 | The EMBO Journal Volume 38, Issue 7 01 April 2019 |
News & Views
Bub1—the zombie protein that CRISPR cannot kill
e101912 | First Published: 08 March 2019
Two recent studies demonstrate potential pitfalls of inferring cellular functions of near‐essential proteins from "knockout" via CRISPR/Cas9 genome editing.
Revealing chromatin organization in metaphase chromosomes
e101699 | First Published: 04 March 2019
Cryo‐electron tomography data revealing plate‐like layers of interdigitated nucleosomes on isolated human chromosomes suggest revised models for mitotic chromatin compaction.
Articles
Open Access Histidine is selectively required for the growth of Myc‐dependent dedifferentiation tumours in the Drosophila CNS
e99895 | First Published: 25 February 2019
Decreased dietary uptake of histidine differentially affects Drosophila brain cancer models, reducing pathological growth of only those neuronal clones that depend on Myc/eIF4E‐mediated cell size increases.
Efficient mitotic checkpoint signaling depends on integrated activities of Bub1 and the RZZ complex
e100977 | First Published: 19 February 2019
Combination of genome editing and RNAi knockdown unveils that two separate pathways fulfill essential functions in kinetochore recruitment of mammalian checkpoint hub Mad1.
HighlightFrozen‐hydrated chromatin from metaphase chromosomes has an interdigitated multilayer structure
e99769 | First Published: 04 January 2019
Cryo‐electron tomography of non‐crosslinked, non‐surface‐absorbed samples implicates stacked planar layers of mononucleosome width in 3D‐assembly of compact mitotic chromatin.
NBS1 promotes the endonuclease activity of the MRE11‐RAD50 complex by sensing CtIP phosphorylation
e101005 | First Published: 20 February 2019
In vitro reconstitution defines the crucial contribution of the accessory subunit in the mammalian MRN complex for end resection of DNA double‐strand breaks.
Open Access Ssu72 phosphatase is a conserved telomere replication terminator
e100476 | First Published: 22 February 2019
Reversal of inhibitory CDK phosphorylation on its Stn1 subunit allows (C)ST complex recruitment for telomeric DNA fill‐in synthesis in both fission yeast and human cells.
Open Access Hfq‐dependent mRNA unfolding promotes sRNA‐based inhibition of translation
e101199 | First Published: 04 March 2019
Different from its canonical role as an RNA interaction platform, the RNA chaperone Hfq regulates biofilm formation by remodeling dgcM mRNA, thus enabling its repression via OmrA/B sRNAs.
Open Access BRD4 directs hematopoietic stem cell development and modulates macrophage inflammatory responses
e100293 | First Published: 06 March 2019
New mouse models and genomic analyses reveal context‐dependent roles for BRD4 during normal hematopoiesis and inflammation.
Open Access The pluripotency factor NANOG controls primitive hematopoiesis and directly regulates Tal1
e99122 | First Published: 27 February 2019
NANOG regulates the transition from mesoderm to primitive hematopoietic system by directly repressing erythroid lineage specification.
Open Access Extracellular matrix sensing by FERONIA and Leucine‐Rich Repeat Extensins controls vacuolar expansion during cellular elongation in Arabidopsis thaliana
e100353 | First Published: 08 March 2019
Extracellular Leucine‐Rich Repeat Extensin proteins link the plasma membrane receptor‐like kinase FERONIA with the cell wall for sensing mechanical constraints affecting vacuolar size and plant cell elongation.
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