Table of Contents Alert: The EMBO Journal, Vol. 38, No. 11, 3 June 2019

The EMBO Journal Volume 38, Issue 11 3 June 2019

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News & Views

Mitochondria and pathogen immunity: from killer to firestarter

Joel S Riley, Stephen WG Tait

e102325 | First Published: 17 May 2019

New work reveals an unexpected, non‐lethal immune defence role of the mitochondrial apoptotic machinery, via mtDNA release and STING activation.

Articles

Actin filaments regulate microtubule growth at the centrosome

Daisuke Inoue, Dorian Obino, Judith Pineau, Francesca Farina, Jérémie Gaillard, Christophe Guerin, Laurent Blanchoin, Ana‐Maria Lennon‐Duménil, Manuel Théry

e99630 | First Published: 22 March 2019

Increasing density of F‐actin nucleating from the main interphase microtubule‐organizing center creates a physical barrier for nascent microtubules in lymphocytes and in vitro.

Open Access

Local actin nucleation tunes centrosomal microtubule nucleation during passage through mitosis

Francesca Farina, Nitya Ramkumar, Louise Brown, Dureen Samandar Eweis, Jannis Anstatt, Thomas Waring, Jessica Bithell, Giorgio Scita, Manuel Thery, Laurent Blanchoin, Tobias Zech, Buzz Baum

e99843 | First Published: 23 April 2019

Centrosomes organize both microtubule and actin filaments during mitosis, with a transient burst of actin nucleation in anaphase correlating with reduced microtubule density.

A non‐death function of the mitochondrial apoptosis apparatus in immunity

Dominik Brokatzky, Benedikt Dörflinger, Aladin Haimovici, Arnim Weber, Susanne Kirschnek, Juliane Vier, Arlena Metz, Julia Henschel, Tobias Steinfeldt, Ian E Gentle, Georg Häcker

e100907 | First Published: 12 April 2019

Different pathogens can trigger sub‐lethal engagement of the mitochondrial apoptosis machinery in epithelial cells, resulting however not in cell death but rather promoting cytokine production and reducing pathogen growth.

Cancer cells induce immune escape via glycocalyx changes controlled by the telomeric protein TRF2

Julien Cherfils‐Vicini, Charlene Iltis, Ludovic Cervera, Sabrina Pisano, Olivier Croce, Nori Sadouni, Balázs Győrffy, Romy Collet, Valérie M Renault, Martin Rey‐Millet, Carlo Leonetti, Pasquale Zizza, Fabrice Allain, Francois Ghiringhelli, Nicolas Soubeiran, Marina Shkreli, Eric Vivier, Annamaria Biroccio, Eric Gilson

e100012 | First Published: 18 April 2019

TRF2 has extratelomeric roles enabling tumor cells to adjust their glycocalyx and to attract immunosuppressive immature myeloid cells.

Open Access

Triggering MSR1 promotes JNK‐mediated inflammation in IL‐4‐activated macrophages

Manman Guo, Anetta Härtlova, Marek Gierliński, Alan Prescott, Josep Castellvi, Javier Hernandez Losa, Sine K Petersen, Ulf A Wenzel, Brian D Dill, Christoph H Emmerich, Santiago Ramon Y Cajal, David G Russell, Matthias Trost

e100299 | First Published: 26 April 2019

The macrophage scavenger receptor 1 (MSR1) promotes the recruitment of the TAK1/MKK7/JNK signalling complex to the phagosome to drive a macrophage phenotypic shift from an anti‐inflammatory to a pro‐inflammatory one.

Open Access

Pten controls B‐cell responsiveness and germinal center reaction by regulating the expression of IgD BCR

Corinna S Setz, Ahmad Khadour, Valerio Renna, Joseena Iype, Eva Gentner, Xiaocui He, Moumita Datta, Marc Young, Lars Nitschke, Jürgen Wienands, Palash C Maity, Michael Reth, Hassan Jumaa

e100249 | First Published: 23 April 2019

Regulation of PI3‐kinase‐FoxO1 by the lipid phosphatase PTEN is critical for the activation of IgD expression, which is needed for the generation of mature B cells fully responsive to antigen complexes.

Human keratin 1/10‐1B tetramer structures reveal a knob‐pocket mechanism in intermediate filament assembly

Sherif A Eldirany, Minh Ho, Alexander J Hinbest, Ivan B Lomakin, Christopher G Bunick

e100741 | First Published: 29 April 2019

New crystal structures reveal modes of keratin assembly in health and keratinopathy.

Open Access

Slx5/Slx8‐dependent ubiquitin hotspots on chromatin contribute to stress tolerance

Markus Höpfler, Maximilian J Kern, Tobias Straub, Roman Prytuliak, Bianca H Habermann, Boris Pfander, Stefan Jentsch

e100368 | First Published: 23 April 2019

Yeast SUMO‐targeted ubiquitin ligases (STUbLs) and ubiquitin co‐localize to seven genomics loci marked by the transcription factor‐like protein Euc1.

Resource

Open Access Highlight

Phospho‐RNA‐seq: a modified small RNA‐seq method that reveals circulating mRNA and lncRNA fragments as potential biomarkers in human plasma

Maria D Giraldez, Ryan M Spengler, Alton Etheridge, Annika J Goicochea, Missy Tuck, Sung Won Choi, David J Galas, Muneesh Tewari

e101695 | First Published: 03 May 2019

A modified RNA‐seq method reveals a large population of mRNA/lncRNA fragments in plasma that are missed by standard small RNA‐seq protocols including ones that are associated with disease.

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