Nature Communications - 02 March 2016

Weekly Content Alert Nature Communications is now fully open access. Read more. 02 March 2016  Featured image: Pierangeli et al. report the spontaneous formation of a ferroelectric super-crystal with micrometric unit cell in KLTN crystals. Latest content: Articles Corrigenda Journal homepage Recommend to library Web feed   Advertisement Nature Outlook Genome Editing The term genetic engineering has been around since the 1970s, but it is only in the past few years that researchers have developed the tools to allow them to engineer the genome with the precision that they had originally envisaged.  This Nature Outlook looks at the risks and benefits of genome editing. Available free online. Produced with support from: KISCO LTD. in association with EditForce Inc.       Advertisement The Geoffrey Beene Cancer Research Center at Memorial Sloan Kettering Cancer Center, Nature, Nature Cell Biology and Nature Reviews Cancer present: CANCER AS AN EVOLVING AND SYSTEMIC DISEASE March 12-15, 2016 | New York, NY, USA REGISTER NOW!       Nature Communications - now fully open access All new submissions, if accepted, will be published open access and an article processing charge (APC) will apply. For more information visit the website. Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding.       Latest Articles View all Articles     Enhanced flight performance by genetic manipulation of wing shape in Drosophila OPEN Robert P. Ray, Toshiyuki Nakata, Per Henningsson and Richard J. Bomphrey Insect wings are under multiple competing selection pressures, but which are important in natural populations is not clear. Using RNAi to modify wing shape, Ray et al. show that aerial agility can be significantly enhanced in Drosophila, suggesting that natural variation does not reflect an optimization solely for flight agility. 01 March 2016 | doi: 10.1038/ncomms10851 Biological Sciences  Genetics  Zoology  A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features OPEN Kaustubh Adhikari, Tania Fontanil, Santiago Cal, Javier Mendoza-Revilla, Macarena Fuentes-Guajardo, Juan-Camilo Chacón-Duque, Farah Al-Saadi, Jeanette A. Johansson, Mirsha Quinto-Sanchez, Victor Acuña-Alonzo, Claudia Jaramillo, William Arias, Rodrigo Barquera Lozano, Gastón Macín Pérez, Jorge Gómez-Valdés, Hugo Villamil-Ramírez, Tábita Hunemeier, Virginia Ramallo, Caio C. Silva de Cerqueira, Malena Hurtado et al. By examining Latin American individuals of mixed European, Native American and African ancestry, Adhikari et al. identify novel loci influencing various features of facial and scalp hair. The study also provides experimental evidence that one of the implicated genes (PRSS53) is expressed in the hair follicle and that the top associated variant alters processing of this enzyme. 01 March 2016 | doi: 10.1038/ncomms10815 Biological Sciences  Genetics  Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination OPEN Caroline P. Le, Cameron J. Nowell, Corina Kim-Fuchs, Edoardo Botteri, Jonathan G. Hiller, Hilmy Ismail, Matthew A. Pimentel, Ming G. Chai, Tara Karnezis, Nicole Rotmensz, Giuseppe Renne, Sara Gandini, Colin W. Pouton, Davide Ferrari, Andreas Möller, Steven A. Stacker and Erica K. Sloan Adverse life events have been associated with reduced survival in cancer patients. Here, the authors explore the mechanism responsible and show that chronic stress in mice activates a signalling cascade in macrophages and tumour cells, which results in restructuring of the tumour lymphatic system, promoting metastasis. 01 March 2016 | doi: 10.1038/ncomms10634 Biological Sciences  Cancer  Medical research  Social amoebae trap and kill bacteria by casting DNA nets OPEN Xuezhi Zhang, Olga Zhuchenko, Adam Kuspa and Thierry Soldati Neutrophils secrete net-like structures made of DNA and anti-microbial peptides, which can trap and kill extracellular pathogens. Here, the authors show that such nets are also produced by so-called Sentinel cells in the multicellular slug stage of the social amoeba Dictyostelium discoideum. 01 March 2016 | doi: 10.1038/ncomms10938 Biological Sciences  Evolution  Immunology  Intensifying the response of distributed optical fibre sensors using 2D and 3D image restoration OPEN Marcelo A. Soto, Jaime A. Ramírez and Luc Thévenaz Optical fibres offer a way of sensing across a wide area, providing a spatial and temporal map of the measured parameter. Here, the authors use image and video processing to remove noise and increase the contrast in such a distributed optical fibre sensor, improving the signal-to-noise ratio by a factor of 100. 01 March 2016 | doi: 10.1038/ncomms10870 Physical Sciences  Optical physics  Lysosome triggered near-infrared fluorescence imaging of cellular trafficking processes in real time OPEN Marco Grossi, Marina Morgunova, Shane Cheung, Dimitri Scholz, Emer Conroy, Marta Terrile, Angela Panarella, Jeremy C. Simpson, William M. Gallagher and Donal F. O’Shea Real time cellular fluorescence imaging requires a probe that displays high degrees of localisation, low toxicity and good photostability. Here, the authors report a near infrared fluorophore that displays pH-sensitive fluorescence based on phenol/phenolate interconversion, showing real time imaging of cellular processes. 01 March 2016 | doi: 10.1038/ncomms10855 Chemical Sciences  Analytical chemistry  Chemical biology  Medicinal chemistry  Observation of a three-dimensional quasi-long-range electronic supermodulation in YBa2Cu3O7−x/La0.7Ca0.3MnO3 heterostructures OPEN Junfeng He, Padraic Shafer, Thomas R. Mion, Vu Thanh Tra, Qing He, J. Kong, Y.-D. Chuang, W. L. Yang, M. J. Graf, J.-Y. Lin, Y.