Nature Reviews Cancer contents September 2016 Volume 16 Number 9 pp549-612

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TABLE OF CONTENTS
September 2016 Volume 16 Number 9		Advertisement
Impact Factor 31.694 *	In this issue Research Highlights Reviews Also this month  Featured article: Engineered T cells: the promise and challenges of cancer immunotherapy Andrew D. Fesnak, Carl H. June & Bruce L. Levine	Springer Nature offers a free open access funding support service to enable authors to discover and apply for article processing charge funding available to them. Visit our website for further advice on the funding options available, and guidance in approaching funders and institutions, or email openaccess@nature.com for more information.
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RESEARCH HIGHLIGHTS Top Chemotherapy: Putting tumours on a diet p549 | doi:10.1038/nrc.2016.90Two papers show that specific diets or pharmacological agents that mimic fasting inhibit tumour growth in combination with chemotherapy through effects on the immune system. PDF Metastasis: Setting up a new home p550 | doi:10.1038/nrc.2016.86In response to tumour-derived signals, fibroblastic reticular cells within tumour-draining lymph nodes acquire a unique gene signature which in turn disrupts the composition and localization of lymph node immune cell populations. PDF Resistance: How to resist immunotherapy p550 | doi:10.1038/nrc.2016.88Acquired resistance to programmed cell death 1 blockade in patients with melanoma is associated with defects in the pathways involved in interferon-receptor signalling. PDF IN BRIEF Metastasis: RIP endothelial cells | Leukaemia: Common driver gets new oncogenic mechanism | Oncogenes: piRNA flies in PDF Cancer JOBS of the week Asst / Assoc / Full Professor - Biology of Cancer The Department of Molecular and Cell Biology UC Berkeley PhD Student in CAR T Cell Engineering & Cancer Immunotherapy (M / F) University Hospital Würzburg Postdoc in Liver Cancer Metabolism German Cancer Research Center (DKFZ). Tumor immunology and head and neck cancer University of Lausanne (UNIL) More Science jobs from Cancer EVENT Epigenetics in Cancer: Translational Medicine Approaches 10.11.16 New York, USA More science events from
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REVIEWS		Top
Pancreatic cancer biology and genetics from an evolutionary perspective Alvin Makohon-Moore & Christine A. Iacobuzio-Donahue p553 | doi:10.1038/nrc.2016.66 This Review brings many aspects of pancreatic ductal adenocarcinoma research into a single concept rooted in Darwinian evolution, with the goal of identifying novel insights and opportunities for future study. Abstract | Full Text | PDF
Engineered T cells: the promise and challenges of cancer immunotherapy Andrew D. Fesnak, Carl H. June & Bruce L. Levine p566 | doi:10.1038/nrc.2016.97 This Review assesses what we have learnt about adoptive cell transfer of engineered T cells for the treatment of patients with B cell malignancies and discusses how this therapy can be improved and applied to other malignancies, including solid tumours. Abstract | Full Text | PDF
The biology and function of fibroblasts in cancer Raghu Kalluri p582 | doi:10.1038/nrc.2016.73 Cancer is associated with fibroblasts at all stages of disease progression. This Review discusses the pleiotropic actions of cancer-associated fibroblasts (CAFs) on tumour cells and postulates that they are likely to be a heterogeneous and plastic population of cells in the tumour microenvironment. Abstract | Full Text | PDF
Hereditary breast and ovarian cancer: new genes in confined pathways Finn Cilius Nielsen, Thomas van Overeem Hansen & Claus Storgaard Sorensen p599 | doi:10.1038/nrc.2016.72 This Review summarizes our current understanding of the functions of established and emerging hereditary breast and ovarian cancer genes in genome maintenance pathways. The authors discuss how classifying variants as pathogenic by structural and functional analysis will aid clinical management. Abstract | Full Text | PDF
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*2014 Journal Citation Report (Thomson Reuters, 2015)

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