Nature Reviews Immunology Contents December 2015 Volume 15 Number 12 pp 725-783

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TABLE OF CONTENTS
December 2015 Volume 15 Number 12
Impact Factor 34.985 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: Regulation of macrophage development and function in peripheral tissues Yonit Lavin, Arthur Mortha, Adeeb Rahman & Miriam Merad
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RESEARCH HIGHLIGHTS Top Cell death: Pathways for cross-priming p725 | doi:10.1038/nri3933 RIPK1 and NF-κB signalling in dying cells are necessary for CD8+ T cell cross-priming. PDF T cell responses: A long-chain reaction p726 | doi:10.1038/nri3934 Dietary long-chain fatty acids enhance the differentiation of TH1 and TH17 cells in the gut, which worsens disease in a mouse model of multiple sclerosis. PDF Immunotherapy: Remote control CARs p726 | doi:10.1038/nri3938 Researchers design switchable therapeutic T cells that can be remotely activated by a small-molecule drug. PDF B cells: Resetting the scene p727 | doi:10.1038/nri3937 B cells expressing GM-CSF activate myeloid cells to drive T cell-mediated multiple sclerosis. PDF Mucosal immunology: A smoke-induced microRNA fires up DCs p728 | doi:10.1038/nri3935 Smoking promotes pathogenic TH17 cell responses by inducing the expression of miR-22 in myeloid cells. PDF T cells: CiShh... p728 | doi:10.1038/nri3943 SOCS family member CISH hushes T cell receptor signalling and limits tumour killing. PDF Reproductive immunology: Evading immunosurveillance in endometriosis p729 | doi:10.1038/nri3942 Oestrogen receptor-β promotes immune evasion of endometriotic tissue by blocking TNF-induced apoptosis and enhancing inflammasome activity. PDF JOURNAL CLUB Tracking the T cell repertoire p730 | doi:10.1038/nri3922 Ron Germain describes two seminal papers by Marc Jenkins and colleagues that introduced new techniques for analysis of the T cell repertoire. PDF Tumour immunology: Reducing silence to improve therapy p730 | doi:10.1038/nri3941 Inhibition of epigenetic modifiers in ovarian cancer cells blocks cancer progression and improves immunotherapy. PDF Immunology JOBS of the week Assistant Research Professor (non-tenure track)- Microbiology & Immunology Indiana University School of Medicine Associate Professor / Full Professor University of Virginia Research Assistant / Associate in Structural Biology (Fixed Term) University of Cambridge Professor of Human Physiology Humanitas University Open Access Advocate Institute of Cancer Research (ICR) More Science jobs from Immunology EVENT Mucosal Immunology Course and Symposium (MICS) 27.07.15 Toronto, Canada More science events from
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Nature Medicine FOCUS ON INFLAMMATORY DISEASE This series of Reviews highlights new data that point toward the influence of environmental factors and addresses recent advances in our knowledge of the cell types and signaling pathways involved in inflammatory disease onset and progression. Produced with support from  Janssen Pharmaceutical Companies of Johnson & Johnson
REVIEWS		Top
Regulation of macrophage development and function in peripheral tissues Yonit Lavin, Arthur Mortha, Adeeb Rahman & Miriam Merad p731 | doi:10.1038/nri3920 Macrophages populate the body's tissues and organs, where they become highly specialized to preserve organ integrity in the event of microbial invasion or injury. A dynamic crosstalk between the macrophages and their surrounding tissue cells is crucial to ensuring this homeostatic function. This Review highlights the key molecules and mechanisms involved in macrophage-tissue interactions. Abstract | Full Text | PDF
New insights into the immunopathology and control of dengue virus infection Gavin Screaton, Juthathip Mongkolsapaya, Sophie Yacoub & Catherine Roberts p745 | doi:10.1038/nri3916 This Review describes the role of the immune system in dengue pathogenesis. The authors also discuss new insights gained from human monoclonal antibodies against dengue virus as well as the recent vaccine trials and the challenges to develop an effective dengue vaccine. Abstract | Full Text | PDF
STING: infection, inflammation and cancer Glen N. Barber p760 | doi:10.1038/nri3921 Activation of STING (stimulator of interferon genes) by cytosolic aberrant DNA species or cyclic dinucleotides triggers transcription of numerous innate immune genes. In this Review, the author summarizes recent insights into the regulation of STING signalling and its role in autoinflammatory disease and cancer. Abstract | Full Text | PDF
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PERSPECTIVES		Top
OPINION IL-15 functions as a danger signal to regulate tissue-resident T cells and tissue destruction Bana Jabri & Valérie Abadie p771 | doi:10.1038/nri3919 This Opinion article proposes that interleukin-15 (IL-15) is a master regulator of tissue-specific T cell responses to promote the destruction of infected cells. Hence, dysregulation of IL-15 production in tissues during sterile inflammation can lead to T cell-mediated autoimmunity. Abstract | Full Text | PDF
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*2014 Journal Citation Report (Thomson Reuters, 2015)

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