Nature Communications - 4 November 2015

Weekly Content Alert Nature Communications is now fully open access. Read more. 04 November 2015  Featured image: St Clair et al. show that food availability alters the social network dynamics and potential for information flow among tool-using New Caledonian crows. Latest content: Articles Corrigenda Erratum Journal homepage Recommend to library Web feed   Advertisement An online-only, open access, multidisciplinary journal dedicated to publishing high-quality original research articles, reviews, editorials, commentaries, and hypothesis generating observations on all areas of breast cancer research. Part of the Nature Partner Journals series, published in partnership with the Breast Cancer Research Foundation. Now open for submissions: http://bit.ly/1xXPzzM       Nature Communications - now fully open access All new submissions, if accepted, will be published open access and an article processing charge (APC) will apply. For more information visit the website. Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding.       Latest Articles View all Articles     Suction-based propulsion as a basis for efficient animal swimming OPEN Brad J. Gemmell, Sean P. Colin, John H. Costello and John O. Dabiri Swimming animals are generally assumed to generate forward thrust by pushing surrounding water rearwards. Here, Gemmell et al. show that efficient swimming in lampreys and jellyfish is achieved primarily through suction, as vortex-associated low pressure regions are synchronized by undulations of the body. 03 November 2015 | doi: 10.1038/ncomms9790 Biological Sciences  Fluids and plasma physics  Zoology  Diamond formation due to a pH drop during fluid–rock interactions OPEN Dimitri A. Sverjensky and Fang Huang The cause of diamond precipitation has previously been attributed to poorly understood redox changes at depth. Here, the authors propose that a drop in pH during water–rock interactions leads to diamond formation as a consequence of the migration of reactive fluids at elevated temperatures and pressures. 03 November 2015 | doi: 10.1038/ncomms9702 Earth Sciences  Geology and geophysics  Experimental resource pulses influence social-network dynamics and the potential for information flow in tool-using crows OPEN James J. H. St Clair, Zackory T. Burns, Elaine M. Bettaney, Michael B. Morrissey, Brian Otis, Thomas B. Ryder, Robert C. Fleischer, Richard James and Christian Rutz Social-network dynamics can influence biological processes such as information flow, but are difficult to measure in the wild. Here, St Clair et al. track networks of New Caledonian crows to show how the potential for information flow can be influenced by changes in resource distribution. 03 November 2015 | doi: 10.1038/ncomms8197 Biological Sciences  Ecology  Zoology  The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling OPEN Theo Klein, Shan-Yu Fung, Florian Renner, Michael A. Blank, Antoine Dufour, Sohyeong Kang, Madison Bolger-Munro, Joshua M. Scurll, John J. Priatel, Patrick Schweigler, Samu Melkko, Michael R. Gold, Rosa I. Viner, Catherine H. Régnier, Stuart E. Turvey and Christopher M. Overall MALT1 mediates NFκB activation. Here the authors perform proteomic analysis of human immunodeficient mutant MALT1 B cells revealing that MALT1 cleaves the HOIL1 subunit of the linear ubiquitin chain assembly complex to dampen late NFκB activation and to invoke negative feedback of NFκB activation. 03 November 2015 | doi: 10.1038/ncomms9777 Biological Sciences  Biochemistry  Immunology  Basal forebrain control of wakefulness and cortical rhythms OPEN Christelle Anaclet, Nigel P. Pedersen, Loris L. Ferrari, Anne Venner, Caroline E. Bass, Elda Arrigoni and Patrick M. Fuller The mammalian basal forebrain controls cortical rhythm and wake-sleep. Anaclet et al. use genetically-targeted chemogenetic systems to activate or inhibit cholinergic, glutamatergic or GABAergic neurons in this region, and reveal their contributions to behavioral and electrocortical arousal in behaving mice. 03 November 2015 | doi: 10.1038/ncomms9744 Biological Sciences  Neuroscience  Onset of two-dimensional superconductivity in space charge doped few-layer molybdenum disulfide OPEN Johan Biscaras, Zhesheng Chen, Andrea Paradisi and Abhay Shukla Inducing phase transitions in atomically thin films of layered materials requires efficient electrostatic doping techniques to reach high carrier densities. Here, the authors present a doping technique which induces superconductivity by reaching high n-doping density in few-layered MoS2 on glass substrates. 