-H. Chu, E. Arenholz and Rui-Hua He Understanding the nature of competing phases is a key to understanding the superconducting mechanism of unconventional superconductors. Here, the authors demonstrate a three-dimensional charge ordering state which competes with superconductivity in epitaxial YBa2Cu3O7-x thin films grown on La0.7Ca0.3MnO3 substrates. 01 March 2016 | doi: 10.1038/ncomms10852 Physical Sciences  Condensed matter  Multiple tipping points and optimal repairing in interacting networks OPEN Antonio Majdandzic, Lidia A. Braunstein, Chester Curme, Irena Vodenska, Sary Levy-Carciente, H. Eugene Stanley and Shlomo Havlin Systems composed of many interacting dynamic networks exhibit complicated collective dynamics. Here, the authors study failure, damage spread and recovery in two interacting networks, constructing the phase diagram and revealing the role of triple points for optimal damage repair. 01 March 2016 | doi: 10.1038/ncomms10850 Physical Sciences  Theoretical physics  Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like OPEN Seham Ebrahim, Matthew R. Avenarius, M’hamed Grati, Jocelyn F. Krey, Alanna M. Windsor, Aurea D. Sousa, Angela Ballesteros, Runjia Cui, Bryan A. Millis, Felipe T. Salles, Michelle A. Baird, Michael W. Davidson, Sherri M. Jones, Dongseok Choi, Lijin Dong, Manmeet H. Raval, Christopher M. Yengo, Peter G. Barr-Gillespie and Bechara Kachar Stereocilia of the inner ear have graded heights that are thought to be regulated by the myosin-III family members MYO3A and MYO3B. Here the authors identify espin-1 and espin-like (ESPNL) as cargo that differentially influence the functions of both motors to regulate stereocilia length. 01 March 2016 | doi: 10.1038/ncomms10833 Biological Sciences  Cell biology  MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis OPEN Hoi Leong Xavier Wong, Guoxiang Jin, Renhai Cao, Shuo Zhang, Yihai Cao and Zhongjun Zhou Blocking lymphangiogenesis holds great therapeutic potential, however, only few inhibitors are known. Here the authors show that membrane type 1-matrix metalloproteinase suppresses lymphangiogenesis by curbing both LYVE-1-mediated proliferation of lymphatic endothelial cells and production of lymphangiogenic factors by macrophages. 01 March 2016 | doi: 10.1038/ncomms10824 Biological Sciences  Developmental biology  Typical fast thermalization processes in closed many-body systems OPEN Peter Reimann The relaxation of closed macroscopic systems towards thermal equilibrium is an ubiquitous experimental fact, but very difficult to characterize theoretically. Here, the author establishes a quantitative description of such relaxation under arbitrary typical conditions, capturing well experimental data. 01 March 2016 | doi: 10.1038/ncomms10821 Physical Sciences  Theoretical physics  Synthetic RNA–protein modules integrated with native translation mechanisms to control gene expression in malaria parasites OPEN Suresh M. Ganesan, Alejandra Falla, Stephen J. Goldfless, Armiyaw S. Nasamu and Jacquin C. Niles Current strategies for regulatory control of gene expression are orthogonal to the host organism mechanisms. Here the authors demonstrate an RNA aptamer controlled system integrated into native regulatory pathways in the parasite Plasmodium falciparum. 01 March 2016 | doi: 10.1038/ncomms10727 Biological Sciences  Microbiology  Molecular biology  Spin-momentum coupled Bose-Einstein condensates with lattice band pseudospins OPEN M. A. Khamehchi, Chunlei Qu, M. E. Mossman, Chuanwei Zhang and P. Engels The optical trapping of ultracold atoms allows for the simulation and controlled exploration of phenomena normally found in condensed matter systems. Here, the authors demonstrate spin–orbit coupling between lattice band pseudospins in a Bose-Einstein condensate of ultracold atoms. 29 February 2016 | doi: 10.1038/ncomms10867 Physical Sciences  Condensed matter  Layer-dependent quantum cooperation of electron and hole states in the anomalous semimetal WTe2 OPEN Pranab Kumar Das, D. Di Sante, I. Vobornik, J. Fujii, T. Okuda, E. Bruyer, A. Gyenis, B. E. Feldman, J. Tao, R. Ciancio, G. Rossi, M. N. Ali, S. Picozzi, A. Yadzani, G. Panaccione and R. J. Cava Tungsten ditelluride is a semi-metallic two-dimensional material that has exhibited large magnetoresistance. Here, the authors use angle- and spin-resolved photoemission spectroscopy to investigate the band structure of this transition metal dichalcogenide and identify layer-dependent electronic behaviour. 29 February 2016 | doi: 10.1038/ncomms10847 Physical Sciences  Condensed matter  Materials science  Nanotechnology  Polycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network OPEN Elena Signaroldi, Pasquale Laise, Silvia Cristofanon, Arianna Brancaccio, Elisa Reisoli, Sina Atashpaz, Maria Rosa Terreni, Claudio Doglioni, Giancarlo Pruneri, Paolo Malatesta and Giuseppe Testa Polycomb-mediated gene regulation has been implicated in gliomas. Here the authors integrate transcriptomic and epigenomic analyses to define Polycomb-dependent networks that promote gliomagenesis, and find that the Polycomb-dependent silencing of the transcription factor Zfp423 hinders survival. 29 February 2016 | doi: 10.1038/ncomms10753 Biological Sciences  Cancer  Molecular biology  Upper- and mid-mantle interaction between the Samoan plume and the Tonga–Kermadec slabs OPEN Sung-Joon Chang, Ana M. G. Ferreira and Manuele Faccenda Plume-slab interaction and its surface expression remain poorly understood. Here, the authors compare 3-D anisotropic tomography and geodynamical models, and show that the stagnation and fastest trench retreat of the Tonga slab are consistent with an interaction with the Samoan plume and the Hikurangi plateau. 