Nature Communications -01 June 2016

Advertisement Check out our NEW PRODUCTS for Frontline Infectious Diseases Antigens, antibodies, and assays for Influenza, HIV, Ebola, MERS, and more... Download our 2016 catalog     Weekly Content Alert Nature Communications is now fully open access. Read more. 01 June 2016  Featured image: De Niz et al. show that proteins involved in malaria parasite virulence are shared between mouse and human malaria parasites. Latest content: Articles Errata Advertisement   Want to use CRISPR in your research? Free CRISPR Handbook Learn about CRISPR and get useful protocols and workflows Download Now   Journal homepage Recommend to library Web feed   Advertisement Launching in January 2017 - Nature Biomedical Engineering Discovery and technology for human health A new online journal for bench scientists, clinicians and medical engineers. Register for the journal's e-alert to receive content and news from the beginning.   Advertisement VIRAL INFECTION AND IMMUNE RESPONSE Presented by: The Wuhan Institute of Virology | Chinese Society for Immunology | Chinese Society for Microbiology | Nature Microbiology October 21-23, 2016 Shangri-la Hotel | Wuhan, China REGISTER NOW!       Nature Communications - now fully open access All new submissions, if accepted, will be published open access and an article processing charge (APC) will apply. For more information visit the website. Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding.       Latest Articles View all Articles     Wolbachia infections in natural Anopheles populations affect egg laying and negatively correlate with Plasmodium development OPEN W. Robert Shaw, Perrine Marcenac, Lauren M. Childs, Caroline O. Buckee, Francesco Baldini, Simon P. Sawadogo, Roch K. Dabiré, Abdoulaye Diabaté and Flaminia Catteruccia Wolbachia bacteria infect insects and could potentially be used to control populations of malaria-transmitting mosquitoes. Here, the authors provide evidence that natural Wolbachia infections affect the rate of egg laying and are associated with reduced presence of malaria parasites in Anopheles mosquitoes. 31 May 2016 | doi: 10.1038/ncomms11772 Biological Sciences  Ecology  Microbiology  Zoology  Quantum teleportation from light beams to vibrational states of a macroscopic diamond OPEN P.-Y. Hou, Y.-Y. Huang, X.-X. Yuan, X.-Y. Chang, C. Zu, L. He and L.-M. Duan Quantum teleportation has found important applications in quantum technologies, but pushing it to macroscopic objects is challenging because of the fragility of quantum states. Here, the authors demonstrate teleportation of states from light beams to the vibrational states of a macroscopic diamond sample. 31 May 2016 | doi: 10.1038/ncomms11736 Physical Sciences  Applied physics  Optical physics  Aurora-A recruitment and centrosomal maturation are regulated by a Golgi-activated pool of Src during G2 OPEN Maria Luisa Barretta, Daniela Spano, Chiara D’Ambrosio, Romina Ines Cervigni, Andrea Scaloni, Daniela Corda and Antonino Colanzi The Golgi mitotic checkpoint couples Golgi inheritance with cell cycle transition, and regulates centrosomal recruitment of the mitotic kinase Aurora-A. Here the authors show that upon Golgi ribbon fragmentation in G2, Src phosphorylates Aurora-A at the Golgi, driving its localization to the centrosomes. 31 May 2016 | doi: 10.1038/ncomms11727 Biological Sciences  Cell biology  Efficient entanglement distillation without quantum memory OPEN Daniela Abdelkhalek, Mareike Syllwasschy, Nicolas J. Cerf, Jaromír Fiurášek and Roman Schnabel Entanglement distribution between distant parties is an essential component to most quantum communication protocols, but losses and decoherence present in real systems degrade it. Here the authors demonstrate an efficient iterative entanglement distillation protocol that does not rely on quantum memories. 31 May 2016 | doi: 10.1038/ncomms11720 Physical Sciences  Applied physics  Optical physics  Theoretical physics  Attosecond nanoscale near-field sampling OPEN B. Förg, J. Schötz, F. Süßmann, M. Förster, M. Krüger, B. Ahn, W. A. Okell, K. Wintersperger, S. Zherebtsov, A. Guggenmos, V. Pervak, A. Kessel, S. A. Trushin, A. M. Azzeer, M. I. Stockman, D. Kim, F. Krausz, P. Hommelhoff and M. F. Kling Photoemission from nanometre-scale structures offer a route toward ultrafast light-field-driven electronic nanocircuits. Here, the authors use attosecond streaking spectroscopy for nanoscale characterization of near-fields in the vicinity of tapered gold nanowires. 