Nature Reviews Genetics Contents March 2016 Volume 17 Number 3 pp 123-188

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TABLE OF CONTENTS
March 2016 Volume 17 Number 3		Advertisement
Impact Factor 36.978 *	In this issue Editorial Research Highlights Reviews Also this month Article series: Study designs Disease mechanisms Single-cell omics  Featured article: Single-cell genome sequencing: current state of the science Charles Gawad, Winston Koh & Stephen R. Quake	Key Advances in Medicine eBook from Nature Reviews - FREE to download!  This essential resource summarizes the groundbreaking clinical and biomedical discoveries of 2015 and highlights the trends to watch out for in 2016, making it a must read eBook for anyone with an interest in medical science.  Download for free
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EDITORIAL		Top
Genetically-modified insects to combat vector-borne diseases — curtain rise or fall? p123 | doi:10.1038/nrg.2016.14 Full Text | PDF
RESEARCH HIGHLIGHTS Top Genetic engineering: In vivo genome editing — growing in strength p124 | doi:10.1038/nrg.2016.2 PDF Cancer genomics: A nucleosome footprint reveals the source of cfDNA p125 | doi:10.1038/nrg.2016.3 PDF Epigenomics: Parallel single-cell sequencing p125 | doi:10.1038/nrg.2016.5 PDF Microbial genetics: Dual RNA-seq for host-pathogen transcriptomics p126 | doi:10.1038/nrg.2016.15 PDF Epigenomics: Custom remodelling p126 | doi:10.1038/nrg.2016.16 PDF Disease genetics: Prion variant pathogenicity through large-scale population sequencing p127 | doi:10.1038/nrg.2016.9 PDF Non-coding RNA: Inheritance of diet-induced metabolic changes via tsRNAs p128 | doi:10.1038/nrg.2016.1 PDF IN BRIEF Technology: Prediction of reprogramming factors | RNA: Exonic splicing mutation prevalence | Technique: Single-cell CNV detection PDF Genetics JOBS of the week Postdoctoral Research Fellow (m / f) in the Department for "Molecular Genetics and Ageing" Max Planck Institute for Biology of Ageing Assistant Professor / PostDoc in Behavioral Genetics / Statistical Genetics VU University Amsterdam (VU) Postdoctoral Research Associate in Gene Expression and Genome Stability The Babraham Institute 4 PhD studentships in Genomics, Epigenetics or Evolution University of Essex Faculty Positions in Cancer Research The Jackson Laboratory More Science jobs from Genetics EVENT Population Variation Genetics: Experimental Strategies and Analysis 23.05.16 Norwic, UK More science events from
REVIEWS		Top
Article series: Study designs Unravelling the human genome-phenome relationship using phenome-wide association studies William S. Bush, Matthew T. Oetjens & Dana C. Crawford p129 | doi:10.1038/nrg.2015.36 Phenotypic data from electronic health records and epidemiological studies can be exploited to study the impact of genetic variation on the phenome. This Review highlights challenges that need to be overcome for the characterization of the complex human genome-phenome relationship using phenome-wide association studies (PheWAS). Abstract | Full Text | PDF
Cheating evolution: engineering gene drives to manipulate the fate of wild populations Jackson Champer, Anna Buchman & Omar S. Akbari p146 | doi:10.1038/nrg.2015.34 RNA-guided endonucleases have the potential to revolutionize the engineering of synthetic gene drives, which may be particularly useful for the control of vector-borne diseases. Here, the authors review different types of engineered gene drives and their potential applications, as well as considerations regarding the safety and regulation of gene drives for the manipulation of wild populations. Abstract | Full Text | PDF
Article series: Disease mechanisms Autoimmune diseases — connecting risk alleles with molecular traits of the immune system Maria Gutierrez-Arcelus, Stephen S. Rich & Soumya Raychaudhuri p160 | doi:10.1038/nrg.2015.33 Genome-wide approaches have advanced the study into mechanisms triggering autoimmunity. This Review illustrates how this has been achieved for twelve common autoimmune diseases, and discusses recent functional genomics approaches that have the potential to help define key immune molecular traits, cell types and cell states. Abstract | Full Text | PDF
Article series: Single-cell omics Single-cell genome sequencing: current state of the science Charles Gawad, Winston Koh & Stephen R. Quake p175 | doi:10.1038/nrg.2015.16 Single-cell genome sequencing can provide detailed insights into the composition of single genomes that are not readily apparent when studying bulk cell populations. This Review discusses the considerable technical challenges of amplifying and interrogating genomes from single cells, emerging innovative solutions and various applications in microbiology and human disease, in particular in cancer. Abstract | Full Text | PDF
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*2013 Journal Citation Report (Thomson Reuters, 2014)

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