, Gunnar Sigurdsson, Kijoung S Song, Timothy D Spector, Ann-Christine Syvänen, Philippa J Talmud, Gudmar Thorleifsson, Unnur Thorsteinsdottir, André G Uitterlinden, Cornelia M van Duijn, Antonio Vidal-Puig, Sarah H Wild, Alan F Wright, Deborah J Clegg, Eric Schadt, James F Wilson, Igor Rudan, Samuli Ripatti, Ingrid B Borecki, Alan R Shuldiner, Erik Ingelsson, John-Olov Jansson, Robert C Kaplan, Vilmundur Gudnason, Tamara B Harris, Leif Groop, Douglas P Kiel, Fernando Rivadeneira, Mark Walker, Inês Barroso, Peter Vollenweider, Gérard Waeber, John C Chambers, Jaspal S Kooner, Nicole Soranzo, Joel N Hirschhorn, Kari Stefansson, H-Erich Wichmann, Claes Ohlsson, Stephen O'Rahilly, Nicholas J Wareham, Elizabeth K Speliotes, Caroline S Fox, Markku Laakso & Ruth J F Loos doi:10.1038/ng.866 Ruth Loos and colleagues use genome-wide association to identify common variants influencing body fat percentage. Unexpectedly, they show that a body-fat-decreasing allele near IRS1 is associated with an impaired metabolic profile, including increased risk of type 2 diabetes and coronary artery disease. Abstract | Full Text | PDF Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility pp761 - 767 The Australo-Anglo-American Spondyloarthritis Consortium (TASC), the Wellcome Trust Case Control Consortium 2 (WTCCC2), David M Evans, Chris C A Spencer, Jennifer J Pointon, Zhan Su, David Harvey, Grazyna Kochan, Udo Opperman, Alexander Dilthey, Matti Pirinen, Millicent A Stone, Louise Appleton, Loukas Moutsianis, Stephen Leslie, Tom Wordsworth, Tony J Kenna, Tugce Karaderi, Gethin P Thomas, Michael M Ward, Michael H Weisman, Claire Farrar, Linda A Bradbury, Patrick Danoy, Robert D Inman, Walter Maksymowych, Dafna Gladman, Proton Rahman, Spondyloarthritis Research Consortium of Canada (SPARCC), Ann Morgan, Helena Marzo-Ortega, Paul Bowness, Karl Gaffney, J S Hill Gaston, Malcolm Smith, Jacome Bruges-Armas, Ana-Rita Couto, Rosa Sorrentino, Fabiana Paladini, Manuel A Ferreira, Huji Xu, Yu Liu, Lei Jiang, Carlos Lopez-Larrea, Roberto Díaz-Peña, Antonio López-Vázquez, Tetyana Zayats, Gavin Band, Céline Bellenguez, Hannah Blackburn, Jenefer M Blackwell, Elvira Bramon, Suzannah J Bumpstead, Juan P Casas, Aiden Corvin, Nicholas Craddock, Panos Deloukas, Serge Dronov, Audrey Duncanson, Sarah Edkins, Colin Freeman, Matthew Gillman, Emma Gray, Rhian Gwilliam, Naomi Hammond, Sarah E Hunt, Janusz Jankowski, Alagurevathi Jayakumar, Cordelia Langford, Jennifer Liddle, Hugh S Markus, Christopher G Mathew, Owen T McCann, Mark I McCarthy, Colin N A Palmer, Leena Peltonen, Robert Plomin, Simon C Potter, Anna Rautanen, Radhi Ravindrarajah, Michelle Ricketts, Nilesh Samani, Stephen J Sawcer, Amy Strange, Richard C Trembath, Ananth C Viswanathan, Matthew Waller, Paul Weston, Pamela Whittaker, Sara Widaa, Nicholas W Wood, Gilean McVean, John D Reveille, B Paul Wordsworth, Matthew A Brown & Peter Donnelly doi:10.1038/ng.873 Matthew Brown, Peter Donnelly and colleagues report results of a genome-wide association meta-analysis and follow-up study of ankylosing spondylitis. They identify three new risk variants and report a genetic interaction between ERAP1 and HLA-B27, implicating aberrant peptide handling in the pathophysiology of this disease. Abstract | Full Text | PDF Increased methylation variation in epigenetic domains across cancer types pp768 - 775 Kasper Daniel Hansen, Winston Timp, Hector Corrada Bravo, Sarven Sabunciyan, Benjamin Langmead, Oliver G McDonald, Bo Wen, Hao Wu, Yun Liu, Dinh Diep, Eirikur Briem, Kun Zhang, Rafael A Irizarry and Andrew P Feinberg doi:10.1038/ng.865 Andrew Feinberg and colleagues report whole-genome bisulfite sequencing of three colon cancers and matched normal tissue and two adenomatous polyps. The authors identify large blocks of relative hypomethylation over half of the genome. Abstract | Full Text | PDF See also: News and Views by Issa A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition pp776 - 784 Francesc R Garcia-Gonzalo, Kevin C Corbit, María Salomé Sirerol-Piquer, Gokul Ramaswami, Edgar A Otto, Thomas R Noriega, Allen D