29 February 2016 | doi: 10.1038/ncomms10799 Earth Sciences  Geology and geophysics  Stem cell and neurogenic gene-expression profiles link prostate basal cells to aggressive prostate cancer OPEN Dingxiao Zhang, Daechan Park, Yi Zhong, Yue Lu, Kiera Rycaj, Shuai Gong, Xin Chen, Xin Liu, Hsueh-Ping Chao, Pamela Whitney, Tammy Calhoun-Davis, Yoko Takata, Jianjun Shen, Vishwanath R. Iyer and Dean G. Tang Gene-expression profiles can be used to predict the prognosis of cancer patients. Here, the authors describe gene expression profiles of human prostate epithelial lineages and show that basal cells have intrinsic stem and neurogenic properties, and molecularly resemble aggressive prostate cancer. 29 February 2016 | doi: 10.1038/ncomms10798 Biological Sciences  Cancer  Hypothalamic leptin action is mediated by histone deacetylase 5 OPEN Dhiraj G. Kabra, Katrin Pfuhlmann, Cristina García-Cáceres, Sonja C. Schriever, Veronica Casquero García, Adam Fiseha Kebede, Esther Fuente-Martin, Chitrang Trivedi, Kristy Heppner, N. Henriette Uhlenhaut, Beata Legutko, Uma D. Kabra, Yuanqing Gao, Chun-Xia Yi, Carmelo Quarta, Christoffer Clemmensen, Brian Finan, Timo D. Müller, Carola W. Meyer, Marcelo Paez-Pereda et al. Histone deacetylases (HDACs) regulate energy metabolism in peripheral tissues, but whether HDACs expressed in the brain influence systemic metabolism is unknown. Here the authors show that hypothalamic HDAC5 expression is affected by the diet and HDAC5 regulates leptin sensitivity by deacetylating STAT3. 29 February 2016 | doi: 10.1038/ncomms10782 Biological Sciences  Medical research  Neuroscience  Increased generation of Foxp3+ regulatory T cells by manipulating antigen presentation in the thymus OPEN Jiqiang Lin, Lu Yang, Hernandez Moura Silva, Alissa Trzeciak, Yongwon Choi, Susan R. Schwab, Michael L. Dustin and Juan J. Lafaille The degree of Treg self-antigen reactivity varies across experimental systems. Here the authors develop a new model of skin autoimmunity and show that the size of tissue-specific Treg pool in the thymus depends on AIRE, the availability of the tissue antigen, and its presentation by dendritic cells. 29 February 2016 | doi: 10.1038/ncomms10562 Biological Sciences  Immunology  Global pulses of organic carbon burial in deep-sea sediments during glacial maxima OPEN Olivier Cartapanis, Daniele Bianchi, Samuel L. Jaccard and Eric D. Galbraith While numerous studies have indicated that carbon export to the deep ocean was greater during glacial periods, quantification is lacking. Here, via analysis of hundreds of sediment cores, the authors show carbon accumulation rate was 50% higher during glacial maxima than during interglacials. 29 February 2016 | doi: 10.1038/ncomms10796 Earth Sciences  Climate science  Oceanography  Efficient linear phase contrast in scanning transmission electron microscopy with matched illumination and detector interferometry OPEN Colin Ophus, Jim Ciston, Jordan Pierce, Tyler R. Harvey, Jordan Chess, Benjamin J. McMorran, Cory Czarnik, Harald H. Rose and Peter Ercius Scanning transmission electron microscopy is a powerful material probe, but constrained to large atomic number samples due to the issues of beam damage and weak scattering. Here, Ophus et al. propose a method that produces linear phase contrast in a focused electron beam to image dose-sensitive objects. 29 February 2016 | doi: 10.1038/ncomms10719 Physical Sciences  Applied physics  Condensed matter  Materials science  Dynamic capsule restructuring by the main pneumococcal autolysin LytA in response to the epithelium OPEN Colin C. Kietzman, Geli Gao, Beth Mann, Lance Myers and Elaine I. Tuomanen Pneumococci produce a carbohydrate capsule that protects them against components of the host immune system but sensitizes them to host antimicrobial peptides. Here, Kietzman et al. show that pneumococci respond to antimicrobial peptides by capsule shedding, which requires the main autolysin LytA. 29 February 2016 | doi: 10.1038/ncomms10859 Biological Sciences  Immunology  Microbiology  Optically controlled electroresistance and electrically controlled photovoltage in ferroelectric tunnel junctions OPEN Wei Jin Hu, Zhihong Wang, Weili Yu and Tom Wu Tunnelling electroresistance is the variation of resistance of a thin-film junction with the polarization state of its ferroelectric tunnel barrier. Here the authors demonstrate a large light-modulated tunnelling electroresistance and a hysteretic photovoltaic effect in a complex oxide heterostructure. 29 February 2016 | doi: 10.1038/ncomms10808 Physical Sciences  Condensed matter  Optical physics  Flexible single-layer ionic organic–inorganic frameworks towards precise nano-size separation OPEN Liang Yue, Shan Wang, Ding Zhou, Hao Zhang, Bao Li and Lixin Wu Membranes composed of ionic frameworks offer applications in nano-size separation thanks to their highly regular pores. Here, the authors devise such a system composed of polyoxometalates and organic pseudorotaxanes, and demonstrate their ability to separate mixed sized CdTe quantum dots. 29 February 2016 | doi: 10.1038/ncomms10742 Chemical Sciences  Inorganic chemistry  Materials science  Nanotechnology  Large elasto-optic effect and reversible electrochromism in multiferroic BiFeO3 OPEN D. Sando, Yurong Yang, E. Bousquet, C. Carrétéro, V. Garcia, S. Fusil, D. Dolfi, A. Barthélémy, Ph. Ghosez, L. Bellaiche and M. Bibes Modern technology such as electronics and photovoltaics requires careful control of optical responses of electronic properties. Here, Sando et al. demonstrate a large variation of optical index and light absorption in multiferroic material BiFeO3 thin films, tunable by in-film strain or electric field. 