Nature Reviews Genetics Contents June 2016 Volume 17 Number 6 pp313-372

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TABLE OF CONTENTS
June 2016 Volume 17 Number 6		Advertisement
Impact Factor 36.978 *	In this issue Research Highlights Reviews Analysis Perspectives Also this month Article series: Epigenetics Applications of next-generation sequencing  Featured article: Coming of age: ten years of next-generation sequencing technologies Sara Goodwin, John D. McPherson & W. Richard McCombie	Immune Profiling in Health and Disease Presented by: Adaptive Biotechnologies | Nature Immunology | Nature Medicine | Nature Biotechnology | Nature Genetics October 3-5, 2016 | Bell Harbor International Conference Center, Seattle, WA, USA Register now!
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RESEARCH HIGHLIGHTS Top Genetic screens: Combination screens for combination therapies p313 | doi:10.1038/nrg.2016.52 PDF Synthetic biology: Automating genetic circuit design p314 | doi:10.1038/nrg.2016.50 PDF Gene regulation: Finding genetic target sites p314 | doi:10.1038/nrg.2016.53 PDF Small RNAs: Regulating transgenerational epigenetics p315 | doi:10.1038/nrg.2016.51 PDF Genetic screens: Finding the resilient few p316 | doi:10.1038/nrg.2016.54 PDF Genetic variation: Linking TF binding to disease risk using pooled ChIP-seq p317 | doi:10.1038/nrg.2016.55 PDF Human genetics: Splicing: linking genetic variation and disease p317 | doi:10.1038/nrg.2016.64 PDF IN BRIEF Genetic Engineering: A CORRECT step forward in disease modelling | Genetic variation: Genomic monomorphism off the scale | Bioinformatics: Benchmarking transcript expression quantification PDF Genetics JOBS of the week Research Assistant Professor in Computational Genomics and Genetics of Alzheimer’s Disease University of Pennsylvania Research Fellow (statistical genetics) - Cardiovascular Diseases Job Mayo Clinic Postdoctoral Fellow in Bioinformatics and Evolutionary Genomics Friedrich Miescher Laboratory Clinical and Biochemical Geneticist Boston Children's Hospital; Harvard Medical School Faculty Positions St. Jude Children's Research Hospital (SJCRH) More Science jobs from Genetics EVENT Short Course on Systems Genetics 16.10.16 Bar Harbor, USA More science events from
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Nature Reviews Disease Primers is 1 year old! April marked the first year anniversary of Nature Reviews Disease Primers. To celebrate, we take a look back on the highlights of the year.  Delve into our interactive site to explore.
REVIEWS		Top
Article series: Epigenetics Genetic sources of population epigenomic variation Aaron Taudt, Maria Colomé-Tatché & Frank Johannes p319 | doi:10.1038/nrg.2016.45 The authors review recent studies into the heritable basis of population epigenomic variation and discuss important challenges when interpreting results from these genetic studies in different species to highlight the state of knowledge regarding how genetic variation can influence differences in chromatin states between individuals. Abstract | Full Text | PDF | Supplementary information
Article series: Applications of next-generation sequencing Coming of age: ten years of next-generation sequencing technologies Sara Goodwin, John D. McPherson & W. Richard McCombie p333 | doi:10.1038/nrg.2016.49 Advances in DNA sequencing technologies have led to vast increases in the diversity of sequencing-based applications and in the amount of data generated. This Review discusses the current state-of-the-art technologies in both short-read and long-read DNA sequencing, their underlying mechanisms, relative strengths and limitations, and emerging applications. Abstract | Full Text | PDF
ANALYSIS		Top
The statistical properties of gene-set analysis Christiaan A. de Leeuw, Benjamin M. Neale, Tom Heskes & Danielle Posthuma p353 | doi:10.1038/nrg.2016.29 This Analysis provides a statistical evaluation of the core structure inherent to all gene-set analyses. The authors examine current implementations in available tools and show which factors affect valid and successful detection of gene sets. Abstract | Full Text | PDF | Supplementary information
PERSPECTIVES		Top
VIEWPOINT RNA modifications: what have we learned and where are we headed? Michaela Frye, Samie R. Jaffrey, Tao Pan, Gideon Rechavi & Tsutomu Suzuki p365 | doi:10.1038/nrg.2016.47 Five experts discuss topical aspects of RNA modifications, highlighting where the research field stands, recommendations for best practices and visions for the future of epitranscriptomics studies. Abstract | Full Text | PDF
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*2013 Journal Citation Report (Thomson Reuters, 2014)

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