Nature Immunology Contents: February 2016 Volume 17 pp 113 - 214

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Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement New! Nature Microbiology - First issue now published. The first issue of Nature Microbiology is now published and free to access online! This new journal covers all aspects of microorganisms, be it their evolution, physiology and cell biology; their interactions with each other, with a host or with an environment; or their societal significance. Ensure you stay up to date with future content by registering to receive the monthly e-alert.   Advertisement npj Vaccines is an online-only, open access, multidisciplinary journal dedicated to publishing cutting-edge research and development on human and veterinary vaccines. npj Vaccines is now open for submissions — explore the benefits of submitting your next manuscript to the journal.   News and Views Top Decoding the immune response to successful influenza vaccination   pp113 - 114 Brian A Kidd doi:10.1038/ni.3372 Systems immunology identifies molecular and cellular signatures associated with adverse clinical events and antibody response to a vaccine against H1N1 influenza virus. See also: Resource by Sobolev et al. Central tolerance: what you see is what you don't get!   pp115 - 116 Douglas G Millar and Pamela S Ohashi doi:10.1038/ni.3373 Thymic selection shapes the repertoire of potentially autoreactive thymocytes that are allowed to mature. The expression pattern of self antigen seen by thymocytes determines the number and functional ability of autoreactive T cells. See also: Article by Malhotra et al. Multilayered ancestry of arterial macrophages   pp117 - 118 Kay Klapproth, Felix Lasitschka and Hans-Reimer Rodewald doi:10.1038/ni.3374 Arteries are colonized by macrophages of multiple origins, derived prenatally from the yolk sac and during an early postnatal wave from the bone marrow. During sepsis, blood monocyte-derived macrophages transiently contribute to, but do not replace, resident arterial macrophages that largely self-renew in situ. See also: Article by Ensan et al. O-linked sugars sound the alarm   pp119 - 120 Smita Gopinath, Yosuke Kumamoto and Akiko Iwasaki doi:10.1038/ni.3364 Viral infection of the mucosa induces a strong host innate immune response involving type I interferons and interferon-stimulated genes. New findings show that mechanical or pathogen-induced disruption of the mucus itself can also trigger 'hyper-early' innate responses independent of type I interferons and major sensing pathways of the innate immune system. See also: Article by Iversen et al. Immunology JOBS of the week Postdoctoral Position in Transplant Immunology Lab Cleveland Clinic Postdoctoral Position in Immunology Indiana University School of Medicine Postdoctoral Positions - Human Systems Immunology, Gut Inflammation and IBD APC Microbiome Institute, University College Cork Postdoc Immunology of IBD at UCSD University of California-San Diego Faculty Positions in Immunology ~ Dana-Farber / Harvard Medical School Dana-Farber Cancer Institute / Harvard Medical School More Science jobs from Immunology EVENT Translational Immunology in Kidney Disease - ISN Nexus Symposium 2016 14th April - 17th April 2016 Berlin, Germany More science events from Research Highlights Top Drivers of metastasis | Sensing cholesterol dynamics | Coinfection enhances inflammation | CCR7 polysialylation | RANK recruiting | Evading hyaluronan danger Review Top Interleukin 33 is a guardian of barriers and a local alarmin   pp122 - 131 Nikolas T Martin and Michael U Martin doi:10.1038/ni.3370 IL-33 has well-described roles in type 2 immune responses; however, the scope of its functions are rapidly widening. Martin and Martin review the latest knowledge on IL-33 as an alarmin, intracellular molecule and cytokine. Perspective Top Amino acid auxotrophy as a system of immunological control nodes   pp132 - 139 Peter J Murray doi:10.1038/ni.3323 Murray reviews how immune cells integrate information about external essential amino acids supplies and transfer signals to growth and activation pathways that dictate cell function. Advertisement All content now free to access including archives! Nature Communications is an open access journal that publishes high-quality research from all areas of the natural sciences. Papers published by the journal represent important advances of significance to specialists within each subject area including the life sciences. Visit the website to explore ALL the content available within your field.    