29 February 2016 | doi: 10.1038/ncomms10718 Physical Sciences  Applied physics  Condensed matter  Optical physics  Tornado outbreak variability follows Taylor’s power law of fluctuation scaling and increases dramatically with severity OPEN Michael K. Tippett and Joel E. Cohen Tornadoes, which cause loss of life and damage to property worldwide, may occur in outbreaks of six or more in rapid succession. Here, the authors show that the annual mean number of tornadoes per US outbreak rose over the last 60 years, with the variance increasing four times faster than the mean. 29 February 2016 | doi: 10.1038/ncomms10668 Earth Sciences  Atmospheric science  Climate science  Cold denaturation induces inversion of dipole and spin transfer in chiral peptide monolayers OPEN Meital Eckshtain-Levi, Eyal Capua, Sivan Refaely-Abramson, Soumyajit Sarkar, Yulian Gavrilov, Shinto P. Mathew, Yossi Paltiel, Yaakov Levy, Leeor Kronik and Ron Naaman Spin selectivity for electron transport through peptide monolayers depends on the dipole moment of the system. Here, the authors show that self-assembled monolayers of peptides with α-helix structures transform to more linear structures upon cooling, inducing a flip in the direction of dipole moment and a change in preferred spin for electron transport. 26 February 2016 | doi: 10.1038/ncomms10744 Chemical Sciences  Atomic and molecular physics  Physical chemistry  Phosphatidylinositol phosphate kinase PIPKIγ and phosphatase INPP5E coordinate initiation of ciliogenesis OPEN Qingwen Xu, Yuxia Zhang, Qing Wei, Yan Huang, Jinghua Hu and Kun Ling The primary cilium is essential for embryonic development and tissue pattern formation. Here the authors show that PIPKIγ localizes to the basal body of the primary cilium and cooperates with the Joubert Syndrome associated protein INPP5E to regulate the initiation of ciliogenesis. 26 February 2016 | doi: 10.1038/ncomms10777 Biological Sciences  Cell biology  Developmental biology  RUNX1 prevents oestrogen-mediated AXIN1 suppression and β-catenin activation in ER-positive breast cancer OPEN Nyam-Osor Chimge, Gillian H. Little, Sanjeev K. Baniwal, Helty Adisetiyo, Ying Xie, Tian Zhang, Andie O’Laughlin, Zhi Y. Liu, Peaches Ulrich, Anthony Martin, Paulette Mhawech-Fauceglia, Matthew J. Ellis, Debu Tripathy, Susan Groshen, Chengyu Liang, Zhe Li, Dustin E. Schones and Baruch Frenkel The tumour suppressor RUNX1 is often lost or mutated in oestrogen receptor-positive breast cancers. In this study, the authors demonstrate that the loss of RUNX1 unleashes oestrogen-mediated inhibition of AXIN1, a negative regulator of β-catenin, resulting in β-catenin signalling-mediated cancer cell proliferation and mitosis deregulation. 26 February 2016 | doi: 10.1038/ncomms10751 Biological Sciences  Cancer  Cell biology  Micro-total envelope system with silicon nanowire separator for safe carcinogenic chemistry OPEN Ajay K. Singh, Dong-Hyeon Ko, Niraj K. Vishwakarma, Seungwook Jang, Kyoung-Ik Min and Dong-Pyo Kim Carcinogenic compounds present difficulties in synthesis not just during reaction but perhaps especially during purification. Here, the authors report a microfluidic device for the use of carcinogenic chloromethyl methyl ether that includes a silicon nanowire separator allowing isolated, automated purification. 26 February 2016 | doi: 10.1038/ncomms10741 Chemical Sciences  Materials science  Nanotechnology  Organic chemistry  Near-field photocurrent nanoscopy on bare and encapsulated graphene OPEN Achim Woessner, Pablo Alonso-González, Mark B. Lundeberg, Yuanda Gao, Jose E. Barrios-Vargas, Gabriele Navickaite, Qiong Ma, Davide Janner, Kenji Watanabe, Aron W. Cummings, Takashi Taniguchi, Valerio Pruneri, Stephan Roche, Pablo Jarillo-Herrero, James Hone, Rainer Hillenbrand and Frank H. L. Koppens Graphene grain boundaries and charge inhomogeneities limit its electronic properties. Here the authors combine scanning near-field optical microscopy with electrical read-out to image these defects at the nanoscale under an encapsulation layer, and show that charges build up along the edges of the flake. 26 February 2016 | doi: 10.1038/ncomms10783 Physical Sciences  Condensed matter  Materials science  Nanotechnology  Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 delivery in mice OPEN Roman Maresch, Sebastian Mueller, Christian Veltkamp, Rupert Öllinger, Mathias Friedrich, Irina Heid, Katja Steiger, Julia Weber, Thomas Engleitner, Maxim Barenboim, Sabine Klein, Sandra Louzada, Ruby Banerjee, Alexander Strong, Teresa Stauber, Nina Gross, Ulf Geumann, Sebastian Lange, Marc Ringelhan, Ignacio Varela et al. CRISPR/Cas9 technology has been used for genome engineering in vivo. Here, the authors use a transfection technique to deliver multiple guide RNAs to the pancreas of adult mice, allowing genetic screening and chromosome engineering in pancreatic cancer. 26 February 2016 | doi: 10.1038/ncomms10770 Biological Sciences  Biotechnology  Cancer  Genetics  Neurogenesis-mediated forgetting minimizes proactive interference OPEN Jonathan R. Epp, Rudy Silva Mera, Stefan Köhler, Sheena A. Josselyn and Paul W. Frankland New neurons are continuously produced throughout adulthood in the hippocampus. Here the authors provide evidence that adult hippocampal neurogenesis weakens existing memories, and facilitates the encoding of new, confliction information in mice. 26 February 2016 | doi: 10.1038/ncomms10838 Biological Sciences  Neuroscience  Impact of ribonucleotide incorporation by DNA polymerases β and λ on oxidative base excision repair OPEN Emmanuele Crespan, Antonia Furrer, Marcel Rösinger, Federica Bertoletti, Elisa Mentegari, Giulia Chiapparini, Ralph Imhof, Nathalie Ziegler, Shana J. Sturla, Ulrich Hübscher, Barbara van Loon and Giovanni Maga Oxidative stress is a common source of DNA damage and is repaired by the base excision repair machinery, including polymerase beta. Here the authors find that polymerase beta, and to a lesser extent lambda, can mistakenly incorporate ribonucleotides during synthesis. 