03 November 2015 | doi: 10.1038/ncomms9826 Physical Sciences  Applied physics  Condensed matter  Materials science  Perfluorocarbon nanoparticles enhance reactive oxygen levels and tumour growth inhibition in photodynamic therapy OPEN Yuhao Cheng, Hao Cheng, Chenxiao Jiang, Xuefeng Qiu, Kaikai Wang, Wei Huan, Ahu Yuan, Jinhui Wu and Yiqiao Hu Photodynamic therapy is used in cancer treatment and generates reactive oxygen species to kill tumour cells but is limited by the availability of oxygen. Here, the authors modify a photodynamic sensitiser so that it produces excess oxygen species and show enhanced tumour cell killing in vitro and in vivo. 03 November 2015 | doi: 10.1038/ncomms9785 Biological Sciences  Cancer  Medical research  Medicinal chemistry  Mechanical instability of monocrystalline and polycrystalline methane hydrates OPEN Jianyang Wu, Fulong Ning, Thuat T. Trinh, Signe Kjelstrup, Thijs J. H. Vlugt, Jianying He, Bjørn H. Skallerud and Zhiliang Zhang Sediment-hosted gas hydrates may release vast quantities of methane upon failure, but destabilizing mechanisms at the molecular level are poorly understood. Here, the authors study the deformation using simulations and find that failure differs between single crystals and polycrystalline hydrates. 02 November 2015 | doi: 10.1038/ncomms9743 Earth Sciences  Geology and geophysics  Materials science  Visualizing the morphology of vortex lattice domains in a bulk type-II superconductor OPEN T. Reimann, S. Mühlbauer, M. Schulz, B. Betz, A. Kaestner, V. Pipich, P. Böni and C. Grünzweig The phase diagram of type-II superconductors exhibits a multitude of different phases, whose study can shed light on domain nucleation and morphology. Here the authors use neutron grating interferometry to investigate the nucleation and phase changes of an intermediate mixed state in a niobium superconductor. 02 November 2015 | doi: 10.1038/ncomms9813 Physical Sciences  Condensed matter  Transmembrane protein sorting driven by membrane curvature OPEN H. Strahl, S. Ronneau, B. Solana González, D. Klutsch, C. Schaffner-Barbero and L. W. Hamoen The accumulation of chemoreceptor proteins at bacterial poles is thought to depend on their clustering into arrays. Strahl et al. show that in Bacillus subtilis, the chemoreceptor TlpA uses high membrane curvature as a spatial cue for polar localization, through the intrinsic curvature sensitivity of the receptor complex. 02 November 2015 | doi: 10.1038/ncomms9728 Biological Sciences  Biophysics  Cell biology  Microbiology  Engineering intracellular biomineralization and biosensing by a magnetic protein OPEN Yuri Matsumoto, Ritchie Chen, Polina Anikeeva and Alan Jasanoff Magnetic manipulation of biological systems requires the development of improved molecular handles. Here the authors isolate ferritin mutants with enhanced biomineralization from a yeast genetic screen and show their application to cell separation, multiscale imaging, and construction of sensors. 02 November 2015 | doi: 10.1038/ncomms9721 Biological Sciences  Biochemistry  Bioengineering  DNA damage-induced metaphase I arrest is mediated by the spindle assembly checkpoint and maternal age OPEN Petros Marangos, Michelle Stevense, Konstantina Niaka, Michaela Lagoudaki, Ibtissem Nabti, Rolf Jessberger and John Carroll DNA damage in mammalian oocytes can lead to infertility and developmental disorders. Here Marangos et al. show that the spindle assembly checkpoint responds to DNA damage by arresting oocytes in metaphase I, and this checkpoint becomes compromised as mice age. 02 November 2015 | doi: 10.1038/ncomms9706 Biological Sciences  Cell biology  Two-dimensional single-cell patterning with one cell per well driven by surface acoustic waves OPEN David J. Collins, Belinda Morahan, Jose Garcia-Bustos, Christian Doerig, Magdalena Plebanski and Adrian Neild Single cell trapping is very useful in biomedical applications, but to date this can only be done via mechanical traps. Here, Collins et al. use a two-dimensional acoustic field with wavelength comparable to cell size to pattern one cell per well in a microfluidic grid. 02 November 2015 | doi: 10.1038/ncomms9686 Physical Sciences  Applied physics  Biotechnology  Fluids and plasma physics  Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization OPEN Tamanna Haq, Mark W. Richards, Selena G. Burgess, Pablo Gallego, Sharon