31 May 2016 | doi: 10.1038/ncomms11717 Physical Sciences  Nanotechnology  Optical physics  BK channels in microglia are required for morphine-induced hyperalgesia OPEN Yoshinori Hayashi, Saori Morinaga, Jing Zhang, Yasushi Satoh, Andrea L. Meredith, Takahiro Nakata, Zhou Wu, Shinichi Kohsaka, Kazuhide Inoue and Hiroshi Nakanishi Long-term use of opioids can lead to a paradoxical increase in pain sensitivity. Here, Hayashi et al. link activation of potassium channels on microglia with morphine-induced hyperalgesia and anti-nociceptive tolerance in mice. 31 May 2016 | doi: 10.1038/ncomms11697 Biological Sciences  Medical research  Neuroscience  Dirac cone protected by non-symmorphic symmetry and three-dimensional Dirac line node in ZrSiS OPEN Leslie M. Schoop, Mazhar N. Ali, Carola Straßer, Andreas Topp, Andrei Varykhalov, Dmitry Marchenko, Viola Duppel, Stuart S. P. Parkin, Bettina V. Lotsch and Christian R. Ast The family of topological materials has been growing rapidly but most members bare limitations hindering the study of exotic behaviour of topological particles. Here, Schoop et al. report a Fermi surface with a diamond-shaped line of Dirac nodes in ZrSiS, providing a promising candidate for studying two-dimensional Dirac fermions. 31 May 2016 | doi: 10.1038/ncomms11696 Physical Sciences  Condensed matter  Materials science  Genome-culture coevolution promotes rapid divergence of killer whale ecotypes OPEN Andrew D. Foote, Nagarjun Vijay, María C. Ávila-Arcos, Robin W. Baird, John W. Durban, Matteo Fumagalli, Richard A. Gibbs, M. Bradley Hanson, Thorfinn S. Korneliussen, Michael D. Martin, Kelly M. Robertson, Vitor C. Sousa, Filipe G. Vieira, Tomáš Vinař, Paul Wade, Kim C. Worley, Laurent Excoffier, Phillip A. Morin, M. Thomas P. Gilbert and Jochen B.W. Wolf et al. Killer whales have evolved into specialized ecotypes based on hunting strategies and ecological niches. Here, Andrew Foote and colleagues sequenced the whole genome of individual killer whales representing 5 different ecotypes from North Pacific and Antarctic, and show expansion of small founder groups to adapt to specific ecological niches. 31 May 2016 | doi: 10.1038/ncomms11693 Biological Sciences  Ecology  Evolution  Genetics  An asteroidal origin for water in the Moon OPEN Jessica J. Barnes, David A. Kring, Romain Tartèse, Ian A. Franchi, Mahesh Anand and Sara S. Russell Recent samples have shown that the Moon's interior, previously thought to be anhydrous, contains water, yet how this water was delivered is unclear. Here, using isotopic analyses and modelling, Barnes et al. show that carbonaceous chondrite-type objects delivered >80% of the Moon's bulk water. 31 May 2016 | doi: 10.1038/ncomms11684 Earth Sciences  Planetary sciences  Rational design of a protein that binds integrin αvβ3 outside the ligand binding site OPEN Ravi Chakra Turaga, Lu Yin, Jenny J. Yang, Hsiauwei Lee, Ivaylo Ivanov, Chunli Yan, Hua Yang, Hans E. Grossniklaus, Siming Wang, Cheng Ma, Li Sun and Zhi-Ren Liu Integrins are transmembrane proteins that have important roles in cell adhesion and signalling. Here the authors design a therapeutic protein that binds integrin αvβ3, has anti-angiogenic activity, and reduces tumour growth in xenograft models, while being seemingly well tolerated. 31 May 2016 | doi: 10.1038/ncomms11675 Biological Sciences  Cancer  Chemical biology  Medical research  CXCL1 mediates obesity-associated adipose stromal cell trafficking and function in the tumour microenvironment OPEN Tao Zhang, Chieh Tseng, Yan Zhang, Olga Sirin, Paul G. Corn, Elsa M. Li-Ning-Tapia, Patricia Troncoso, John Davis, Curtis Pettaway, John Ward, Marsha L. Frazier, Christopher Logothetis and Mikhail G. Kolonin Adipose stromal cells (ASC) have been shown to migrate to tumours and promote tumour growth. Using animal models and human tissue samples, the authors show here that ASC recruitment to prostate cancers is mediated by the chemokine CXCL1, which is secreted from tumour cells, and acts on CXCR1 on ASCs. 31 May 2016 | doi: 10.1038/ncomms11674 Biological Sciences  Cancer  Medical research  Graphene ballistic nano-rectifier with very high responsivity OPEN Gregory Auton, Jiawei Zhang, Roshan Krishna Kumar, Hanbin Wang, Xijian Zhang, Qingpu Wang, Ernie Hill and Aimin Song The high mobility of graphene has the potential to enable design of devices working in a collisionless regime of carrier transport. Here the authors fabricate a ballistic nano-rectifier based on encapsulated graphene, showing intrinsic performances comparable to those of superconducting bolometers. 