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Advertisement | | | | | Latest Articles | View all Articles | | | | | Estimating economic losses to tourism in Africa from the illegal killing of elephants OPEN | | | Robin Naidoo, Brendan Fisher, Andrea Manica and Andrew Balmford | | | An ongoing elephant poaching crisis is threatening not only elephant populations but also the local economies that rely on nature-based tourism. Here, Naidoo and colleagues use an economic model to estimate the financial contribution of elephants to tourism and the possible consequences of their loss. | | | 01 November 2016 | doi: 10.1038/ncomms13379 | | |
| Altruistic punishment does not increase with the severity of norm violations in the field OPEN | | | Loukas Balafoutas, Nikos Nikiforakis and Bettina Rockenbach | | | Lab experiments have shown that people will punish violators of social norms, with the severity of punishment increasing with the degree of violation. Here, Balafoutas et al. show that, outside of the lab, larger violations are not punished more severely and are associated with a greater risk of reprisal. | | | 01 November 2016 | doi: 10.1038/ncomms13327 | | |
| Social support reduces stress hormone levels in wild chimpanzees across stressful events and everyday affiliations OPEN | | | Roman M. Wittig, Catherine Crockford, Anja Weltring, Kevin E. Langergraber, Tobias Deschner and Klaus Zuberbühler | | | The stress-reducing effects of social bonds have been hypothesized to accrue either during stressful events or across daily affiliations. Here, Wittig et al. show that the presence of social partners reduces levels of stress hormones in wild chimpanzees beyond stressful contexts, supporting the latter hypothesis. | | | 01 November 2016 | doi: 10.1038/ncomms13361 | | |
| Seismic evidence for a cold serpentinized mantle wedge beneath Mount St Helens OPEN | | | S. M. Hansen, B. Schmandt, A. Levander, E. Kiser, J. E. Vidale, G. A. Abers and K. C. Creager | | | Mount St Helens is the most active volcano in the Cascades but is located 50 km west of the arc axis. Hansen et al. use high resolution seismic data to image a boundary in Moho reflectivity beneath St Helens implying a serpentinized mantle wedge and a melt source region that lies to the east towards Mount Adams. | | | 01 November 2016 | doi: 10.1038/ncomms13242 | | |
| Quantifying unobserved protein-coding variants in human populations provides a roadmap for large-scale sequencing projects OPEN | | | James Zou, Gregory Valiant, Paul Valiant, Konrad Karczewski, Siu On Chan, Kaitlin Samocha, Monkol Lek, Shamil Sunyaev, Mark Daly and Daniel G. MacArthur | | | Accurate estimations of the frequency distribution of rare variants are needed to quantify the discovery power and guide large-scale human sequencing projects. This study describes an algorithm called UnseenEst to estimate the distribution of genetic variations using tens of thousands of exomes. | | | 31 October 2016 | doi: 10.1038/ncomms13293 | | |
| In situ single-atom array synthesis using dynamic holographic optical tweezers OPEN | | | Hyosub Kim, Woojun Lee, Han-gyeol Lee, Hanlae Jo, Yunheung Song and Jaewook Ahn | | | It would be desirable to have a reliable and scalable method to manipulate neutral-atoms for the creation of controllable quantum systems. Here the authors demonstrate real-time transport of single rubidium atoms in holographic microtraps controlled by liquid-crystal spatial light modulators. | | | 31 October 2016 | doi: 10.1038/ncomms13317 | | |
| Ultrafast photocurrents at the surface of the three-dimensional topological insulator Bi2Se3 OPEN | | | Lukas Braun, Gregor Mussler, Andrzej Hruban, Marcin Konczykowski, Thomas Schumann, Martin Wolf, Markus Münzenberg, Luca Perfetti and Tobias Kampfrath | | | Surface currents in topological insulators can be controlled by light, but the underlying mechanisms are not well understood. Here, Braun et al. report an ultrafast shift photocurrent at the surface of Ca-doped Bi2Se3, whereas injection currents are much smaller than expected from asymmetric depopulation of the Dirac cone. | | | 31 October 2016 | doi: 10.1038/ncomms13259 | | |
| In situ electrochemical quantification of active sites in Fe–N/C non-precious metal catalysts OPEN | | | Daniel Malko, Anthony Kucernak and Thiago Lopes | | | Fe-N/C catalysts show surprising activity towards oxygen reduction in fuel cells. However, there is significant uncertainty as to the structure of the active site. Here, the authors quantify the number and turnover frequency of the active sites by reversibly blocking those sites with nitrite (NO2¯). | | | 31 October 2016 | doi: 10.1038/ncomms13285 | | |
| Imparting amphiphobicity on single-crystalline porous materials OPEN | | | Qi Sun, Hongming He, Wen-Yang Gao, Briana Aguila, Lukasz Wojtas, Zhifeng Dai, Jixue Li, Yu-Sheng Chen, Feng-Shou Xiao and Shengqian Ma | | | The inherent instabilities of metal-organic frameworks (MOFs) in the presence of water or organic compounds have limited their real-world applicability. Here, Ma and co-workers present a coating strategy to fabricate MOFs with amphiphobic surfaces, simultaneously protecting them from moisture and organic vapours. | | | 31 October 2016 | doi: 10.1038/ncomms13300 | | |
| Plants capable of selfing are more likely to become naturalized OPEN | | | Mialy Razanajatovo, Noëlie Maurel, Wayne Dawson, Franz Essl, Holger Kreft, Jan Pergl, Petr Pyšek, Patrick Weigelt, Marten Winter and Mark van Kleunen | | | Plants with the capability to reproduce easily without mates and pollinators could have an advantage when colonizing new territory. Here, Razanajatovo et al. use a global database to infer that flowering plants capable of selfing have become naturalized in a larger number of regions than those that must outcross. | | | 31 October 2016 | doi: 10.1038/ncomms13313 | | |
| Atomic intercalation to measure adhesion of graphene on graphite OPEN | | | Jun Wang, Dan C. Sorescu, Seokmin Jeon, Alexei Belianinov, Sergei V. Kalinin, Arthur P. Baddorf and Petro Maksymovych | | | Analysis of the mechanical properties of two-dimensional materials is important for device development. Here, the authors report a microscopic method for measuring the adhesion of graphene on top of highly ordered pyrolytic graphite, which exploits atomic-scale blisters formed upon neon atom intercalation. | | | 31 October 2016 | doi: 10.1038/ncomms13263 | | |
| Evolution of heterogeneous genome differentiation across multiple contact zones in a crow species complex OPEN | | | Nagarjun Vijay, Christen M. Bossu, Jelmer W. Poelstra, Matthias H. Weissensteiner, Alexander Suh, Alexey P. Kryukov and Jochen B. W. Wolf | | | Genetic changes accumulate as populations diverge and new species emerge. Here, Vijay et al. resequence the genomes of crow populations at various stages of genetic differentiation, and shed light on the evolutionary processes acting during the origin and hybridization of crows in Europe and Asia. | | | 31 October 2016 | doi: 10.1038/ncomms13195 | | |
| Disposal of iron by a mutant form of lipocalin 2 OPEN | | | Jonathan Barasch, Maria Hollmen, Rong Deng, Eldad A. Hod, Peter B. Rupert, Rebecca J. Abergel, Benjamin E. Allred, Katherine Xu, Shaun F. Darrah, Yared Tekabe, Alan Perlstein, Rebecca Wax, Efrat Bruck, Jacob Stauber, Kaitlyn A. Corbin, Charles Buchen, Vesna Slavkovich, Joseph Graziano, Steven L. Spitalnik, Guanhu Bao et al. | | | Iron overload can be either hereditary or acquired via transfusions, and current treatments include the use of iron chelators that have adverse effects in some patients. Here the authors modify siderocalin to enhance iron excretion in urine, and demonstrate therapeutic efficacy in iron overload mouse models. | | | 31 October 2016 | doi: 10.1038/ncomms12973 | | |
| PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation OPEN | | | Hiroshi Iwata, Claudia Goettsch, Amitabh Sharma, Piero Ricchiuto, Wilson Wen Bin Goh, Arda Halu, Iwao Yamada, Hideo Yoshida, Takuya Hara, Mei Wei, Noriyuki Inoue, Daiju Fukuda, Alexander Mojcher, Peter C. Mattson, Albert-László Barabási, Mark Boothby, Elena Aikawa, Sasha A. Singh and Masanori Aikawa | | | Signalling pathways that mediate macrophage activation in disease are poorly understood. Here the authors show that inhibition of PARP9 and/or activation of PARP14 may attenuate macrophage-mediated vascular diseases, and also provide new insight into the development of effective therapies for other inflammatory disorders. | | | 31 October 2016 | doi: 10.1038/ncomms12849 | | |
| Structure of the bacterial plant-ferredoxin receptor FusA OPEN | | | Rhys Grinter, Inokentijs Josts, Khedidja Mosbahi, Aleksander W. Roszak, Richard J. Cogdell, Alexandre M. J. J. Bonvin, Joel J. Milner, Sharon M. Kelly, Olwyn Byron, Brian O. Smith and Daniel Walker | | | Many bacteria use TonB-dependent outer membrane receptors to scavenge iron from their host during infection. Here, the authors report on the structure and function of FusA, which is a bacterial receptor that is used to obtain iron from plants. | | | 31 October 2016 | doi: 10.1038/ncomms13308 | | |
| The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines OPEN | | | Zhuoyi Liang, Yi Zhan, Yang Shen, Catherine C. L. Wong, John R. Yates, Florian Plattner, Kwok-On Lai and Nancy Y. Ip | | | CaMKv is a pseduokinase of unknown function. Here, the authors identify the protein as a substrate of the protein kinase Cdk5, and show that CaMKv is synthesized in response to neural activity and plays an important role in maintaining dendritic spines, synaptic plasticity, and hippocampal memory via RhoA inhibition. | | | 31 October 2016 | doi: 10.1038/ncomms13282 | | |
| Room-temperature Tamm-plasmon exciton-polaritons with a WSe2 monolayer OPEN | | | Nils Lundt, Sebastian Klembt, Evgeniia Cherotchenko, Simon Betzold, Oliver Iff, Anton V. Nalitov, Martin Klaas, Christof P. Dietrich, Alexey V. Kavokin, Sven Höfling and Christian Schneider | | | Thanks to their strong light-matter interaction, atomically thin transition metal dichalcogenides are ideal active materials for cavity quantum electrodynamics. Here, the authors embed a WSe2 monolayer within a Tamm-plasmon-polariton cavity, and observe exciton-polariton formation at room temperature. | | | 31 October 2016 | doi: 10.1038/ncomms13328 | | |
| Spontaneous emergence of fast attractor dynamics in a model of developing primary visual cortex OPEN | | | Thomas Miconi, Jeffrey L. McKinstry and Gerald M. Edelman | | | Sensory cortices represent stimuli through joint activity of competing neuronal assemblies. Here the authors show that a model of visual cortex with plastic feedforward and recurrent synapses, exposed to natural images, spontaneously develops attractor dynamics between groups of similarly tuned neurons. | | | 31 October 2016 | doi: 10.1038/ncomms13208 | | |
| Structural basis of checkpoint blockade by monoclonal antibodies in cancer immunotherapy OPEN | | | Ju Yeon Lee, Hyun Tae Lee, Woori Shin, Jongseok Chae, Jaemo Choi, Sung Hyun Kim, Heejin Lim, Tae Won Heo, Kyeong Young Park, Yeon Ji Lee, Seong Eon Ryu, Ji Young Son, Jee Un Lee and Yong-Seok Heo | | | Immunotherapy is offering patients with cancer new therapy options. Here, the authors report on the crystal structures of some of these therapies bound to their targets. | | | 31 October 2016 | doi: 10.1038/ncomms13354 | | |
| KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification OPEN | | | Marjorie Fournier, Meritxell Orpinell, Cédric Grauffel, Elisabeth Scheer, Jean-Marie Garnier, Tao Ye, Virginie Chavant, Mathilde Joint, Fumiko Esashi, Annick Dejaegere, Pierre Gönczy and László Tora | | | The acetyltransferases KAT2A and KAT2B are essential regulators of transcription, cell cycle progression and DNA repair. Here the authors describe a KAT2A/2B-dependent acetylome, and show that acetylation of the protein kinase PLK4 contributes to the regulation of centrosome number. | | | 31 October 2016 | doi: 10.1038/ncomms13227 | | |
| How EF-Tu can contribute to efficient proofreading of aa-tRNA by the ribosome OPEN | | | Jeffrey K. Noel and Paul C. Whitford | | | The translation of mRNA by the ribosome is governed by a series of large-scale conformational transitions. Here the authors use MD simulations to demonstrate how the rate of dissociation of elongation factor Tu affects the dynamics of tRNA accommodation and proofreading. | | | 31 October 2016 | doi: 10.1038/ncomms13314 | | |
| Hair cell force generation does not amplify or tune vibrations within the chicken basilar papilla OPEN | | | Anping Xia, Xiaofang Liu, Patrick D. Raphael, Brian E. Applegate and John S. Oghalai | | | The avian auditory papilla has many similarities to the mammalian cochlea but whether force generation by hair cells amplifies the travelling wave, as it does in mammals, remains unknown. Here the authors show that the chicken basilar papilla does not have a ‘cochlear amplifier’ and that sharp frequency tuning does not derive from mechanical vibrations. | | | 31 October 2016 | doi: 10.1038/ncomms13133 | | |
| C14ORF39/SIX6OS1 is a constituent of the synaptonemal complex and is essential for mouse fertility OPEN | | | Laura Gómez-H, Natalia Felipe-Medina, Manuel Sánchez-Martín, Owen R. Davies, Isabel Ramos, Ignacio García-Tuñón, Dirk G. de Rooij, Ihsan Dereli, Attila Tóth, José Luis Barbero, Ricardo Benavente, Elena Llano and Alberto M. Pendas | | | The synaptonemal complex is a meiosis-specific proteinaceous structure that supports homologous chromosome pairs during meiosis. Here, the authors show that SIX6OS1 (of previously unknown function) is part of the synaptonemal complex central element and upon deletion in mice, causes defective chromosome synapsis and infertility. | | | 31 October 2016 | doi: 10.1038/ncomms13298 | | |
| Solar water splitting by photovoltaic-electrolysis with a solar-to-hydrogen efficiency over 30% OPEN | | | Jieyang Jia, Linsey C. Seitz, Jesse D. Benck, Yijie Huo, Yusi Chen, Jia Wei Desmond Ng, Taner Bilir, James S. Harris and Thomas F. Jaramillo | | | In order to be practical for large-scale deployment, the cost of solar hydrogen generation must be significantly reduced. Here, the authors employ a triple-junction solar cell with two series connected polymer electrolyte membrane electrolysers to achieve solar to hydrogen efficiency of 30%. | | | 31 October 2016 | doi: 10.1038/ncomms13237 | | |
| EGFR oligomerization organizes kinase-active dimers into competent signalling platforms OPEN | | | Sarah R. Needham, Selene K. Roberts, Anton Arkhipov, Venkatesh P. Mysore, Christopher J. Tynan, Laura C. Zanetti-Domingues, Eric T. Kim, Valeria Losasso, Dimitrios Korovesis, Michael Hirsch, Daniel J. Rolfe, David T. Clarke, Martyn D. Winn, Alireza Lajevardipour, Andrew H. A. Clayton, Linda J. Pike, Michela Perani, Peter J. Parker, Yibing Shan, David E. Shaw et al. | | | Epidermal growth factor receptors have been shown to oligomerise upon binding to their cognate ligands. Here, the authors use biochemical, biophysical and cell biology techniques to analyse the structures of these oligomers, and argue that these formations are required for signalling. | | | 31 October 2016 | doi: 10.1038/ncomms13307 | | |
| Thick filament mechano-sensing is a calcium-independent regulatory mechanism in skeletal muscle OPEN | | | L. Fusi, E. Brunello, Z. Yan and M. Irving | | | Recent data suggest that muscle contraction is regulated by thick filament mechano-sensing in addition to the well-known thin filament-mediated calcium signalling pathway. Here the authors provide direct evidence that myosin activation in skeletal muscle is controlled by thick filament stress independently of calcium. | | | 31 October 2016 | doi: 10.1038/ncomms13281 | | |
| Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging OPEN | | | Feng Tian, Wenlong Yang, Daniel A. Mordes, Jin-Yuan Wang, Johnny S. Salameh, Joanie Mok, Jeannie Chew, Aarti Sharma, Ester Leno-Duran, Satomi Suzuki-Uematsu, Naoki Suzuki, Steve S. Han, Fa-Ke Lu, Minbiao Ji, Rosanna Zhang, Yue Liu, Jack Strominger, Neil A. Shneider, Leonard Petrucelli, X. Sunney Xie et al. | | | Sensitive and label-free imaging methods to visualize nerve degeneration are currently lacking. Here authors show that stimulated Raman scattering (SRS) microscopy can be used to monitor peripheral nerve degeneration in mouse models of amyotrophic lateral sclerosis (ALS) and in postmortem tissue from ALS patients. | | | 31 October 2016 | doi: 10.1038/ncomms13283 | | |
| Mitochondrial function controls intestinal epithelial stemness and proliferation OPEN | | | Emanuel Berger, Eva Rath, Detian Yuan, Nadine Waldschmitt, Sevana Khaloian, Michael Allgäuer, Ori Staszewski, Elena M. Lobner, Theresa Schöttl, Pieter Giesbertz, Olivia I. Coleman, Marco Prinz, Achim Weber, Markus Gerhard, Martin Klingenspor, Klaus-Peter Janssen, Mathias Heikenwalder and Dirk Haller | | | It is unclear what role mitochondrial function plays in maintaining intestinal epithelial cell (IEC) homeostasis. Here, the authors deplete a mitochondrial chaperone, heat shock protein 60 (HSP60) in IEC and observe a loss of stemness and cell proliferation, and suggest this is accompanied by a compensatory release of WNT-related factors. | | | 27 October 2016 | doi: 10.1038/ncomms13171 | | |
| Induced sensorimotor brain plasticity controls pain in phantom limb patients OPEN | | | Takufumi Yanagisawa, Ryohei Fukuma, Ben Seymour, Koichi Hosomi, Haruhiko Kishima, Takeshi Shimizu, Hiroshi Yokoi, Masayuki Hirata, Toshiki Yoshimine, Yukiyasu Kamitani and Youichi Saitoh | | | Pain in a phantom limb after limb deafferentation may be due to maladaptive sensorimotor representation. Here the authors find that sensorimotor plasticity induced by BMI training with the phantom hand, contrary to expectation, increased pain while dissociating prosthetic movements from the phantom arm relieved the pain. | | | 27 October 2016 | doi: 10.1038/ncomms13209 | | |
| Molecular basis of cooperativity in pH-triggered supramolecular self-assembly OPEN | | | Yang Li, Tian Zhao, Chensu Wang, Zhiqiang Lin, Gang Huang, Baran D. Sumer and Jinming Gao | | | Understanding stimuli responsiveness on a molecular level can help with the rational design of nanomaterials with sharp responses. Here, Gao and co-workers have shown the molecular pathway of the supramolecular self-assembly of a series of ultra-pH sensitive block copolymers. | | | 27 October 2016 | doi: 10.1038/ncomms13214 | | |
