Nature Cell Biology contents: March 2016 Volume 18 Number 3, pp 235 - 347

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TABLE OF CONTENTS March 2016 Volume 18, Issue 3 Editorial Commentary Reviews News and Views Articles Letters Resource Corrigenda Erratum Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement The Geoffrey Beene Cancer Research Center at Memorial Sloan Kettering Cancer Center, Nature, Nature Cell Biology and Nature Reviews Cancer present: CANCER AS AN EVOLVING AND SYSTEMIC DISEASE March 12-15, 2016 | New York, NY, USA REGISTER NOW!   Advertisement Key Issues in Alzheimer's Disease- a community forum  Nature Neuroscience presents a forum on Alzheimer's Disease research. ACCESS NOW to view videos of our panel event at SfN 2015, read related articles for free, and post questions for our editors and featured experts. Produced with support from  Eli Lilly and Company and vTv Therapeutics     Editorial Top Stem cells in the limelight   p235 doi:10.1038/ncb3315 Stem cell biology has emerged as one of the most exciting areas of basic and biomedical research. This month, we launch a series of specially commissioned articles that discuss recent advances and challenges in this field. Commentary Top Raising the standards of stem cell line quality   pp236 - 237 Michael P. Yaffe, Scott A. Noggle and Susan L. Solomon doi:10.1038/ncb3313 Yaffe and colleagues discuss the issues surrounding the authentication and quality of induced pluripotent stem cells. Reviews Top Stem cells versus plasticity in liver and pancreas regeneration   pp238 - 245 Janel L. Kopp, Markus Grompe and Maike Sander doi:10.1038/ncb3309 Sander and colleagues discuss recent evidence for and against the roles of stem cells versus the plasticity of mature cell types in response to injury during regeneration of the adult liver and pancreas. Organoids as an in vitro model of human development and disease   pp246 - 254 Aliya Fatehullah, Si Hui Tan and Nick Barker doi:10.1038/ncb3312 Barker and colleagues review the history and recent developments of organoid cultures derived from pluripotent stem cells and adult epithelia, and discuss how the technology can be used for basic research as well as translational applications. News and Views Top Biomechanical guidance helps elongate a lumen   pp255 - 257 Kenneth Wee and Alpha S. Yap doi:10.1038/ncb3319 Transporting epithelia commonly consist of tubes that mediate between the body and its environment. Lumen formation is closely linked to epithelial morphogenesis, but an open question is how luminal symmetry is broken to generate tubes rather than hollow cysts. A report about the biomechanics of intercellular contacts might now provide some answers. See also: Letter by Li et al. Chromosomes at loose ends   pp257 - 259 Yuko Nakajima and James E. Haber doi:10.1038/ncb3321 Broken ends of a budding yeast chromosome exhibit increased mobility, presumably to facilitate repair by recombination. A new study reports that increased mobility reflects the untethering of the broken chromosome, triggered by a DNA damage response that phosphorylates the Cep3 kinetochore protein and weakens the association between the centromere and the spindle pole body. See also: Article by Strecker et al. Cell Biology JOBS of the week Assistant / Associate / Full Professor in Cell Biology University of California - San Francisco Group leader on Integrative Biology of the Cell Institute for Integrative Biology of the Cell Senior Scientist - Cancer Cell Biology in vitro F. Hoffmann-La Roche AG More Science jobs from Cell Biology EVENT More science events from Advertisement Roles for mesenchymal stem cells as medicinal signaling cells Understanding the in vivo identity and function of mesenchymal stem cells (MSCs) is vital to fully exploit their therapeutic potential. This poster summarizes current thinking regarding the role of MSCs in vivo and also describes how to isolate MSCs and grow them in vitro. Download the poster free online. Produced with support from:  STEMCELL Technologies     Articles Top Modular activation of Rho1 by GPCR signalling imparts polarized myosin II activation during morphogenesis   pp261 - 270 Stephen Kerridge, Akankshi Munjal, Jean-Marc Philippe, Ankita Jha, Alain Garcia de las Bayonas et al. doi:10.1038/ncb3302 Lecuit and colleagues show that, depending on its interaction partner, the G-protein-coupled receptor Smog regulates myosin II activation in different locations during Drosophila morphogenesis. EXD2 promotes homologous recombination by facilitating DNA end resection   pp271 - 280 Ronan Broderick, Jadwiga Nieminuszczy, Hannah