Seol, Jon F Robinson, Christopher L Bennett, Dragana J Josifova, José Manuel García-Verdugo, Nicholas Katsanis, Friedhelm Hildebrandt & Jeremy F Reiter doi:10.1038/ng.891 Jeremy Reiter and colleagues show that Tctn1 is a component of a transition zone complex that regulates ciliogenesis and ciliary membrane composition. They also identify a likely causal mutation in TCTN1 in two siblings with Joubert syndrome. Abstract | Full Text | PDF See also: News and Views by Benzing & Schermer Advertisement Whole Genome Sequencing & Comparative Interpretation Bring the power of comparative whole genome interpretation to your research. We sequence, annotate, and compare the genomes in your study, delivering a shortlist of suspect variants, genes, and networks. Our project-driven curation integrates diverse streams of public and proprietary reference data to provide insights from whole genomes in studies of cancer, rare/common disease, and drug response. Now $4,998/genome (min 10). Visit www.knome.com.   Letters Top Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study pp785 - 791 Zsofia Kote-Jarai, Ali Amin Al Olama, Graham G Giles, Gianluca Severi, Johanna Schleutker, Maren Weischer, Daniele Campa, Elio Riboli, Tim Key, Henrik Gronberg, David J Hunter, Peter Kraft, Michael J Thun, Sue Ingles, Stephen Chanock, Demetrius Albanes, Richard B Hayes, David E Neal, Freddie C Hamdy, Jenny L Donovan, Paul Pharoah, Fredrick Schumacher, Brian E Henderson, Janet L Stanford, Elaine A Ostrander, Karina Dalsgaard Sorensen, Thilo Dörk, Gerald Andriole, Joanne L Dickinson, Cezary Cybulski, Jan Lubinski, Amanda Spurdle, Judith A Clements, Suzanne Chambers, Joanne Aitken, R A Frank Gardiner, Stephen N Thibodeau, Dan Schaid, Esther M John, Christiane Maier, Walther Vogel, Kathleen A Cooney, Jong Y Park, Lisa Cannon-Albright, Hermann Brenner, Tomonori Habuchi, Hong-Wei Zhang, Yong-Jie Lu, Radka Kaneva, Ken Muir, Sara Benlloch, Daniel A Leongamornlert, Edward J Saunders, Malgorzata Tymrakiewicz, Nadiya Mahmud, Michelle Guy, Lynne T O'Brien, Rosemary A Wilkinson, Amanda L Hall, Emma J Sawyer, Tokhir Dadaev, Jonathan Morrison, David P Dearnaley, Alan Horwich, Robert A Huddart, Vincent S Khoo, Christopher C Parker, Nicholas Van As, Christopher J Woodhouse, Alan Thompson, Tim Christmas, Chris Ogden, Colin S Cooper, Aritaya Lophatonanon, Melissa C Southey, John L Hopper, Dallas R English, Tiina Wahlfors, Teuvo L J Tammela, Peter Klarskov, Børge G Nordestgaard, M Andreas Røder, Anne Tybjærg-Hansen, Stig E Bojesen, Ruth Travis, Federico Canzian, Rudolf Kaaks, Fredrik Wiklund, Markus Aly, Sara Lindstrom, W Ryan Diver, Susan Gapstur, Mariana C Stern, Roman Corral, Jarmo Virtamo, Angela Cox, Christopher A Haiman, Loic Le Marchand, Liesel FitzGerald, Suzanne Kolb, Erika M Kwon, Danielle M Karyadi, Torben Falck Ørntoft, Michael Borre, Andreas Meyer, Jürgen Serth, Meredith Yeager, Sonja I Berndt, James R Marthick, Briony Patterson, Dominika Wokolorczyk, Jyotsna Batra, Felicity Lose, Shannon K McDonnell, Amit D Joshi, Ahva Shahabi, Antje E Rinckleb, Ana Ray, Thomas A Sellers, Hui-Yi Lin, Robert A Stephenson, James Farnham, Heiko Muller, Dietrich Rothenbacher, Norihiko Tsuchiya, Shintaro Narita, Guang-Wen Cao, Chavdar Slavov, Vanio Mitev, The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology, The UK ProtecT Study Collaborators, The Australian Prostate Cancer BioResource, The PRACTICAL Consortium, Douglas F Easton & Rosalind A Eeles doi:10.1038/ng.882 Rosalind Eeles and colleagues report a multistage genome-wide association study of prostate cancer, identifying seven new prostate cancer susceptibility loci. First paragraph | Full Text | PDF A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese pp792 - 796 Zhibin Hu, Chen Wu, Yongyong Shi, Huan Guo, Xueying Zhao, Zhihua Yin, Lei Yang, Juncheng Dai, Lingmin Hu, Wen Tan, Zhiqiang Li, Qifei Deng, Jiucun Wang, Wei Wu, Guangfu Jin, Yue Jiang, Dianke Yu, Guoquan Zhou, Hongyan Chen, Peng Guan, Yijiang Chen, Yongqian Shu, Lin Xu, Xiangyang Liu, Li Liu, Ping Xu, Baohui Han, Chunxue Bai, Yuxia Zhao, Haibo Zhang, Ying