Laboratory Investigation - Table of Contents alert Volume 96 Issue 7

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TABLE OF CONTENTS Volume 96, Issue 7 (July 2016) In this issue Inside the USCAP Journals Pathobiology in Focus Research Articles Technical Report Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement We are pleased to announce that the Impact Factor* for Laboratory Investigation is now 4.202 - an increase from 3.676 last year. LI is ranked 23 of 124 titles in the medicine, research & experimental category and 12 of 78 titles in the pathology category. The journal would like to thank all our authors, reviewers and readers for their continued support. (*Thomson Reuters 2015 Journal Citation Reports®) Submit your research   Inside the USCAP Journals Top Inside the USCAP Journals 2016 96: 706-707; 10.1038/labinvest.2016.67 Full Text Pathobiology in Focus Top ApoA1 and ApoA1-specific self-antibodies in cardiovascular disease Dimitry A Chistiakov, Alexander N Orekhov and Yuri V Bobryshev 2016 96: 708-718; advance online publication, May 16, 2016; 10.1038/labinvest.2016.56 Abstract | Full Text Research Articles Top PERIPHERAL AND CENTRAL NERVOUS SYSTEM Downregulation of c-Myc is involved in TLR3-mediated tumor death of neuroblastoma xenografts This study demonstrates that high c-myc protein expression may increase tumor cell sensitivity to the toll-like receptor 3 (TLR3) agonist-polyinosinic-polycytidylic acid treatment in MYCN-non-ampli?ed neuroblastoma xenografts. Downregulation of c-myc might be involved in TLR3-mediated tumor growth arrest and reactive oxygen species-mediated apoptosis. Therefore, c-myc protein expression may play an important role in TLR3-induced innate immune responses, providing future treatment options. Li-Ling Lin, Chao-Cheng Huang, Chia-Ling Wu, Min-Tsui Wu, Wen-Ming Hsu and Jiin-Haur Chuang 2016 96: 719-730; advance online publication, May 16, 2016; 10.1038/labinvest.2016.57 Abstract | Full Text BLOOD, LYMPHATICS AND IMMUNE SYSTEM Alpha-2, 3-sialyltransferases regulate the multidrug resistance of chronic myeloid leukemia through miR-4701-5p targeting ST3GAL1 The expression of the sialyltransferase ST3GAL1 was found to correspond to the drug-resistant phenotype of chronic myeloid leukemia (CML) cell lines both in vitro and in vivo. Micro RNA (miR)-4701-5p directly targets ST3GAL1 to reduce CML cells' resistance. These results indicate that interfering with miR-4701-5p and ST3GAL1 may be of therapeutic value in CML. Yan Li, Shihua Luo, Weijie Dong, Xiaobo Song, Huimin Zhou, Lifen Zhao and Li Jia 2016 96: 731-740; advance online publication, April 18, 2016; 10.1038/labinvest.2016.50 Abstract | Full Text BREAST, SKIN, SOFT TISSUE AND BONE ILK–PI3K/AKT pathway participates in cutaneous wound contraction by regulating fibroblast migration and differentiation to myofibroblast Integrin-linked kinase (ILK) is a key mediator in integrin signaling, which regulates the interactions between fibroblasts and extracellular matrix in wounds. This study found that ILK participates in wound and the fibroblast-populated collagen lattice contraction, probably due to the regulation of fibroblast migration and fibroblast-to-myofibroblast differentiation. Therefore, ILK may be a potential molecular target in regulating wound contraction and treating excessive scar contracture. Gang Li, Ye-Yang Li, Jing-En Sun, Wei-hua Lin and Ri-xing Zhou 2016 96: 741-751; advance online publication, April 25, 2016; 10.1038/labinvest.2016.48 Abstract | Full Text Explant culture of sarcoma patients’ tissue The tissue explant technique here described provides an alternative to enzymatic digestion in order to obtain sarcoma patient-derived cells with a high content of cancer cells in a reasonable time frame. The cells generated by this method can be used for patient-oriented molecular and pharmacological analysis, as well as for the development of new patient-derived animal models. Roman Muff, Sander M Botter, Knut Husmann, Joelle Tchinda, Philomina