31 May 2016 | doi: 10.1038/ncomms11670 Physical Sciences  Applied physics  Materials science  Nanotechnology  Genome-wide association study identifies 8p21.3 associated with persistent hepatitis B virus infection among Chinese OPEN Yuanfeng Li, Lanlan Si, Yun Zhai, Yanling Hu, Zhibin Hu, Jin-Xin Bei, Bobo Xie, Qian Ren, Pengbo Cao, Fei Yang, Qingfeng Song, Zhiyu Bao, Haitao Zhang, Yuqing Han, Zhifu Wang, Xi Chen, Xia Xia, Hongbo Yan, Rui Wang, Ying Zhang et al. This genome-wide association study on persistent hepatitis B virus (HBV) infection among Chinese confirms previously associated genetic loci while discovering a novel protective locus at 8p21.3. The study also demonstrates the nearby gene INST10 suppresses HBV replication in vitro. 31 May 2016 | doi: 10.1038/ncomms11664 Biological Sciences  Genetics  Medical research  Virology  Microwave a.c. conductivity of domain walls in ferroelectric thin films OPEN Alexander Tselev, Pu Yu, Ye Cao, Liv R. Dedon, Lane W. Martin, Sergei V. Kalinin and Petro Maksymovych Conducting charged ferroelectric domain walls, as potential building blocks for future electronic devices, are unstable and uncommon in ferroelectric materials. Here, Tselev et al. show that neutral insulating domain walls in PbZrO3 and BiFeO3 thin films are conductive under microwave excitation, allowing for non-destructive read-out. 31 May 2016 | doi: 10.1038/ncomms11630 Physical Sciences  Applied physics  Condensed matter  Nanotechnology  Non-cultivated plants present a season-long route of pesticide exposure for honey bees OPEN Elizabeth Y. Long and Christian H. Krupke The extent to which non-crop plants may be contaminated by insecticides is not known. Here, the authors show that pollen collected by honey bees living in areas of intensive maize production is contaminated by a wide range of pesticides throughout the growing season, with the principle pollen source being non-crop plants. 31 May 2016 | doi: 10.1038/ncomms11629 Biological Sciences  Ecology  Mining 3D genome structure populations identifies major factors governing the stability of regulatory communities OPEN Chao Dai, Wenyuan Li, Harianto Tjong, Shengli Hao, Yonggang Zhou, Qingjiao Li, Lin Chen, Bing Zhu, Frank Alber and Xianghong Jasmine Zhou 3D genome structures are plastic and vary from cell to cell even in an isogenic sample. Here, the authors present an approach to identify frequent 3D chromatin clusters across a population of genome structures, either deconvoluted from ensemble-averaged Hi-C data or from a collection of single-cell Hi-C data. 31 May 2016 | doi: 10.1038/ncomms11549 Biological Sciences  Bioinformatics  Molecular biology  Fasting induces a subcutaneous-to-visceral fat switch mediated by microRNA-149-3p and suppression of PRDM16 OPEN Hanying Ding, Shasha Zheng, Daniel Garcia-Ruiz, Dongxia Hou, Zhe Wei, Zhicong Liao, Limin Li, Yujing Zhang, Xiao Han, Ke Zen, Chen-Yu Zhang, Jing Li and Xiaohong Jiang Visceral adiposity is associated with metabolic diseases, whereas subcutaneous adiposity is comparatively benign. Here, the authors report that subcutaneous adipose tissue adopts visceral-like characteristics in response to prolonged fasting, and show this is mediated by miR-149-3p and its target, PRDM16. 31 May 2016 | doi: 10.1038/ncomms11533 Biological Sciences  Medical research  Bipartite electronic superstructures in the vortex core of Bi2Sr2CaCu2O8+δ OPEN T. Machida, Y. Kohsaka, K. Matsuoka, K. Iwaya, T. Hanaguri and T. Tamegai Field-induced electronic structures with spatial, momentum and energy resolution reveal the nature of interaction among multiple phases in correlated materials. Here, Machida et al. report two magnetic field-induced electronic superstructures in Bi2Se2CaCu2O8+δ , evidencing competition between superconductivity and emerging states. 27 May 2016 | doi: 10.1038/ncomms11747 Physical Sciences  Condensed matter  Materials science  Mapping the electrostatic force field of single molecules from high-resolution scanning probe images OPEN Prokop Hapala, Martin Švec, Oleksandr Stetsovych, Nadine J. van der Heijden, Martin Ondráček, Joost van der Lit, Pingo Mutombo, Ingmar Swart and Pavel Jelínek The chemical properties of molecules are largely determined by the distribution of charge across them. Here, the authors demonstrate how the electrostatic force field, originating from the inhomogeneous charge distribution in a molecule, can be measured with sub-molecular resolution. 27 May 2016 | doi: 10.1038/ncomms11560 Chemical Sciences  Applied physics  Organic chemistry  Physical chemistry  A method to rapidly create protein aggregates in living cells OPEN Yusuke Miyazaki, Kota Mizumoto, Gautam Dey, Takamasa Kudo, John Perrino, Ling-chun Chen, Tobias Meyer and Thomas J. Wandless Protein aggregates are associated with a wide variety of diseases. Here, in order to address how protein aggregation affects cellular homoeostasis, the authors describe a method to rapidly create protein aggregates in living cells and organisms with precise spatial and temporal control. 