Nature Reviews Cancer contents July 2016 Volume 16 Number 7 pp409-478

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TABLE OF CONTENTS
July 2016 Volume 16 Number 7		Advertisement
Impact Factor 37.4 *	In this issue Research Highlights Reviews Also this month  Featured article: RNA splicing factors as oncoproteins and tumour suppressors Heidi Dvinge, Eunhee Kim, Omar Abdel-Wahab & Robert K. Bradley	Want to accelerate antibody drug development? Acrobiosystems' Biotinylated antigen proteins will facilitate antibody screening, analysis and optimization. Visit our website to see the full list of biotinylated drug target and their applications in Biopanning, SPR, antibody enrichment, ELISA and FACS.  Yes, Take me to your website.
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RESEARCH HIGHLIGHTS Top Tumorigenesis: Cancer goes tick tock p409 | doi:10.1038/nrc.2016.60 Two new studies present novel insights into how cancer can control or be controlled by the body's circadian clock and suggest that chronotherapies could have a wider therapeutic impact. PDF Epigenetics: Misdirecting methylation to drive oncogenesis p410 | doi:10.1038/nrc.2016.61 Lu et al. identify a potential mechanism driving chondroblastoma and sarcoma development in patients with lysine-to-methionine mutations in histone H3 at position 36 (H3K36M). PDF Metastasis: Brain metastasis bridges the gap p410 | doi:10.1038/nrc.2016.64 Cancer cells form CX43-based gap junctions with astrocytes via PCDH7 to promote brain metastatic outgrowth and chemoresistance. PDF Genetics: Evading antitumour immunity p410 | doi:10.1038/nrc.2016.65 A recent article published in Nature describes a novel genetic mechanism of immune evasion in a number of cancers that is caused by structural variants (SVs) disrupting the 3′ regulatory region of programmed cell death ligand 1 (PDL1). PDF IN BRIEF Metastasis: CXCR2-targeted therapy for pancreatic cancer | Genetics: Transfer RNAs in the driver's seat | Pancreatic cancer: Connecting obesity and cancer mechanistically | Epigenetics: Histone mutations reprogramme chondroblastoma PDF Cancer JOBS of the week Postdoctoral Research Fellow Bioinformatics Memorial Sloan Kettering Cancer Center (MSKCC) Postdoctoral position in Cancer Biology Thomas Jefferson Univesrity Postdoctoral Fellowships in Prostate Cancer Cleveland Clinic Postdoctoral Fellow - Diamond lab - Pre-clinical Development and Evaluation of Cancer Therapeutics City of Hope Postdoctoral Research Scientist - Cancer Metabolism Cancer Research UK More Science jobs from Cancer EVENT Cancer Stem Cell Conference 2016 20.09.16 Cleveland, USA More science events from
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REVIEWS		Top
RNA splicing factors as oncoproteins and tumour suppressors Heidi Dvinge, Eunhee Kim, Omar Abdel-Wahab & Robert K. Bradley p413 | doi:10.1038/nrc.2016.51 This Review discusses the current genetic and functional links between dysregulated and/or mutated RNA splicing factors and cancer, as well as the therapeutic opportunities presented by alterations in alternative splicing in cancer. Abstract | Full Text | PDF
Neutrophils in cancer: neutral no more Seth B. Coffelt, Max D. Wellenstein & Karin E. de Visser p431 | doi:10.1038/nrc.2016.52 The traditionally held belief that neutrophils are inert bystanders in cancer has been challenged by the recent literature. This Review discusses the involvement of neutrophils in cancer initiation and progression, and their potential as biomarkers and therapeutic targets. Abstract | Full Text | PDF
The role of myeloid cells in cancer therapies Camilla Engblom, Christina Pfirschke & Mikael J. Pittet p447 | doi:10.1038/nrc.2016.54 This Review describes recent advances in our understanding of tumour-associated myeloid cells in tumour progression and responses to therapy, discussing possible avenues to manipulate these cells in the tumour microenvironment. Abstract | Full Text | PDF
The isomerase PIN1 controls numerous cancer-driving pathways and is a unique drug target Xiao Zhen Zhou & Kun Ping Lu p463 | doi:10.1038/nrc.2016.49 This Review discusses PIN1-catalysed prolyl isomerization as a common signalling mechanism to regulate the balance of oncogenes and tumour suppressors. PIN1 inhibitors may be able to restore the balance in cancer cells and cancer stem cells to treat aggressive and drug-resistant tumours. Abstract | Full Text | PDF | Supplementary information
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*2014 Journal Citation Report (Thomson Reuters, 2015)

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