Nature Reviews Microbiology contents July 2016 Volume 14 Number 7 pp 401-471

TABLE OF CONTENTS
July 2016 Volume 14 Number 7
Impact Factor 24.727 *	In this issue Research Highlights News and Analysis Reviews Perspectives Also this month Article series: Microbiome Article series: New technologies: methods and applications  Featured article: Reassortment in segmented RNA viruses: mechanisms and outcomes Sarah M. McDonald, Martha I. Nelson, Paul E. Turner & John T. Patton
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RESEARCH HIGHLIGHTS Top Viral Pathogenesis: Tracing the steps of Zika virus p401 | doi:10.1038/nrmicro.2016.80 Three studies in pregnant mice provide direct experimental evidence for a causal link between ZIKV infection and microcephaly. PDF Bacterial pathogenesis: Populations drifting apart p402 | doi:10.1038/nrmicro.2016.78 This study identifies a non-genetic colistin-resistant subpopulation that is distinct from persisters as it causes acute infection and lethality during the course of treatment with antibiotics. PDF Parasite physiology: Trypanosomes chew the fat p402 | doi:10.1038/nrmicro.2016.86 Adipose tissue is a novel niche for T. brucei in mammalian hosts, and the parasite may adapt its metabolism in this niche to use fatty acids as a carbon source. PDF Fungal Biology: A fungal quorum-sensing system p404 | doi:10.1038/nrmicro.2016.85 This study shows that Qsp1 is an autoregulatory signalling peptide that matures extracellularly and is imported into the cell by Opt1 to regulate virulence. This is the first description of the molecular mechanisms that are involved in eukaryotic quorum sensing. PDF Bacterial transcription: A tale of two specificities p404 | doi:10.1038/nrmicro.2016.88 Super-resolution microscopy shows that the localization of each mRNA in Escherichia coli is determined by whether the mRNA encodes an inner-membrane protein. PDF IN BRIEF Microbiome: Spore formation in the human gut microbiota | Microbiome: Autophagy genes link OMVs to IBD | Microbiome: Why you're stuck with the skin you're in | Bacterial pathogenesis: An interspecies role for SpA | Viral infection: Moving and splicing M1 mRNA | Bacterial genomics: Finding the connection PDF
NEWS AND ANALYSIS		Top
GENOME WATCH Bacterial GWAS: not just gilding the lily John A. Lees & Stephen D. Bentley p406 | doi:10.1038/nrmicro.2016.82 This month's Genome Watch discusses recent improvements to bacterial GWAS methods that have been inspired by techniques developed for human genetics. PDF
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REVIEWS		Top
Opportunistic intruders: how viruses orchestrate ER functions to infect cells Madhu Sudhan Ravindran, Parikshit Bagchi, Corey Nathaniel Cunningham & Billy Tsai p407 | doi:10.1038/nrmicro.2016.60 Many host structures are vital for viral infection and the endoplasmic reticulum (ER), in particular, is essential. In this Review, Tsai and colleagues highlight examples of subversion of the ER by diverse viruses to promote all stages of their life cycle, from entry to egress. Abstract | Full Text | PDF
Human norovirus transmission and evolution in a changing world Miranda de Graaf, Janko van Beek & Marion P. G. Koopmans p421 | doi:10.1038/nrmicro.2016.48 In the modern world, several factors have increased the global health challenge posed by noroviruses. In this Review, Koopmans and colleagues describe advances in the study of norovirus transmission, pathogenesis and evolution, and consider future prospects for therapeutics. Abstract | Full Text | PDF
Article series: Microbiome Dimensions of biodiversity in the Earth mycobiome Kabir G. Peay, Peter G. Kennedy & Jennifer M. Talbot p434 | doi:10.1038/nrmicro.2016.59 Molecular-based studies of fungal biodiversity have revealed fundamental differences from the biodiversity of bacteria, plants and animals. In this Review, Peay and colleagues consider the roles of ecology and fungal biology in determining fungal biodiversity at different spatial scales. Abstract | Full Text | PDF | Supplementary information
Reassortment in segmented RNA viruses: mechanisms and outcomes Sarah M. McDonald, Martha I. Nelson, Paul E. Turner & John T. Patton p448 | doi:10.1038/nrmicro.2016.46 In this Review, McDonald et al. describe the mechanisms and outcomes of reassortment for three well-studied viral families — Cystoviridae, Orthomyxoviridae and Reoviridae — and discuss how these findings provide new perspectives on the replication and evolution of segmented RNA viruses. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Article series: New technologies: methods and applications Advancing microbial sciences by individual-based modelling Ferdi L. Hellweger, Robert J. Clegg, James R. Clark, Caroline M. Plugge & Jan-Ulrich Kreft p461 | doi:10.1038/nrmicro.2016.62 In this Opinion article, Kreft and colleagues discuss how the combination of individual-based observations with individual-based models (IBMs) can lead to the new approach of microbial individual-based ecology (μIBE). They illustrate this point by describing how IBMs help to explore competitive and cooperative microbial interactions, which include the emergence of spatial patterns in biofilms and bacteria-phage dynamics. Abstract | Full Text | PDF | Supplementary information
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*2015 Journal Citation Report (Thomson Reuters, 2016)

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