Nature Immunology Contents: March 2016 Volume 17 pp 215 - 343

If you are unable to see the message below, click here to view.

Advertisement Key Advances in Medicine eBook from Nature Reviews - FREE to download!  This essential resource summarizes the groundbreaking clinical and biomedical discoveries of 2015 and highlights the trends to watch out for in 2016, making it a must read eBook for anyone with an interest in medical science.  Download for free   TABLE OF CONTENTS March 2016 Volume 17, Issue 3 Correspondence Meeting Report News and Views Research Highlights Review Articles Advertisement Nature Immunology Inside View: huNOG-EXL Mouse Nature recently spoke with molecular biologist Michael P. Seiler PhD, Taconic's Associate Director of Product Management, Immune System Models and GEMS Design, about a new strain, the huNOG-EXL, its application and the promise these human immune system mice hold for scientific advancement and drug discovery.  Download Your Copy Now! Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement nature.com webcasts Join us for our upcoming webcast with live Q&A: COMBATING ANTIBIOTIC RESISTANCE Presented by BioPharma Dealmakers Date: Wednesday, March 9, 2016 Time: 8AM PST, 11AM EST, 4PM GMT, 5PM CET REGISTER FOR FREE Sponsored by: Antabio, Cempra, Helperby, Motif Bio, Polyphor     Correspondence Top Reflections on immunological nomenclature: in praise of imperfection   pp215 - 216 Alberto Mantovani doi:10.1038/ni.3354 Fatty acid oxidation in macrophage polarization   pp216 - 217 Mitsunori Nomura, Jie Liu, Ilsa I Rovira, Elsie Gonzalez-Hurtado, Jieun Lee et al. doi:10.1038/ni.3366 Meeting Report Top Contemplating autoimmunity in the Aegean islands   pp218 - 220 Lucy S K Walker, Steven Ziegler and Burkhard Becher doi:10.1038/ni.3367 News and Views Top SHARPINing the knowledge of TCR signal control   pp221 - 222 Melissa Bowman, Fan Pan and Edward W Harhaj doi:10.1038/ni.3387 SHARPIN acts independently of the ubiquitin-assembly complex LUBAC to attenuate proximal signaling downstream of TCRs by inhibiting the interaction of Zap70 with the TCRζ chain through Lys63 (K63)-linked polyubiquitination. SHARPIN deficiency enhanced TCR signaling and impaired the development and function of Treg cells. See also: Article by Park et al. The NEK-sus of the NLRP3 inflammasome   pp223 - 224 Filip Van Hauwermeiren and Mohamed Lamkanfi doi:10.1038/ni.3391 The NLRP3 inflammasome has broad biomedical relevance, but its activation mechanisms are incompletely understood. NEK7, a kinase that regulates microtubules during mitosis, is identified as a critical and selective upstream regulator of NLRP3 inflammasome activation. See also: Article by Shi et al. A PTENtial cause for the selectivity of oncolytic viruses?   pp225 - 226 Brian R Champion, Kerry Fisher and Len Seymour doi:10.1038/ni.3394 An important new function for the phosphatase PTEN in regulating interferon responses to viral infection has been delineated. This finding could help explain the remarkable cancer selectivity of many oncolytic viruses. See also: Article by Li et al. Trabid epigenetically drives expression of IL-12 and IL-23   pp227 - 228 Inna S Afonina and Rudi Beyaert doi:10.1038/ni.3388 The production of interleukin 12 (IL-12) and IL-23 in dendritic cells is strictly regulated via epigenetic silencing. This transcriptional repression is overcome with the help of the deubiquitinase Trabid and has functional implications in a mouse model of multiple sclerosis. See also: Article by Jin et al. Immunology JOBS of the week Post-Doctoral Research Scientist in Avian Immunology The Pirbright Institute Assistant, Associate, or Full Member, Cancer Immunology Fred Hutchinson Cancer Research Center Postdoctoral positions in Immunology, Cancer, and Stem Cells University of Connecticut (UConn) Postdoctoral Research Associate in Clinical Immunology Benaroya Research Institute at Virginia Mason (BRI) Lung Immunology Program Assistant / Associate Professor, Department of Pediatrics Indiana University School of Medicine More Science jobs from Research Highlights Top Plasma cell checkpoint | ILC3 aggression | Gut macrophage specialization | Neutralizing malaria | Instructing TFH cells | Deacetylation for viral sensing Review Top Inflammatory networks underlying colorectal cancer   pp230 - 240 Audrey Lasry, Adar Zinger and Yinon Ben-Neriah doi:10.1038/ni.3384 Inflammation is one of the hallmarks of cancer. Ben-Neriah and colleagues review the inflammatory networks underlying colorectal cancer. Advertisement Nature Immunology & Nature Reviews Immunology: Poster on Innate lymphoid cells This poster provides a visual summary of our current understanding of the development, classification, plasticity and functional diversity of innate lymphoid cells. Available to download free online. The Poster is freely available thanks to support from STEMCELL Technologies Inc.     