Yeoh, Laura O’Regan, David Reverter, Joan Roig, Andrew M. Fry and Richard Bayliss NEK7, a kinase involved in mitosis, is regulated by the kinase NEK9. Here the authors identify the region in NEK9 that binds NEK7 and find that the mechanism of regulation involves dimerization coupled to structural changes in the active site. 02 November 2015 | doi: 10.1038/ncomms9771 Biological Sciences  Biochemistry  Biophysics  Compound heterozygous mutations in the noncoding RNU4ATAC cause Roifman Syndrome by disrupting minor intron splicing OPEN Daniele Merico, Maian Roifman, Ulrich Braunschweig, Ryan K. C. Yuen, Roumiana Alexandrova, Andrea Bates, Brenda Reid, Thomas Nalpathamkalam, Zhuozhi Wang, Bhooma Thiruvahindrapuram, Paul Gray, Alyson Kakakios, Jane Peake, Stephanie Hogarth, David Manson, Raymond Buncic, Sergio L. Pereira, Jo-Anne Herbrick, Benjamin J. Blencowe, Chaim M. Roifman et al. Roifman Syndrome is a rare disorder whose disease manifestations include growth retardation, spondyloepiphyseal dysplasia and immunodeficiency. Here, the authors use whole-genome sequencing to discover that rare compound heterozygous variants disrupting the small nuclear RNA gene RNU4ATAC cause Roifman Syndrome. 02 November 2015 | doi: 10.1038/ncomms9718 Biological Sciences  Genetics  Molecular biology  BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages OPEN Alessandra Rosati, Anna Basile, Raffaella D’Auria, Morena d’Avenia, Margot De Marco, Antonia Falco, Michelina Festa, Luana Guerriero, Vittoria Iorio, Roberto Parente, Maria Pascale, Liberato Marzullo, Renato Franco, Claudio Arra, Antonio Barbieri, Domenica Rea, Giulio Menichini, Michael Hahne, Maarten Bijlsma, Daniela Barcaroli et al. BAG3 is found in the serum of pancreatic cancer patients and can be used as a marker of disease, but its role in cancer is unclear. Here, the authors show that BAG3 secreted from tumour cells binds to and activates macrophages, which in turn promotes cell growth, and an antibody blocking BAG3 binding reduces tumour formation in mice. 02 November 2015 | doi: 10.1038/ncomms9695 Biological Sciences  Cancer  Immunology  Medical research  High-throughput 3D tracking of bacteria on a standard phase contrast microscope OPEN K.M. Taute, S. Gude, S.J. Tans and T.S. Shimizu Microscopy techniques used to study the movement of swimming microbes are limited to two dimensions or require sophisticated devices. Here, Taute et al. present a simple method for high-throughput 3D tracking of bacteria using standard phase contrast microscopy. 02 November 2015 | doi: 10.1038/ncomms9776 Biological Sciences  Biophysics  Cell biology  Microbiology  DNA damage induces a meiotic arrest in mouse oocytes mediated by the spindle assembly checkpoint OPEN Josie K. Collins, Simon I. R. Lane, Julie A. Merriman and Keith T. Jones Damage to maternal DNA during meosis can lead to birth defects, abortion or infertility. Here, the authors show that the spindle assembly checkpoint can respond to DNA damage in oocytes by blocking anaphase promoting complex activity and arresting oocytes in meiosis I. 02 November 2015 | doi: 10.1038/ncomms9553 Biological Sciences  Cell biology  Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism OPEN Charlotte Lussey-Lepoutre, Kate E. R. Hollinshead, Christian Ludwig, Mélanie Menara, Aurélie Morin, Luis-Jaime Castro-Vega, Seth J. Parker, Maxime Janin, Cosimo Martinelli, Chris Ottolenghi, Christian Metallo, Anne-Paule Gimenez-Roqueplo, Judith Favier and Daniel A. Tennant Evidence suggests that the TCA cycle enzyme complex succinate dehydrogenase (SDH) may be dispensable for cell proliferation in some cancer cells. Here the authors show that SDH deficient cells become dependent on the mitochondrial enzyme pyruvate carboxylase for aspartate production and proliferation. 02 November 2015 | doi: 10.1038/ncomms9784 Biological Sciences  Biochemistry  Cell biology  The evolutionary landscape of intergenic trans-splicing events in insects OPEN Yimeng Kong, Hongxia Zhou, Yao Yu, Longxian Chen, Pei Hao and Xuan Li In intergenic trans-splicing, exons from two independent primary transcripts are joined. Here, the authors show that evolutionarily trans-splicing activity in insects is tightly controlled, with mod(mdg4) being a unique case of functional diversification involving trans-splicing. 