The EMBO Journal Table of Contents for 15 October 2018; Vol. 37, No. 20

15 October 2018 | Volume 37, Number 20 Submit Table of Contents News & Views Review Articles Volume 37, Number 20 News & Views ATF4‐amino acid circuits: a recipe for resistance in melanoma A new study shows that ATF4‐mediated rewiring of amino acid metabolism mediates resistance to lactate dehydrogenase A inhibitors. Mario R Fernandez and John L Cleveland Published online 28.09.2018 Epigenetically jump starting de novo shoot regeneration The histone acetyltransferase HAG1 drives plant regeneration from callus by promoting the expression of root stem cell factors. Ning Zhang and Thomas Laux Published online 01.10.2018 Review Postsynaptic localization and regulation of AMPA receptors and Cav1.2 by β2 adrenergic receptor/PKA and Ca2+/CaMKII signaling A comprehensive review of postsynaptic signaling pathways illustrates the complex structural and functional framework required to accurately regulate synaptic strength. Tommaso Patriarchi, Olivia R Buonarati and Johannes W Hell Published online 24.09.2018 Articles Pool size estimations for dense‐core vesicles in mammalian CNS neurons A quantitative analysis of neuropeptide‐secreting dense‐core vesicles (DCVs) using super‐resolution and electron microscopy provides insight into DCV distribution, abundance and release probability. Claudia M Persoon, Alessandro Moro, Joris P Nassal, Margherita Farina, Jurjen H Broeke, Swati Arora, Natalia Dominguez, Jan RT van Weering, Ruud F Toonen and Matthijs Verhage Published online 05.09.2018 Targeting the Warburg effect via LDHA inhibition engages ATF4 signaling for cancer cell survival An ATF4‐dependent increase in the uptake of glutamine and essential amino acids allows melanoma cells to overcome pharmacological LDHA blockade by stimulating mTORC1 activity. Gaurav Pathria, David A Scott, Yongmei Feng, Joo Sang Lee, Yu Fujita, Gao Zhang, Avinash D Sahu, Eytan Ruppin, Meenhard Herlyn, Andrei L Osterman and Ze'ev A Ronai Published online 12.09.2018 Epigenetic reprogramming by histone acetyltransferase HAG1/AtGCN5 is required for pluripotency acquisition in Arabidopsis Histone acetyltransferase activity in the developing callus is essential for de novo shoot regeneration by regulating key pluripotency factors. Ji‐Yun Kim, Woorim Yang, Joachim Forner, Jan U Lohmann, Bosl Noh and Yoo‐Sun Noh Published online 30.07.2018 CPEB2‐dependent translation of long 3′‐UTR Ucp1 mRNA promotes thermogenesis in brown adipose tissue Isoform‐specific translation of Ucp1, stimulated by cytoplasmic polyA‐binding protein CPEB2 and adrenergic signaling, is required for thermogenesis in vivo. Hui‐Feng Chen, Chen‐Ming Hsu and Yi‐Shuian Huang Published online 03.09.2018 CDK1‐mediated BCL9 phosphorylation inhibits clathrin to promote mitotic Wnt signalling A mechanism by which core cell cycle regulators prevent degradation of the LRP6 signalosome during mitosis may be involved in promoting tumorigenesis. Jianxiang Chen, Muthukumar Rajasekaran, Hongping Xia, Shik Nie Kong, Amudha Deivasigamani, Karthik Sekar, Hengjun Gao, Hannah LF Swa, Jayantha Gunaratne, London Lucien Ooi, Tian Xie, Wanjin Hong and Kam Man Hui Published online 14.09.2018 Endolysosomal degradation of Tau and its role in glucocorticoid‐driven hippocampal malfunction Glucocorticoids induce Tau accumulation and downstream hippocampal dysfunction by suppressing endolysosomal degradation of Tau via the small GTPase Rab35 and the ESCRT machinery. João Vaz‐Silva, Patrícia Gomes, Qi Jin, Mei Zhu, Viktoriya Zhuravleva, Sebastian Quintremil, Torcato Meira, Joana Silva, Chrysoula Dioli, Carina Soares‐Cunha, Nikolaos P Daskalakis, Nuno Sousa, Ioannis Sotiropoulos and Clarissa L Waites Published online 30.08.2018 Ubiquitin‐specific protease USP34 controls osteogenic differentiation and bone formation by regulating BMP2 signaling Combining in vitro and in vivo approaches, this study identifies USP34 as a new regulator of osteogenesis via targeted stabilization of Smad1 and RUNX2, illustrating a role for protein deubiquitination in bone formation. Yu‐chen Guo, Meng‐yuan Wang, Shi‐wen Zhang, Yun‐shu Wu, Chen‐chen Zhou, Ri‐xin Zheng, Bin Shao, Yuan Wang, Liang Xie, Wei‐qing Liu, Ning‐yuan Sun, Jun‐jun Jing, Ling Ye, Qian‐ming Chen and Quan Yuan Published online 04.09.2018   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation.