Molecular Systems Biology - New articles published - 1 Nov 2016

October 2016 | Volume 12, Number 10 Submit Table of Contents Articles News & Views Articles Volume 12, Number 10 Articles Gene‐specific correlation of RNA and protein levels in human cells and tissues A comparison of absolute protein copy numbers with mRNA levels across human tissues and cell lines shows that protein levels correlate well with transcript levels, if a gene‐specific and cell/tissue‐independent RNA‐to‐protein (RTP) conversion factor is introduced. Fredrik Edfors, Frida Danielsson, Björn M Hallström, Lukas Käll, Emma Lundberg, Fredrik Pontén, Björn Forsström, and Mathias Uhlén Published online 20.10.2016 News & Views Quantifying gene expression: the importance of being subtle Gene expression is regulated at both the mRNA and protein level through on–off switches and fine‐tuned control. In their recent study, Edfors et al (2016) find that the protein/mRNA ratio for a given gene is constant across cell types, but varies by several orders of magnitude across genes. Gustavo Monteiro Silva and Christine Vogel Published online 20.10.2016 Articles A gene‐centered C. elegans protein–DNA interaction network provides a framework for functional predictions A protein–DNA interaction network for 15% of C. elegans genes predicts the regulatory and biological functions of transcription factors and target genes. Juan I Fuxman Bass, Carles Pons, Lucie Kozlowski, John S Reece‐Hoyes, Shaleen Shrestha, Amy D Holdorf, Akihiro Mori, Chad L Myers, and Albertha JM Walhout Published online 24.10.2016   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2016 by the European Molecular Biology Organisation.