Articles Top The tumor suppressor PTEN has a critical role in antiviral innate immunity   pp241 - 249 Shun Li, Mingzhu Zhu, Ruangang Pan, Ting Fang, Yuan-Yuan Cao et al. doi:10.1038/ni.3311 PTEN functions as a tumor suppressor. Guo and colleagues now find PTEN also serves a critical role in antiviral innate immunity by inducing the production of type I interferon. See also: News and Views by Champion et al. NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component   pp250 - 258 Hexin Shi, Ying Wang, Xiaohong Li, Xiaoming Zhan, Miao Tang et al. doi:10.1038/ni.3333 NEK7 is a serine-threonine kinase linked to mitosis. Beutler and colleagues show that NEK7 is required for assembly of the NLRP3 inflammasome and restricts NLRP3 activation to interphase of the cell cycle. See also: News and Views by Van Hauwermeiren & Lamkanfi Epigenetic regulation of the expression of Il12 and Il23 and autoimmune inflammation by the deubiquitinase Trabid   pp259 - 268 Jin Jin, Xiaoping Xie, Yichuan Xiao, Hongbo Hu, Qiang Zou et al. doi:10.1038/ni.3347 Sun and colleagues show that the deubiquitinase Trabid mediates the TLR-induced deubiqutination and stabilization of the histone demethylase Jmjd2d at the Il12 and Il23 promoters in dendritic cells. See also: News and Views by Afonina & Beyaert Single-cell analysis defines the divergence between the innate lymphoid cell lineage and lymphoid tissue-inducer cell lineage   pp269 - 276 Isabel E Ishizuka, Sylvestre Chea, Herman Gudjonson, Michael G Constantinides, Aaron R Dinner et al. doi:10.1038/ni.3344 The precise lineage relationship between innate lymphoid cells and lymphoid tissue-inducer cells is poorly understood. Using single-cell transcriptional analysis and cultures of fetal liver precursor cells, Bendelac and colleagues define the divergence of these cells. Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis   pp277 - 285 Jun Wei, Lingyun Long, Kai Yang, Cliff Guy, Sharad Shrestha et al. doi:10.1038/ni.3365 Regulatory T (Treg) cells have a distinct cellular metabolism compared to effector T cells. Chi and colleagues show that autophagy is required to maintain the functional integrity and metabolic homeostasis of Treg cells in the face of inflammatory environmental cues. SHARPIN controls regulatory T cells by negatively modulating the T cell antigen receptor complex   pp286 - 296 Yoon Park, Hyung-seung Jin, Justine Lopez, Jeeho Lee, Lujian Liao et al. doi:10.1038/ni.3352 SHARPIN is a component of the linear-ubiquitin-chain-assembly complex that positively regulates activation of the transcription factor NF-κB. Liu and colleagues show that SHARPIN regulates TCR signaling independently of NF-κB and that its deficiency impairs Treg cell generation. See also: News and Views by Bowman et al. Conditioning of naive CD4+ T cells for enhanced peripheral Foxp3 induction by nonspecific bystander inflammation   pp297 - 303 Lucas J Thompson, Jen-Feng Lai, Andrea C Valladao, Tennille D Thelen, Zoe L Urry et al. doi:10.1038/ni.3329 Inflammation can boost antigen-specific adaptive immune responses. Ziegler and colleagues show that type I interferon-mediated inflammation can also affect bystander naive CD4+ T cells by transiently increasing their expression of Foxp3, which might limit aggressive responses against self-antigens. CD4+ T cell anergy prevents autoimmunity and generates regulatory T cell precursors   pp304 - 314 Lokesh A Kalekar, Shirdi E Schmiel, Sarada L Nandiwada, Wing Y Lam, Laura O Barsness et al. doi:10.1038/ni.3331 T cell anergy is a well-established phenomenon, but its physiological role is unclear. Mueller and colleagues demonstrate that anergic self-reactive T cells are present at steady state and that these are predisposed to generate peripheral regulatory T cells. A septin requirement differentiates autonomous and contact-facilitated T cell proliferation   pp315 - 322 Adriana M Mujal, Julia K Gilden, Audrey Gérard, Makoto Kinoshita and Matthew F Krummel doi:10.1038/ni.3330 T cells proliferate in response to cues provided by antigen-presenting cells or high concentrations of cytokines. Krummel and colleagues reveal a distinct requirement for the cytoskeletal protein septin 7 for cytokine-driven bystander T cell proliferation. Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response   pp323 - 330 Julie Tellier, Wei Shi, Martina Minnich, Yang Liao, Simon Crawford et al. doi:10.1038/ni.3348 The transcription factor Blimp-1 is required for the differentiation of activated B cells into plasmablasts. Nutt and colleagues show that plasma cells need Blimp-1 to maintain antibody production by regulating the kinase mTOR and unfolded-protein-response pathways. Multifunctional role of the transcription factor Blimp-1 in coordinating plasma cell differentiation   pp331 - 343 Martina Minnich, Hiromi Tagoh, Peter Bönelt, Elin Axelsson, Maria Fischer et al. doi:10.1038/ni.3349 Blimp-1 is known to act as a transcriptional repressor by suppressing genes associated with mature and activated germinal center B cells. Busslinger and colleagues show that Blimp-1 can also directly activate gene expression in plasma cells, including those encoding proteins that regulate the production of membrane-bound immunoglobulin versus secreted immunoglobulin. Top Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant) For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our customer feedback department Nature Publishing Group | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2016 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.