27 May 2016 | doi: 10.1038/ncomms11689 Biological Sciences  Biochemistry  Cell biology  Chemical biology  Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism–dystonia OPEN Karin Tuschl, Esther Meyer, Leonardo E. Valdivia, Ningning Zhao, Chris Dadswell, Alaa Abdul-Sada, Christina Y. Hung, Michael A. Simpson, W. K. Chong, Thomas S. Jacques, Randy L. Woltjer, Simon Eaton, Allison Gregory, Lynn Sanford, Eleanna Kara, Henry Houlden, Stephan M. Cuno, Holger Prokisch, Lorella Valletta, Valeria Tiranti et al. Karin Tuschl, Philippa Mills and colleagues report mutations in the manganese (Mn) transporter gene SLC39A14 in childhood-onset parkinsonism-dystonia. Using functional recapitulation, the authors also show that slc39A14 loss-of-function in zebrafish can lead to Mn dysregulation and locomotor impairment. 27 May 2016 | doi: 10.1038/ncomms11601 Biological Sciences  Genetics  Medical research  Neuroscience  A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair OPEN Monica Florio, Kannan Gunasekaran, Marina Stolina, Xiaodong Li, Ling Liu, Barbara Tipton, Hossein Salimi-Moosavi, Franklin J. Asuncion, Chaoyang Li, Banghua Sun, Hong Lin Tan, Li Zhang, Chun-Ya Han, Ryan Case, Amy N. Duguay, Mario Grisanti, Jennitte Stevens, James K. Pretorius, Efrain Pacheco, Heidi Jones et al. Antibodies that block the Wnt inhibitors sclerostin and DKK- 1 enhance bone formation and fracture repair. Here the authors show these monospecific antibodies induce compensatory mechanisms that limit efficacy, and have designed a sclerostin/DKK-1 bispecific antibody that promotes superior fracture repair in rodents and bone formation in primates. 27 May 2016 | doi: 10.1038/ncomms11505 Biological Sciences  Medical research  Observation of the quantum Hall effect in δ-doped SrTiO3 OPEN Y. Matsubara, K. S. Takahashi, M. S. Bahramy, Y. Kozuka, D. Maryenko, J. Falson, A. Tsukazaki, Y. Tokura and M. Kawasaki Observation of quantum phenomena in correlated electron systems is challenging due to low mobility and high concentration of carriers. Here, Matsubara et al. report a two-dimensional electron system with high mobility-low carrier density in δ-doped SrTiO3, demonstrating quantum Hall effect in d-electron systems. 27 May 2016 | doi: 10.1038/ncomms11631 Physical Sciences  Condensed matter  Materials science  Quantum annealing for the number-partitioning problem using a tunable spin glass of ions OPEN Tobias Graß, David Raventós, Bruno Juliá-Díaz, Christian Gogolin and Maciej Lewenstein Spin models appear in several fields of physics and beyond, but solving many of them is a task for which no general efficient classical algorithm is known to exist. Here the authors demonstrate how a variety of spin glass models can be implemented and solved, via quantum simulation, in a system of trapped ions. 27 May 2016 | doi: 10.1038/ncomms11524 Physical Sciences  Atomic and molecular physics  Theoretical physics  The CsrA-FliW network controls polar localization of the dual-function flagellin mRNA in Campylobacter jejuni OPEN Gaurav Dugar, Sarah L. Svensson, Thorsten Bischler, Sina Wäldchen, Richard Reinhardt, Markus Sauer and Cynthia M. Sharma The CsrA protein binds to and represses translation of certain bacterial mRNAs. Here, Dugar et al. show for the human pathogen Campylobacter jejuni that the major flagellin mRNA acts as both a target and a regulatory 'sponge' for CsrA, and is localized at the cell poles in a translation-dependent manner. 27 May 2016 | doi: 10.1038/ncomms11667 Biological Sciences  Cell biology  Genetics  Microbiology  Structure of the intact ATM/Tel1 kinase OPEN Xuejuan Wang, Huanyu Chu, Mengjuan Lv, Zhihui Zhang, Shuwan Qiu, Haiyan Liu, Xuetong Shen, Weiwu Wang and Gang Cai The ataxia-telangiectasia mutated (ATM) protein kinase is a key player in the response to DNA damage and is essential for the maintenance of cellular homeostasis. Here the authors describe the cryo-EM structure of ATM/Tel1 from fission yeast that suggests how dimerization regulates its activity. 27 May 2016 | doi: 10.1038/ncomms11655 Biological Sciences  Biochemistry  Biophysics  Pre-bilaterian origin of the blastoporal axial organizer OPEN Yulia Kraus, Andy Aman, Ulrich Technau and Grigory Genikhovich In vertebrate embryos, Wnt/β-catenin signaling induces an organizer area guiding the formation of body axes and inducing extra axes upon transplantation. Here, Kraus et al. show that Wnt ligands also induce an organizer in a sea anemone, indicating that the organizer dates back over 600 million years. 