Yan, Hongxia Ma, Jiaping Chen, Mingjie Chu, Feng Lu, Zhengdong Zhang, Feng Chen, Xinru Wang, Li Jin, Jiachun Lu, Baosen Zhou, Daru Lu, Tangchun Wu, Dongxin Lin & Hongbing Shen doi:10.1038/ng.875 Hongbing Shen and colleagues report a genome-wide association study for lung cancer in individuals of Han Chinese ancestry. The authors identify two new lung cancer susceptibility loci. First paragraph | Full Text | PDF Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers pp797 - 800 Daiki Miki, Hidenori Ochi, C Nelson Hayes, Hiromi Abe, Tadahiko Yoshima, Hiroshi Aikata, Kenji Ikeda, Hiromitsu Kumada, Joji Toyota, Takashi Morizono, Tatsuhiko Tsunoda, Michiaki Kubo, Yusuke Nakamura, Naoyuki Kamatani and Kazuaki Chayama doi:10.1038/ng.876 Kazuaki Chayama and colleagues report a genome-wide association study for progression to hepatocellular carcinoma in individuals with chronic hepatitis C. The authors identify a common variant within DEP2DC that is associated with risk of HCV-induced HCC. First paragraph | Full Text | PDF Comparing strategies to fine-map the association of common SNPs at chromosome 9p21 with type 2 diabetes and myocardial infarction pp801 - 805 Jessica Shea, Vineeta Agarwala, Anthony A Philippakis, Jared Maguire, Eric Banks, Mark DePristo, Brian Thomson, Candace Guiducci, Robert C Onofrio, The Myocardial Infarction Genetics Consortium, Sekar Kathiresan, Stacey Gabriel, Noël P Burtt, Mark J Daly, Leif Groop & David Altshuler doi:10.1038/ng.871 David Altshuler and colleagues compare strategies to fine map the association of common variants at 9p21 with type 2 diabetes and myocardial infarction. Their study provides an empirical assessment of the performance of targeted sequencing and imputation-based approaches to comprehensively assess genetic variation in disease-associated regions. First paragraph | Full Text | PDF Mitochondrial aging is accelerated by anti-retroviral therapy through the clonal expansion of mtDNA mutations pp806 - 810 Brendan A I Payne, Ian J Wilson, Charlotte A Hateley, Rita Horvath, Mauro Santibanez-Koref, David C Samuels, D Ashley Price and Patrick F Chinnery doi:10.1038/ng.863 Patrick Chinnery and colleagues analyze the effects on mitochondrial DNA of nucleoside analogue anti-retroviral (NRTIs) drugs in patients infected with HIV. The authors find that patients treated with commonly used NRTIs accumulate somatic mitochondrial DNA mutations in a process similar to normal aging. First paragraph | Full Text | PDF See also: News and Views by Khrapko Dynamic CpG island methylation landscape in oocytes and preimplantation embryos pp811 - 814 Sébastien A Smallwood, Shin-ichi Tomizawa, Felix Krueger, Nico Ruf, Natasha Carli, Anne Segonds-Pichon, Shun Sato, Kenichiro Hata, Simon R Andrews & Gavin Kelsey doi:10.1038/ng.864 Gavin Kelsey and colleagues report methylation landscapes in mouse oocytes, sperm and blastocysts. They find that the majority of methylated CpG islands in oocytes display incomplete demethylation in preimplantation embryos. First paragraph | Full Text | PDF Erratum Top Erratum: CTCF-mediated functional chromatin interactome in pluripotent cells p815 Lusy Handoko, Han Xu, Guoliang Li, Chew Yee Ngan, Elaine Chew, Marie Schnapp, Charlie Wah Heng Lee, Chaopeng Ye, Joanne Lim Hui Ping, Fabianus Mulawadi, Eleanor Wong, Jianpeng Sheng, Yubo Zhang, Thompson Poh, Chee Seng Chan, Galih Kunarso, Atif Shahab, Guillaume Bourque, Valere Cacheux-Rataboul, Wing-Kin Sung, Yijun Ruan and Chia-Lin Wei doi:10.1038/ng0811-815a Full Text | PDF Corrigendum Top Corrigendum: A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL) p815 Konstantinos J Mavrakis, Joni Van Der Meulen, Andrew L Wolfe, Xiaoping Liu, Evelien Mets, Tom Taghon, Aly A Khan, Manu Setti, Pieter Rondou, Peter Vandenberghe, Eric Delabesse, Yves Benoit, Nicholas B Socci, Christina S Leslie, Pieter Van Vlierberghe, Frank Speleman and Hans-Guido Wendel doi:10.1038/ng0811-815b Full Text | PDF Top Advertisement Nature.com is offering access to selected free articles on next generation sequencing. 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