| Phasic dopamine release in the rat nucleus accumbens predicts approach and avoidance performance OPEN | | | Ronny N. Gentry, Brian Lee and Matthew R. Roesch | | | Reward seeking behaviors involve dopamine (DA) release but the circuits underlying avoidance behavior remain comparatively understudied. Here the authors show that phasic increases in DA release in rats are higher for reward and avoidance cues compared with neutral cues and are positively correlated with poor avoidance. | | | 27 October 2016 | doi: 10.1038/ncomms13154 | | |
| mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation OPEN | | | Xiaolei Ding, Wilhelm Bloch, Sandra Iden, Markus A. Rüegg, Michael N. Hall, Maria Leptin, Linda Partridge and Sabine A. Eming | | | mTOR regulates cell growth via a protein complex including mTORC1 and mTORC2, but their role in skin morphogenesis is unclear. Here, the authors delete mTORC1 and mTORC2 from the epidermis and see epidermal deficiencies but both mTORCs play distinct roles in skin morphogenesis. | | | 27 October 2016 | doi: 10.1038/ncomms13226 | | |
| Irminger Sea deep convection injects oxygen and anthropogenic carbon to the ocean interior OPEN | | | F. Fröb, A. Olsen, K. Våge, G. W. K. Moore, I. Yashayaev, E. Jeansson and B. Rajasakaren | | | Deep convection in the Irminger Sea has been shown to be highly variable on annual timescales. Here, the authors provide a direct link between atmospheric forcing and anthropogenic carbon storage and oxygen ventilation based on a unique cruise dataset acquired during active deep water formation. | | | 27 October 2016 | doi: 10.1038/ncomms13244 | | |
| Coupling optogenetic stimulation with NanoLuc-based luminescence (BRET) Ca++ sensing OPEN | | | Jie Yang, Derrick Cumberbatch, Samuel Centanni, Shu-qun Shi, Danny Winder, Donna Webb and Carl Hirschie Johnson | | | The coupling of optogenetics with fluorescent Ca2+ sensors is confounded by sensitivity of optogenetic probes to light used to excite the sensors. Here the authors develop a Ca2+ sensor based on bioluminescence resonance energy transfer (BRET) that monitors Ca2+ fluxes in darkness without excitation. | | | 27 October 2016 | doi: 10.1038/ncomms13268 | | |
| T cell receptor recognition of CD1b presenting a mycobacterial glycolipid OPEN | | | Stephanie Gras, Ildiko Van Rhijn, Adam Shahine, Tan-Yun Cheng, Mugdha Bhati, Li Lynn Tan, Hanim Halim, Kathryn D. Tuttle, Laurent Gapin, Jérôme Le Nours, D. Branch Moody and Jamie Rossjohn | | | Germline-encoded mycolyl lipid-reactive (GEM) T cells recognize CD1b proteins presenting mycobacterial mycolates via their T-cell receptors (TCRs). Here, the authors present the structure of this interaction and provide a molecular basis for the co-recognition of CD1b and a mycobacterial glycolipid. | | | 27 October 2016 | doi: 10.1038/ncomms13257 | | |
| Self-motion evokes precise spike timing in the primate vestibular system OPEN | | | Mohsen Jamali, Maurice J. Chacron and Kathleen E. Cullen | | | Early vestibular pathways are thought to code sensory inputs regarding self-motion via changes in firing rate. Here, the authors record from both regular and irregular afferents in macaques, and find both irregular afferents and central neurons also represent self-motion via temporally precise spike timing. | | | 27 October 2016 | doi: 10.1038/ncomms13229 | | |
| Engineered AAA+ proteases reveal principles of proteolysis at the mitochondrial inner membrane OPEN | | | Hui Shi, Anthony J. Rampello and Steven E. Glynn | | | Human YME1L is a membrane-anchored AAA+ protease that maintains proteostasis in the mitochondrial inner membrane and intermembrane space. Here the authors probe the substrate-binding and degradation activities of YME1L and suggest the existence of sequence-specific degradation signals in mitochondrial proteostasis. | | | 27 October 2016 | doi: 10.1038/ncomms13301 | | |
| The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation OPEN | | | Kwok Ho Yip, Natasha Kolesnikoff, Nicholas Hauschild, Lisa Biggs, Angel F. Lopez, Stephen J. Galli, Sharad Kumar and Michele A. Grimbaldeston | | | Aberrant activation of the IgE receptor on mast cells leads to allergic responses. Here, the authors identify an E3 ligase and adaptor protein that can reduce IgE signalling by targeting phosphorylated-Syk for degradation. | | | 27 October 2016 | doi: 10.1038/ncomms13198 | | |
| Bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction OPEN | | | Shuting Zhao, Zhaobin Xu, Hai Wang, Benjamin E. Reese, Liubov V. Gushchina, Meng Jiang, Pranay Agarwal, Jiangsheng Xu, Mingjun Zhang, Rulong Shen, Zhenguo Liu, Noah Weisleder and Xiaoming He | | | Stem cell therapy of myocardial infarction is hampered by poor survival of injected cells. Here the authors develop injectable aggregates of stem cells differentiated to an early cardiac stage and encapsulated in a biodegradable micromatrix, and show their enhanced therapeutic efficacy in a heart infarction mouse model. | | | 27 October 2016 | doi: 10.1038/ncomms13306 | | |