27 May 2016 | doi: 10.1038/ncomms11694 Biological Sciences  Developmental biology  Evolution  A dual molecular analogue tuner for dissecting protein function in mammalian cells OPEN Ran Brosh, Iryna Hrynyk, Jessalyn Shen, Avinash Waghray, Ning Zheng and Ihor R. Lemischka Loss-of-function approaches are fundamental for dissecting the roles played by genes but methods to simultaneously perturb several proteins in the same mammalian cell are scarce. Here the authors harness the plant auxin and jasmonate hormone-degradation pathways and RNAi technology, to control the levels of two proteins and validate its application in stem cells. 27 May 2016 | doi: 10.1038/ncomms11742 Biological Sciences  Bioengineering  Cell biology  RPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNA OPEN Christine Wolf, Alexander Rapp, Nicole Berndt, Wolfgang Staroske, Max Schuster, Manuela Dobrick-Mattheuer, Stefanie Kretschmer, Nadja König, Thomas Kurth, Dagmar Wieczorek, Karin Kast, M. Cristina Cardoso, Claudia Günther and Min Ae Lee-Kirsch A central antiviral defence is immune recognition of cystolic DNA. Here the authors show that RPA and RAD51, in cooperation with TREX1, function to protect the cytosol from self-DNA. 27 May 2016 | doi: 10.1038/ncomms11752 Biological Sciences  Immunology  Molecular biology  ATP6AP1 deficiency causes an immunodeficiency with hepatopathy, cognitive impairment and abnormal protein glycosylation OPEN Eric J. R. Jansen, Sharita Timal, Margret Ryan, Angel Ashikov, Monique van Scherpenzeel, Laurie A. Graham, Hanna Mandel, Alexander Hoischen, Theodore C. Iancu, Kimiyo Raymond, Gerry Steenbergen, Christian Gilissen, Karin Huijben, Nick H. M. van Bakel, Yusuke Maeda, Richard J. Rodenburg, Maciej Adamowicz, Ellen Crushell, Hans Koenen, Darius Adams et al. Here, Dirk Lefeber and colleagues identify functional mutations in ATP6AP1 encoding Ac45. The authors show that Ac45 is the functional ortholog of yeast V-ATPase assembly factor Voa1 and provide evidence for tissue-specific Ac45 processing, associated with the clinical phenotype of immunodeficiency, hepatopathy, and neurocognitive abnormalities. 27 May 2016 | doi: 10.1038/ncomms11600 Biological Sciences  Genetics  Immunology  Neuroscience  The machinery underlying malaria parasite virulence is conserved between rodent and human malaria parasites OPEN Mariana De Niz, Ann-Katrin Ullrich, Arlett Heiber, Alexandra Blancke Soares, Christian Pick, Ruth Lyck, Derya Keller, Gesine Kaiser, Monica Prado, Sven Flemming, Hernando del Portillo, Chris J. Janse, Volker Heussler and Tobias Spielmann Proteins SBP1 and MAHRP1 of the human malaria parasite are required for sequestration of infected red blood cells in major organs. Here, De Niz et al. identify homologous proteins in the rodent parasite Plasmodium berghei, showing that they play similar roles and supporting the usefulness of malaria mouse models. 26 May 2016 | doi: 10.1038/ncomms11659 Biological Sciences  Cell biology  Microbiology  EB1 regulates attachment of Ska1 with microtubules by forming extended structures on the microtubule lattice OPEN Geethu E. Thomas, K. Bandopadhyay, Sabyasachi Sutradhar, M. R. Renjith, Puja Singh, K. K. Gireesh, Steny Simon, Binshad Badarudeen, Hindol Gupta, Manidipa Banerjee, Raja Paul, J. Mitra and Tapas K. Manna Ska1 is a kinetochore-localised protein that couples kinetochore movement to microtubule (MT) depolymerisation. Here Thomas et al. show that the MT +TIP binding protein EB1 recruits Ska1 to the MT-kinetochore interface and stabilises the interaction between Ska1 and MTs. 26 May 2016 | doi: 10.1038/ncomms11665 Biological Sciences  Cell biology  Dynamic heterogeneity and non-Gaussian statistics for acetylcholine receptors on live cell membrane OPEN W. He, H. Song, Y. Su, L. Geng, B. J. Ackerson, H. B. Peng and P. Tong Molecular motion in living cells is known to be more complicated than those determined solely by thermal equilibrium, but a quantitative analysis is still missing. Here, He et al. quantify the lateral motion of proteins on live muscle cell membranes, which doesn’t follow the normal Brownian diffusion. 