Nature Reviews Genetics Contents December 2016 Volume 17 Number 12 pp715-772

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TABLE OF CONTENTS
December 2016 Volume 17 Number 12		Advertisement
2015 2-year Impact Factor 35.898 Journal Metrics 2-year Median 32	In this issue Research Highlights Reviews Also this month Article series: Non-coding RNA Article series: Epigenetics Article series: Applications of next-generation sequencing  Featured article: The state of play in higher eukaryote gene annotation Jonathan M. Mudge & Jennifer Harrow	WE SEQUENCE, YOU DISCOVER We offer complete NGS services to support your Genomic Research programs or Clinical Trial projects, executed in our CAP and ISO accredited laboratories around the world. For small projects, or for large-scale population studies, we are at your service with fast, high quality and affordable results.  Learn More About BGI Preferred Sequencing Services.
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RESEARCH HIGHLIGHTS Top Development: Sonic snakes and regulation of limb formation p715 | doi:10.1038/nrg.2016.149 PDF Genetic variation: Diving deep into the genome p716 | doi:10.1038/nrg.2016.144 PDF Genomics: Mapping meiotic breaks p716 | doi:10.1038/nrg.2016.146 PDF Chromatin: Going a TAD out on a limb p717 | doi:10.1038/nrg.2016.140 PDF Technique: See and seq the regulome p718 | doi:10.1038/nrg.2016.143 PDF Non-coding RNA: Deciphering the rules of microRNA targeting p718 | doi:10.1038/nrg.2016.148 PDF Genetics JOBS of the week More Science jobs from Genetics EVENT Norwich, UK More science events from
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REVIEWS		Top
Article series: Non-coding RNA A network-biology perspective of microRNA function and dysfunction in cancer Cameron P. Bracken, Hamish S. Scott & Gregory J. Goodall p719 | doi:10.1038/nrg.2016.134 MicroRNAs (miRNAs) have emerged as crucial components of gene-regulatory networks, in which they act alone or cooperatively to regulate gene expression. Here, the authors provide a systems-biological view of miRNA function and how disruption of miRNA networks can lead to malignancy. Abstract | Full Text | PDF
Article series: Epigenetics Epigenetic inheritance of acquired traits through sperm RNAs and sperm RNA modifications Qi Chen, Wei Yan & Enkui Duan p733 | doi:10.1038/nrg.2016.106 Studies have demonstrated that paternal traits acquired in response to environmental conditions can be inherited by the offspring, sometimes persisting for multiple generations. In this Review, the authors discuss the accumulating evidence of a major role for sperm RNAs and RNA modifications in the inheritance of acquired traits and the mechanisms that may underlie this. Abstract | Full Text | PDF
The origin and evolution of cell types Detlev Arendt et al. p744 | doi:10.1038/nrg.2016.127 In this article, the authors review the current understanding of the molecular mechanisms underlying cell type identity and discuss how new phenotypic features of cell types evolve. They explain how evolutionary lineage differs from developmental lineage and highlight how an evolutionary view of cell type identity can facilitate research in comparative cell biology. Abstract | Full Text | PDF
Article series: Applications of next-generation sequencing The state of play in higher eukaryote gene annotation Jonathan M. Mudge & Jennifer Harrow p758 | doi:10.1038/nrg.2016.119 A genome sequence is only useful once the information encoded in it can be deciphered. In this Review, Mudge and Harrow describe the latest approaches to higher eukaryote gene annotation, including making the best use of complex transcriptome data sets, integrating evidence for functionality and extending annotations to encompass regulatory features. Abstract | Full Text | PDF
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Have you read these highly downloaded articles published by Human Genome Variation, an open access journal to provide genome variation reports and database? Integrated small copy number variations and epigenome maps of disorders of sex development Two novel mutations in the KHDC3L gene in Asian patients with recurrent hydatidiform mole Read more open access contents.
Corrigendum: Organization and function of the 3D genome Boyan Bonev & Giacomo Cavalli p772 | doi:10.1038/nrg.2016.147 Full Text | PDF
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*2015 Journal Citation Report (Thomson Reuters, 2016)

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