Selvam, Franziska Seeli-Maduz and Bruno Fuchs 2016 96: 752-762; advance online publication, April 25, 2016; 10.1038/labinvest.2016.49 Abstract | Full Text Apolipoprotein A-1 regulates osteoblast and lipoblast precursor cells in mice Several lines of evidence propose a link between bone mass and high-density lipoprotein (HDL). The present paper reveals that Apolipoprotein A-1 (ApoA-1), vital component of HDL biosynthesis, serves as a key modulator of osteoblast and lipoblast function and generates changes in the bone cell precursor population that increase adipoblast and decrease osteoblast production, resulting in reduced bone mass and impaired bone quality. Harry C Blair, Elena Kalyvioti, Nicholaos I Papachristou, Irina L Tourkova, Spryros A Syggelos, Despina Deligianni, Malvina G Orkoula, Christos G Kontoyannis, Eleni A Karavia, Kyriakos E Kypreos and Dionysios J Papachristou 2016 96: 763-772; advance online publication, April 18, 2016; 10.1038/labinvest.2016.51 Abstract | Full Text ANGIOGENESIS, CARDIOVASCULAR AND PULMONARY SYSTEMS Fibulin-2 is essential for angiotensin II-induced myocardial fibrosis mediated by transforming growth factor (TGF)-β Fibrosis is an ominous pathological process in failing myocardium. This study demonstrates a regulatory role of fibulin-2 in angiotensin II-induced myocardial fibrosis by enhancing transforming growth factor (TGF)-β activation. Up-regulation of fibulin-2 is likely to interact with latent TGF-β in the extracellular matrix to induce biologically active TGF-β. Fibulin-2 may become a new therapeutic target in preventing heart failure. Shaukat A Khan, Hailong Dong, Jennifer Joyce, Takako Sasaki, Mon-Li Chu and Takeshi Tsuda 2016 96: 773-783; advance online publication, April 25, 2016; 10.1038/labinvest.2016.52 Abstract | Full Text Activation of the vitamin D receptor selectively interferes with calcineurin-mediated inflammation: a clinical evaluation in the abdominal aortic aneurysm This study evaluates the potential of the vitamin D receptor agonist Paricalcitol to quench vascular inflammation. The authors found that a brief course of Paricalcitol has profound effects on local inflammation via reduced T-cell activation and appears to be mediated by an effect on calcineurin-mediated responses. Arend Jan Nieuwland, Vivianne BC Kokje, Olivier H Koning, Jaap F Hamming, Karoly Szuhai, Frans H J Claas and Jan H N Lindeman 2016 96: 784-790; advance online publication, May 30, 2016; 10.1038/labinvest.2016.55 Abstract | Full Text HEPATIC AND PANCREATIC SYSTEMS Perilipin 5 restores the formation of lipid droplets in activated hepatic stellate cells and inhibits their activation Suppression of perilipin 5 expression is coupled with depletion of lipid droplets (LD) and activation of hepatic stellate cell (HSC) in vitro and in vivo. Introduction of exogenous perilipin 5 inhibits HSC activation by elevating cellular lipid content, restoring LD formation and attenuating oxidative stress. Perilipin 5 might therefore be a candidate for gene therapy in treatment of liver fibrosis. Jianguo Lin and Anping Chen 2016 96: 791-806; advance online publication, May 2, 2016; 10.1038/labinvest.2016.53 Abstract | Full Text Technical Report Top MODELS AND TECHNIQUES Modeling fibrosis using fibroblasts isolated from scarred rat vocal folds In this study, the authors provide detailed, multiplatform characterization of vocal fold (VF) fibroblasts from scarred rat VF mucosae, compared to those from naïve tissue. The scar and naïve VF fibroblast phenotypes are defined and the parameters of an in vitro model for future VF fibrosis research is outlined. Yo Kishimoto, Ayami Ohno Kishimoto, Shuyun Ye, Christina Kendziorski and Nathan V Welham 2016 96: 807-816; advance online publication, April 25, 2016; 10.1038/labinvest.2016.43 Abstract | Full Text Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to Laboratory Investigation. In order to do so, please purchase a subscription. 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