 | The EMBO Journal Volume 38, Issue 12 17 June 2019 |
News & Views
Autophagy: clocking in for the night shift
e102434 | First Published: 27 May 2019
A new study reveals that transcription factors TFEB and TFE3 transactivate the molecular clock component Rev‐erbα during fasting and rest phase, thereby linking feeding and autophagy to circadian physiology of the whole animal.
BASC‐ing in the glow: bronchioalveolar stem cells get their place in the lung
e102344 | First Published: 28 May 2019
New work reveals a rare population of airway stem cells to contribute to regeneration of epithelia upon injury in vivo.
Review
Epigenetic aberrations in human pluripotent stem cells
e101033 | First Published: 14 May 2019
This review summarises our current knowledge on the epigenetic abnormalities occurring in human pluripotent stem cells, their origins as well as consequences for modeling development and disease.
Articles
Nutrient‐sensitive transcription factors TFEB and TFE3 couple autophagy and metabolism to the peripheral clock
e101347 | First Published: 24 May 2019
Crosstalk between TFEB/TFE3 transcription factors and REV‐ERBα repressor contributes to the circadian oscillation of autophagy.
Bronchioalveolar stem cells are a main source for regeneration of distal lung epithelia in vivo
e102099 | First Published: 26 April 2019
A genetic complementation approach identifies lung stem cells located at the bronchioalveolar duct junction as a critical component of the mouse distal airway repair.
Open Access The Nucleosome Remodelling and Deacetylation complex suppresses transcriptional noise during lineage commitment
e100788 | First Published: 29 April 2019
Paralogous NuRD chromatin remodeler components Mta1, Mta2, and Mta3 are functionally redundant and non‐essential in mouse ES cells, but required for transcriptional repression to ensure appropriate lineage specification.
Live‐cell imaging reveals the interplay between transcription factors, nucleosomes, and bursting
e100809 | First Published: 17 May 2019
Single‐molecule approaches to correlate Gal4 transcription factor binding with target gene transcriptional bursting kinetics suggests that multiple RNA polymerases initiate transcription during one burst as long as the transcription factor is bound to DNA.
Expression of endogenous retroviruses reflects increased usage of atypical enhancers in T cells
e101107 | First Published: 08 May 2019
Stress‐responsive cis‐enhancer activity of human endogenous retroviruses is chronically induced in the context of autoimmune diseases.
Anoctamin 8 tethers endoplasmic reticulum and plasma membrane for assembly of Ca2+ signaling complexes at the ER/PM compartment
e101452 | First Published: 06 May 2019
Anoctamin 8 exerts channel‐independent roles in ER/PM junction formation and receptor‐stimulated Ca2+ oscillations.
Open Access Extracellular interface between APP and Nicastrin regulates Aβ length and response to γ‐secretase modulators
e101494 | First Published: 20 May 2019
A direct interaction between the gamma secretase subunit Nicastrin and APP regulates the stability and processivity of the γ‐secretase/substrate complex to affect Aβ length and Alzheimer disease pathogenicity.
Resource
3D model for CAR‐mediated cytotoxicity using patient‐derived colorectal cancer organoids
e100928 | First Published: 29 April 2019
A preclinical organoid co‐culture allows testing of immunotherapy with chimeric antigen receptor (CAR)‐engineered lymphocytes in a personalised tissue‐like environment.
Retraction
Retraction: "CITRX thioredoxin interacts with the tomato Cf‐9 resistance protein and negatively regulates defence"
e102435 | First Published: 17 June 2019
This article is a retraction.
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