The EMBO Journal Table of Contents for 17 May 2016; Vol. 35, No. 10

17 May 2016 | Volume 35, Number 10 Submit Table of Contents News & Views Review Articles Volume 35, Number 10 News & Views eIF4A moonlights as an off switch for TORC1 A new study shows that eIF4A negatively regulates TOR complex 1 activity upon amino acid starvation, revealing a translation‐independent function of eIF4A‐containing eIF4F complex. Marta M Swierczynska and Michael N Hall Published online 04.04.2016 FUScinating insights into motor neuron degeneration Novel mouse models reveal that amyotrophic lateral sclerosis‐associated mutant FUS protein triggers motor neuron degeneration in mice via a toxic gain‐of‐function mechanism rather than a loss of function one. Dorothee Dormann Published online 06.04.2016 Eyes without a ribbon The enigmatic synaptic ribbon found in sensory cells of eye and ear facilitates calcium channel–exocytosis coupling for fast and sustained neurotransmitter release. Tobias Moser Published online 22.03.2016 Review Cerebral cortex expansion and folding: what have we learned? Cortical expansion and folding are key processes in mammalian brain development and evolution. This review outlines recent advances in our understanding of the cellular and molecular mechanisms regulating the cerebral cortex formation. Virginia Fernández, Cristina Llinares‐Benadero, and Víctor Borrell Published online 07.04.2016 Articles The mitochondrial outer membrane protein MDI promotes local protein synthesis and mtDNA replication MDI recruits translational activator Larp to the outer mitochondrial membrane to regulate mitochondrial protein expression and mtDNA replication in Drosophila ovaries. Yi Zhang, Yong Chen, Marjan Gucek, and Hong Xu Published online 06.04.2016 eIF4A inactivates TORC1 in response to amino acid starvation The eIF4A‐containing eIF4F translation initiation complex negatively regulates TOR complex 1 activity in response to amino acid starvation, revealing a translation‐independent function of eIF4F. Foivos‐Filippos Tsokanos, Marie‐Astrid Albert, Constantinos Demetriades, Kerstin Spirohn, Michael Boutros, and Aurelio A Teleman Published online 17.03.2016 Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss Cytoplasmic accumulation of ALS‐associated FUS mutants not only leads to nuclear loss‐of‐function phenotypes, but also to motor neuron degeneration via toxic gain‐of‐function mechanisms. Jelena Scekic‐Zahirovic, Oliver Sendscheid, Hajer El Oussini, Mélanie Jambeau, Ying Sun, Sina Mersmann, Marina Wagner, Stéphane Dieterlé, Jérome Sinniger, Sylvie Dirrig‐Grosch, Kevin Drenner, Marie‐Christine Birling, Jinsong Qiu, Yu Zhou, Hairi Li, Xiang‐Dong Fu, Caroline Rouaux, Tatyana Shelkovnikova, Anke Witting, Albert C Ludolph, Friedemann Kiefer, Erik Storkebaum, Clotilde Lagier‐Tourenne, and Luc Dupuis Published online 07.03.2016 How to make a synaptic ribbon: RIBEYE deletion abolishes ribbons in retinal synapses and disrupts neurotransmitter release Synaptic ribbon formation requires a ribbon‐specific protein, whose coupling of calcium channels to synaptic vesicle exocytosis facilitates sustained high‐frequency neurotransmitter release in sensory cells. Stephan Maxeiner, Fujun Luo, Alison Tan, Frank Schmitz, and Thomas C Südhof Published online 29.02.2016 Nucleosomal arrays self‐assemble into supramolecular globular structures lacking 30‐nm fibers An in vitro system for chromatin packaging shows that short array of nucleosomes has the intrinsic ability to self‐assemble into large chromatin globules devoid of folded 30‐nm fibers. Kazuhiro Maeshima, Ryan Rogge, Sachiko Tamura, Yasumasa Joti, Takaaki Hikima, Heather Szerlong, Christine Krause, Jake Herman, Erik Seidel, Jennifer DeLuca, Tetsuya Ishikawa, and Jeffrey C Hansen Published online 12.04.2016 Regulators of complement activity mediate inhibitory mechanisms through a common C3b‐binding mode Structural insights into how complement factor C3b binds to human and viral regulators of complement activation aid our understanding of disease‐related mutations and SNPs affecting complement control. Federico Forneris, Jin Wu, Xiaoguang Xue, Daniel Ricklin, Zhuoer Lin, Georgia Sfyroera, Apostolia Tzekou, Elena Volokhina, Joke CM Granneman, Richard Hauhart, Paula Bertram, M Kathryn Liszewski, John P Atkinson, John D Lambris, and Piet Gros Published online 24.03.2016   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2016 by the European Molecular Biology Organisation.