02 November 2015 | doi: 10.1038/ncomms9734 Biological Sciences  Evolution  Genetics  Microscale insights into pneumococcal antibiotic mutant selection windows Robin A. Sorg and Jan-Willem Veening The emergence of antibiotic resistance in bacteria is driven by inhibitory but non-lethal antibiotic concentrations. Here, Sorg and Veening study the effects of different antibiotics on the pneumococcus, with a focus on inhibition dynamics, metabolic activity and processes at the single-cell level. 30 October 2015 | doi: 10.1038/ncomms9773 Biological Sciences  Evolution  Microbiology  Optical meta-atom for localization of light with quantized energy OPEN Sylvain Lannebère and Mário G. Silveirinha Plasmonics enables the medication of light on length-scales smaller than the wavelength of the light. Here, the authors present a theoretical investigation of optical meta-atoms based on core-shell plasmonic nanostructures, where light is confined into a small region of space. 30 October 2015 | doi: 10.1038/ncomms9766 Physical Sciences  Nanotechnology  Optical physics  Implementation of continuous-variable quantum key distribution with composable and one-sided-device-independent security against coherent attacks OPEN Tobias Gehring, Vitus Händchen, Jörg Duhme, Fabian Furrer, Torsten Franz, Christoph Pacher, Reinhard F. Werner and Roman Schnabel When quantum key distribution is composed with other secure protocols the overall security has to be guaranteed, which adds further security requirements. Here, the authors demonstrate continuous-variable quantum key distribution with composable security and one-sided-device independence. 30 October 2015 | doi: 10.1038/ncomms9795 Physical Sciences  Applied physics  Optical physics  Theoretical physics  Ultra-high modulation depth exceeding 2,400% in optically controlled topological surface plasmons OPEN Sangwan Sim, Houk Jang, Nikesh Koirala, Matthew Brahlek, Jisoo Moon, Ji Ho Sung, Jun Park, Soonyoung Cha, Seongshik Oh, Moon-Ho Jo, Jong-Hyun Ahn and Hyunyong Choi For optical control of plasmons metals require a large amount of power in the control pulse, yielding a small modulation depth. Here, Sim et al. fabricate arrays of Bi2Se3 and report a modulation depth of 2,400% at 1.5 THz with an optical fluence of 45 μJ/cm2, demonstrating a novel route for controlling plasmons. 30 October 2015 | doi: 10.1038/ncomms9814 Physical Sciences  Materials science  Nanotechnology  Optical physics  Measurement of geometric dephasing using a superconducting qubit OPEN S. Berger, M. Pechal, P. Kurpiers, A. A. Abdumalikov, C. Eichler, J. A. Mlynek, A. Shnirman, Yuval Gefen, A. Wallraff and S. Filipp Open quantum systems are subject to dephasing that ultimately destroys the information they hold. Here, the authors use a superconducting qubit to show that dephasing also has a geometric origin, which can either reduce or restore coherence depending on the path of the quantum system in its Hilbert space. 30 October 2015 | doi: 10.1038/ncomms9757 Physical Sciences  Applied physics  Theoretical physics  Allelic variation contributes to bacterial host specificity OPEN Min Yue, Xiangan Han, Leon De Masi, Chunhong Zhu, Xun Ma, Junjie Zhang, Renwei Wu, Robert Schmieder, Radhey S. Kaushik, George P. Fraser, Shaohua Zhao, Patrick F. McDermott, François-Xavier Weill, Jacques G. Mainil, Cesar Arze, W. Florian Fricke, Robert A. Edwards, Dustin Brisson, Nancy R. Zhang, Shelley C. Rankin et al. One of the key aspects for controlling infectious diseases is understanding how pathogens cross host species. Here the authors conduct a genome-wide analysis of Salmonella and show a high degree of variation, enabling host-adapted colonization among Salmonella intestinal and systemic serovars. 30 October 2015 | doi: 10.1038/ncomms9754 Biological Sciences  Genetics  Microbiology  Experimental quantum fingerprinting with weak coherent pulses OPEN Feihu Xu, Juan Miguel Arrazola, Kejin Wei, Wenyuan Wang, Pablo Palacios-Avila, Chen Feng, Shihan Sajeed, Norbert Lütkenhaus and Hoi-Kwong Lo Quantum communication allows exponential reductions in the information that must be transmitted to solve distributed computational tasks. Here, the authors demonstrate with weak coherent optical pulses a quantum fingerprinting system that transmits less information that the best known classical protocol. 