26 May 2016 | doi: 10.1038/ncomms11701 Physical Sciences  Applied physics  Biophysics  Store-independent modulation of Ca2+ entry through Orai by Septin 7 OPEN Bipan Kumar Deb, Trayambak Pathak and Gaiti Hasan Orai channels are well known to mediate store-operated calcium entry. Here authors show that in neurons of the Drosophila flight circuit, Septin 7 acts as a negative regulator of Orai channels, surprisingly, by modulating store-independent calcium entry through Orai. 26 May 2016 | doi: 10.1038/ncomms11751 Biological Sciences  Cell biology  Neuroscience  Generating giant and tunable nonlinearity in a macroscopic mechanical resonator from a single chemical bond OPEN Pu Huang, Jingwei Zhou, Liang Zhang, Dong Hou, Shaochun Lin, Wen Deng, Chao Meng, Changkui Duan, Chenyong Ju, Xiao Zheng, Fei Xue and Jiangfeng Du Macroscopic mechanical systems typically respond linearly to external force, and generating nonlinearity is challenging. Here, the authors generate nonlinearity in a macroscopic mechanical resonator by linking it to a gold contact and exploiting the anharmonicity in the chemical bonding interactions. 26 May 2016 | doi: 10.1038/ncomms11517 Physical Sciences  Applied physics  Nanotechnology  Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicans OPEN Michelle D. Leach, Rhys A. Farrer, Kaeling Tan, Zhengqiang Miao, Louise A. Walker, Christina A. Cuomo, Robert T. Wheeler, Alistair J. P. Brown, Koon Ho Wong and Leah E. Cowen The transcription factor Hsf1 and the molecular chaperone Hsp90 modulate the heat shock response in the pathogen Candida albicans. Here, Leach et al. reveal a complex interplay between the two factors that regulates the expression of genes involved in the heat shock response and virulence. 26 May 2016 | doi: 10.1038/ncomms11704 Biological Sciences  Genetics  Microbiology  Macrofossil evidence for a rapid and severe Cretaceous–Paleogene mass extinction in Antarctica OPEN James D. Witts, Rowan J. Whittle, Paul B. Wignall, J. Alistair Crame, Jane E. Francis, Robert J. Newton and Vanessa C. Bowman Debate surrounds the causes, timing, and effects of the Cretaceous-Paleogene mass extinction, 66 Ma. Here, using new collections of marine macrofossils from Seymour Island, Antarctica, the authors show that the extinction was both rapid and severe in the high southern latitudes, contrary to previous studies. 26 May 2016 | doi: 10.1038/ncomms11738 Earth Sciences  Geology and geophysics  Palaeontology  A lateral signalling pathway coordinates shape volatility during cell migration OPEN Liang Zhang, Valbona Luga, Sarah K. Armitage, Martin Musiol, Amy Won, Christopher M. Yip, Sergey V. Plotnikov and Jeffrey L. Wrana Migrating cells display dynamic morphologies that are coordinated by signalling pathways. Here the authors identify a lateral signalling pathway, comprised of the planar cell polarity protein Pk1 and Arhgap21/23, that regulates fluctuations in cell shape during productive cell migration. 26 May 2016 | doi: 10.1038/ncomms11714 Biological Sciences  Cell biology  Electron–phonon coupling in hybrid lead halide perovskites OPEN Adam D. Wright, Carla Verdi, Rebecca L. Milot, Giles E. Eperon, Miguel A. Pérez-Osorio, Henry J. Snaith, Feliciano Giustino, Michael B. Johnston and Laura M. Herz Phonon scattering limits charge transport in perovskite solar cells, yet the interactions involved are still poorly understood. Here, Wright et al. show by photoluminescence measurements and first-principles calculations that longitudinal optical phonons dominate the electron-phonon coupling at room temperature. 26 May 2016 | doi: 10.1038/ncomms11755 Physical Sciences  Condensed matter  Materials science  Physical chemistry  A spin-liquid with pinch-line singularities on the pyrochlore lattice OPEN Owen Benton, L.D.C. Jaubert, Han Yan and Nic Shannon Neutron scattering measurements of spin-ice materials contain signature pinch-point singularities, demonstrating the existence of an emergent electromagnetic gauge field. Here, the authors propose a system in which correlations manifest in pinch lines, which may have already been observed experimentally. 26 May 2016 | doi: 10.1038/ncomms11572 Physical Sciences  Condensed matter  Theoretical physics  BDNF rescues BAF53b-dependent synaptic plasticity and cocaine-associated memory in the nucleus accumbens OPEN André O. White, Enikö A. Kramár, Alberto J. López, Janine L. Kwapis, John Doan, David Saldana, M. Felicia Davatolhagh, Yasaman Alaghband, Mathew Blurton-Jones, Dina P. Matheos and Marcelo A. Wood Epigenetic mechanisms play a key role in drug-associated memories and behaviors. Here authors show that mice deficient of BAF53b, a nucleosome remodeling complex subunit, display deficits in synaptic plasticity and cocaine-associated memory, both of which can be rescued by BDNF application. 26 May 2016 | doi: 10.1038/ncomms11725 Biological Sciences  Neuroscience  A zwitterionic gel electrolyte for efficient solid-state supercapacitors OPEN Xu Peng, Huili Liu, Qin Yin, Junchi Wu, Pengzuo Chen, Guangzhao Zhang, Guangming Liu, Changzheng Wu and Yi Xie Gel electrolytes are promising for solid-state supercapacitors, due to their favourable properties such as high ion migration rate, mechanical strength, and water retention. Here, the authors report on a zwitterionic gel electrolyte giving robust performance in graphene-based solid-state supercapacitors. 