26 February 2016 | doi: 10.1038/ncomms10805 Biological Sciences  Molecular biology  Local T/B cooperation in inflamed tissues is supported by T follicular helper-like cells OPEN Dana Vu Van, Katja C. Beier, Lea-Jean Pietzke, Maysun S. Al Baz, Randi K. Feist, Stephanie Gurka, Eckard Hamelmann, Richard A. Kroczek and Andreas Hutloff In secondary lymphoid organs T follicular helper (Tfh) cells help B cells to develop into memory B and plasma cells. Here, the authors show that inflamed lung becomes a reservoir of activated B cells with a germinal centre phenotype, and T cells that exhibit Tfh-like properties despite not expressing classical Tfh markers. 26 February 2016 | doi: 10.1038/ncomms10875 Biological Sciences  Immunology  Organic–inorganic supramolecular solid catalyst boosts organic reactions in water OPEN Pilar García-García, José María Moreno, Urbano Díaz, Marta Bruix and Avelino Corma Coordination polymers and metal-organic frameworks are appealing synthetic hosts for mediating reactions. Here, the authors report a mesoscopic metal-organic structure that is shown to accelerate condensation reactions in water in the absence of acid or base, owing to the hydrophobic environment of the host. 25 February 2016 | doi: 10.1038/ncomms10835 Chemical Sciences  Catalysis  Inorganic chemistry  Organic chemistry  The Bub1–Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation OPEN Luying Jia, Bing Li and Hongtao Yu The mitotic checkpoint complex (MCC) inhibits the anaphase-promoting complex (APC/C) bound to Cdc20 in response to spindle defects. Here, the authors show that Bub1-Plk1-mediated phosphorylation of Cdc20 constitutes a parallel, non-redundant APC/C-inhibitory mechanism in addition to MCC activity. 25 February 2016 | doi: 10.1038/ncomms10818 Biological Sciences  Cell biology  Calcium imaging of sleep–wake related neuronal activity in the dorsal pons OPEN Julia Cox, Lucas Pinto and Yang Dan Dreaming occurs in REM sleep, yet the neural mechanisms involved in generating it are not understood. Here Cox and colleagues show that glutamatergic neurons in the dorsal pons are activated most during transition to REM sleep while GABAergic neurons are more active during waking state. 25 February 2016 | doi: 10.1038/ncomms10763 Biological Sciences  Neuroscience  BTG2 bridges PABPC1 RNA-binding domains and CAF1 deadenylase to control cell proliferation OPEN Benjamin Stupfler, Catherine Birck, Bertrand Séraphin and Fabienne Mauxion BTG2 promotes mRNA poly(A) tail shortening and regulates cellular differentiation. Here, Stupfler et al. show that the BTG2 APRO domain interacts with PABPC1 RRM1, allowing the former to recruit and stimulate the poly(A) tail shortening activity of CAF1 deadenylase and to control cell proliferation. 25 February 2016 | doi: 10.1038/ncomms10811 Biological Sciences  Biochemistry  Molecular biology  Possible observation of highly itinerant quantum magnetic monopoles in the frustrated pyrochlore Yb2Ti2O7 OPEN Y. Tokiwa, T. Yamashita, M. Udagawa, S. Kittaka, T Sakakibara, D. Terazawa, Y. Shimoyama, T. Terashima, Y. Yasui, T. Shibauchi and Y. Matsuda Spin excitations above the ground state of spin ices, geometrically frustrated pyrochlore magnets, are equivalent to pairs of oppositely charged deconfined magnetic monopoles which may propagate through the system. Here, the authors evidence highly itinerant quantum magnetic monopole excitations in Yb2Ti2O7. 25 February 2016 | doi: 10.1038/ncomms10807 Physical Sciences  Condensed matter  Signatures of the Adler–Bell–Jackiw chiral anomaly in a Weyl fermion semimetal OPEN Cheng-Long Zhang, Su-Yang Xu, Ilya Belopolski, Zhujun Yuan, Ziquan Lin, Bingbing Tong, Guang Bian, Nasser Alidoust, Chi-Cheng Lee, Shin-Ming Huang, Tay-Rong Chang, Guoqing Chang, Chuang-Han Hsu, Horng-Tay Jeng, Madhab Neupane, Daniel S. Sanchez, Hao Zheng, Junfeng Wang, Hsin Lin, Chi Zhang et al. Anomalous conducting behavior of solids may reflect the presence of novel quantum states. Here, Zhang et al. report an increased conductivity in TaAs with a magnetic field applied along the direction of the current, which reveals an inherent property of the Weyl Fermion. 25 February 2016 | doi: 10.1038/ncomms10735 Physical Sciences  Condensed matter  Materials science  Theoretical physics  1s-intraexcitonic dynamics in monolayer MoS2 probed by ultrafast mid-infrared spectroscopy OPEN Soonyoung Cha, Ji Ho Sung, Sangwan Sim, Jun Park, Hoseok Heo, Moon-Ho Jo and Hyunyong Choi Excitons—bound electron-hole pairs—in two-dimensional transition-metal dichalcogenides can exhibit a rich spectrum of excited states. Here, the authors use ultrafast mid-infrared spectroscopy to explore the dynamics of these so-called 1s-intraexcitonic transitions in monolayer molybdenum disulphide. 25 February 2016 | doi: 10.1038/ncomms10768 Physical Sciences  Materials science  Nanotechnology  Magnon spectrum of the helimagnetic insulator Cu2OSeO3 OPEN P. Y. Portnichenko, J. Romhányi, Y. A. Onykiienko, A. Henschel, M. Schmidt, A. S. Cameron, M. A. Surmach, J. A. Lim, J. T. Park, A. Schneidewind, D. L. Abernathy, H. Rosner, Jeroen van den Brink and D. S. Inosov Cu2OSeO3 possesses a helical spin structure which supports a rich phase diagram of magnetic states, including a lattice of particle-like skyrmions. Here, the authors use inelastic neutron scattering to elucidate the three-dimensional magnon spectrum and underlying spin Hamiltonian of Cu2OSeO3. 25 February 2016 | doi: 10.1038/ncomms10725 Physical Sciences  Condensed matter  Top–down assessment of the Asian carbon budget since the mid 1990s OPEN R. L. Thompson, P. K. Patra, F. Chevallier, S. Maksyutov, R. M. Law, T. Ziehn, I. T. van der Laan-Luijkx, W. Peters, A. Ganshin, R. Zhuravlev, T. Maki, T. Nakamura, T. Shirai, M. Ishizawa, T. Saeki, T. Machida, B. Poulter, J. G. Canadell and P. Ciais Land biosphere uptake of carbon is important in mitigating the anthropogenic increase in atmospheric CO2 and its climate forcing. Here, the authors show that land biosphere uptake of carbon in Asia has increased substantially since the mid 1990s, likely owing to reforestation and regional climate change. 