30 October 2015 | doi: 10.1038/ncomms9735 Physical Sciences  Optical physics  Theoretical physics  Gut mucosal microbiome across stages of colorectal carcinogenesis OPEN Geicho Nakatsu, Xiangchun Li, Haokui Zhou, Jianqiu Sheng, Sunny Hei Wong, William Ka Kai Wu, Siew Chien Ng, Ho Tsoi, Yujuan Dong, Ning Zhang, Yuqi He, Qian Kang, Lei Cao, Kunning Wang, Jingwan Zhang, Qiaoyi Liang, Jun Yu and Joseph J. Y. Sung Changes in gut microbial communities contribute to the development of colorectal cancer. Here, the authors analyse the gut mucosal microbiome of patients and healthy subjects and identify distinct microbial consortia associated with different stages of colorectal cancer tumorigenesis. 30 October 2015 | doi: 10.1038/ncomms9727 Biological Sciences  Cancer  Medical research  Microbiology  Genetic pathways for differentiation of the peripheral nervous system in ascidians OPEN Kana Waki, Kaoru S. Imai and Yutaka Satou The evolutionary origin of the peripheral nervous systems (PNSs) is poorly understood. Here, the authors show that two mechanisms activate gene circuits in ascidians to differentiate epidermal sensory neurons, which suggests that vertebrate PNSs arose via cooption of the ancient PNS gene circuit. 30 October 2015 | doi: 10.1038/ncomms9719 Biological Sciences  Developmental biology  Evolution  A CpG-methylation-based assay to predict survival in clear cell renal cell carcinoma OPEN Jin-Huan Wei, Ahmed Haddad, Kai-Jie Wu, Hong-Wei Zhao, Payal Kapur, Zhi-Ling Zhang, Liang-Yun Zhao, Zhen-Hua Chen, Yun-Yun Zhou, Jian-Cheng Zhou, Bin Wang, Yan-Hong Yu, Mu-Yan Cai, Dan Xie, Bing Liao, Cai-Xia Li, Pei-Xing Li, Zong-Ren Wang, Fang-Jian Zhou, Lei Shi et al. Using molecular markers is a useful way to predict the prognosis of cancer patients. Here, Wei et al. describe a five gene methylation signature that can predict the prognosis of renal clear cell cancer and validate its use in multiple patient cohorts. 30 October 2015 | doi: 10.1038/ncomms9699 Biological Sciences  Bioinformatics  Cancer  Medical research  Resident c-kit+ cells in the heart are not cardiac stem cells OPEN Nishat Sultana, Lu Zhang, Jianyun Yan, Jiqiu Chen, Weibin Cai, Shegufta Razzaque, Dongtak Jeong, Wei Sheng, Lei Bu, Mingjiang Xu, Guo-Ying Huang, Roger J. Hajjar, Bin Zhou, Anne Moon and Chen-Leng Cai The issue whether the cell surface protein c-kit identifies resident cardiac stem cells (CSC) is controversial. By using novel reporter mouse models, Sultana et al. show that c-kit+ cells represent a subpopulation of endothelial cells in the developing and adult heart and do not exhibit CSC traits in health or disease. 30 October 2015 | doi: 10.1038/ncomms9701 Biological Sciences  Developmental biology  Medical research  A mutational signature in gastric cancer suggests therapeutic strategies OPEN Ludmil B. Alexandrov, Serena Nik-Zainal, Hoi Cheong Siu, Suet Yi Leung and Michael R Stratton Cancer genome analysis has demonstrated that some breast and ovarian tumours show reduced homologous recombination, a feature that can be therapeutically exploited. Here, Alexandrov et al. search for this mutational signature in 36 different cancer types and find that some gastric tumours also harbour this mutational spectrum. 29 October 2015 | doi: 10.1038/ncomms9683 Biological Sciences  Cancer  Genetics  Medical research  Opposite correlations between cation disordering and amorphization resistance in spinels versus pyrochlores OPEN Blas Pedro Uberuaga, Ming Tang, Chao Jiang, James A. Valdez, Roger Smith, Yongqiang Wang and Kurt E. Sickafus Radiation can cause the amorphization of crystalline materials, which needs to be understood if they are to be used in nuclear reactors. Here, the authors show a direct correlation between amorphization resistance and disordering energetics in spinel crystals, the opposite of that observed in pyrochlores. 29 October 2015 | doi: 10.1038/ncomms9750 Physical Sciences  Condensed matter  Materials science  Unravelling structural ambiguities in lithium- and manganese-rich transition metal oxides OPEN Alpesh Khushalchand Shukla, Quentin M. Ramasse, Colin Ophus, Hugues Duncan, Fredrik Hage and Guoying Chen Lithium and manganese-rich transition metal oxides are a class of promising battery electrodes but their structures are a subject of a controversial debate. Here, the authors use a variety of materials characterization tools to unravel the structural ambiguities in these materials. 29 October 2015 | doi: 10.1038/ncomms9711 Chemical Sciences  Applied physics  Materials science  General synthesis of inorganic single-walled nanotubes OPEN Bing Ni, Huiling Liu, Peng-peng Wang, Jie He and Xun Wang Single walled nanotubes are promising materials for both fundamental research and advanced applications. Here, the authors develop the synthesis of four types of inorganic single walled nanotube, and show that their formation is initiated by the self-coiling of their ultrathin building blocks. 