Nature Reviews Cancer contents March 2016 Volume 16 Number 3 pp127-196

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TABLE OF CONTENTS
March 2016 Volume 16 Number 3		Advertisement
Impact Factor 37.4 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: Leukaemia 'firsts' in cancer research and treatment Mel Greaves	NEW WHITE PAPER: Xenograft Host Selection - Important Factors for Experimental Success Genetically engineered mouse models are an integral part of understanding tumor biology, validating in vitro findings, and mimicking disease progression. This paper explores: 5 critical elements to in-vivo study design Spontaneous immune deficient mice utility GEM application in Oncology research Download Now
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BEATSON INTERNATIONAL CANCER CONFERENCE Modelling the Mechanisms of Malignancy - In Vivo Veritas 3 July - 6 July 2016 - Glasgow, Scotland The conference will focus on the latest developments in the generation of animal models of cancer, with particular emphasis on how diverse aspects of the human disease may be faithfully recapitulated in the laboratory. Register here
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Nature Outlook Prostate Cancer Most men, if they live long enough, will get prostate cancer. New biomarker approaches promise more accurate prognoses, whereas treatment advances offer hope for metastatic cancers that so far have been beyond our control. Available free online. Produced with support from Ferring Pharmaceuticals and a grant from Astellas Pharma Global Development, Inc. and Medivation, Inc.
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The Geoffrey Beene Cancer Research Center at Memorial Sloan Kettering Cancer Center, Nature, Nature Cell Biology and Nature Reviews Cancer present: CANCER AS AN EVOLVING AND SYSTEMIC DISEASE March 12-15, 2016 | New York, NY, USA REGISTER NOW!
RESEARCH HIGHLIGHTS Top Signalling: Putting the brakes on KRAS-G12C nucleotide cycling p127 | doi:10.1038/nrc.2016.13 Two new studies characterize a potent and selective inhibitor of KRAS-G12C and provide new insights into the function of this oncoprotein. PDF Immunotherapy: Two antigens are better than one p128 | doi:10.1038/nrc.2016.17 Roybal et al. have designed a system in which two tumour antigens are required to effectively induce T cell activation through chimeric antigen receptors, which in principle could improve the efficacy and safety of T cell therapies. PDF Resistance: Following different paths p128 | doi:10.1038/nrc.2016.23 Hata, Niederst et al. present data suggesting that genetic resistance to the epidermal growth factor receptor (EGFR) inhibitor gefitinib can develop either through selection of clones carrying a pre-existing resistance mutation, or through the eventual de novo development of a resistance mutation in cells that survive initial therapy. PDF IN BRIEF Pancreatic cancer: Splicing a metastatic switch | Senescence: Preventing ageing | Leukaemia: Not all stem cells are equal | Immunotherapy: Biomarkers of immunotherapy-induced colitis PDF Cancer JOBS of the week Assistant, Associate, or Full Member, Cancer Immunology Fred Hutchinson Cancer Research Center Faculty Positions in Cancer Research The Jackson Laboratory Postdoctoral Fellowship in Prostate Cancer and Cancer Metabolism Cleveland Clinic, Cleveland, OH Postdoctoral Fellow-Cancer Biology Washington University School of Medicine Experienced postdoctoral fellow in lung cancer research German Cancer Research Center (DKFZ). More Science jobs from
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REVIEWS		Top
Antitumour actions of interferons: implications for cancer therapy Belinda S. Parker, Jai Rautela & Paul J. Hertzog p131 | doi:10.1038/nrc.2016.14 Interferons (IFNs) activate and regulate antitumour immune responses. This Review discusses lessons that can be learnt from using type I IFNs in oncology and our current understanding of the interferome in modifying antitumour immune responses. Abstract | Full Text | PDF | Supplementary information
The molecular pathogenesis of chronic lymphocytic leukaemia Giulia Fabbri & Riccardo Dalla-Favera p145 | doi:10.1038/nrc.2016.8 This Review discusses the molecular biology underlying chronic lymphocytic leukaemia (CLL). Emphasizing the role of genetic lesions in CLL initiation and clinical progression, the article also considers the clinical implications of these findings. Abstract | Full Text | PDF
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PERSPECTIVES		Top
TIMELINE Leukaemia 'firsts' in cancer research and treatment Mel Greaves p163 | doi:10.1038/nrc.2016.3 One interesting theme in the history of cancer research is the extent to which new biological insights and novel clinical applications have their origins in haematopoietic cancers. This Timeline article examines the roles that studies in leukaemia have had in this progress. Abstract | Full Text | PDF
OPINION Aspirin and colorectal cancer: the promise of precision chemoprevention David A. Drew, Yin Cao & Andrew T. Chan p173 | doi:10.1038/nrc.2016.4 This Opinion article summarizes the evidence supporting the use of aspirin to prevent colorectal cancer. By considering the pathways that mediate the anticancer effects of aspirin, the authors evaluate potential biomarkers that may enable a precision medicine approach to aspirin chemoprevention. Abstract | Full Text | PDF
OPINION Optimizing mouse models for precision cancer prevention Clémentine Le Magnen, Aditya Dutta & Cory Abate-Shen p187 | doi:10.1038/nrc.2016.1 This Opinion article discusses the opportunities and challenges for 'precision mouse modelling', including the proposed essential criteria of mouse models for prevention research, representative success stories and opportunities for improved analyses in future studies of precision cancer prevention. Abstract | Full Text | PDF
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*2014 Journal Citation Report (Thomson Reuters, 2015)

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