25 February 2016 | doi: 10.1038/ncomms10724 Earth Sciences  Atmospheric science  Climate science  Control of antiferromagnetic domain distribution via polarization-dependent optical annealing OPEN Takuya Higuchi and Makoto Kuwata-Gonokami The control of magnetic domains in antiferromagnets is limited by the lack of a net magnetic moment which may be manipulated by external stimuli. Here, the authors present an optical method for switching such domain states in MnF2 based on azimuth-dependent absorption of linearly polarized light. 25 February 2016 | doi: 10.1038/ncomms10720 Physical Sciences  Condensed matter  Photoresponse of supramolecular self-assembled networks on graphene–diamond interfaces OPEN Sarah Wieghold, Juan Li, Patrick Simon, Maximilian Krause, Yuri Avlasevich, Chen Li, Jose A. Garrido, Ueli Heiz, Paolo Samorì, Klaus Müllen, Friedrich Esch, Johannes V. Barth and Carlos-Andres Palma Two-dimensional, self-assembled heteromolecular networks often lack functionality. Here the authors study the photoresponse of self-assembled heteromolecular networks, while controlling their positions and interfaces at an atomic level, suggesting bottom-up assembly of optoelectronics devices. 25 February 2016 | doi: 10.1038/ncomms10700 Physical Sciences  Atomic and molecular physics  Materials science  Nanotechnology  In situ stress observation in oxide films and how tensile stress influences oxygen ion conduction OPEN Aline Fluri, Daniele Pergolesi, Vladimir Roddatis, Alexander Wokaun and Thomas Lippert Strain engineering is used to tune physiochemical material properties, but detailed insights of how the crystal growth affects the stress are yet lacking. Here, the authors analyse in situ simultaneously the induced stress and growth mode during the epitaxial growth of an oxygen ion conductor. 25 February 2016 | doi: 10.1038/ncomms10692 Physical Sciences  Applied physics  Condensed matter  Materials science  Drug design from the cryptic inhibitor envelope OPEN Chul-Jin Lee, Xiaofei Liang, Qinglin Wu, Javaria Najeeb, Jinshi Zhao, Ramesh Gopalaswamy, Marie Titecat, Florent Sebbane, Nadine Lemaitre, Eric J. Toone and Pei Zhou The conformational dynamics of a compound has a large effect on ligand/receptor binding. Here, the authors employ NMR spectroscopy to study ligand binding to the enzyme LpxC, discovering an inhibitor envelope that was not identifiable by crystallography and subsequently developing a highly potent inhibitor. 25 February 2016 | doi: 10.1038/ncomms10638 Chemical Sciences  Biochemistry  Chemical biology  Medicinal chemistry  Chlamydia trachomatis from Australian Aboriginal people with trachoma are polyphyletic composed of multiple distinctive lineages OPEN Patiyan Andersson, Simon R. Harris, Helena M. B. Seth Smith, James Hadfield, Colette O’Neill, Lesley T. Cutcliffe, Fiona P. Douglas, L. Valerie Asche, John D. Mathews, Susan I. Hutton, Derek S. Sarovich, Steven Y. C. Tong, Ian N. Clarke, Nicholas R. Thomson and Philip M. Giffard Chlamydia trachomatis isolates causing a blinding disease (trachoma) form a single lineage that is different from the lineages causing urogenital infections. Here, Andersson et al. show however that trachoma isolates from Australia are more closely related to urogenital strains than to other trachoma isolates. 25 February 2016 | doi: 10.1038/ncomms10688 Biological Sciences  Evolution  Medical research  Microbiology  A workflow to process 3D+time microscopy images of developing organisms and reconstruct their cell lineage OPEN Emmanuel Faure, Thierry Savy, Barbara Rizzi, Camilo Melani, Olga Stašová, Dimitri Fabrèges, Róbert Špir, Mark Hammons, Róbert Čúnderlík, Gaëlle Recher, Benoît Lombardot, Louise Duloquin, Ingrid Colin, Jozef Kollár, Sophie Desnoulez, Pierre Affaticati, Benoît Maury, Adeline Boyreau, Jean-Yves Nief, Pascal Calvat et al. Quantitative analysis of embryonic cell dynamics from large data sets remains a major challenge in the field of developmental biology. Here the authors develop software and a workflow to reconstruct cell lineage trees from 3D time lapse imaging data sets from several developing organisms including zebrafish, tunicates and sea urchins. 25 February 2016 | doi: 10.1038/ncomms9674 Biological Sciences  Bioinformatics  Developmental biology  Enhanced spin–orbit torques by oxygen incorporation in tungsten films OPEN Kai-Uwe Demasius, Timothy Phung, Weifeng Zhang, Brian P. Hughes, See-Hun Yang, Andrew Kellock, Wei Han, Aakash Pushp and Stuart S. P. Parkin When interfaced with a current-carrying heavy metal, spin orbit effects can generate a torque on the magnetization of a ferromagnet, understood as a bulk effect. Here, the authors show evidence of an interfacial contribution to such spin orbit torque in O-doped W/CoFeB thin film systems. 25 February 2016 | doi: 10.1038/ncomms10644 Physical Sciences  Condensed matter  Directional charge separation in isolated organic semiconductor crystalline nanowires OPEN J. A. Labastide, H. B. Thompson, S. R. Marques, N. S. Colella, A. L. Briseno and M. D. Barnes Photo-induced charge separation in organic semiconductors usually occurs at interfaces between electron donors and acceptors. Here, the authors show using photoluminescence measurements that charge separation is intrinsic and directional in organic crystalline nanowires made of stacked monomers. 25 February 2016 | doi: 10.1038/ncomms10629 Physical Sciences  Atomic and molecular physics  Condensed matter  Materials science  Subnanometre enzyme mechanics probed by single-molecule force spectroscopy OPEN Benjamin Pelz, Gabriel Žoldák, Fabian Zeller, Martin Zacharias and Matthias Rief Adenylate kinase catalyses the interconversion of adenosine phosphates, and plays a crucial role in maintaining cellular energy homeostasis. Here, the authors use single molecule optical tweezers to understand how the enzyme’s conformation dynamics modulates catalysis. 