Nature Reviews Molecular Cell Biology contents June 2016 Volume 17 Number 7 pp 395-459

If you are unable to see the message below, click here to view.

Advertisement
QScience.com Highlights is a regularly updated online platform which highlights the best of published research, handpicked by Nature Journals? editors, from QScience.com. Stay up-to-date with the latest research and reviews  qscience.nature.com
TABLE OF CONTENTS
July 2016 Volume 17 Number 7
Impact Factor 38.602 *	In this issue Research Highlights Reviews Perspectives Also this month Article series: Adult stem cells Article series: Technologies and techniques  Featured article: SMC complexes: from DNA to chromosomes Frank Uhlmann
Subscribe   Facebook   RSS   Recommend to library   Twitter
Advertisement
Special Issue on Dying Cell Recognition The studies collected in this special issue of Cell Death and Differentiation contribute to the understanding of the process of cell death and its effects by highlighting the importance of cell death for the health and function of neighbouring tissues and the organism as a whole. Access the special issue and watch the accompanying video summaries online.
RESEARCH HIGHLIGHTS Top Translation: Live stream: translation at single-mRNA resolution p395 | doi:10.1038/nrm.2016.78 Four research groups have developed, independently, an imaging technique that enables us, for the first time, to track and study the translation of single mRNA molecules in living cells. PDF Chromatin: BRD4 kicks out nucleosomes with its HAT p396 | doi:10.1038/nrm.2016.72 Bromodomain protein 4 (BRD4) is shown to possess histone acetyltransferase activity, through which it mediates nucleosome eviction from chromatin, contributing to chromatin decompaction. PDF Membrane trafficking: The second job of ULKs p396 | doi:10.1038/nrm.2016.77 Autophagy-initiating kinases ULK1 and ULK2 are now shown to function independently of autophagy in regulating protein trafficking from the ER. PDF Post-translational modifications: ADP-ribosylation promotes transcription elongation p397 | doi:10.1038/nrm.2016.83 The use of a chemical genetics approach to identify poly(ADP-ribose) polymerase (PARP) targets revealed that PARP1 promotes transcription elongation. PDF JOURNAL CLUB A four-lane highway to cancer p398 | doi:10.1038/nrm.2016.73 Galluzzi and Kroemer take advantage of a large study of somatic copy number alterations to revisit the previously suggested idea that cancer aneuploidy frequently arises from genome duplication. PDF Stem cells: Engineering an artificial niche for cell quiescence p398 | doi:10.1038/nrm.2016.82 The engineering of an artificial niche for the maintenance of quiescent muscle stem cells in vitro is reported. PDF IN BRIEF Small RNAs: New microRNA-like molecules | Autophagy: Shrinking through cilia-induced self-eating | DNA damage response: Cell thriving despite DNA damage PDF
REVIEWS		Top
SMC complexes: from DNA to chromosomes Frank Uhlmann p399 | doi:10.1038/nrm.2016.30 SMC (structural maintenance of chromosomes) complexes are found in all living organisms and include condensin, cohesin and the SMC5-SMC6 complex. Recent mechanistic insight into these ring-shaped protein machines, which topologically encircle DNA, shed light on how they function to mediate chromosome condensation, sister chromatid cohesion and DNA repair. Abstract | Full Text | PDF
Article series: Adult stem cells Adult cell plasticity in vivo: de-differentiation and transdifferentiation are back in style Allyson J. Merrell & Ben Z. Stanger p413 | doi:10.1038/nrm.2016.24 Some terminally differentiated cells have the capacity to de-differentiate or transdifferentiate under physiological conditions as part of a normal response to injury. Recent insights have been gained into the role of this cell plasticity in maintaining tissue and organ homeostasis, and this has important implications for cell-based therapies. Abstract | Full Text | PDF
The multiple functions of RNA helicases as drivers and regulators of gene expression Cyril F. Bourgeois, Franck Mortreux & Didier Auboeuf p426 | doi:10.1038/nrm.2016.50 RNA helicases can either remodel or lock the composition of messenger ribonucleoprotein complexes, and thus they have pleiotropic functions in the regulation of gene expression. RNA helicases can drive the progression of mRNAs between various RNA-processing factories, leading to protein synthesis or to mRNA storage or decay. Abstract | Full Text | PDF | Supplementary information
Hitchhiking on the heptahelical highway: structure and function of 7TM receptor complexes John J. G. Tesmer p439 | doi:10.1038/nrm.2016.36 Seven transmembrane domain (7TM) receptors are a vast group of proteins that respond to various cues and transmit signals intracellularly by interacting with heterotrimeric G proteins, arrestins and G protein-coupled receptor kinases. Recent structural analyses reveal common means of interaction between 7TM receptors and these intracellular signalling components. Abstract | Full Text | PDF | Supplementary information
Advertisement
Nature Publishing Group offers a free open access funding support service to enable authors to discover and apply for article processing charge funding available to them. Visit our website for further advice on the funding options available, and guidance in approaching funders and institutions, or email openaccess@nature.com for more information.
PERSPECTIVES		Top
INNOVATION Article series: Technologies and techniques Metabolomics: beyond biomarkers and towards mechanisms Caroline H. Johnson, Julijana Ivanisevic & Gary Siuzdak p451 | doi:10.1038/nrm.2016.25 Metabolomics has been utilized extensively for the identification of single metabolites and their use as biomarkers. Owing to recent technical advances, it is now possible to use metabolomics to better understand whole metabolic pathways and to more precisely pinpoint the involvement of metabolites in physiology and pathology. Abstract | Full Text | PDF | Supplementary information
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

*2015 Journal Citation Report (Thomson Reuters, 2015)

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our feedback department Nature Publishing Group | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at The Campus, 4 Crinan Street, London, N1 9XW. © 2016 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.