29 October 2015 | doi: 10.1038/ncomms9756 Chemical Sciences  Materials science  Nanotechnology  Physical chemistry  CCR2 defines in vivo development and homing of IL-23-driven GM-CSF-producing Th17 cells OPEN Ervin E. Kara, Duncan R. McKenzie, Cameron R. Bastow, Carly E. Gregor, Kevin A. Fenix, Abiodun D. Ogunniyi, James C. Paton, Matthias Mack, Diana R. Pombal, Cyrill Seillet, Bénédicte Dubois, Adrian Liston, Kelli P. A. MacDonald, Gabrielle T. Belz, Mark J. Smyth, Geoffrey R. Hill, Iain Comerford and Shaun R. McColl Little is known regarding migration of Th17 cells that produce distinct cytokines implicated in protection and pathology. Kara et al. show that a switch from CCR6 to CCR2 by Th17 cells defines a signature (CCR6−CCR2+) of GM-CSF+ Th17 cells and drives pathology in a mouse model of autoimmunity. 29 October 2015 | doi: 10.1038/ncomms9644 Biological Sciences  Immunology  Magnetotactic molecular architectures from self-assembly of β-peptide foldamers OPEN Sunbum Kwon, Beom Jin Kim, Hyung-Kyu Lim, Kyungtae Kang, Sung Hyun Yoo, Jintaek Gong, Eunyoung Yoon, Juno Lee, Insung S. Choi, Hyungjun Kim and Hee-Seung Lee Controlling organic materials with magnetic fields in a dynamic fashion is a challenging task. Here, the authors show that synthetic ß-peptide foldamers can be rotated at will under a dynamic magnetic field and that this can be extended to macroscopic scale objects containing these materials. 29 October 2015 | doi: 10.1038/ncomms9747 Chemical Sciences  Materials science  Organic chemistry  POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation OPEN Boshi Wang, Aihui Ma, Li Zhang, Wei-Lin Jin, Yu Qian, Guiqin Xu, Bijun Qiu, Zhaojuan Yang, Yun Liu, Qiang Xia and Yongzhong Liu The transcription factor E2F1 controls the expression of multiple genes and is frequently overactivated in cancer. Here, the authors show that E2F1 is deubiquitinated by POH1 and that this enhances the role of E2F1 in cell survival, and contributes to the pathogenesis of liver cancer. 29 October 2015 | doi: 10.1038/ncomms9704 Biological Sciences  Cancer  Cell biology  Dilp8 requires the neuronal relaxin receptor Lgr3 to couple growth to developmental timing OPEN Andres Garelli, Fabiana Heredia, Andreia P. Casimiro, Andre Macedo, Catarina Nunes, Marcia Garcez, Angela R. Mantas Dias, Yanel A. Volonte, Thomas Uhlmann, Esther Caparros, Takashi Koyama and Alisson M. Gontijo The orphan ligand Dilp8 has been shown to coordinate growth and developmental timing in Drosophila. Here, using Gal4 drivers and CRISPR/Cas9 approaches, Garelli et al. identify a role for relaxin-like receptor Lgr3 in regulating the Dilp8 developmental delay pathway. 29 October 2015 | doi: 10.1038/ncomms9732 Biological Sciences  Cell biology  Neuroscience  Stem and progenitor cell division kinetics during postnatal mouse mammary gland development OPEN Rajshekhar R. Giraddi, Mona Shehata, Mercedes Gallardo, Maria A. Blasco, Benjamin D. Simons and John Stingl The stem and progenitor populations that regulate mammary gland development are debated. Giraddi et al. use experimental and mathematical approaches to show that the three lineages of the mammary gland are maintained by their own restricted progenitors, and that cycling status links to the oestrus cycle. 29 October 2015 | doi: 10.1038/ncomms9487 Biological Sciences  Cell biology  Developmental biology  Efficient purification of ethene by an ethane-trapping metal-organic framework OPEN Pei-Qin Liao, Wei-Xiong Zhang, Jie-Peng Zhang and Xiao-Ming Chen The separation of high purity ethene from the mixed gaseous products of cracking poses significant obstacles. Here, the authors present a metal-organic framework which, in contrast to most absorbents, selectively binds the less polar ethane thus allowing the efficient collection of the target product. 29 October 2015 | doi: 10.1038/ncomms9697 Chemical Sciences  Inorganic chemistry  Materials science  Integrin-beta3 clusters recruit clathrin-mediated endocytic machinery in the absence of traction force OPEN Cheng-han Yu, Nisha Bte Mohd Rafiq, Fakun Cao, Yuhuan Zhou, Anitha Krishnasamy, Kabir Hassan Biswas, Andrea Ravasio, Zhongwen Chen, Yu-Hsiu Wang, Keiko Kawauchi, Gareth E. Jones and Michael P. Sheetz Force is known to recruit adaptor proteins to the intracellular tails of integrin extracellular matrix receptors. Here the authors show that matrix force-dependent β3 integrin signals block endocytosis by preventing the recruitment of the clathrin adaptor Dab2. 