The EMBO Journal Table of Contents for 15 June 2016; Vol. 35, No. 12

15 June 2016 | Volume 35, Number 12 Submit Table of Contents News & Views Articles Volume 35, Number 12 News & Views Lost & found: C9ORF72 and the autophagy pathway in ALS/FTD While C9ORF72 is known to display toxic gain of function in ALS, its normal role has remained unclear. New findings show that C9ORF72 acts as a GEF for specific RAB proteins, thereby modulating autophagosome formation. Sandra Almeida and Fen‐Biao Gao Published online 06.05.2016 Articles Higher‐order oligomerization promotes localization of SPOP to liquid nuclear speckles Self‐association of the ubiquitin ligase adaptor and tumor suppressor SPOP is required for its recruitment to liquid nuclear bodies, likely generating hotspots of SPOP‐mediated ubiquitination. Melissa R Marzahn, Suresh Marada, Jihun Lee, Amanda Nourse, Sophia Kenrick, Huaying Zhao, Gili Ben‐Nissan, Regina‐Maria Kolaitis, Jennifer L Peters, Stanley Pounds, Wesley J Errington, Gilbert G Privé, J Paul Taylor, Michal Sharon, Peter Schuck, Stacey K Ogden, and Tanja Mittag Published online 23.05.2016 Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin‐2 to induce motor neuron dysfunction and cell death The ALS‐linked factor C9orf72 forms a novel complex with SMCR8 and WDR41 to regulate GEF activity for Rab8a and Rab39b and autophagy. Loss of function of C9ORF72 synergizes with Ataxin‐2 toxicity, suggesting a double‐hit pathological mechanism in ALS‐FTD. Chantal Sellier, Maria‐Letizia Campanari, Camille Julie Corbier, Angeline Gaucherot, Isabelle Kolb‐Cheynel, Mustapha Oulad‐Abdelghani, Frank Ruffenach, Adeline Page, Sorana Ciura, Edor Kabashi, and Nicolas Charlet‐Berguerand Published online 21.04.2016 Parental epigenetic asymmetry of PRC2‐mediated histone modifications in the Arabidopsis endosperm Genomewide mapping of the epigenetic state in early plant endosperm links polycomb to the maintenance of parental imprinting and explains how DNA hypomethylation of the maternal genome is maintained after fertilization. Jordi Moreno‐Romero, Hua Jiang, Juan Santos‐González, and Claudia Köhler Published online 25.04.2016 Redox regulation of SUMO enzymes is required for ATM activity and survival in oxidative stress Identification of a Ubc9 mutant deficient only for ROS‐induced disulfide formation allows to characterize the cellular roles of redox control of global SUMOylation. Nicolas Stankovic‐Valentin, Katarzyna Drzewicka, Cornelia König, Elmar Schiebel, and Frauke Melchior Published online 12.05.2016 Phosphorylation of Cav1.2 on S1928 uncouples the L‐type Ca2+ channel from the β2 adrenergic receptor Cav1.2 S1928 phosphorylation is a key negative feedback mechanism for Ca2+ channel regulation by β2AR/cAMP/PKA signaling in neurons. Tommaso Patriarchi, Hai Qian, Valentina Di Biase, Zulfiquar A Malik, Dhrubajyoti Chowdhury, Jennifer L Price, Erik A Hammes, Olivia R Buonarati, Ruth E Westenbroek, William A Catterall, Franz Hofmann, Yang K Xiang, Geoffrey G Murphy, Chao‐Ye Chen, Manuel F Navedo, and Johannes W Hell Published online 21.04.2016 Phosphorylation‐dependent Akt–Inversin interaction at the basal body of primary cilia Akt–Inversin interplay exemplifies a new Akt role in ciliary physiology, ensuring spindle axis integrity during cell division and kidney development. Futoshi Suizu, Noriyuki Hirata, Kohki Kimura, Tatsuma Edamura, Tsutomu Tanaka, Satoko Ishigaki, Thoria Donia, Hiroko Noguchi, Toshihiko Iwanaga, and Masayuki Noguchi Published online 23.05.2016   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2016 by the European Molecular Biology Organisation.