T. Baddock, Rajashree A. Deshpande, Opher Gileadi et al. doi:10.1038/ncb3303 DNA resection is the first step of double-strand break repair by homologous recombination. Broderick et al. find that EXD2 plays a key role in this process by acting as an essential cofactor for the MRN complex. DNA damage signalling targets the kinetochore to promote chromatin mobility   pp281 - 290 Jonathan Strecker, Gagan D. Gupta, Wei Zhang, Mikhail Bashkurov, Marie-Claude Landry et al. doi:10.1038/ncb3308 Durocher and colleagues find that in budding yeast, the movement of chromosomes induced by DNA breaks is due to the loss of attachment of kinetochores to spindle pole bodies and of telomeres to the nuclear periphery, and may promote checkpoint arrest. See also: News and Views by Nakajima & Haber CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3   pp291 - 302 Jinho Seo, Eun-Woo Lee, Hyerim Sung, Daehyeon Seong, Yves Dondelinger et al. doi:10.1038/ncb3314 Receptor-interacting protein kinase 3 (RIPK3) is a key regulator of necroptosis. Seo et al. show that the E3 ligase CHIP mediates ubiquitylation and lysosomal degradation of RIPK3, thus regulating both necrosome formation and necroptosis. Advertisement Two NO COST pilot projects to be awarded. Register for our webcast on Building Better Therapeutics with Metabolomics and be eligible to submit your abstract for 1 of 2 50 sample projects using metabolomics.  Register for the webcast free online.     Letters Top β-Arrestin drives MAP kinase signalling from clathrin-coated structures after GPCR dissociation   pp303 - 310 K. Eichel, D. Jullié and M. von Zastrow doi:10.1038/ncb3307 Eichel et al. show that β-arrestin-mediated MAPK activation by GPCRs involves dissociation of β-arrestin from its activating GPCR, and accumulation of β-arrestin in clathrin-coated structures, where it promotes MAPK signalling. Extracellular matrix scaffolding guides lumen elongation by inducing anisotropic intercellular mechanical tension   pp311 - 318 Qiushi Li, Yue Zhang, Perrine Pluchon, Jeffrey Robens, Keira Herr et al. doi:10.1038/ncb3310 By culturing rat hepatocyte doublets in microwells with controlled ECM environments, Viasnoff and colleagues show that the lumen between the cells extends anisotropically towards regions of lower intercellular tension. See also: News and Views by Wee & Yap Secreted IGFBP5 mediates mTORC1-dependent feedback inhibition of IGF-1 signalling   pp319 - 327 Ming Ding, Richard K. Bruick and Yonghao Yu doi:10.1038/ncb3311 By proteomics analysis of conditioned media from cells with constitutive mTORC1 activity, Yu and colleagues identify IGF binding protein 5 (IGFBP5) as a protein that is induced by mTORC1 through HIF1 and that blocks IGF-1 signalling. Dicer1–miR-328–Bace1 signalling controls brown adipose tissue differentiation and function   pp328 - 336 Matteo Oliverio, Elena Schmidt, Jan Mauer, Catherina Baitzel, Nils Hansmeier et al. doi:10.1038/ncb3316 Kornfeld and colleagues identify miRNAs that are dysregulated in brown adipose tissue in mouse models of obesity and ageing, and show that miR-328 targets Bace1 to promote brown adipogenesis. Resource Top A combined binary interaction and phenotypic map of C. elegans cell polarity proteins   pp337 - 346 Thijs Koorman, Diana Klompstra, Monique van der Voet, Irma Lemmens, João J. Ramalho et al. doi:10.1038/ncb3300 Boxem and colleagues perform a yeast two-hybrid screen to identify interactions between C. elegans polarity genes, followed by an RNAi screen to identify the functions of interaction pairs in the establishment and maintenance of cell polarity in various tissues. Corrigenda Top Corrigendum: Independent and coordinate trafficking of single Drosophila germ plasm mRNAs   p347 Shawn C. Little, Kristina S. Sinsimer, Jack J. Lee, Eric F. Wieschaus and Elizabeth R. Gavis doi:10.1038/ncb3317 Corrigendum: Systematic proteomics of the VCP–UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis   p347 Malavika Raman, Mikhail Sergeev, Maija Garnaas, John R. Lydeard, Edward L. Huttlin et al. doi:10.1038/ncb3318 Erratum Top Erratum: Actin puts the squeeze on Drosophila glue secretion   p347 Christien J. Merrifield doi:10.1038/ncb3322 Top Advertisement nature.com webcasts Join us for our upcoming webcast with live Q&A: COMBATING ANTIBIOTIC RESISTANCE Presented by BioPharma Dealmakers Date: Wednesday, March 9, 2016 Time: 8AM PST, 11AM EST, 4PM GMT, 5PM CET REGISTER FOR FREE Sponsored by: Antabio, Cempra, Helperby, Motif Bio, Polyphor     Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. 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