28 October 2015 | doi: 10.1038/ncomms9672 Biological Sciences  Cell biology  Torso-like mediates extracellular accumulation of Furin-cleaved Trunk to pattern the Drosophila embryo termini OPEN Travis K. Johnson, Michelle A. Henstridge, Anabel Herr, Karyn A. Moore, James C. Whisstock and Coral G. Warr Activation of the growth factor Trunk patterns the Drosophila embryonic termini but how this is regulated is unclear. Here, Johnson et al. report that Trunk is cleaved intracellularly by Furin proteases, and its extracellular accumulation is then mediated by the perforin-like protein Torso-like. 28 October 2015 | doi: 10.1038/ncomms9759 Biological Sciences  Cell biology  Developmental biology  Formation of bimetallic clusters in superfluid helium nanodroplets analysed by atomic resolution electron tomography OPEN Georg Haberfehlner, Philipp Thaler, Daniel Knez, Alexander Volk, Ferdinand Hofer, Wolfgang E. Ernst and Gerald Kothleitner Advancing electron tomography to atomic resolution is a powerful and challenging process. Here, the authors demonstrate atomic resolution electron tomography on silver-gold core-shell nanoclusters grown in superfluid helium nanodroplets, revealing their three-dimensional morphology and composition. 28 October 2015 | doi: 10.1038/ncomms9779 Physical Sciences  Materials science  Nanotechnology  Physical chemistry  Early Pliocene onset of modern Nordic Seas circulation related to ocean gateway changes OPEN Stijn De Schepper, Michael Schreck, Kristina Marie Beck, Jens Matthiessen, Kirsten Fahl and Gunn Mangerud The cause and timing of early Pliocene cooling in the Nordic Seas remains uncertain. Here, the authors present palynological data from the Norwegian and Iceland Seas that demonstrate regional cooling and the development of modern surface circulation around 4.5 Ma, likely related to Bering Strait gateway changes. 28 October 2015 | doi: 10.1038/ncomms9659 Earth Sciences  Climate science  Oceanography  Ultrafast spin exchange-coupling torque via photo-excited charge-transfer processes OPEN X. Ma, F. Fang, Q. Li, J. Zhu, Y. Yang, Y. Z. Wu, H. B. Zhao and G. Lüpke Light can provide ultrafast ways of spin manipulation in magnetic materials, but existing methods are limited by long thermal recovery or low temperature. Here, the authors demonstrate ultrafast spin precession via optical charge-transfer processes in exchange-coupled Fe/CoO at room temperature. 28 October 2015 | doi: 10.1038/ncomms9800 Physical Sciences  Condensed matter  Optical physics  Mussel adhesion is dictated by time-regulated secretion and molecular conformation of mussel adhesive proteins OPEN Luigi Petrone, Akshita Kumar, Clarinda N. Sutanto, Navinkumar J. Patil, Srinivasaraghavan Kannan, Alagappan Palaniappan, Shahrouz Amini, Bruno Zappone, Chandra Verma and Ali Miserez Interfacial water constitutes a formidable barrier to strong surface bonding, hampering the development of water-resistant synthetic adhesives. Here, the authors elucidate the precise time-regulated secretion of mussel adhesive proteins in Perna viridis, probing their surface structures and subsequent roles. 28 October 2015 | doi: 10.1038/ncomms9737 Chemical Sciences  Biochemistry  Materials science  Physical chemistry  Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes OPEN Elena Viganò, Catherine Emma Diamond, Roberto Spreafico, Akhila Balachander, Radoslaw M. Sobota and Alessandra Mortellaro Human monocytes exhibit an unconventional one-step pathway of inflammasome activation and IL-1 release in response to LPS. Here the authors show that it is mediated by caspases 4 and 5, and characterize caspase 5 cleavage, Syk and calcium signalling as key mediators of this pathway. 28 October 2015 | doi: 10.1038/ncomms9761 Biological Sciences  Immunology  Uniform yolk-shell iron sulfide–carbon nanospheres for superior sodium–iron sulfide batteries OPEN Yun-Xiao Wang, Jianping Yang, Shu-Lei Chou, Hua Kun Liu, Wei-xian Zhang, Dongyuan Zhao and Shi Xue Dou There is intensive research into the development of sodium–metal sulfide batteries. Here, the authors report a yolk-shell-like iron sulfide–carbon nanosphere structure as the cathode material which displays exceptionally high performance. 