| Sulfur mass-independent fractionation in subsurface fracture waters indicates a long-standing sulfur cycle in Precambrian rocks OPEN | | | L. Li, B. A. Wing, T. H. Bui, J. M. McDermott, G. F. Slater, S. Wei, G. Lacrampe-Couloume and B. Sherwood Lollar | | | Precambrian rocks host a deep hydrosphere, but where dissolved sulfate, crucial for microbial life, comes from is unclear. At 2.4 km depth in the Canadian shield, Li et al. find that oxidation of sulfides in the host rocks creates sulfate thus providing a long-term mechanism for the deep biosphere sulfate. | | | 27 October 2016 | doi: 10.1038/ncomms13252 | | |
| Reorganization between preparatory and movement population responses in motor cortex OPEN | | | Gamaleldin F. Elsayed, Antonio H. Lara, Matthew T. Kaufman, Mark M. Churchland and John P. Cunningham | | | Single neuron responses are highly complex and dynamic yet they are able to flexibly represent behaviour through their collective activity. Here the authors demonstrate that population activity patterns of motor cortex neurons are orthogonal during successive task epochs that are linked through a simple linear function. | | | 27 October 2016 | doi: 10.1038/ncomms13239 | | |
| Crystal structures of the ATP-binding and ADP-release dwells of the V1 rotary motor OPEN | | | Kano Suzuki, Kenji Mizutani, Shintaro Maruyama, Kazumi Shimono, Fabiana L. Imai, Eiro Muneyuki, Yoshimi Kakinuma, Yoshiko Ishizuka-Katsura, Mikako Shirouzu, Shigeyuki Yokoyama, Ichiro Yamato and Takeshi Murata | | | V1-ATPases are rotary molecular motors that are powered by ATP hydrolysis. Here, the authors report two of the missing rotary states of this protein complex, and perform biochemical analysis to investigate the binding mode of the nucleotides. | | | 27 October 2016 | doi: 10.1038/ncomms13235 | | |
| Evaluating frequency and quality of pathogen-specific T cells OPEN | | | Nadia Anikeeva, Dolores Grosso, Neal Flomenberg and Yuri Sykulev | | | Characterization of T cell antigen specificity human blood is challenging due to the low clonal frequencies. Here the authors develop a fluorescent microscopy-based method to detect antigen-specific CD8 T cell activation, and apply it to characterize the anti-CMV repertoire. | | | 27 October 2016 | doi: 10.1038/ncomms13264 | | |
| Hybrid metamaterials for electrically triggered multifunctional control OPEN | | | Liu Liu, Lei Kang, Theresa S. Mayer and Douglas H. Werner | | | Despite their exotic properties active metamaterials, where active materials are introduced to advance tunability, switchability and nonlinearity, are seldom reported. Here, Liu et al. demonstrate a vanadium dioxide integrated photonic metamaterial as a transformative platform for multifunctional control. | | | 27 October 2016 | doi: 10.1038/ncomms13236 | | |
| The fungal-specific β-glucan-binding lectin FGB1 alters cell-wall composition and suppresses glucan-triggered immunity in plants OPEN | | | Stephan Wawra, Philipp Fesel, Heidi Widmer, Malte Timm, Jürgen Seibel, Lisa Leson, Leona Kesseler, Robin Nostadt, Magdalena Hilbert, Gregor Langen and Alga Zuccaro | | | β-glucans derived from fungal cell walls can trigger immune responses in animals, yet their roles in plant-fungal interactions are less well known. Here, Wawra et al. show that the FGB1 proteins, secreted by the fungal endophyte P. indica, can alter fungal cell wall composition and suppress immune responses in plants. | | | 27 October 2016 | doi: 10.1038/ncomms13188 | | |
| A robust gene-stacking method utilizing yeast assembly for plant synthetic biology OPEN | | | Patrick M. Shih, Khanh Vuu, Nasim Mansoori, Leïla Ayad, Katherine B. Louie, Benjamin P. Bowen, Trent R. Northen and Dominique Loqué | | | Plant synthetic biology offers the potential to re-engineer crops, but requires efficient methods to prepare constructs for transformation. Here Shih et al. develop jStack, a method that utilizes yeast homologous recombination and a library of DNA parts, to efficiently assemble plant transformation vectors. | | | 26 October 2016 | doi: 10.1038/ncomms13215 | | |
