Nature Reviews Immunology Contents June 2016 Volume 16 Number 6 pp 335-400

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TABLE OF CONTENTS
June 2016 Volume 16 Number 6		Advertisement
Impact Factor 34.985 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: The influence of skin microorganisms on cutaneous immunity Yasmine Belkaid & Samira Tamoutounour	WEBINAR: Transgenic HLA mice for applications in immuno-oncology, vaccine research, infectious disease and more.   View the webinar to learn more about:  Development and validation of transgenic HLA mouse models Why chimeric HLA molecules are used  How the vast family of HLA alleles can be divided into supertype families  How a limited number of models can represent those supertypes  View the webinar today
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RESEARCH HIGHLIGHTS Top Neonatal immunity: Maternal IgG promotes intestinal homeostasis p335 | doi:10.1038/nri.2016.64 Maternally derived commensal-specific IgG helps to limit mucosal T cell responses in neonates. PDF Innate immunity: Sensing broken antibody p336 | doi:10.1038/nri.2016.59 The innate immune receptor LILRA2 (leukocyte immunoglobulin-like receptor subfamily A member 2) senses microbially cleaved immunoglobulin. PDF Inflammation: Inflammatory pathology of Fanconi anaemia p336 | doi:10.1038/nri.2016.60 The Fanconi anaemia DNA repair pathway also has cytoplasmic functions in selective autophagy that might contribute to an inflammatory pathology of Fanconi anaemia disease. PDF Infection: Go wild? p337 | doi:10.1038/nri.2016.57 Exposing mice to a dirty environment helps to 'humanize' their immune system. PDF Lymphocyte responses: Hunker down with HOBIT and BLIMP1 p338 | doi:10.1038/nri.2016.61 HOBIT and BLIMP1 identified as universal regulators of tissue residency in lymphocytes. PDF Mucosal immunology: Tryptophan triggers tranquillity p338 | doi:10.1038/nri.2016.66 Mice lacking CARD9 have altered microbiota with impaired tryptophan metabolism and therefore increased susceptibility to colitis. PDF JOURNAL CLUB Antiviral responses of inbred mice p339 | doi:10.1038/nri.2016.44 Akiko Iwasaki describes a 1980 study by Haller et al. that revealed a limitation of using inbred mice to study antiviral responses. PDF Immunology JOBS of the week Postdoctoral Position in Tumor Immunology Memorial Sloan Kettering Cancer Center (MSKCC) PostDoc Position Immunology Saarland University, Department of Internal Medicine IV, Nephrology Postdoctoral Fellow in Immunology New York University (NYU) Medical Center Post-doctoral fellowship in Biochemistry and Immunology University of Sao Paulo/ FAPESP Center for Research in Inflammatory Diseases Academic research group leader in Immunology at CIML CIML More Science jobs from Immunology EVENT International Conference on Human & Translational Immunology 16.09.16 Rhodes, Greece More science events from
REVIEWS		Top
Gut microbiota, metabolites and host immunity Michelle G. Rooks & Wendy S. Garrett p341 | doi:10.1038/nri.2016.42 The microbiota and host immune system engage in a complex crosstalk that is being increasingly revealed thanks to advances in technological and computational approaches. Here, the authors highlight some of the microbial metabolites and components that are vital for immune system development and homeostasis. Abstract | Full Text | PDF
The influence of skin microorganisms on cutaneous immunity Yasmine Belkaid & Samira Tamoutounour p353 | doi:10.1038/nri.2016.48 The skin is home to diverse microbial communities that constantly interact with host epithelial and immune cells. In this Review, the authors summarize how the skin microbiota can control innate and adaptive immunity to skin pathogens, as well as its influence on skin inflammatory diseases. Abstract | Full Text | PDF
T cell responses to cytomegalovirus Paul Klenerman & Annette Oxenius p367 | doi:10.1038/nri.2016.38 Infection with cytomegalovirus induces an unusually high level of long-lasting memory T cells that have potent effector functions. Understanding how and why this occurs might help to improve responses to vaccination. Abstract | Full Text | PDF
Neutrophil migration in infection and wound repair: going forward in reverse Sofia de Oliveira, Emily E. Rosowski & Anna Huttenlocher p378 | doi:10.1038/nri.2016.49 Neutrophils follow a multitude of signals to reach sites of injury or infection. Understanding how this occurs and what the fate of these neutrophils is provides insight into how immune responses are controlled and chronic inflammation is avoided. In this Review, the authors describe the movement of neutrophils during inflammation. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Harnessing the beneficial heterologous effects of vaccination Helen S. Goodridge et al. p392 | doi:10.1038/nri.2016.43 Clinical evidence, including results from randomized controlled clinical trials, strongly suggests that certain live vaccines can reduce all-cause mortality, most probably through protection against non-targeted pathogens. This Opinion article examines the potential immunological mechanisms underlying these effects. Abstract | Full Text | PDF
Corrigendum: MicroRNAs as regulatory elements in immune system logic Arnav Mehta & David Baltimore p400 | doi:10.1038/nri.2016.65 Full Text | PDF
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*2014 Journal Citation Report (Thomson Reuters, 2015)

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