Table of Contents Alert: The EMBO Journal, Vol. 38, No. 5, 1 March 2019

The EMBO Journal Volume 38, Issue 5 1 March 2019

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News & Views

Ubiquitin—a beacon for all during quality control on the ribosome

Liewei L Yan, Hani S Zaher

e101633 | First Published: 15 February 2019

Two recent studies reveal the importance of ribosomal protein ubiquitination within the unique structural context of collided ribosomes for mRNA no‐go decay and proteolysis of aborted nascent peptides.

Length doesn't matter—telomere damage triggers cellular senescence in the ageing heart

Thomas Brand

e101571 | First Published: 15 February 2019

A new study shows that DNA damage at chromosome ends causes deterioration of post‐mitotic cardiomyocytes independently of telomere replication and length maintenance.

Articles

Collided ribosomes form a unique structural interface to induce Hel2‐driven quality control pathways

Ken Ikeuchi, Petr Tesina, Yoshitaka Matsuo, Takato Sugiyama, Jingdong Cheng, Yasushi Saeki, Keiji Tanaka, Thomas Becker, Roland Beckmann, Toshifumi Inada

e100276 | First Published: 04 January 2019

Yeast Hel2 ubiquitin ligase functions in both ribosome‐associated protein quality control and canonical mRNA no‐go decay pathways coupled to disome units.

Open Access Highlight

Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence

Rhys Anderson, Anthony Lagnado, Damien Maggiorani, Anna Walaszczyk, Emily Dookun, James Chapman, Jodie Birch, Hanna Salmonowicz, Mikolaj Ogrodnik, Diana Jurk, Carole Proctor, Clara Correia‐Melo, Stella Victorelli, Edward Fielder, Rolando Berlinguer‐Palmini, Andrew Owens, Laura C Greaves, Kathy L Kolsky, Angelo Parini, Victorine Douin‐Echinard, Nathan K LeBrasseur, Helen M Arthur, Simon Tual‐Chalot, Marissa J Schafer, Carolyn M Roos, Jordan D Miller, Neil Robertson, Jelena Mann, Peter D Adams, Tamara Tchkonia, James L Kirkland, Jeanne Mialet‐Perez, Gavin D Richardson, João F Passos

e100492 | First Published: 08 February 2019

Mitochondria derived reactive oxygen species trigger persistent DNA damage at telomeres, cardiomyocyte senescence and heart dysfunction during ageing.

Open Access Highlight

The herpesviral antagonist m152 reveals differential activation of STING‐dependent IRF and NF‐κB signaling and STING's dual role during MCMV infection

Markus Stempel, Baca Chan, Vanda Juranić Lisnić, Astrid Krmpotić, Josephine Hartung, Søren R Paludan, Nadia Füllbrunn, Niels AW Lemmermann, Melanie M Brinkmann

e100983 | First Published: 29 January 2019

The murine cytomegalovirus (MCMV) protein m152 specifically antagonizes the cGAS‐STING mediated antiviral type I IFN response but not STING‐mediated NF‐κB signaling to promote CMV infection.

Abnormal TDP‐43 function impairs activity‐dependent BDNF secretion, synaptic plasticity, and cognitive behavior through altered Sortilin splicing

Jason Y Tann, Lik‐Wei Wong, Sreedharan Sajikumar, Carlos F Ibáñez

e100989 | First Published: 29 January 2019

Knock‐down, aggregation or neurodegeneration‐associated mutation of TDP‐43 equally culminate in impaired secretion of neurotrophin BDNF, whose restoration is sufficient to rescue major disease phenotypes caused by aberrant TDP‐43 activity.

Localized incorporation of outer membrane components in the pathogen Brucella abortus

Victoria Vassen, Claire Valotteau, Cécile Feuillie, Cécile Formosa‐Dague, Yves F Dufrêne, Xavier De Bolle

e100323 | First Published: 11 January 2019

Cell envelope proteins and saccharides of Brucella abortus are targeted to active membrane growth sites and exhibit low mobility increasing surface antigen variability.

EZH2 cooperates with gain‐of‐function p53 mutants to promote cancer growth and metastasis

Yu Zhao, Liya Ding, Dejie Wang, Zhenqing Ye, Yundong He, Linlin Ma, Runzhi Zhu, Yunqian Pan, Qiang Wu, Kun Pang, Xiaonan Hou, Saravut J Weroha, Conghui Han, Roger Coleman, Ilsa Coleman, R Jeffery Karnes, Jun Zhang, Peter S Nelson, Liguo Wang, Haojie Huang

e99599 | First Published: 05 February 2019

A non‐methyltransferase function of EZH2 controls cap‐independent translation of wildtype and mutant p53 in prostate cancer.

Endophilin‐A regulates presynaptic Ca2+ influx and synaptic vesicle recycling in auditory hair cells

Jana Kroll, Lina M Jaime Tobón, Christian Vogl, Jakob Neef, Ilona Kondratiuk, Melanie König, Nicola Strenzke, Carolin Wichmann, Ira Milosevic, Tobias Moser

e100116 | First Published: 07 February 2019

Endophilins regulate Ca²⁺ channel abundance, Ca²⁺ influx and synaptic vesicle recycling in inner hair cells by coupling exocytosis to endocytosis, contributing to membrane retrieval and synaptic vesicle reformation.

Structures of the heart specific SERCA2a Ca2+‐ATPase

Aljona Sitsel, Joren De Raeymaecker, Nikolaj Düring Drachmann, Rita Derua, Susanne Smaardijk, Jacob Lauwring Andersen, Ilse Vandecaetsbeek, Jialin Chen, Marc De Maeyer, Etienne Waelkens, Claus Olesen, Peter Vangheluwe, Poul Nissen

e100020 | First Published: 18 February 2019

The first crystal structures of the major driver and regulator of heart contractility SERCA2a explain the kinetic differences between SERCA1a and SERCA2a.

Corrigendum

Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1

María J Caloca, José L Zugaza, David Matallanas, Piero Crespo, Xosé R Bustelo

e101432 | First Published: 01 March 2019

This article is a correction.

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