24 February 2016 | doi: 10.1038/ncomms10848 Biological Sciences  Biophysics  Chemical biology  Nanotechnology  Ferroelasticity and domain physics in two-dimensional transition metal dichalcogenide monolayers OPEN Wenbin Li and Ju Li The atoms in two-dimensional transition-metal dichalcogenides can arrange into a number of different structures, or polymorphs. Here, the authors use first-principles calculations to show that one such polymorph, 1T', can exhibit a large mechanical response to external applied strain. 24 February 2016 | doi: 10.1038/ncomms10843 Physical Sciences  Condensed matter  Materials science  Nanotechnology  The role of kinetic context in apparent biased agonism at GPCRs OPEN Carmen Klein Herenbrink, David A. Sykes, Prashant Donthamsetti, Meritxell Canals, Thomas Coudrat, Jeremy Shonberg, Peter J. Scammells, Ben Capuano, Patrick M. Sexton, Steven J. Charlton, Jonathan A. Javitch, Arthur Christopoulos and J. Robert Lane Biased agonists act at a receptor to preferentially induce distinct intracellular signalling responses over others. Here the authors show how kinetics of ligand binding and signaling responses greatly influence observed bias profiles, and hence must be considered when studying biased agonists. 24 February 2016 | doi: 10.1038/ncomms10842 Biological Sciences  Cell biology  Medical research  Observation of Zeeman effect in topological surface state with distinct material dependence OPEN Ying-Shuang Fu, T. Hanaguri, K. Igarashi, M. Kawamura, M. S. Bahramy and T. Sasagawa The knowledge of how electrons behave under magnetic field provides inherent information for exotic quantum states. Here, Fu et al. find different g-factors of topological surface states in Bi2Se3 and Sb2Te2Se, which suggests possible control of such states in spin-related applications. 24 February 2016 | doi: 10.1038/ncomms10829 Physical Sciences  Condensed matter  Materials science  Nanotechnology  FAT1 mutations cause a glomerulotubular nephropathy OPEN Heon Yung Gee, Carolin E. Sadowski, Pardeep K. Aggarwal, Jonathan D. Porath, Toma A. Yakulov, Markus Schueler, Svjetlana Lovric, Shazia Ashraf, Daniela A. Braun, Jan Halbritter, Humphrey Fang, Rannar Airik, Virginia Vega-Warner, Kyeong Jee Cho, Timothy A. Chan, Luc G. T. Morris, Charles ffrench-Constant, Nicholas Allen, Helen McNeill, Rainer Büscher et al. Steroid-sensitive nephrotic syndrome (SRNS) can cause CKD and necessitate kidney transplant. Here the authors identify FAT1 mutations by homozygosity mapping and whole-exome sequencing in families with SRNS and provide functional mouse and zebrafish evidence that FAT1 is required for normal glomerular and tubular function and that FAT1 mutations can cause SRNS. 24 February 2016 | doi: 10.1038/ncomms10822 Biological Sciences  Genetics  Medical research  Structural hot spots for the solubility of globular proteins OPEN Ashok Ganesan, Aleksandra Siekierska, Jacinte Beerten, Marijke Brams, Joost Van Durme, Greet De Baets, Rob Van der Kant, Rodrigo Gallardo, Meine Ramakers, Tobias Langenberg, Hannah Wilkinson, Frederik De Smet, Chris Ulens, Frederic Rousseau and Joost Schymkowitz Mutations in aggregation prone regions of recombinant proteins often improve their solubility, although they might cause negative effects on their structure and function. Here, the authors identify proteins hot spots that can be exploited to optimize solubility without compromising stability. 24 February 2016 | doi: 10.1038/ncomms10816 Biological Sciences  Biochemistry  Bioinformatics  Biotechnology  Orbital two-channel Kondo effect in epitaxial ferromagnetic L10-MnAl films OPEN L. J. Zhu, S. H. Nie, P. Xiong, P. Schlottmann and J. H. Zhao In metals, electronic scattering from defects by the two-channel Kondo effect is expected to cause deviation from standard low temperature behaviour, however this effect has not been unambiguously shown. Here, the authors present evidence consistent with all transport signatures of the effect in ferromagnetic L10-MnAl films. 24 February 2016 | doi: 10.1038/ncomms10817 Physical Sciences  Condensed matter  Effects of cytosine modifications on DNA flexibility and nucleosome mechanical stability OPEN Thuy T. M. Ngo, Jejoong Yoo, Qing Dai, Qiucen Zhang, Chuan He, Aleksei Aksimentiev and Taekjip Ha Cytosine modifications are important epigenetic markers yet their physical influence on DNA is not well understood. Here, Ngo et al. show that different alterations affect DNA flexibility, suggesting a mechanism where modifications change accessibility of nucleosome bound DNA. 24 February 2016 | doi: 10.1038/ncomms10813 Biological Sciences  Biochemistry  Biophysics  Human oocyte developmental potential is predicted by mechanical properties within hours after fertilization OPEN Livia Z. Yanez, Jinnuo Han, Barry B. Behr, Renee A. Reijo Pera and David B. Camarillo Reliable assessments of oocyte developmental potential are lacking, making it difficult to select the best quality embryos for transfer after in vitro fertilization. Here, the authors show that a non-invasive measurement of viscoelastic properties predicts developmental potential in both humans and mice. 24 February 2016 | doi: 10.1038/ncomms10809 Biological Sciences  Cell biology  Developmental biology  Creating single-atom Pt-ceria catalysts by surface step decoration OPEN Filip Dvořák, Matteo Farnesi Camellone, Andrii Tovt, Nguyen-Dung Tran, Fabio R. Negreiros, Mykhailo Vorokhta, Tomáš Skála, Iva Matolínová, Josef Mysliveček, Vladimír Matolín and Stefano Fabris Single metal atoms promise high catalytic performances, but their implementation in future systems depends on an understanding of how their underlying support medium can offer stabilization. Here, the authors investigate Pt2+ on ceria to elucidate this important fundamental consideration. 