26 May 2016 | doi: 10.1038/ncomms11782 Chemical Sciences  Inorganic chemistry  Materials science  Physical chemistry  Revealing the mechanism of passive transport in lipid bilayers via phonon-mediated nanometre-scale density fluctuations OPEN Mikhail Zhernenkov, Dima Bolmatov, Dmitry Soloviov, Kirill Zhernenkov, Boris P. Toperverg, Alessandro Cunsolo, Alexey Bosak and Yong Q. Cai The molecular transport through bio-membranes of cells heavily relies on the dynamics of lipids, but the related mechanism remains unknown. Here, Zhernenkov et al. observe the propagating transverse phonon mode with a finite band gap and suggest its connection to short-lived local lipid clustering. 26 May 2016 | doi: 10.1038/ncomms11575 Biological Sciences  Biochemistry  Biophysics  Materials science  A conserved leucine occupies the empty substrate site of LeuT in the Na+-free return state OPEN Lina Malinauskaite, Saida Said, Caglanur Sahin, Julie Grouleff, Azadeh Shahsavar, Henriette Bjerregaard, Pernille Noer, Kasper Severinsen, Thomas Boesen, Birgit Schiøtt, Steffen Sinning and Poul Nissen Neurotransmitter:sodium symporters (NSS) perform Na+-dependent amino-acid uptake, but a full structural description of their function is lacking. Here the authors present a structure of the bacterial NSS LeuT in the outward-oriented empty state and show that a Leu residue occupies the empty substrate site and is essential for function. 25 May 2016 | doi: 10.1038/ncomms11673 Biological Sciences  Biochemistry  klf2a couples mechanotransduction and zebrafish valve morphogenesis through fibronectin synthesis OPEN Emily Steed, Nathalie Faggianelli, Stéphane Roth, Caroline Ramspacher, Jean-Paul Concordet and Julien Vermot In the developing heart, blood flow transmits mechanical signals to progenitor cells that ultimately leads to valve formation. Here, the authors identify the origin of the valve progenitor cells and fibronectin1b as a transcriptional target of the mechanotransduced signals responsible for valve formation. 25 May 2016 | doi: 10.1038/ncomms11646 Biological Sciences  Cell biology  Developmental biology  NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells OPEN Hani Alrefai, Khalid Muhammad, Ronald Rudolf, Duong Anh Thuy Pham, Stefan Klein-Hessling, Amiya K. Patra, Andris Avots, Valesca Bukur, Ugur Sahin, Stefan Tenzer, Matthias Goebeler, Andreas Kerstan and Edgar Serfling Regulatory B cells are important for preventing skin autoimmunity. Here the authors show that NFATc1 suppresses IL-10 transcription in regulatory B cells, and inhibiting NFATc1 decreases immunopathology in a mouse model of imiquimod-induced skin inflammation. 25 May 2016 | doi: 10.1038/ncomms11724 Biological Sciences  Immunology  Stepwise phosphorylation of p65 promotes NF-κB activation and NK cell responses during target cell recognition OPEN Hyung-Joon Kwon, Go-Eun Choi, Sangryeol Ryu, Soon Jae Kwon, Sun Chang Kim, Claire Booth, Kim E. Nichols and Hun Sik Kim NK cell activation requires multiple signals. Here the authors show that while NKG2D, 2B4, or DNAM-1 receptor activation is insufficient to induce cytokine production, these signals synergize by Vav-1-mediated NF-κB multiphosphorylation, and this signaling checkpoint is defective in X-linked lymphoproliferative disease. 25 May 2016 | doi: 10.1038/ncomms11686 Biological Sciences  Immunology  Molecular biology  CRISPR-dCas9 and sgRNA scaffolds enable dual-colour live imaging of satellite sequences and repeat-enriched individual loci OPEN Yi Fu, Pedro P. Rocha, Vincent M. Luo, Ramya Raviram, Yan Deng, Esteban O. Mazzoni and Jane A. Skok The ability to target Cas9 to specific genomic loci offers the potential for applications beyond genome editing. Here the authors use deactivated Cas9 and chimeric guide RNAs to visualise individual repetitive loci in living cells. 25 May 2016 | doi: 10.1038/ncomms11707 Biological Sciences  Molecular biology  Plastic anisotropy and dislocation trajectory in BCC metals OPEN Lucile Dezerald, David Rodney, Emmanuel Clouet, Lisa Ventelon and François Willaime Low-temperature plasticity in BCC metals is atypical, marked by an anisotropic elastic limit in violation of the Schmid law. Here, the authors show that these deviations can be quantified from subatomic deviations of the screw dislocation trajectory away from its average glide plane. 