| Multi-omic data integration enables discovery of hidden biological regularities OPEN | | | Ali Ebrahim, Elizabeth Brunk, Justin Tan, Edward J. O'Brien, Donghyuk Kim, Richard Szubin, Joshua A. Lerman, Anna Lechner, Anand Sastry, Aarash Bordbar, Adam M. Feist and Bernhard O. Palsson | | | Translating omics data sets into biological insight is one of the great challenges of our time. Here, the authors make headway by synchronising pairs of omics data types via invariants across conditions and by integrating datasets into a genome-scale model of E. coli metabolism and gene expression. | | | 26 October 2016 | doi: 10.1038/ncomms13091 | | |
| Permanent ferroelectric retention of BiFeO3 mesocrystal OPEN | | | Ying-Hui Hsieh, Fei Xue, Tiannan Yang, Heng-Jui Liu, Yuanmin Zhu, Yi-Chun Chen, Qian Zhan, Chun-Gang Duan, Long-Qing Chen, Qing He and Ying-Hao Chu | | | Ferroelectric reliability must be solved prior to practical non-volatile electronic devices based on magnetoelectric multiferroics. Here, Hsieh et al. report a long lasting ferroelectric retention in the heteroepitaxially constrained multiferroic mesocrystal. | | | 26 October 2016 | doi: 10.1038/ncomms13199 | | |
| Wnt and Neuregulin1/ErbB signalling extends 3D culture of hormone responsive mammary organoids OPEN | | | Thierry Jardé, Bethan Lloyd-Lewis, Mairian Thomas, Howard Kendrick, Lorenzo Melchor, Lauriane Bougaret, Peter D. Watson, Kenneth Ewan, Matthew J. Smalley and Trevor C. Dale | | | Three-dimensional culture systems and organoids for mammary glands are important to understand mammary gland development. Here, the authors identify conditions (including Neuregulin 1 and R-spondin 1) that allow the culture of organoids that are responsive to hormonal stimulation for up to 2.5 months. | | | 26 October 2016 | doi: 10.1038/ncomms13207 | | |
| AtSWEET13 and AtSWEET14 regulate gibberellin-mediated physiological processes OPEN | | | Yuri Kanno, Takaya Oikawa, Yasutaka Chiba, Yasuhiro Ishimaru, Takafumi Shimizu, Naoto Sano, Tomokazu Koshiba, Yuji Kamiya, Minoru Ueda and Mitsunori Seo | | | SWEET proteins are known to function as sugar transporters. Here, Kanno et al. show that Arabidopsis SWEET13 and SWEET14 are also able to transport the plant hormone gibberellin (GA) in heterologous systems and that sweet mutants display phenotypes consistent with altered GA response. | | | 26 October 2016 | doi: 10.1038/ncomms13245 | | |
| In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery OPEN | | | Raman Bahal, Nicole Ali McNeer, Elias Quijano, Yanfeng Liu, Parker Sulkowski, Audrey Turchick, Yi-Chien Lu, Dinesh C. Bhunia, Arunava Manna, Dale L. Greiner, Michael A. Brehm, Christopher J. Cheng, Francesc López-Giráldez, Adele Ricciardi, Jagadish Beloor, Diane S. Krause, Priti Kumar, Patrick G. Gallagher, Demetrios T. Braddock, W. Mark Saltzman et al. | | | Gene editing approaches are widely used for correcting mutations, but their application is largely limited to cells and not living animals. Here the authors show that in vivo γPNA-mediated editing of a β-globin mutation is promoted by SCF and leads to sustained normalization of blood haemoglobin levels β-thalassemic mice. | | | 26 October 2016 | doi: 10.1038/ncomms13304 | | |
| Stoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagents OPEN | | | Barbara Bernardim, Pedro M.S.D. Cal, Maria J. Matos, Bruno L. Oliveira, Nuria Martínez-Sáez, Inês S. Albuquerque, Elizabeth Perkins, Francisco Corzana, Antonio C.B. Burtoloso, Gonzalo Jiménez-Osés and Gonçalo J. L. Bernardes | | | Current cysteine bioconjugation strategies for protein-drug conjugates synthesis often yield heterogeneous and poorly stable products. Here, the authors use carbonylacrylic derivatives to selectively modify cysteine residues and synthesize biologically functional antibody conjugates highly stable in plasma. | | | 26 October 2016 | doi: 10.1038/ncomms13128 | | |
| Direct penetration of spin-triplet superconductivity into a ferromagnet in Au/SrRuO3/Sr2RuO4 junctions OPEN | | | M. S. Anwar, S. R. Lee, R. Ishiguro, Y. Sugimoto, Y. Tano, S. J. Kang, Y. J. Shin, S. Yonezawa, D. Manske, H. Takayanagi, T. W. Noh and Y. Maeno | | | The injection of spin-polarized supercurrent into a ferromagnet presents the possibility of zero-resistance spintronic devices. Here, the authors evidence the direct injection of spin polarized supercurrent into ferromagnetic SrRuO3 from a candidate spin-triplet superconductor Sr2RuO4. | | | 26 October 2016 | doi: 10.1038/ncomms13220 | | |
| Time-resolved single dopant charge dynamics in silicon OPEN | | | Mohammad Rashidi, Jacob A. J. Burgess, Marco Taucer, Roshan Achal, Jason L. Pitters, Sebastian Loth and Robert A. Wolkow | | | Probing individual impurities will become increasingly important as devices shrink towards the nanoscale. Here Rashidi et al., introduce a method based on time-resolved scanning tunnelling spectroscopy of surface dangling bonds to investigate the dynamics of individual dopants in silicon. | | | 26 October 2016 | doi: 10.1038/ncomms13258 | | |