28 October 2015 | doi: 10.1038/ncomms9689 Chemical Sciences  Materials science  Nanotechnology  Influence of chemical disorder on energy dissipation and defect evolution in concentrated solid solution alloys OPEN Yanwen Zhang, G. Malcolm Stocks, Ke Jin, Chenyang Lu, Hongbin Bei, Brian C. Sales, Lumin Wang, Laurent K. Béland, Roger E. Stoller, German D. Samolyuk, Magdalena Caro, Alfredo Caro and William J. Weber The understanding of complex electronic correlation and non-equilibrium atomic interactions is a grand challenge. Here, the authors show that chemical disorder in single-phase concentrated solid solution alloys can lead to reduction in electron mean free path and electrical and thermal conductivity. 28 October 2015 | doi: 10.1038/ncomms9736 Physical Sciences  Materials science  Ndrg1 is a T-cell clonal anergy factor negatively regulated by CD28 costimulation and interleukin-2 OPEN Yu Mi Oh, Hyung Bae Park, Jae Hun Shin, Ji Eun Lee, Ha Young Park, Dhong Hyo Kho, Jun Sung Lee, Heonsik Choi, Tomohiko Okuda, Koichi Kokame, Toshiyuki Miyata, In-Hoo Kim, Seung Hoon Lee, Ronald H. Schwartz and Kyungho Choi T cell clonal anergy is mediated by Egr2 but its downstream effectors have not been characterized. Here the authors show that Egr2 activates Ndrg1, which is critical for the anergy state, while anergy-counteracting signals IL-2 or CD-28 promote Ndrg1 phosphorylation and degradation. 28 October 2015 | doi: 10.1038/ncomms9698 Biological Sciences  Immunology  Auditory feedback blocks memory benefits of cueing during sleep OPEN Thomas Schreiner, Mick Lehmann and Björn Rasch Exposure to memory cues during sleep improves subsequent memory recall. Here the authors demonstrate that presenting an additional auditory stimulus during a critical time window following the memory cue abolishes the memory benefit of cueing and its oscillatory correlates during sleep in humans. 28 October 2015 | doi: 10.1038/ncomms9729 Biological Sciences  Neuroscience  Synthesis of large-area multilayer hexagonal boron nitride for high material performance OPEN Soo Min Kim, Allen Hsu, Min Ho Park, Sang Hoon Chae, Seok Joon Yun, Joo Song Lee, Dae-Hyun Cho, Wenjing Fang, Changgu Lee, Tomás Palacios, Mildred Dresselhaus, Ki Kang Kim, Young Hee Lee and Jing Kong Multilayer h-BN films are highly desired for various applications in 2D nanoelectronics. Here, the authors demonstrate the synthesis of large-area and high-quality multi-layer h-BN films on Fe foil with high 2D material performance. 28 October 2015 | doi: 10.1038/ncomms9662 Physical Sciences  Materials science  Nanotechnology    Nature Communications JOBS of the week One PhD Position Leibniz-Institut für Polymerforschung Dresden e.V. (IPF) Staff Scientist Wellcome Trust Sanger Institute Postdoctoral Research Associate University of Texas Health Science Center at Tyler Research Associate in Primary Care University of Bristol Senior Fellow in Structural Biology Dana-Farber Cancer Institute (DFCI) Research Associate Imperial College London Research Technician King's College London Postdoctoral Research Scientist Columbia University Postdoctoral Scientist - PNAC Medical Research Council Genomics Technician Guy's and St Thomas' NHS Foundation Trust More Science jobs from Nature Communications EVENT The Alzheimer's Association International Conference 2016 24.07.16 Toronto, Canada More science events from       Latest Corrigenda     Corrigendum: The reverse evolution from multicellularity to unicellularity during carcinogenesis Han Chen, Fangqin Lin, Ke Xing and Xionglei He 29 October 2015 | doi: 10.1038/ncomms9812 Biological Sciences  Cancer  Evolution      Corrigendum: BMP signalling differentially regulates distinct haematopoietic stem cell types OPEN Mihaela Crisan, Parham Solaimani Kartalaei, Chris S. Vink, Tomoko Yamada-Inagawa, Karine Bollerot, Wilfred van IJcken, Reinier van der Linden, Susana M. Chuva de Sousa Lopes, Rui Monteiro, Christine Mummery and Elaine Dzierzak 29 October 2015 | doi: 10.1038/ncomms9793 Biological Sciences  Cell biology  Developmental biology        Latest Erratum     Erratum: Structural diversity of supercoiled DNA OPEN Rossitza N. Irobalieva, Jonathan M. Fogg, Daniel J. Catanese, Thana Sutthibutpong, Muyuan Chen, Anna K. Barker, Steven J. Ludtke, Sarah A. Harris, Michael F. Schmid, Wah Chiu and Lynn Zechiedrich 29 October 2015 | doi: 10.1038/ncomms9851 Biological Sciences  Biochemistry  Biophysics      Advertisement Nature Microbiology: Call for Papers Launching in January 2016, Nature Microbiology is now open for submissions and inviting high-quality submissions. 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