Articles Top Sumoylation coordinates the repression of inflammatory and anti-viral gene-expression programs during innate sensing   pp140 - 149 Adrien Decque, Olivier Joffre, Joao G Magalhaes, Jack-Christophe Cossec, Ronnie Blecher-Gonen et al. doi:10.1038/ni.3342 Sumolyation regulates wide-ranging biological processes, but its influence on innate immunity is unclear. Amigorena and colleagues show that sumoylation negatively regulates interferon-[beta] expression and anti-viral immunity. An innate antiviral pathway acting before interferons at epithelial surfaces   pp150 - 158 Marie B Iversen, Line S Reinert, Martin K Thomsen, Ieva Bagdonaite, Ramya Nandakumar et al. doi:10.1038/ni.3319 Mucosal surfaces often represent the first point of entry for pathogens. Paludan and colleagues demonstrate that disruption of the mucus itself can initiate a hyperacute innate immune response that precedes even the production of type I interferons. See also: News and Views by Gopinath et al. Self-renewing resident arterial macrophages arise from embryonic CX3CR1+ precursors and circulating monocytes immediately after birth   pp159 - 168 Sherine Ensan, Angela Li, Rickvinder Besla, Norbert Degousee, Jake Cosme et al. doi:10.1038/ni.3343 Macrophages densely populate the arterial wall, yet their origin and homeostasis are poorly understood. Robbins and colleagues show that arterial macrophages arise from CX3CR1+ embryonic precursors and adult bone marrow-derived monocytes that colonize the tissue immediately after birth. See also: News and Views by Klapproth et al. Group 3 innate lymphoid cells continuously require the transcription factor GATA-3 after commitment   pp169 - 178 Chao Zhong, Kairong Cui, Christoph Wilhelm, Gangqing Hu, Kairui Mao et al. doi:10.1038/ni.3318 Group 3 innate lymphoid cells have low expression of the transcription factor GATA-3. Zhu and colleagues show that despite its low expression, GATA-3 is essential for the homeostasis, further maturation and effector function of lineage-committed group 3 innate lymphoid cells. Complementarity and redundancy of IL-22-producing innate lymphoid cells   pp179 - 186 Lucille C Rankin, Mathilde J H Girard-Madoux, Cyril Seillet, Lisa A Mielke, Yann Kerdiles et al. doi:10.1038/ni.3332 The function of group 3 innate lymphoid cells (ILC3 cells) is still being determined. Vivier and colleagues describe the development of ILC3 subsets and show that NCR+ ILC3 cells are not needed to control infection with Citrobacter rodentium in the presence of an intact T cell compartment. Tolerance is established in polyclonal CD4+ T cells by distinct mechanisms, according to self-peptide expression patterns   pp187 - 195 Deepali Malhotra, Jonathan L Linehan, Thamotharampillai Dileepan, You Jeong Lee, Whitney E Purtha et al. doi:10.1038/ni.3327 CD4+ T cell tolerance can be enforced by various mechanisms. Jenkins and colleagues use mice with entirely intact polyclonal T cell repertoires to comprehensively define the mechanisms of self-tolerance. See also: News and Views by Millar & Ohashi Self-reactive IgE exacerbates interferon responses associated with autoimmunity   pp196 - 203 Jill Henault, Jeffrey M Riggs, Jodi L Karnell, Vladimir M Liarski, Jianqing Li et al. doi:10.1038/ni.3326 A hallmark of systemic lupus erythematosus is the production of type I interferons in response to immunocomplexes containing self DNA from dead cells and DNA-specific IgG. Sanjuan and colleagues find that IgE specific for self DNA also exacerbates this disease. Resource Top Adjuvanted influenza-H1N1 vaccination reveals lymphoid signatures of age-dependent early responses and of clinical adverse events   pp204 - 213 Olga Sobolev, Elisa Binda, Sean O'Farrell, Anna Lorenc, Joel Pradines et al. doi:10.1038/ni.3328 Vaccination offers protection against infectious diseases, yet pre-existing criteria that predict vaccine efficacy or adverse events remain unknown. Hayday and colleagues identify cellular and molecular signatures in humans immunized with adjuvanted swine flu vaccine. See also: News and Views by Kidd Corrigenda Top Corrigendum: The burgeoning family of unconventional T cells   p214 Dale I Godfrey, Adam P Uldrich, James McCluskey, Jamie Rossjohn and D Branch Moody doi:10.1038/ni0216-214a Corrigendum: Eosinophils orchestrate cancer rejection by normalizing tumor vessels and enhancing infiltration of CD8+ T cells   p214 Rafael Carretero, Ibrahim M Sektioglu, Natalio Garbi, Oscar C Salgado, Philipp Beckhove et al. doi:10.1038/ni0216-214b Erratum Top Erratum: Group 3 innate lymphoid cells continuously require the transcription factor GATA-3 after commitment   p214 Chao Zhong, Kairong Cui, Christoph Wilhelm, Gangqing Hu, Kairui Mao et al. doi:10.1038/ni0216-214c Top Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. 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