Nature Reviews Genetics Contents January 2016 Volume 17 Number 1 pp 1-62

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TABLE OF CONTENTS
January 2016 Volume 17 Number 1
Impact Factor 36.978 *	In this issue Comment Research Highlights Reviews Also this month Article series: Applications of next-generation sequencing Disease mechanisms Non-coding RNA  Featured article: Unique features of long non-coding RNA biogenesis and function Jeffrey J. Quinn & Howard Y. Chang
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Comment: Principle of proportionality in genomic data sharing Caroline F. Wright, Matthew E. Hurles & Helen V. Firth p1 | doi:10.1038/nrg.2015.5 Caroline Wright, Matthew Hurles and Helen Firth propose that a principle of proportionality be applied to genomic data that weighs the depth of data (what is shared) against the breadth of sharing (with whom) to find a proportionate approach that balances beneficence and non-maleficence. Abstract | Full Text | PDF
RESEARCH HIGHLIGHTS Top Chromatin: Moving a TAD closer to unravelling chromosome architecture p3 | doi:10.1038/nrg.2015.7 PDF Disease genetics: SNP location helps predict disease aetiology p4 | doi:10.1038/nrg.2015.12 PDF Complex traits: A diamond in the ruff p4 | doi:10.1038/nrg.2015.15 PDF Gene regulation: Landscape and mechanisms of transcription factor cooperativity p5 | doi:10.1038/nrg.2015.11 PDF Molecular evolution: Regulatory runaways p6 | doi:10.1038/nrg.2015.14 PDF Techniques: Exploring protein-RNA interactions with RNA Tagging p6 | doi:10.1038/nrg.2015.6 PDF Molecular genetics: Through the cracked lens of cancer genomes p7 | doi:10.1038/nrg.2015.13 PDF IN BRIEF Epigenomics: Sperm as obesity propagator? | Technique: Mapping open chromatin in single cells | Genetic screens: CRISPR knockout screens for human fitness genes PDF Genetics JOBS of the week Assistant / Associate / Co- Director of the Cytogenetics Laboratory Indiana University - Purdue University Indianapolis PhD position: Decoding gene regulation in cancer KU Leuven, The Center for Human Genetics PhD projects in Organismal Biology IMPRS for Organismal Biology Genomics and Bioinformatics Cluster University of Central Florida Tenure-track position in Plant Genomics University of Alberta More Science jobs from Genetics EVENT More science events from
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Nature Reviews Molecular Cell Biology FREE POSTER - Stem cell states: naive to primed pluripotency This Poster provides an overview of the signalling pathways currently known to promote or suppress the naive and primed pluripotency states in mice, and highlights potential differences between mice and humans. It also provides an overview of culture conditions that confer naive and/or primed features to cells. Produced with support from STEMCELL Technologies
REVIEWS		Top
Article series: Applications of next-generation sequencing Genetic studies in intellectual disability and related disorders Lisenka E. L. M. Vissers, Christian Gilissen & Joris A. Veltman p9 | doi:10.1038/nrg3999 The phenotypic heterogeneity of intellectual disability (ID) disorders has hampered studies of the underlying genetics, but major progress has been achieved by recent applications of next-generation sequencing. This Review discusses our latest understanding of ID genetics, including the identification of de novo and inherited mutations of various types, strategies for assigning disease causality to the mutations, emerging pathological mechanisms and future research directions. Abstract | Full Text | PDF | Supplementary information
Article series: Disease mechanisms RNA mis-splicing in disease Marina M. Scotti & Maurice S. Swanson p19 | doi:10.1038/nrg.2015.3 Complex and intricate RNA splicing mechanisms are crucial for gene regulation and for maximizing proteomic diversity. This Review discusses how alterations to splicing mechanisms — such as mutations in pre-mRNAs, or mutations and dysregulation of core spliceosome proteins and other RNA-binding proteins — results in diverse molecular consequences and various diseases. Opportunities for therapeutic correction of these defects are also explored. Abstract | Full Text | PDF
Evolution of vertebrate sex chromosomes and dosage compensation Jennifer A. Marshall Graves p33 | doi:10.1038/nrg.2015.2 The differentiation of sex chromosomes in vertebrates created a need for mechanisms that compensate for differences in dosage of gene expression between the sexes. The author reviews the diversity of these mechanisms, their effects on gene expression, and their origin and evolution across the major vertebrate groups. Abstract | Full Text | PDF
Article series: Non-coding RNA Unique features of long non-coding RNA biogenesis and function Jeffrey J. Quinn & Howard Y. Chang p47 | doi:10.1038/nrg.2015.10 Long non-coding RNAs (lncRNAs) are a class of RNAs with great molecular and regulatory diversity. This Review discusses how, beyond their lack of protein-coding potential, some types of lncRNAs are known to exhibit features that are distinct from mRNAs, including their transcriptional regulation, localization, processing, biological capabilities and degradation. Such properties underlie many of the key cellular functions of lncRNAs. Abstract | Full Text | PDF
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