24 February 2016 | doi: 10.1038/ncomms10801 Chemical Sciences  Catalysis  Nanotechnology  Physical chemistry  Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease OPEN Vikram Shettigar, Bo Zhang, Sean C. Little, Hussam E. Salhi, Brian J. Hansen, Ning Li, Jianchao Zhang, Steve R. Roof, Hsiang-Ting Ho, Lucia Brunello, Jessica K. Lerch, Noah Weisleder, Vadim V. Fedorov, Federica Accornero, Jill A. Rafael-Fortney, Sandor Gyorke, Paul M. L. Janssen, Brandon J. Biesiadecki, Mark T. Ziolo and Jonathan P. Davis et al. Heart contraction, which is decreased in disease, is determined by Ca2+ binding to troponin C. Here, the authors combine a protein engineering approach with gene therapy to modulate heart contractility in mice with the use of rationally designed Troponin C variants, suggesting a new therapy for diseased hearts. 24 February 2016 | doi: 10.1038/ncomms10794 Biological Sciences  Medical research  Mutation allele burden remains unchanged in chronic myelomonocytic leukaemia responding to hypomethylating agents OPEN Jane Merlevede, Nathalie Droin, Tingting Qin, Kristen Meldi, Kenichi Yoshida, Margot Morabito, Emilie Chautard, Didier Auboeuf, Pierre Fenaux, Thorsten Braun, Raphael Itzykson, Stéphane de Botton, Bruno Quesnel, Thérèse Commes, Eric Jourdan, William Vainchenker, Olivier Bernard, Noemie Pata-Merci, Stéphanie Solier, Velimir Gayevskiy et al. Chronic myelomonocytic leukaemia is treated with agents that modify DNA methylation but whether they have direct cytotoxic effects is unclear. Here, the authors show that cells from treated patients show marked methylation changes without altered somatic mutation burden, suggesting that cytotoxicity is not a major factor in therapeutic efficacy. 24 February 2016 | doi: 10.1038/ncomms10767 Biological Sciences  Cancer  Genetics  Multiscale deformations lead to high toughness and circularly polarized emission in helical nacre-like fibres OPEN Jia Zhang, Wenchun Feng, Huangxi Zhang, Zhenlong Wang, Heather A. Calcaterra, Bongjun Yeom, Ping An Hu and Nicholas A. Kotov The mechanical properties and hierarchical structure of nacre have been widely investigated as a biomimetic template for applications. Here, the authors demonstrate that nacre-like fibres made from nanoplatelets and polymers show exceptional stretchability and toughness. 24 February 2016 | doi: 10.1038/ncomms10701 Physical Sciences  Materials science  Nanotechnology  Super-crystals in composite ferroelectrics OPEN D. Pierangeli, M. Ferraro, F. Di Mei, G. Di Domenico, C. E. M. de Oliveira, A. J. Agranat and E. DelRe Crystalline materials are formed by the periodic order of atomic unit cells. Here, Pierangeli et al. report the formation of a ferrelectric super-crystal with micrometric unit cell from modulated nanoscale disorder in potassium-lithium-tantalate-niobate, which is potentially useful for engineering ordered states out of disorder. 24 February 2016 | doi: 10.1038/ncomms10674 Physical Sciences  Applied physics  Materials science  Optical physics  Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice OPEN Andrew T. McGuire, Matthew D. Gray, Pia Dosenovic, Alexander D. Gitlin, Natalia T. Freund, John Petersen, Colin Correnti, William Johnsen, Robert Kegel, Andrew B. Stuart, Jolene Glenn, Michael S. Seaman, William R. Schief, Roland K. Strong, Michel C. Nussenzweig and Leonidas Stamatatos The induction of broadly neutralizing antibodies (bNAbs) is a goal of HIV-1 vaccine research. Here the authors demonstrate the ability of an HIV Env-derived immunogen to bind germline precursors of a class of bNAbs and to activate the corresponding B cells in a knock-in mouse model 24 February 2016 | doi: 10.1038/ncomms10618 Biological Sciences  Immunology    Nature Communications JOBS of the week PhD students and Postdocs Karlsruhe Institute of Technology (KIT). Senior Researcher Kew Gardens Research Fellow New York Blood Center Research Associate University of Bristol Research Fellow Boston Children's Hospital; Harvard Medical School Postdoctoral Research Fellow Thomas Jefferson University (TJU) Postdoctoral Training Fellow The Francis Crick Institute Senior Research Associate Ref: RA1273 University of East Anglia (UEA) Senior Research Associate The Babraham Institute Research Associate Position University of Zurich More Science jobs from Nature Communications EVENT 8th Excellence in Pediatrics Conference 08.12.16 London, UK More science events from       Latest Corrigenda     Corrigendum: Polaronic metal state at the LaAlO3/SrTiO3 interface OPEN C. Cancellieri, A. S. Mishchenko, U. Aschauer, A. Filippetti, C. Faber, O. S. Barišić, V. A. Rogalev, T. Schmitt, N. Nagaosa and V. N. Strocov 26 February 2016 | doi: 10.1038/ncomms10920 Physical Sciences  Condensed matter  Materials science      Corrigendum: TRIP13 promotes error-prone nonhomologous end joining and induces chemoresistance in head and neck cancer Rajat Banerjee, Nickole Russo, Min Liu, Venkatesha Basrur, Emily Bellile, Nallasivam Palanisamy, Christina S. Scanlon, Elizabeth van Tubergen, Ronald C. Inglehart, Tarek Metwally, Ram-Shankar Mani, Anastasia Yocum, Mukesh K. Nyati, Rogerio M. Castilho, Sooryanarayana Varambally, Arul M. Chinnaiyan and Nisha J. D’Silva 24 February 2016 | doi: 10.1038/ncomms10726 Biological Sciences  Cancer  Molecular biology      Advertisement All content now free to access including archives! Nature Communications is an open access journal that publishes high-quality research from all areas of the natural sciences. Papers published by the journal represent important advances of significance to specialists within each subject area including physics. 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