25 May 2016 | doi: 10.1038/ncomms11695 Physical Sciences  Materials science  Production of fatty acid-derived oleochemicals and biofuels by synthetic yeast cell factories OPEN Yongjin J. Zhou, Nicolaas A. Buijs, Zhiwei Zhu, Jiufu Qin, Verena Siewers and Jens Nielsen While yeast is an attractive alternative to bacteria for the production of biofuels it currently has low production yields. Here, the authors systematically engineer Saccharomyces cerevisiae for high-level production of fatty acids, alkanes and fatty alcohols, which are important fuel precursors. 25 May 2016 | doi: 10.1038/ncomms11709 Biological Sciences  Bioengineering  Biotechnology  Differences in the efficacy of climate forcings explained by variations in atmospheric boundary layer depth OPEN Richard Davy and Igor Esau Correctly detecting surface temperature responses to a climate forcing requires consideration of their spatio-temporal variability. Here, the authors demonstrate that forcing efficacy is governed by the effective heat capacity of the atmosphere, itself a function of planetary boundary layer depth. 25 May 2016 | doi: 10.1038/ncomms11690 Earth Sciences  Atmospheric science  Climate science  Microscopic origins of the terahertz carrier relaxation and cooling dynamics in graphene OPEN Momchil T. Mihnev, Faris Kadi, Charles J. Divin, Torben Winzer, Seunghyun Lee, Che-Hung Liu, Zhaohui Zhong, Claire Berger, Walt A. de Heer, Ermin Malic, Andreas Knorr and Theodore B. Norris Design of high-speed graphene-based devices relies on understanding of its ultrafast carrier dynamics. Here, the authors combine time-resolved terahertz spectroscopy and microscopic modelling to unveil the interplay between the scattering mechanisms dominating the ultrafast relaxation pathways in graphene. 25 May 2016 | doi: 10.1038/ncomms11617 Physical Sciences  Condensed matter  Nanotechnology  Optical physics  Molecular evidence of functional progesterone withdrawal in human myometrium OPEN Lubna Nadeem, Oksana Shynlova, Elzbieta Matysiak-Zablocki, Sam Mesiano, Xuesen Dong and Stephen Lye How human labour is initiated in the presence of high circulating progesterone is still unclear. Here, the authors show that during a reduction in myometrial nuclear progesterone levels, there is an increased transcription of the key labour gene, Cx43, mediated by unliganded progesterone receptor A. 25 May 2016 | doi: 10.1038/ncomms11565 Biological Sciences  Cell biology  Developmental biology  Cox process representation and inference for stochastic reaction–diffusion processes OPEN David Schnoerr, Ramon Grima and Guido Sanguinetti Stochastic reaction-diffusion systems are used for modelling spatial dynamics in many disciplines, but parameter inference and model selection remain challenging. Here the authors offer a solution enabled by a connection between reaction-diffusion and the well-studied spatio-temporal Cox processes. 25 May 2016 | doi: 10.1038/ncomms11729 Biological Sciences  Applied physics  Systems biology    Nature Communications JOBS of the week Research Technician Roskamp Institute Research Associate (Assistant Professor) University of Chicago Associate Research Fellow University of Exeter Early Career Development Fellowships Manchester Cancer Research Centre Group Leaders European Molecular Biology Laboratory (EMBL) Postdoctoral Research Assistant University of Dundee Doctoral student positions University of Oulu Postdoctoral Training Fellow Institute of Cancer Research (ICR) Diabetes UK RD Lawrence Fellowships Diabetes UK Associate Research Scientist Herbert Irving Comprehensive Cancer Center More Science jobs from Nature Communications EVENT Chatham House Climate Change 2016 10.10.16 London, UK More science events from       Latest Errata     Erratum: Transcriptomes of parents identify parenting strategies and sexual conflict in a subsocial beetle OPEN Darren J. Parker, Christopher B. Cunningham, Craig A. Walling, Clare E. Stamper, Megan L. Head, Eileen M. Roy-Zokan, Elizabeth C. McKinney, Michael G. Ritchie and Allen J. Moore 27 May 2016 | doi: 10.1038/ncomms11737     Erratum: Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression OPEN Matthias Eden, Benjamin Meder, Mirko Völkers, Montatip Poomvanicha, Katrin Domes, M. Branchereau, P. Marck, Rainer Will, Alexander Bernt, Ashraf Rangrez, Matthias Busch, Martin Hrabě de Angelis, Christophe Heymes, Wolfgang Rottbauer, Patrick Most, Franz Hofmann and Norbert Frey 26 May 2016 | doi: 10.1038/ncomms11835 Cell biology  Medical research      Advertisement Nature Outlook Open Innovation In the competitive world of drug discovery and development, secrecy is no longer as important as it was. 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