| Stretching magnetism with an electric field in a nitride semiconductor OPEN | | | D. Sztenkiel, M. Foltyn, G. P. Mazur, R. Adhikari, K. Kosiel, K. Gas, M. Zgirski, R. Kruszka, R. Jakiela, Tian Li, A. Piotrowska, A. Bonanni, M. Sawicki and T. Dietl | | | The wurtzite crystal structure of nitride semiconductors results in strong piezoelectricity. Here, the authors also achieve electric-field control of the magnetization of gallium manganese nitride, thus showing that piezoelectric and magnetoelectric effects can be combined in the same material. | | | 26 October 2016 | doi: 10.1038/ncomms13232 | | |
| Carbon nanotubes allow capture of krypton, barium and lead for multichannel biological X-ray fluorescence imaging OPEN | | | Christopher J. Serpell, Reida N. Rutte, Kalotina Geraki, Elzbieta Pach, Markus Martincic, Magdalena Kierkowicz, Sonia De Munari, Kim Wals, Ritu Raj, Belén Ballesteros, Gerard Tobias, Daniel C. Anthony and Benjamin G. Davis | | | Biological applications of x-ray fluorescence (XRF) imaging are currently limited to mapping naturally occurring elements in tissues. Here, the authors encapsulate toxic elements in functionalized single walled nanotubes, and use them as non-toxic XRF contrast agents for imaging specific cellular organelles. | | | 26 October 2016 | doi: 10.1038/ncomms13118 | | |
| Donor polymer design enables efficient non-fullerene organic solar cells OPEN | | | Zhengke Li, Kui Jiang, Guofang Yang, Joshua Yuk Lin Lai, Tingxuan Ma, Jingbo Zhao, Wei Ma and He Yan | | | In organic photovoltaics, electron acceptors are developed to replace fullerenes, and new donors need to be designed to match these acceptors. Here, the authors show that a polymer with strong temperature dependent aggregation and intentionally reduced crystallinity matches non-fullerene acceptors. | | | 26 October 2016 | doi: 10.1038/ncomms13094 | | |
| Biotic and abiotic controls on co-occurring nitrogen cycling processes in shallow Arctic shelf sediments OPEN | | | N. D. McTigue, W. S. Gardner, K. H. Dunton and A. K. Hardison | | | Arctic continental shelves could store a significant amount of nitrogen, yet the specific nitrogen transformation pathways in these sediments remain unknown. Using nitrogen tracers, McTigue et al. simultaneously measure multiple pathways in the Chukchi Sea, confirming the Arctic as a major nitrogen sink. | | | 26 October 2016 | doi: 10.1038/ncomms13145 | | |
| Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank–Starling response OPEN | | | Jenna Scotcher, Oleksandra Prysyazhna, Andrii Boguslavskyi, Kornel Kistamas, Natasha Hadgraft, Eva D. Martin, Jenny Worthington, Olena Rudyk, Pedro Rodriguez Cutillas, Friederike Cuello, Michael J. Shattock, Michael S. Marber, Maria R. Conte, Adam Greenstein, David J. Greensmith, Luigi Venetucci, John F. Timms and Philip Eaton | | | The stroke volume of the heart increases in response to an increase in the blood volume filling the heart. Here the authors reveal that this coordinated process is mediated in part by oxidative activation of the protein kinase G Iα, which phosphorylates phospholamban to enhance diastolic relaxation in mice. | | | 26 October 2016 | doi: 10.1038/ncomms13187 | | |
| Surpassing the no-cloning limit with a heralded hybrid linear amplifier for coherent states OPEN | | | Jing Yan Haw, Jie Zhao, Josephine Dias, Syed M. Assad, Mark Bradshaw, Rémi Blandino, Thomas Symul, Timothy C. Ralph and Ping Koy Lam | | | Cloning an unknown quantum state is challenging and the limit on the quality of clones is set by the no-cloning theorem. Here, the authors demonstrated the surpassing of such a limit using an effective quantum cloner based on a hybrid probabilistic-deterministic linear amplifier. | | | 26 October 2016 | doi: 10.1038/ncomms13222 | | | | | | | | | | | | | Latest Corrigenda | | | | |
| | | | | Corrigendum: Geographic population structure analysis of worldwide human populations infers their biogeographical origins OPEN | | | Eran Elhaik, Tatiana Tatarinova, Dmitri Chebotarev, Ignazio S. Piras, Carla Maria Calò, Antonella De Montis, Manuela Atzori, Monica Marini, Sergio Tofanelli, Paolo Francalacci, Luca Pagani, Chris Tyler-Smith, Yali Xue, Francesco Cucca, Theodore G. Schurr, Jill B. Gaieski, Carlalynne Melendez, Miguel G. Vilar, Amanda C. Owings, Rocío Gómez et al. | | | 31 October 2016 | doi: 10.1038/ncomms13468 | | | Biological Sciences Genetics | | | | | | | | Latest Retraction | | | | | | | | | | | | | | | | Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here.
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